Education and Training
- B.Sc. (Biochemistry) – Hong Kong University of Science and Technology
- M.Sc. (Biotechnology) – Hong Kong University of Science and Technology
- Ph.D. (Molecular Biology/Anatomy) – University of Hong Kong
- Postdoctoral training – Yale University, MD Anderson Cancer Center, University of Texas at Austin
- DNA damage response (DDR) pathway
- Chromatin biology
- Genome stability
- Cancer Biology
- Leung JW, Makharashvili N, Agarwal P, Pourpre R, Cammarata M, Cannon J, Sherker A, Durocher D, Brodbelt J, Paull TT & Miller KM. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Genes and Development, 2017 Feb; 31:260-274.
- Huang Y, Leung JW, Lowery M, Matsushita N, Wang Y, Shen X, Huong D, Takata M, Chen J, Li L. Modularized functions of the Fanconi anemia core complex. Cell Reports. 2014 Jun 26;7(6):1849-57.
- Leung JW, Agarwal P, Canny MD, Gong, Robison AD, Finkelstein IJ, Durocher D & Miller KM. Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling. PLoS Genetics, 2014 Mar 6;10(3):e1004178.
- Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Research. 2013 Oct; 23(10):1215-28.
- Leung JW, Ghosal G, Wang W, Shen X, Li L, Chen J. Alpha thalassemia/mental retardaation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. Journal of Biological Chemistry. 2013 Mar 1;288(9):6342-50.
- Wang Y, Leung JW, Jiang Y, Lowery MG, Vasquez KM, Chen J, Wang W, Li L. FANCM and FAAP24 maintain genomic stability through cooperative as well as unique functions. Molecular Cell. 2013 Mar 7;49(5):997-1009.
- Ghosal G, Leung JW, Nair BC, Chen J. PCNA-binding protein C1orf124 is a regulator of translesion synthesis. Journal of Biological Chemistry, 2012 Oct 5;287(41):34225-33.
- Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proceeding of the National Academy of Sciences. 2012 Mar 20;109(12):4491-6 .
- Leung JW, Leitch A, Wood JL, Shaw-Smith C, Metcalfe K, Bicknell LS, Jackson AP, Chen J. SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation. Journal of Biological Chemistry. 2011 Jun 17;286(24):21393-400.
- Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Molecular Cell. 2010 Mar 26;37(6):854-64 .