Title
Professor Emeritus
Ph.D.
Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR
Post Doctoral Training
Dept. of Medicine, University of California, San Francisco, CA
Dept. of Dermatology, Stanford University, CA Dept. of Biological Sciences, Stanford University, CA
Email: kanecynthiaj@uams.edu
Address: Office: Biomed II, Room 560-2
Mailing address: Department of Neurobiology & Developmental Sciences
University of Arkansas for Medical Sciences
4301 W. Markham, # 846
Little Rock, AR 72205
Phone: 501-686-7022
Fax: 501-686-6382
Research Interests
Our studies focus on interactions between neurons and glia in the brain. The role of neuroprotective and neurotoxic molecules secreted by microglia and astrocytes in neuronal proliferation, survival and function is being defined. Mechanisms that control these interactions including cell-surface receptors, intracellular signal transduction pathways, and gene and protein expression are being identified. This laboratory has discovered that ethanol exposure during brain development disrupts specific interactions between microglia and neurons. Mechanistic analyses of the molecular targets of ethanol in the developing brain have led to new strategies for pharmacological intervention in the neuropathology of Fetal Alcohol Syndrome and Alcohol-Related Neurodevelopmental Disorder.
Selected Publications
- Kane, C.J.M., K.D. Phelan, L. Han, R. R. Smith, J. Xie, J.C. Douglas and P.D. Drew [2011] Protection of Neurons and Microglia Against Ethanol in a Mouse Model of Fetal Alcohol Spectrum Disorders by Peroxisome Proliferator Activated Receptor Gamma Ligands. Brain, Behavior and Immunity, 25:S137-S145, PMID 21376806
- Kane, C.J.M., K.D. Phelan and P.D. Drew [2012] Neuroimmune Mechanisms in Fetal Alcohol Spectrum Disorder. Developmental Neurobiology 72: 1302-1316, PMID 22623427, doi 10.1002/dneu.22035
- Kane, C.J.M., K.D. Phelan, J.C. Douglas, G. Wagoner, J. Johnson, J. Xu and P.D. Drew [2013] Effects of Ethanol on Immune Response in the Brain: Region-Specific Changes in Aged Mice. Journal of Neuroinflammation, 10:66, doi: 10.1186/1742-2094-10-66
- Kane, C.J.M., K.D. Phelan and P.D. Drew [2013] Molecular Targets of Ethanol in the Developing Brain. In: Biological Research on Addiction: Comprehensive Addictive Behaviors and Disorders, Volume 2, Chapter 29. Encyclopedia of Addictive Behaviors, First Edition. P. Miller, Editor-in-chief. Elsevier Inc., San Diego: Academic Press, pp. 281–290. ISBN: 9780123983350
- Drew, P.D. and C.J.M. Kane [2013] Neuroimmune Mechanisms of Glia and Their Interplay with Alcohol Exposure across the Lifespan. Neural-Immune Interactions in Brain Function and Alcohol Related Disorders, C. Cui, L. Grandison, and A. Noronha, Editors, Springer, New York, NY. pp. 359-386. doi 10.1007/978-1-4614-4729-0_11