Title: A Multi-Scale Biomechanical Model of the Infant Hip to Progress Innovation in Pediatric Hip Dysplasia Rehabilitation
This proposal will be the first to experimentally and computationally assess the mechanical impact of closed reduction treatment on infants with developmental dysplasia of the hip (DDH). This novel work will enable the development of innovative pediatric rehabilitation interventions and therapies to decrease treatment duration and improve outcomes for infants.
- Aim 1 – Quantify passive and active hip mechanics of infants undergoing DDH treatment.
- Aim 2 – Evaluate mechanical loading of the healthy hip by the Pavlik harness.
- Aim 3 – Develop computational models of the infant hip undergoing closed reduction. The expected outcome of this work is a more complete understanding of how the Pavlik harness works to translate passive and active forces to the infant hip.
The results will have a positive impact because they will provide new and valid experimental data and computational models that can serve as the basis for our future investigations aimed at developing improved and innovative solutions for infants and families impacted by DDH.
Dr. Mannen has a B.S. in Mechanical Engineering, from the University of Kansas, 2009, her Ph.D. in Mechanical Engineering, from the University of Kansas, 2014 and her Postdoctoral Fellowship in Mechanical and Materials Engineering, from the University of Denver, 2017.
Dr. Mannen’s Mentors
Andrew Anderson, Ph.D. His research interests and areas of expertise include computational modeling (finite element analysis, discrete element analysis, muscle modeling), medical image analysis, clinical gait and movement analysis, clinical imaging (CT, fluoroscopy, MRI), dynamic imaging, bone and soft tissue experimental biomechanics, and statistical shape modeling.
Laura James, M.D., serves as the Director of the Translational Research Institute (TRI) and Associate Vice Chancellor for Clinical and Translational Research at the University of Arkansas for Medical Sciences (UAMS). TRI is home to the UAMS Clinical and Translational Science Award. Dr. James’ research focus at ACH is on acetaminophen toxicity and addresses the development of a rapid assay for the diagnosis of acetaminophen-related acute liver injury.
Erin Mannen was approved as leader of Project 1 on September 3, 2019, replacing Dr. Ambrogini. Dr. Mannen resigned as leader of Project 4 on July 06, 2020, to accept a position at the Boise State Mechanical & Biomedical Engineering Department, ID.