Physiology and Cell Biology
Jesus Delgado-Calle, Ph.D.
Grants that have been awarded or will be awarded, from July 2022 throughout 2028
- 4/1/2023-3/31/2028: P20GM125503 (NIH/NIGMS). P.I.: O’Brien.
Title: Center for Musculoskeletal Disease Research (CMDR).
Role: Core Director, Bone Imaging Core. Cal. 1.8. ($100,000 direct costs/yr) - 7/01/2023-06/30/2028: R01CA209882 (NIH/NCI). MPI: Delgado-Calle, Bellido. Title: Contribution of osteocytes to the musculoskeletal effects of Multiple Myeloma.Role: contact PI. Cal. 2.4 ($293,900,922 direct costs/yr)
- 11/15/2022-11/14/2023: Pilot Award (UAMS Musculoskeletal Hub).
Title: Role of Extrachromosomal DNA in Bone.
Role: PI, Nookaew co-PI. Cal. 0.0. ($20,000 direct costs/yr) - 03/01/2023-02/29/2024: Seeds of Sciences (UAMS Cancer Institute).
Title: Characterization of the Senescent Secretome of the Bone Metastatic Tumor Niche Role: PI. Cal. 0.0. ($50,000 direct costs/year)
Manuscripts published during the same period
- Doubling Down on Wnt Signaling to Overcome Myeloma Bone Disease.
Delgado-Calle J, Roodman GD. J Bone Miner Res. 2023 Jun;38(6):812-813. doi: 10.1002/jbmr.4863. Epub 2023 Jun 5. PMID: 37277117 - Osteocytes: New Kids on the Block for Cancer in Bone Therapy.
Anloague A, Delgado-Calle J. Cancers (Basel). 2023 May 7;15(9):2645. doi: 10.3390/cancers15092645. PMID: 37174109 - Editorial: The role of the bone marrow microenvironment in multiple myeloma evolution and therapy.
Schinke C, Weinhold N, Delgado-Calle J. Front Oncol. 2023 Feb 21;13:1157555. doi: 10.3389/fonc.2023.1157555. eCollection 2023. PMID: 36895479 - CReSIL: accurate identification of extrachromosomal circular DNA from long-read sequences. Wanchai V, Jenjaroenpun P, Leangapichart T, Arrey G, Burnham CM, Tümmler MC, Delgado-Calle J, Regenberg B, Nookaew I. Brief Bioinform. 2022 Nov 19;23(6):bbac422. doi: 10.1093/bib/bbac422. PMID: 36198068
- Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction.
Sabol HM, Amorim T, Ashby C, Halladay D, Anderson J, Cregor M, Sweet M, Nookaew I, Kurihara N, Roodman GD, Bellido T, Delgado-Calle J. Neoplasia. 2022 Jun;28:100785. doi: 10.1016/j.neo.2022.100785. Epub 2022 Apr 4. PMID: 35390742
Abstracts submitted to the ORS MSK Workshop which will take place in Midway, Utah, July 2023 or to the 2023 ASBMR annual meeting in Vancouver.
- Bimodal Bone-Targeted Therapy Repairs Damage Bone and Overcomes Drug Resistance in Multiple Myeloma. Hayley M. Sabol, Manish Adhikari, Aric Anloague, Japneet Kaur, Sharmin Khan, Michaela Palmier, Lawry Barnes, Elena Ambrogini,Venkatesan Srinivasan, Alison Frontier, Frank H. Ebetino, Jesus Delgado-Calle. ASBMR annual meeting.
- Osteocytes Induce Drug Resistance via the NOTCH3-CXCL12 Signaling Axis in Multiple Myeloma. Hayley M. Sabol, Cody Ashby, Manish Adhikari, Japneet Kaur, Aric Anloague, Sharmin Khan, Samrat Roy Chodhury, Michaela Palmieri, Lawry Barnes, Elena Ambrogini, Carolina Schinke, Intawat Nookaew, and Jesus Delgado-Calle. ASBMR annual meeting.
- Metastatic Breast Cancer Cells Induce Osteocyte Senescence Contributing to Osteolytic Bone Destruction. Kaur J, Adhikari M, Sabol HM, Anloague A, Khan S, Barnes L, Stambough JB, Palmieri M, Reyes-Castro O, Ambrogini E, Almeida M, O’Brien CA, Nookaew I, Delgado-Calle J. ASBMR annual meeting.
- The MIP-1α/HMGB1 Signaling Axis Regulates Osteocyte RANKL expression in Multiple Myeloma. Anloague A, Adhikari M, Sabol HM1, Khan S, Roodman GD, Bellido T, and Delgado-Calle J. ASBMR annual meeting.
- Extrachromosomal circular DNA is produced by bone cells and may regulate cellular and molecular events during physiological and pathological bone remodeling. Alongkorn Kurilung, Pratomporn Krangvichian, Manish Adhikari, Michela Palmieri, Elena Embrogini, Jesus Delgado-Calle, Intawat Nookaew. ASBMR annual meeting.
- Bidirectional notch signaling in osteocytes and myeloma cells. Jesus Delgado-Calle. ASBMR pre-meeting. Invited speaker.
- Clinical Updates and Uncertainties in Bone Targeted Therapies and Cancer. Jesus Delgado-Calle. ASBMR annual meeting. Invited speaker.
- A Novel Multimodal Bone-Targeted Combination Therapy Repairs Damaged Bone in Mice with Established Myeloma Disease. Hayley M. Sabol, Manish Adhikari, Aric Anloague, Japneet Kaur, Sharmin Khan, Venkatesan Srinivasan, Alison Frontier, Frank H. Ebetino, Jesus Delgado-Calle. ORS MSK meeting. Harold Frost Award
- Impact of bone-targeted therapies on bone health. Jesus Delgado-Calle. ORS MSK meeting. Invited speaker.
Melda Onal, Ph.D.
Grants awarded 2024
- Loss of chaperone-mediated autophagy does not alter age-related bone loss in male mice.
Hendrixson JA, James A, Akel NS, Laster DJ, Crawford JA, Berryhill SB, Onal M.FASEB Bioadv. 2024 Feb 20;6(3):73-84. doi: 10.1096/fba.2023-00133. eCollection 2024 Mar.PMID: 38463697
Grants that have been awarded or will be awarded, from July 2022 throughout 2023
- 4/01/2023: NIH/NIGMS (Onal Project Leader, PI grant O’Brien),to 7/1/2024P20GM125503, Phase 2, $280,000 for direct costs
“The Role of Autophagy in Bone Remodeling.”
Manuscripts published during the same period:
- Akel N., MacLeod R.S., Berryhill S.B., Dimori M., Crawford J.A., Fu Q. and Onal M. Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass. Scientific Reports 2022 Feb 24;12(1):3134. doi: 10.1038/s41598-022-07157-9.
- Cassidy A., Onal M. and Pelletier S. Novel methods for the generation of genetically engineered animal models. Bone. 2023 Feb;167:116612. doi: 10.1016/j.bone.2022.116612. Epub 2022 Nov 13. PMID: 36379415
- Laster D.J., Akel N.S., Hendrixson J.A., James A., Crawford J.A., Fu Q., Berryhill S.B., Thostenson J.D., Nookew I., O’Brien C.A., and Onal M. CRISPR interference provides increased cell type-specificity for loss of function studies compared to the Cre-loxP System. Under review in iScience
- Abstracts submitted to the ORS MSK Workshop which will take place in Midway, Utah, July 2023 or to the 2023 ASBMR annual meeting in Vancouver.
ORS:
- In vivo induction of Tfeb, a master regulator of autophagy and lysosomal biogenesis, via CRISPR activation increases cortical thickness and strength in young adult mice. Alicen W. James, James Hendrixson, Ilham Kadhim, Jacob Laster, Stuart Berryhill, Julie Crawford, Amy Sato, Charles A. O’Brien, and Melda Onal.
ASBMR:
- In vivo stimulation of Tfeb, a master regulator of autophagy and lysosomal biogenesis, via in vivo CRISPR activation increases bone mass and strength. Alicen W. James, James Hendrixson, Ilham Kadhim, Jacob Laster, Stuart Berryhill, Julie Crawford, Amy Sato, Charles A. O’Brien, and Melda Onal
- Lack of osteoblast lineage autophagy does not alter the response to mechanical load. James Hendrixson, Robert Shaver, Alicen W. James, Jacob Laster, Julie Crawford, Jinhu Xiong and Melda Onal
Roy Morello, Ph.D.
Grants that have been awarded or will be awarded, from July 2022 throughout 2024
- 07/01/2022 – 06/30/2024: IA-941372 Innovation Award PI: Morello, R
$75,000/year 1.2 cal. Mths American Lung Association - 07/01/23 – 06/30/27: 1 R01 HL166748-01 PI: Morello, R
$1,536,059 total with indirect cost 3 cal. mths. NIH/NHLBI
Manuscripts published during the same period
- Dimori M, Fett J, Leikin S, Otsuru S, Thostenson JD, Carroll JL, Morello R: Distinct type I collagen alterations cause intrinsic lung and respiratory defects of variable severity in mouse models of osteogenesis imperfecta.J Physiology, published October 26, 2022. https://doi.org/10.1113/JP283452
- Esteban-Lopez M, Wilson KJ, Myhr C, Kaftanovskaya EM, Henderson MJ, Southall NT, Xu X, Wang A, Hu X, Barnaeva E, Ye W, George ER, Sherrill JT, Ferrer M, Morello R, Agoulnik IU, Marugan JJ, Agoulnik AA: Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2. Commun. Biol, published November 04, 2022
- Warren A, Porter RM, Reyes-Castro O, Ali M, Marques-Carvalho A, Kim H, Gatrell LB, Schipani E, Nookaew I, O’Brien CA, Morello R, Almeida M: The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development. Nat Comm, 2023 IN PRESS
- Dimori M, Pokrovskaya ID, Liu S, Sherrill JT, Gomez-Acevedo H, Fu Q, Storrie B, Lupashin V, Morello R: A Rab33b missense mouse model for Smith-McCort dysplasia shows bone resorption defects and altered protein glycosylation. Front Genet. 2023 (section Genetics of Common and Rare Diseases) IN PRESS
Abstracts submitted to the ORS MSK Workshop which will take place in Midway, Utah, July 2023 or to the 2023 ASBMR annual meeting in Vancouver.
ASBMR 2023 abstract:
- Title: Generation of a Col1a1 conditional knock-in mouse model for the study of osteogenesis imperfecta
- Authors: Roy Morello, Milena Dimori, Charles O’Brien
- Several mouse models are available to study the pathophysiology of osteogenesis imperfecta (OI). Some of these have been genetically modified to introduce a mutation in Col1a1 or Col1a2 to mimic classic dominant OI while others, carrying mutations in other genes, are mimicking rarer, recessive forms of the disease. While these models have been very useful to better understand the disease, they express the underlying mutation in all tissues and thus prevent the study of its potential effects in a tissue-specific manner. To address this important limitation, we designed the first conditional knock-in allele for Col1a1 and generated mice that express the p.Gly1146Arg mutation, known to cause severe OI in human subjects, but only after Cre-specific recombination of the floxed allele. To validate our design we then crossed our Col1a1Gly1146Arg-Floxed/+ mice with the EIIA-Cre mouse strain to verify that offspring with global expression of the mutation exhibit an OI phenotype. Analysis of mice from several litters at 9 weeks of age revealed the presence of runted mice that upon genotyping harbored the recombined allele, Col1a1Gly1146Arg-Floxed/+;EIIA-Cre+. By digital X-ray these mice showed multiple fractures, including bilateral pelvic fractures and severe kypo-scoliosis. Both DEXA and microCT analysis showed severely reduced BMD and BMC, with dramatic reduction of trabecular bone and thinning of cortical bone. Importantly, these mice also showed severe morphological lung defects, confirming our findings in other OI mouse models. In conclusion, we successfully generated a conditional knock-in allele for Col1a1 and verified that its global expression using EIIA-Cre mice causes severe OI. We are breeding these mice with mice expressing Cre in all lung fibroblasts to assess the role of an OI mutation on respiratory function in the context of a healthy skeleton, and with mice expressing Cre in osteocytes to determine whether osteocytes play a significant role in OI disease manifestations compared to osteoblasts. We will also use these mice to study the impact of a severe type I collagen mutation in other tissues as well as during different developmental time points using an inducible Cre.
Amy Sato, Ph.D.
Grants that have been awarded or will be awarded, from July 2022 throughout 2023
- National Center for Advancing Translational Sciences of the National Institutes of Health.
- 7/1/2022-6/30/2024 KL2TR003108 and UL1TR003107. Translational Research Institute (TRI), KL2 Mentored Research Career Development Scholar Awards, College of Medicine (COM) UAMS, $119,875/yr
- Role: PI
- Directors: Arthur, J. M.D., Ph.D.; Borsheim, E. Ph.D.; Greene, C. Ph.D.,
Goal: The goal of this project is to identify cardioprotective mechanisms and novel targets for therapeutic intervention in the context of glucocorticoid-induced cardiovascular disease.
Manuscripts published during the same period
- Marino S, Akel N, Li S, Cregor M, Jones M, Perez B, Troncoso G, Meeks J, Stuart S, Sato AY, Nookaew I, Bellido T. 2023. Reversal of the diabetic bone signature with anabolic therapies in mice. Bone Research. 11(1):19. doi: 10.1038/s41413-023-00261-0. PubMed PMID: 37076478; PubMed Central PMCID: PMC10115794. https://doi.org/10.1038/s41413-023
- Clark A, Ghatak S, Guda PR, El Masry MS, Xuan Y, Sato AY, Bellido T, Sen CK. 2022. Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss. NPJ Regenerative Medicine. 7(1):63. doi: 10.1038/s41536-022-00259-y. PubMed PMID: 36266362; PubMed Central PMCID: PMC9585072. https://doi.org/10.1038/s41536-022-00259-y
Center for MSK Disease Research COBRE (CMDR)
Ha-neui Kim, Ph.D.
Grants:
- NIH/NIAMS R01 AR080736, ‘Role of Mitochondrial Quality Control in Bone Homeostasis and Disease’, Role: PI
Manuscripts published:
- Warren A, Porter RM, Reyes-Castro O, Ali MM, Marques-Carvalho A, Kim HN, Gatrell LB, Schipani E, Nookaew I, O’Brien CA, Morello R, Almeida M. The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice. Nat Commun. 2023 Jun 17;14(1):3616. doi: 10.1038/s41467-023-39392-7. PMID: 37330524.
- Marques-Carvalho A, Sardão VA, Kim HN, Almeida M. ECSIT is essential for RANKL-induced stimulation of mitochondria in osteoclasts and a target for the anti-osteoclastogenic effects of estrogens. Front Endocrinol (Lausanne). 2023 Apr 20;14:1110369. doi: 10.3389/fendo.2023.1110369. eCollection 2023. PMID: 37152948.
- Marques-Carvalho A, Kim HN, Almeida M. The role of reactive oxygen species in bone cell physiology and pathophysiology, Bone Reports, 2023, 101664, https://doi.org/10.1016/j.bonr.2023.101664.
- Wang X, Shao L, Richardson KK, Ling W, Warren A, Krager K, Aykin-Burns N, Hromas R, Zhou D, Almeida M, Kim HN. Hematopoietic Cytoplasmic Adaptor Protein Hem1 Promotes Osteoclast Fusion and Bone Resorption in Mice. J Biol Chem 2023 Feb;299(2):102841. doi: 10.1016/j.jbc.2022.102841. Epub 2022 Dec 24. PMID: 36574841.
- Li X, Kordsmeier J, Nookaew I, Kim HN, Xiong J. Piezo1 stimulates mitochondrial function via cAMP signaling. FASEB J. 2022, Oct;36(10):e22519. doi: 10.1096/fj.202200300R. PMID: 36052712.
ASMBR Abstracts 2023:
- Adriana Marques-Carvalho, Kimberly K. Richardson, Aaron Warren, Maria Almeida, Ha-Neui Kim. Attenuation of NAD+ Metabolism in Osteoclasts Contributes to the Bone Protective Effects of Estrogens.
- Kimberly K. Richardson, Aaron Warren, Maria Almeida, Ha-Neui Kim. Deletion of the Mitochondrial Kinase PINK1 Does Not Affect Age-Related Bone Loss
Maria Schuller De Almeida, Ph.D.
- Piezo1 opposes age-associated cortical bone loss.
Li X, Zhang C, Bowman HH, Stambough JB, Stronach BM, Mears SC, Barnes LC, Ambrogini E, Xiong J.Aging Cell. 2023 May 5:e13846. doi: 10.1111/acel.13846. Online ahead of print.PMID: 37147884 Free article.
- Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass.
Palmieri M, Joseph TE, O’Brien CA, Gomez-Acevedo H, Kim HN, Manolagas SC, Ambrogini E.Bone. 2023 May;170:116702. doi: 10.1016/j.bone.2023.116702. Epub 2023 Feb 10.PMID: 36773885 Free PMC article.
ASBMR Abstracts
- Wnt10b is required for the bone anabolic effect of a natural antibody that blocks oxidized phospholipids.Michela Palmieri1, Intawat Nookaew2, Maria Almeida1, Ha-Neui Kim1, Teenamol E. Joseph1, Stavros C. Manolagas1,Charles O’Brien1, and Elena Ambrogini1.
- RANKL and OPG mRNA are produced by separate cell populations in murine and human bone Cecile Bustamante-Gomez, Humberto Reyes-Pardo, Melda Onal, Michela Palmieri, C. Lowry Barnes, Jeffrey Stambough, Jinhu Xiong, Elena Ambrogini and Charles A. O’Brien
- Bimodal Bone-Targeted Therapy Repairs Damage Bone and Overcomes Drug Resistance in Multiple Myeloma Hayley M. Sabol1, Manish Adhikari1, Aric Anloague1, Japneet Kaur1, Sharmin Khan1, Michaela Palmier2, C. Lowry Barnes3, Elena Ambrogini2,Venkatesan Srinivasan4, Amy Sato1, Alison Frontier4, Frank H. Ebetino4,5 Jesus Delgado-Calle
- Metastatic Breast Cancer Cells Induce Osteocyte Senescence Contributing to Osteolytic Bone Destruction.
Kaur J1, Adhikari M1, Sabol HM1, Anloague A1, Khan S1, Barnes CL2, Stambough JB2, Palmieri M3, Reyes-Castro O3, Ambrogini E3, Almeida M3, O’Brien CA3, Nookaew I4,5, Delgado-Calle J1,5. - A NOTCH3-CXCL12 Driven Myeloma-Osteocyte Signaling Axis confers Drug Resistance to Multiple Myeloma Cells Hayley M. Sabol1, Cody Ashby2,7, Manish Adhikari1, Japneet Kaur1, Aric Anloague1, Sharmin Khan1, Samrat Roy Chodhury5,7, Michaela Palmieri3, C. Lowry Barnes4, Elena Ambrogini3, Carolina Schinke6,7, Intawat Nookaew2,7, and Jesus Delgado-Calle1,7
- Extrachromosomal circular DNA is produced by bone cells and may regulate cellular and molecular events during physiological and pathological bone remodeling. Alongkorn Kurilung1,2, Pratomporn Krangvichian2, Manish Adhikari3, Michela Palmieri1,4, C. Lowry Barnes5, Simon C Mears5, Jeffrey B Stambough5, Benjamin Stronach5, Elena Embrogini1,4, Jesus Delgado-Calle1,3,56, Intawat Nookaew1,2,3
Orthopedics and Sports Medicine
David Bumpass, M.D.
- Dastagirzada YM, Alexiades NG, Kurland DB, Anderson SN, Brockmeyer DL, Bumpass DB, Chatterjee S, Groves ML, Hankinson TC, Harter D, Hedequist D, Jea A, Leonard JR, Martin JE, Oetgen ME, Pahys J, Rozzelle C, Strahle JM, Thompson D, Yaszay B, Anderson RCE. Developing consensus for the management of pediatric cervical spine disorders and stabilization: a modified Delphi study. J Neurosurg Pediatr. 2022 Oct 28:1-11. doi: 10.3171/2022.9.PEDS22319. Epub ahead of print. PMID: 36308472.
- Dalal SS, Dupree DA, Samuel AM, Vaishnav AS, Gang CH, Qureshi SA, Bumpass DB, Overley SC. Reoperations after primary and revision lumbar discectomy: study of a national-level cohort with eight years follow-up. Spine J. 2022 Dec;22(12):1983-1989. doi: 10.1016/j.spinee.2022.06.005. Epub 2022 Jun 18. PMID: 35724809.
- Dr. David Bumpass publications in PubMed
- Dr. David Bumpass publications in Research Gate
ADULT RECONSTRUCTION
C. Lowry Barnes, MD
- Burke JF, Quinlan ND, Werner BC, Barnes CL, Browne JA. Osteopetrosis is Associated With an Increased Risk for Intraoperative Periprosthetic Fracture in Total Hip Arthroplasty but not in Total Knee Arthroplasty. J Arthroplasty. 2022 Aug 13:S0883-5403(22)00773-2. doi: 10.1016/j.arth.2022.08.016. Epub ahead of print. PMID: 35973574.
- Sustich SJ, Stronach BM, Stambough JB, Barnes CL, Mears SC. Considerations in the Sickle Cell Patient Undergoing Hip Reconstructive Surgery. Orthop Clin North Am. 2022 Oct;53(4):421-430. doi: 10.1016/j.ocl.2022.06.006. Epub 2022 Sep 14. PMID: 36208885.
- Drummer DJ, Lavin KM, Graham ZA, O’Bryan SM, McAdam JS, Lixandrão ME, Seay R, Aban I, Siegel HJ, Ghanem E, Singh JA, Bonfitto A, Antone J, Reiman R, Hutchins E, Van Keuren-Jensen K, Schutzler SE, Barnes CL, Ferrando AA, Bridges SL Jr, Bamman MM. Muscle transcriptomic circuits linked to periarticular physiology in end-stage osteoarthritis. Physiol Genomics. 2022 Dec 1;54(12):501-513. doi: 10.1152/physiolgenomics.00092.2022. Epub 2022 Oct 24. PMID: 36278270.
- Pruitt BP, Mears SC, Apple AE, Stambough JB, Barnes CL, Stronach BM. Catastrophic Trunnion Failure in an Anatomic Titanium Alloy Stem. Geriatr Orthop Surg Rehabil. 2022 Nov 28;13:21514593221142726. doi: 10.1177/21514593221142726. PMID: 36465993; PMCID: PMC9709190.
- Kinder KD, Apple AE, Barnes CL, Stronach BM, Mears SC, Stambough JB. Articulating Knee Spacers in the Treatment of Periprosthetic Joint Infection: All Polyethylene Tibia or Tibial Insert? J Arthroplasty. 2023 Mar 5:S0883-5403(23)00210-3. doi: 10.1016/j.arth.2023.02.079. Epub ahead of print. PMID: 36878440.
- Anderson JT, McLeod CB, Anderson LA, Pelt CE, Gililland JM, Peters CL, Stronach BM, Barnes CL, Mears SC, Stambough JB. Extensor Mechanism Disruption Remains a Challenging Problem. J Arthroplasty. 2023 Mar 29:S0883-5403(23)00317-0. doi: 10.1016/j.arth.2023.03.067. Epub ahead of print. PMID: 37001620.
SPINE
David B. Bumpass, MD
- Dastagirzada YM, Alexiades NG, Kurland DB, Anderson SN, Brockmeyer DL, Bumpass DB, Chatterjee S, Groves ML, Hankinson TC, Harter D, Hedequist D, Jea A, Leonard JR, Martin JE, Oetgen ME, Pahys J, Rozzelle C, Strahle JM, Thompson D, Yaszay B, Anderson RCE. Developing consensus for the management of pediatric cervical spine disorders and stabilization: a modified Delphi study. J Neurosurg Pediatr. 2022 Oct 28:1-11. doi: 10.3171/2022.9.PEDS22319. Epub ahead of print. PMID: 36308472.
- Dalal SS, Dupree DA, Samuel AM, Vaishnav AS, Gang CH, Qureshi SA, Bumpass DB, Overley SC. Reoperations after primary and revision lumbar discectomy: study of a national-level cohort with eight years follow-up. Spine J. 2022 Dec;22(12):1983-1989. doi: 10.1016/j.spinee.2022.06.005. Epub 2022 Jun 18. PMID: 35724809.
GRANTS
- Patrick O’Brien, MD PGY-3 Resident (as of July 1, current PGY-2) received a $6,000 Multi-purpose Residency Grant from Mid-America Orthopaedic Association to support his study, “Total Knee Under Tourniquet (TUT): The Effect of Tourniquet Use on Muscle Recovery after Total Knee Replacement.” The faculty PI for this study is Benjamin Stronach, MD.
- C. Lowry Barnes, MD received a VCRI (Vice Chancellor for Research & Innovation) Equipment Award for $27,000 to fund the purchase of an instrumented staircase with force plates to further orthopaedic research at the off-campus UAMS Biomechanics Lab.
- Samuel C. Overley, MD received a $50,000 grant from Medtronic to support the adult spine surgery fellowship.
- Samuel C. Overley, MD received an AO SNA (Spine North America) education award to fund 2 educational trips for the adult spine fellow and faculty sponsor.
ABSTRACTS
- Jinhu Xiong, PhD submitted an abstract titled “A novel periosteal cell type, identified by single cell RNA sequencing, senses mechanical loading and in response to it differentiates into osteoblasts” to ORS MSK.
Cancer Institute
Fenghuang Zhan, Ph.D.
Publications
- Sun F, Cheng Y, Chen JR, Wanchai V, Mery D, Xu H, Gai D, Hadidi S, Schinke C, Thanendrarajan S, Zangari M, van Rhee F, Bishop G, Tricot G, Shaughnessy J, Zhan F. BCMA-CAR-T Cells Secreting CST6 Lyse Tumor Cells and Suppress Osteolytic Lesions in Multiple Myeloma. JCI (In press).
- Sun F, Cheng Y, Ying J, Mery D, Hadidi S, Wanchai V, Siegel E, Gai D, Ashby C, Bailey C,Chen JR, Schinke C, Thanendrarajan S, Zangari M, Janz S,Barlogie B, van Rhee F, Janz S, Tricot G, Shaughnessy J, Zhan F. A Gene Signature Can Predict Risk of MGUS Progressing to Multiple Myeloma. JHO (In press). Xu L, Wang Y, Wang G, Guo S, Yu D, Feng Q, Hu K, Chen G,
- Li B, Xu Z, Jia X, Zhan F, Zhu W, Shi J. Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma. Leukemia. 2023 May.
- Za’nouneh F, Ababneh O, Schinke C, Thanendrarajan S, Zangari M, Shaughnessy J, Zhan F, Van Rhee F, Hadidi S. Variability of definition of high‐risk multiple myeloma across phase III clinical trials. eJhaem. 2023 March.
- Mazahreh F, Mazahreh L, Schinke C, Thanendrarajan S, Zangari M, Shaughnessy J, Zhan F, Van Rhee F, Hadidi S. Risk of infections associated with the use of bispecific antibodies in multiple myeloma: a pooled analysis. Blood Adv. 2023 March 1; PMID: 36857755.
- Thalambedu N, Ogunsesan Y, Sethi J, Hussain M, Yarlagagga L, Gundarlapalli S, Hadidi S, Thanendrarajan S, Zangari M, Spencer H, Bailey C, Shaughnessy J, Zhan F, Rico J, Van Rhee F, Schinke C. Immunogenicity of Covid-19 Vaccine Among Multiple Myeloma Patients Post Autologous Stem Cell Transplant. Transplantation and Cellular Therapy. 2023 February.
- Choudhury S, Byrum S, Alkam D, Ashby C, Zhan F, Tackett A, van Rhee F. Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics. Clin Epigenetics. 2023 Feb 4;15(1):18. doi: 10.1186/s13148-023-01433-9. PMID: 36737807; PMCID: PMC9898982.
- Bloedjes T, Wilde G, Khan G, Ashby T, Shaughnessy J, Zhan F, Houtkooper R, Bende R, Noesel C, Spaargaren M, Guikema J. AKT supports the metabolic fitness of multiple myeloma cells by restricting FOXO activity. Blood Adv.2022 Nov 2; DOI: 10.1182/bloodadvances.2022007383. PMID: 36322819.
- Fahmawi S, Schinke C, Zangari M, Thanendrarajan S, Shaughnessy J, Zhan F, Van Rhee F, Hadidi S. Under-Representation of Black Patients with Multiple Myeloma in Studies Supporting International Myeloma Working Group Guidelines. Blood Volume 140, Issue Supplement 1.2022 Nov 15; DOI: 10.1182/blood-2022– 158346.
- AI-Zawahreh H, Schinke C, Thanendrarajan S, Zangari M, Zhan F, Shaughnessy J, Van Rhee F, Hadidi S. Clinical Research Focused on Supportive Care in Multiple Myeloma: A Cross Sectional Analysis. Blood Volume 140, Issue Supplement 1.2022 Nov 15; DOI: 10.1182/blood-2022-159652.
- Gai D, Chen JR, Stewart J, Nookaew I, Habelhah H, Ashby T, Sun F, Cheng Y, Li C, Xu H, Peng B, Gary T, Schinke C, Thanendrarajan S, Zangari M, Chen F, Barlogie B, Van Rhee F, Tricot G, Shaughnessy J, Zhan F*. CST6 suppresses