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Department of Biochemistry and Molecular Biology: Summer Research

SURF Related Publications

Although 10 weeks is not a long time in terms of research, there are SURF students who are able to produce enough work to achieve authorship on manuscripts. Here is a sampling of SURF-related publications. The students are highlighted in bold.

  • Barnette, DA, Johnson, B, Pouncey, DL, Nshimiyimana, R, Desrochers, LP, Goodwin, TE, Miller, GP (2018) Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases, Drug Metab Dispos 45, 1000-1007. PMID: 29543105. PMC5539582
  • Pouncey, DL, Hartman, JH, Moore, PC, Dillinger, DJ, Dickerson, KW, Sappington, DR, Smith 3rd, ES, Kodell, RL, Boysen, G, Miller, GP (2018) Novel Isomeric Metabolite Profiles Correlate with Warfarin Metabolism Phenotype during Maintenance Dosing in a Pilot Study of 29 Patients, Blood Coagul Fibrinolysis 29, 602-612. PMID30334816
  • Barnette, DA, Davis, MA, Dang, NL, Pidugu, AS, Hughes, T, Swamidass, SH, Boysen, G, Miller, GP (2018) Lamisil (terbinafine) Toxicity:  Determining pathways to bioactivation through computational and experimental approaches, Biochem Pharmacol 156, 10-21. PMC6188815
  • Davis, MA, Barnette, DA, Flynn NR, Pidugu, AS, Swamidass, SH, Boysen, G, Miller, GP (2019) CYP2C19 and 3A4 dominate metabolic clearance and bioactivation of terbinafine based on computational and experimental approaches, Chem Res Toxicol 32, 1151-1164. PMC6692898
  • Barnette, DA, Davis, MA, Flynn, N, Pidugu, AS, Swamidass, SH, Boysen, G, Miller, GP (2019) Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation, Biochem Pharmacol 170, 113661. PMC6905088
  • Barnette, DA, Davis, MA, Osborn, L, Flynn, N, Matlock, M, Swamidass, SJ, Miller, GP (2020) Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam, Toxicol 44, 152478. PMC8716319
  • Pinson, AO, Pouncey, DL, Schleiff, MA, Fantegrossi, WE, Prather, PL, Radominska-Pandya, A, Boysen, G, Miller, GP (2020) Significance of Competing Metabolic Pathways for 5F-APINACA Based on Quantitative Kinetics, Molecules 25, 4820. PMCID: PMC7587938
  • Schleiff, MA, Flynn, NR, Payakachat, S, Schleiff, BM, Pinson, AO, Province, DW, Swamidass, SJ, Boysen, G, Miller, GP (2021) Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics, Drug Metab Dispos 49, 133-141. PMCID: PMC7841419
  • Schleiff, MA, Payakachat, S, Schleiff, BM, Swamidass, SJ, Boysen, G, Miller, GP (2021) Impacts of diphenylamine NSAID halogenation on bioactivation risks, Toxicology 458, 152832. PMID: 34107285
  • Pouncey, DL, Barnette, DA, Sinnott, RW, Phillips, SJ, Flynn, NR, Hendrickson, HP, Swamidass, SJ, Miller, GP (2022) Discovery of Novel Reductive Elimination Pathway for 10-Hydroxywarfarin, Front Pharmacol 12, 805133. PMC8793337
  • Jun S-R, Boerma M, Udaondo Z, Richardson S, Thrall KD, Miousse IR, Seng J, Pathak R, Hauer-Jensen M. (2021) “Plasma metabolomics in a nonhuman primate model of abdominal radiation exposure.” Metabolites 11:540
  • Bostian, AC, Maddukuri, L, Reed, MR, Savenka, T, Hartman, JH, Davis, LE, Pouncey, DL, Miller, GP, Eoff, RL (2015) “Kynurenine signaling increases DNA polymerase kappa expression and promotes genomic instability in glioblastoma cells” Chem Res Tox, (2016) 29:101-8
  • Hartman, JH, Martin, HC, Caro, AA, Pearce AR, Miller, GP (2015) “Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates,” Toxicol 338:47-58.
  • Hartman, JH, Miller, GP, Boysen, G (2014) “Inhibitory Potency of 4-Carbon Alkanes and Alkenes toward CYP2E1 Activity,” Toxicol, 318:51-8.
  • Pugh, CP, Pouncey, DL, Hartman, JH, Nshimiyimana, R, Desrochers, LP, Goodwin, TE, Boysen G, Miller, GP (2014) “Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites,” Arch Biochem Biophys 564:244-53
  • Kovak MR, Saraswati S., Goddard, SD, Diekman AB (2013) Proteomic identification of galectin-3 binding ligands and characterization of galectin-3 proteolytic cleavage in human prostasomes. Andrology 1: 682-691. DOI: 10.1111/j.2047-2927.2013.00099.x.
  • Pawlowska, M, Chu, R, Fedejko-Kap, B, Augustin, E, Mazerska, Z, Radominska-Pandya, A, Chambers, TC. (2013) “Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.” Drug Metab Dispos 41:414-21.
  • Pianalto,KM, Hartman, JH, Boysen, G, Miller, GP (2013) “Differences in Butadiene Adduct Formation between Rats and Mice Not Due to Selective Inhibition of CYP2E1 by Butadiene Metabolites,” Toxicol Lett 223, 221-227. PMC3831829
  • Hartman, JH, Knott, AK, Miller GP (2013) “CYP2E1 Hydroxylation of Aniline Involves Negative Cooperativity,” Biochem Pharmacol 87, 523-33. PMID24345333
  • Byrum SD, Larson SK, Avaritt NL, Moreland LE, Mackintosh SG, Cheung W, Tackett AJ (2013) Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma. J Proteomics Bioinform, 6 (3), 43-50.
  • Hartman, JH, Bradley, AM, Laddusaw, RM, Perry Jr, MD, Miller, GP (2013) “Structure of Pyrazole Derivatives Impact their Affinity, Stoichiometry, and Cooperative Interactions for CYP2E1 Complexes.” Arch Biochem Biophys 537, 12-20. PMC3781954
  • Byrum, S, Smart, SK, Larson, SK, and Tackett, AJ (2012) Analysis of Stable and Transient Protein-Protein Interactions. Methods in Mol Biol, 833, 143-52.
  • Hartman, JH, Boysen, G, Miller, GP, (2012) “CYP2E1 Metabolism of Styrene Involves Allostery,” Drug Metab Dispos, 40:1976-83.
  • Ketkar A, Zafar MK, Banerjee S, Marquez VE, Egli M, Eoff RL (2012) A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota. J. Am. Chem. Soc. 2012 Jun 27;134(25): 10698-705. Epub 2012 Jun 14
  • Jones DR, Kim SY, Guderyon M, Yun CH, Moran JH, Miller GP (2010) Hydroxywarfarin metabolites potently inhibit CYP2C9 metabolism of S-warfarin. Chem Res Toxicol. 2010 May 17;23(5):939-45.  [Abstract]
  • Elbein, AD, Pastuszak, I, Tackett, AJ, Wilson, T, Pan, YT (2010) The last step in the conversion of trehalose to glycogen:A mycobacterial enzyme that transfers maltose from maltose-1-phosphate to glycogen. J Biol Chem, in press.  [Abstract]
  • Ounpraseuth S, Rafferty TM, McDonald-Phillips RE, Gammill WM, Siegel ES, Wheeler KL, Nilsson EA, Cooney CA (2009) A Method to Quantify Mouse Coat-Color Proportions. PLoS ONE in press  [Abstract]
  • Collom, SL, Laddusaw, RM, Kuzmic, P, Burch, AM, Perry, Jr, MD, Miller, GP (2008) CYP2E1 Substrate Inhibition: Mechanistic interpretation through an effector site for monocyclic compounds. J Biol Chem, in press.  [Abstract]
  • Jamakhandi, AP, Kuzmic, P, Sanders, DA, Miller, GP (2007) Global Analysis of Protein-Protein Interactions Reveals Multiple CYP2E1-Reductase Complexes. Biochemistry 46, 10192-201.  [Abstract]
  • Collom, SL, Jamakhandi, AP, Tackett, AJ, Radominska-Pandya, A, and Miller, GP (2006) CYP2E1 active site residues in Substrate Recognition Sequence 5 identified by photoaffinity labeling and homology modeling. Archives Biochem Biophys, 459, 59-69.[Abstract]
  • Upreti, M, Lyle, CS, Skaug, B, Du, L, and Chambers, TC.  (2006) Vinblastine-induced apoptosis is mediated by discrete alterations in the subcellular distribution, oligomeric structure, and activation status of specific Bcl-2 family members.  J. Biol. Chem. 281, 15941-15950. [Abstract]
  • Kurmasheva RT, Peterson CA, Parham DM, Chen B, McDonald RE, Cooney CA. (2005) Upstream CpG island methylation of the PAX3 gene in human rhabdomyosarcomas. Pediatr Blood Cancer. 44:328-37. [Abstract]
  • Ebert RH II, Shammas MA, Sohal BH, Sohal RS, Egilmez NK, Ruggles S, Shmookler Reis RJ. (1996) Defining genes that govern longevity in Caenorhabditis elegans. Devel. Genet. 18:131-143. [Abstract]
  • Ebert RH II, Cherkasova VA, Dennis RA, Wu JH, Ruggles S, Eudy Perrin T, and Shmookler Reis RJ. (1993) Longevity-determining genes in Caenorhabditis elegans: Chromosomal mapping of multiple noninteractive loci. Genetics 135: 1003-1010. [Abstract]