• Skip to main content
  • Skip to main content
Choose which site to search.
University of Arkansas for Medical Sciences Logo University of Arkansas for Medical Sciences
College of Medicine: Department of Neurobiology and Developmental Sciences
  • UAMS Health
  • Jobs
  • Giving
  • About Us
    • Department News
    • Anatomical Gift Program
  • Faculty and Staff
    • Primary Faculty
      • Noor Akhter, Ph.D.
      • Gwen V. Childs, Ph.D.
      • David L. Davies, Ph.D.
      • Paul D. Drew, Ph.D.
      • Abdallah Hayar, Ph.D.
      • Angus M. MacNicol, Ph.D.
      • Melanie C. MacNicol, Ph.D.
      • Erica Malone, Ph.D.
      • Mark S. Mennemeier, Ph.D.
      • Angela Odle, Ph.D.
      • Kevin D. Phelan, Ph.D.
      • Laura C. Stanley, Ph.D.
      • Mohsin M. Syed, Ph.D.
    • Secondary and Adjunct Faculty
      • Steve W. Barger, Ph.D.
      • Puran S. Bora, Ph.D.
      • Yuzhi Chen, Ph.D.
      • Maxim Dobretsov, Ph.D.
      • John Dornhoffer, M.D.
      • W. Sue T. Griffin, Ph.D.
      • Linda Larson-Prior, Ph.D.
      • Sang-hun Lee, Ph.D.
      • Stacy A. Rudnicki, M.D.
    • Retired Faculty
      • Helen Beneš, Ph.D.
      • E. Robert Burns, Ph.D.
      • Jason Y. Chang, Ph.D.
      • M. Donald Cave, Ph.D.
      • Edgar Garcia-Rill, Ph.D.
      • Cynthia (Cindy) J.M. Kane, Ph.D.
      • Robert D. Skinner, Ph.D.
    • Support Staff
  • Graduate Students
    • Graduate Student News
  • Education
    • Graduate Program
    • Medical School Courses
      • Human Structure Module
        • Class Details
        • Faculty
        • Facilities
        • Anatomy Tables
    • In Memoriam: Patrick W. Tank, Ph.D.
  • Seminars
    • Seminars (Archive)
  • Outreach
    • Arkansas Big Data Science
      • Arkansas Big Data Science Teacher Workshops
        • Workshop 1: Incorporating Data Science in Middle School/Junior High Science Classrooms (In Person)
        • Workshop 2: Incorporating Data Science into Middle School/Junior High Science Classrooms (Virtual)
    • ArkanSONO
      • Anatomy & Histopathology I: Focus on Cancer Webinar Series
      • SONOcamp 2023
      • External Advisory Committee
      • ArkanSONO in the News
      • STEM Grants
      • Teacher Workshops
        • Incorporating Ultrasound and CT Imaging into Anatomy & Physiology Classrooms
    • Past Program: UAMS Partners in Health Science
  • Research Centers
    • Cellular and Molecular Neuroscience Emphasis
    • Center for Translational Neuroscience
      • About Us
        • Be a Part of the Cure
        • Contact Us
        • Distinguished Lecturer Series
        • Events
      • Core Facilities
        • Animal Electrophysiology Core
        • Human Brain Tissue Core
        • Human Electrophysiology Core
        • Imaging Core
        • Molecular Core
        • Telemedicine Core
        • Transcranial Magnetic Core
      • Faculty
      • Funding
      • Publications
      • Research
        • Research Highlights
          • Consciousness and Dreaming
          • Hyper-reflexia
          • Leptin
          • Modafinil
          • Preconscious Awareness
          • Premature Babies
          • Sleep-Wake Control
          • Telemedicine
          • Tinnitus
        • Brown Lab
        • Charlesworth Lab
        • Chen Lab
        • Dornhoffer Lab
        • Fantegrossi Lab
        • Garcia-Rill Lab
        • Hall Lab
        • Hayar Lab
        • Kaiser Lab
        • Kiser Lab
        • MacNicol Lab
        • Mancino Lab
        • Mennemeier Lab
        • Sheffer Lab
        • Skinner Lab
        • Yates Lab
    • J. Thomas May Center For ALS Research
  1. University of Arkansas for Medical Sciences
  2. College of Medicine
  3. Department of Neurobiology and Developmental Sciences
  4. Faculty and Staff
  5. Primary Faculty
  6. Angus M. MacNicol, Ph.D.

Angus M. MacNicol, Ph.D.

Angus MacNicol

Title
Professor

Ph.D.
University of London/National Institute for Medical Research

Email: Angus@uams.edu

Address:
Dept. of Neurobiology and Developmental Sciences,
and the Winthrop P. Rockefeller Cancer Institute,
University of Arkansas for Medical Sciences,
4301 W. Markham St. Slot 814,
Little Rock, AR 72205

Phone: 501-686-8164

Fax: 501-686-6517

Major Interests

Stem cells, cell cycle control and differentiation, vertebrate development, cancer biology, regulated mRNA translation, signal transduction and drug discovery

Research Interests

My research interests lie in understanding regulation of cell differentiation during both embryonic development as well as in the adult organism as it strives to maintain homeostasis or adapt to injury or changing organismal demands. We study regulation of signal transduction pathways as well as their targets within responding cells. Of late, our research has focused on control of specific mRNA translational control programs exerted by sequence-specific RNA binding proteins, including Musashi. By applying molecular biology techniques and proteomic approaches, we have sought to identify Musashi target mRNAs, elucidate the mechanism(s) by which Musashi exerts repression or activation of target mRNAs in a cell context-dependent manner and characterize the signaling pathways that control Musashi function. Our current studies seek to characterize the role of regulated mRNA translation in general, and Musashi specifically, in controlling stem cell function and cellular differentiation in the mammalian anterior pituitary gland as it adapts to meet the fluctuating hormonal needs of the body.

While stem cell self-renewal is directed and regulated at multiple levels, this process appears to be particularly sensitive to mechanisms that impinge upon the control of mRNA translation. However the co-associated factors mediating, and the molecular processes controlling, regulated mRNA translation remain poorly characterized. A better understanding of the molecular events governing regulated mRNA translation in stem cells may identify new druggable targets to enhance regeneration after injury and conversely, present new therapeutic opportunities to mitigate tumor growth or relapse after conventional treatment regimes.

Selected Publications

Link to Dr. MacNicol’s PubMed publications

UAMS College of Medicine LogoUAMS College of MedicineUniversity of Arkansas for Medical Sciences
Mailing Address: 4301 West Markham Street, Little Rock, AR 72205
Phone: (501) 686-7000
  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • LinkedIn
  • Pinterest
  • Disclaimer
  • Terms of Use
  • Privacy

© 2023 University of Arkansas for Medical Sciences