Title
Chair of Neurobiology & Developmental Sciences
Ph.D.
University of Maryland
Post Doctoral Training
National Institutes of Health
Major Interests
Neurodegenerative disorders including multiple sclerosis and fetal alcohol spectrum disorders
Research Interests
Dr. Drew conducts research in the field of Neuroimmunology. Normally, immune activity in the brain is limited. However, in diseases including multiple sclerosis, Alzheimer’s disease, and alcohol abuse activated immune cells are observed in the brain. These immune cells produce cytokines which may be toxic to brain cells as well as chemokines which direct cells to sites of inflammation, resulting in neuropathology. Dr. Drew’s research involves modern cellular and molecular biology techniques.
Office: Biomedical Research Building II, Room 562-2
Slot 846
Publications
Drew, P.D. 2024. Targeting the NLRP3 inflammasome as potential treatment for ethanol-induced non-communicable diseases. 2024. American Journal Drug Alcohol Abuse. 50: 125-127. PMID: 38563505; doi: 10.1080/00952990.2024.2332951.
Cealie M.Y., J.C. Douglas, H.K. Swan, E.D. Vonkaenel, M.N. McCall, P.D. Drew, and A.K. Majewska. 2024. Developmental ethanol exposure impacts Purkinje cells but not microglia in young adult cerebellum. Cells. 13, 386. doi.org/10.3390/cells13050386.
Holloway, K.N., J.C. Douglas, T. M. Rafferty, A.K. Majewska, C.J.M. Kane, and P.D. Drew. 2023. Ethanol induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders. Frontiers in Neuroscience. 17:1154637. doi: 10.3389/fnins.2023.1154637.
Cealie, M.Y, J.C. Douglas, L. Le, E. Vonkaenel, M.N. McCall, P.D. Drew, and A.K. Majewska. 2023. Developmental ethanol exposure does not affect the dynamics of adolescent cerebellar microglia and purkinje cells. Frontiers in Neuroscience. 17:1176581. doi: 10.3389/fnins.2023.1176581.
Niedzwiedz-Massey, V.M., J.C. Douglas, T. Rafferty, J.W. Johnson, K.N. Holloway, M.D. Berquist, C.J.M. Kane, and P.D. Drew. 2023. Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation. American Journal Drug Alcohol Abuse. 49: 345-358. doi:10.1080/00952990.2022.2128361. PMID: 36345683
Holloway, K.N., M.R. Pinson, J.C. Douglas, T.M. Rafferty, C.J.M. Kane, and P.D. Drew. 2023. Cerebellar transcriptomic analysis in a chronic plus binge model of alcohol use disorder demonstrates ethanol induced neuroinflammation and altered glial gene expression. Cells. 12:745 doi:10.3390/cells 12050745.
Holloway, K.N., J.C. Douglas, T.M. Rafferty, C.J.M. Kane, and P.D. Drew. 2023. Ethanol induces neuroinflammation in a chronic plus binge model of alcohol use disorder via TLR4 and MyD88-dependent signaling. Cells. 12:2109. doi: 10.3390/cells12162109.