Current Research Studies
DOVE — Drager Oscillatory Ventilation Evaluation
Sponsor: Drager Inc.
Location: UAMS and ACH
Inclusion Criteria:
- Gestational Age at birth: 23 – 30 weeks
- Birth weight: 400 – 1200 grams
- Chronologic Age: less than 96 hours
- 5-minute Apgar > 3
- Clinician would like HFOV
Exclusion Criteria:
- Already ventilated ≥ 96 hours
- Major respiratory or cardiac anomalies
- Pre-existing air leak
- Known grade III/IV IVH
Contact any of the following:
- Dr. Courtney 631-682-0812
- Denise Pearson: 501-364-1065
Sildenafil for PPHN
Sponsor: Pfizer Labs
Location: ACH
Inclusion Criteria:
- Gestational Age at birth: 34 weeks or greater
- Chronologic Age: less than 96 hours
- Diagnosis of PPHN on iNO
Exclusion Criteria:
- Life-threatening anomalies
- Diaphragmatic hernia
- 5-minute Apgar Score < 5
Contact either:
- Allen Harrison: 501-364-7192 or 404-734-3777 (text preferred) or pager 405-0829
- Dr. Courtney: 631-682-0812 (text okay)
HIP — Hernia in Premies
Sponsor: Vanderbilt University
Location: ACH and UAMS (for recruitment)
Inclusion Criteria:
- Gestational Age at birth: less than 37 weeks
- The presence of an inguinal hernia
Exclusion Criteria:
- Major anomalies
- Simultaneous other surgery planned for hernia repair
Contact any of the following:
- Dr. Dassinger:501-364-2943
- Kathy Hummel:501-364-2715
Furosemide — Safety in Premature Infants at Risk of Bronchopulmonary Dysplasia
Sponsor: NIH/NICHD and the Pediatric Trials Network
Location: ACH
Inclusion Criteria:
- Gestational Age at birth: less than 29 weeks
- Chronologic age: 7–28 days
- On nCPAP, NIPPV, NC, or mechanical ventilation
Exclusion Criteria:
- Previous diuretics
- Significant PDA
- Certain abnormal lab at admission
Contact any of the following:
- Andrea Ross: 501-364-3122
- Dr. Courtney: 631-682-0812
Remodulin — Intravenous Remodulin (Treprostinil) as Add-On Therapy for the Treatment of PPHN
Sponsor: United Therapeutics
Location: ACH
Inclusion Criteria:
- Gestational age ≥ 34 weeks and weight ≥ 2 kg
- Chronologic Age: ≤ 14 days
- Diagnosis of PPHN and currently requiring ventilator support
- Two consecutive OIs of 15 or greater separated by at least 30 minutes, after receiving iNo for at least 3 hours
Exclusion Criteria:
- Significant congenital heart disease (CHD)
- Uncontrolled coagulopathy and/or untreated thrombocytopenia
- History of severe (Grade 3 or 4) intracranial hemorrhage
Contact any of the following:
- Allen Harrison: 501-364-7192 or 404-734-3777 (text preferred) or pager 405-0829
- Dr. Courtney: 631-682-0812
PaTTerN Registry — Use of iNO in infants
Sponsor: Malenkrodt
Location: ACH and UAMS
- A multicenter observational registry of premature (27 to 34 weeks) and term or near-term infants (34 to 40 weeks) with pulmonary hypertension who are receiving inhaled nitric oxide by either invasive or non-invasive ventilator support.
Contact any of the following:
- Dr. Courtney 631-682-0812
- Denise Pearson: 501-364-1065
Tele-intubation Study
Sponsor: NIH/NIGMS (National Institute for General Medical Sciences)
Location: UAMS
Inclusion Criteria:
- Pediatric and Med-Peds Residents
- Willing to participate during NICU rotation
Contact:
- Dr. Whit Hall, 501-296-1397
- Jimmy Birdsong, RN, 501-526-7838
Early Diagnosis of Acute Kidney Injury Using Urinary Biomarkers and Renal Oximetry in Neonates with HIE
Sponsor: ACRI
Location: ACH
Inclusion Criteria:
- Gestational Age at birth ≥ 36 weeks
- Receiving active or passive cooling prior to 6 hours of age
- Perinatal depression/moderate to severe encephalopathy
Exclusion Criteria:
- < 1800 g
- Known severe renal anomaly
- Severe congenital anomalies
Contact any of the following:
- Dr. Jenny Rumpel: 630-363-8963
- Dr. Courtney: 631-682-0812
Closed to New Enrollment
PENUT Trial — Preterm Epo Neuroprotection
Sponsor: NIH/NINDS
Location: UAMS and ACH
All PENUT patients will be followed through two years corrected age
Follow-up is in progress
SCAMP — Antibiotic Safety in Infants with Complicated Intra-Abdominal Infections (SCAMP)
Sponsor: NIH/NICHD and the Pediatric Trials Network
Location: ACH
Data analysis and follow-up are in progress
IBT — A Trial of Lactobacillus reuteri (A Probiotic) in Preterm Infants
Sponsor: Infant Bacterial Therapeutics
Location: UAMS and ACH
Data analysis is in progress; Phase III randomized trial starting soon
AEROSURF — Aerosolized Surfactant for Treatment of RDS
Sponsor: Discovery Labs
Location: UAMS
Data analysis is in progress