Title
Assistant Professor
Ph.D.
University of California, Los Angeles, Ph.D., 1986
Email: macnicolmelanie@uams.edu
Address:
University of Arkansas for Medical Sciences
4301 W. Markham St., Slot 510
Little Rock, AR 72205
Research Interests
We are interested in the mechanisms which control neuronal development. Specifically, we are using the PC12 cell model system to study the role of regulated mRNA translation in neuronal differentiation, cell cycle control and apoptosis. We are studying the signal transduction mechanisms which regulate mRNA translational control. Regulated mRNA translation in neurons is important for learning and memory and problems with mRNA translation may contribute to the progression of neurodegenerative disorders.
Selected Publications
- MacNicol, M.C. and MacNicol, A.M. (1999) “Nerve growth factor-stimulated B-Raf catalytic activity is refractory to inhibition by cAMP-dependent protein kinase.” J. Biol. Chem., 274, 13193-13197.
- MacNicol, M.C., Muslin, A.J. and MacNicol, A.M. (2000) “Mutation of serine 728 disrupts 14-3-3 interaction and uncouples B-Raf kinase activity from biological action.” J. Biol. Chem., 275, 3803-3809.
- Charlesworth, A., Ridge, J., King, L.A., MacNicol, M.C. and MacNicol, A.M. (2002) novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation.” EMBO J., 2798-2806.