Professor and Vice Chair
University of Maryland
Post Doctoral Training
National Institutes of Health
Curriculum Vitae: Word
Address: Office: Biomedical Research Building II, Room 563-2
Mailing address: University of Arkansas for Medical Sciences
4301 W. Markham, Slot Slot 846
Little Rock, AR 72205
Neurodegenerative disorders including multiple sclerosis and fetal alcohol spectrum disorders
Dr. Drew conducts research in the field of Neuroimmunology. Normally, immune activity in the brain is limited. However, in diseases including multiple sclerosis, Alzheimer’s disease, and alcohol abuse activated immune cells are observed in the brain. These immune cells produce cytokines which may be toxic to brain cells as well as chemokines which direct cells to sites of inflammation, resulting in neuropathology. Dr. Drew’s research involves modern cellular and molecular biology techniques.
- Solt, L.A., N. Kumar, P. Nuhant, Y. Wang, J.L. Lauer, J. Liu, M.A. Istrate, T.M. Kamenecka, W. R. Roush, D. Vidovic, S. C. Schurer, J. Xu, G. Wagoner, P.D. Drew, P. R. Griffin, and T.P. Burris. 2011. Inhibition of T(H)17 differentiation and suppression of autoimmunity by a selective ROR ligand. Nature. 472:491-494.
- Kane, C.J.M., K.D. Phelan, J.C. Douglas, G. Wagoner, J. Walker-Johnson, J. Xu, and P.D. Drew. 2013. Effects of ethanol on immune response in the brain: region specific changes in aged mice. J. Neuroinflammation. 10:66-69.
- Kane, C.J.M., K.D. Phelan, J.C. Douglas, G. Wagoner, J. Walker-Johnson, J. Xu, P.S. Phelan, and P.D. Drew. 2014. Effects of ethanol on immune response in the brain: region specific changes in adolescent versus adult mice. Alcohol Clin. Exp. Res. 38:384-391.
- Drew, P.D., J.W. Johnson, J.C. Douglas, K.D. Phelan, and C.J.M. Kane. 2015. Pioglitazone Blocks Ethanol Induction of Microglial Activation and Immune Responses in the Hippocampus, Cerebellum, and Cerebral Cortex in a Mouse Model of Fetal Alcohol Spectrum Disorders. Alcohol Clin. Exp. Res. 39:445-454.
- Kane, C.J.M., and P.D. Drew. 2016. Inflammatory Responses to Alcohol in the CNS: Nuclear Receptors as Potential Therapeutics for Alcohol-Induced Neuropathologies. Journal of Leukocyte Biology. 100:951-959.
- Chen, J., J.L. Martindale, C. Cramer, M. Gorospe, U. Atasoy, P.D. Drew, and S. Yu. 2017. RNA-binding Protein HuR Deficiency Reduced CCR6 Expression on Th17 cells and ameliorated autoimmune neuroinflammation. J Biological Chemistry. 292:14532-14543.