If you’re interested in pediatric neurology research, the Arkansas Children’s Section of Neurology is well-versed and ready to help you take your project from idea to publication. Whatever your objective, whether publications, involvement in clinical trials or active participation in research programs, research remains a focus in neurology to stimulate innovation and improve health outcomes for children. We are proud to highlight some of our achievements in research within our section.
- Implementation Science Scholar Program
- Using the principles of implementation science, the program includes 10 didactic sessions per year and oversight and mentoring for experiential implementation science projects. The two-year program provides 20% salary support and prepares faculty to publish the results of their implementation science projects
- Dr. Aravindhan Veerapandiyan
- 2020 Scholar: Implementation of evidence-based practice to improve care for children with headaches
- Dr. Debopam Samanta
- 2019 Scholar: Quality/implementation gap in epilepsy surgery evaluation
- Dr. Kapil Arya
- 2019 Scholar: Implementation of newborn screening (NBS) for Spinal Muscular Atrophy (SMA) and operationalizing appropriate patient management
- Dr. Aravindhan Veerapandiyan
- Using the principles of implementation science, the program includes 10 didactic sessions per year and oversight and mentoring for experiential implementation science projects. The two-year program provides 20% salary support and prepares faculty to publish the results of their implementation science projects
Areas of Research Interest Within the Section
- Timothy R. Koscik, Ph.D.
- Emerging evidence suggests that Huntington’s Disease (HD) begins early in life with maladaptive development of cortical layering that starts a cascade of events that lead to the neurodegeneration and motor symptoms observed in HD. The layered structure of the cerebral cortex is beyond the resolution of typical neuroimaging paradigms, and thus a shift to ultra high-resolution imaging of postmortem HD brains will provide the resolution needed to explore these features with current technology. We predict that the severity of disruption to cortical layering will relate to the length of the HD gene mutation in a dose-dependent manner and will provide insight that will help guide the development of therapies to appropriate brain targets and optimal times during brain development.
- Mark McManis, Ph.D.
- The primary goal of my research program is to improve the speed, efficiency, and accuracy of diagnoses of neurological disorders, particularly seizures. In practice, this includes the development and implementation of new technology into the 19 clinical environments. My research supports the development of two products that use machine learning/artificial intelligence to aid physicians in their clinical An important aspect of my research is to enable physicians and healthcare professionals in under-resourced and/or rural healthcare settings access to expertise that is usually only available at larger hospitals and medical schools.
- Tara Johnson, M.D.
- Integrating my biomedical engineering research background with my neurodevelopmental medicine clinical knowledge, I will identify and evaluate high-risk children at an early age to provide more effective treatment and rehabilitative alternatives for individuals with neurodevelopmental disorders. In my KL2 work, to improve the early detection of neurodevelopmental disabilities, I developed a novel multimodal screening protocol, and I tested it in 98 high-risk 3- month-old infants from the NICU. The protocol is highly predictive of neurodevelopmental disorders, specifically cerebral palsy diagnosis when the children reach 2 years of age. Using the same protocol in 28 infants and children with critical congenital heart disease (CHD), I prospectively quantified their early language development, from birth to three years of age. Children with critical CHD are at some of the highest risk for decreased brain volumes and neurodevelopmental disabilities. Using both structural and functional imaging modalities at UAMS and ACH, I will characterize anatomic and neurophysiologic differences in the developing infant brain; I anticipate that these will serve as predictive clinical markers for future neurodevelopment. I will perform functional mapping of the developing brain, by measuring brain anatomy and activity in fetuses, neonates, and infants, and I will identify the relationships between early neuroanatomic and neurophysiologic findings with subsequent development. I expect to identify specific early neuroanatomic and neurophysiologic markers of neurodevelopmental outcomes in children with critical CHD. Determining neuroanatomic and neurophysiologic precursors to longitudinal neurodevelopment will ultimately guide management strategies to improve long-term neurodevelopmental outcomes and quality of life in children with critical CHD.
- Diana Escalona-Vargas, Ph.D.
- The broad objective of our research group is to expand the applications of multimodal neuroimaging to study cognitive brain development and function across the lifespan. Neuroimaging allows for measuring subtle variations in cognitive function. Our research group uses multimodal neuroimaging methods to explore changes in neural network function in children and adults in health and disease. We have a strong interest in studying the language and memory circuitry using multimodal neuroimaging to optimize pre-surgical planning and improve postsurgical outcomes in pediatric epilepsy patients. Another major thrust of our research is on studying the impact of environmental factors such as weight status, stress, and emotional regulation on brain function in children. Our research group has a strong collaboration with the fetal laboratory at UAMS to pursue common interests in brain development using electrophysiological techniques. Our fetal research focuses on studying maternal-fetal physiology in low- and high-risk pregnancies such as the effect of clinical drugs on fetal brain development. Our research group nurtures multi-disciplinary efforts to understand more about the mechanistic nature of brain functions and complex behavior, especially in childhood.
Recent Publications by Neurology Faculty
More in formation is available on our faculty member’s research profiles.
- Ramani PK, Fawcett K, Guntrum D, Samuel H, Ciafaloni E, Veerapandiyan A. Epilepsy Characteristics in Duchenne and Becker Muscular Dystrophies. Child Neurol Open. 2023 Feb 22;10:2329048X231159484. doi: 10.1177/2329048X231159484. PMID: 36844469; PMCID: PMC9950600.
- Zhang L, Guo Z, Zhang H, van der Plas E, Koscik TR, Nopoulos PC, Sonka M. Assisted annotation in Deep LOGISMOS: Simultaneous multi-compartment 3D MRI segmentation of calf muscles. Med Phys. 2023 Feb 7. doi: 10.1002/mp.16284. Epub ahead of print. PMID: 36750977.
- Schultz JL, Langbehn DR, Al-Kaylani HM, van der Plas E, Koscik TR, Epping EA, Espe-Pfeifer PB, Martin EP, Moser DJ, Magnotta VA, Nopoulos PC. Longitudinal Clinical and Biological Characteristics in Juvenile-Onset Huntington’s Disease. Mov Disord. 2023 Jan;38(1):113-122. doi: 10.1002/mds.29251. Epub 2022 Nov 1. PMID: 36318082; PMCID: PMC9851979.
- Agostinelli LJ, Seaman SC, Saper CB, Fykstra DP, Hefti MM, Koscik TR, Dlouhy BJ, Bassuk AG. Human Brainstem and Cerebellum Atlas: Chemoarchitecture and Cytoarchitecture Paired to MRI. J Neurosci. 2023 Jan 11;43(2):221-239. doi: 10.1523/JNEUROSCI.0587-22.2022. Epub 2022 Nov 28. PMID: 36442999; PMCID: PMC9838717.
- Samanta D. Recent developments in stereo electroencephalography monitoring for epilepsy surgery. Epilepsy Behav. 2022 Oct;135:108914. doi: 10.1016/j.yebeh.2022.108914. Epub 2022 Sep 15. PMID: 36116362.
- Samanta D. The role of implementation science in improving epilepsy surgery utilization. Epilepsy Behav. 2022 May;130:108669. doi: 10.1016/j.yebeh.2022.108669. Epub 2022 Mar 22. PMID: 35334257; PMCID: PMC9064925.
- Newmaster K, Zhu Z, Bolt E, Chang RJ, Day C, Mhanna A, Paudel S, Farooq O, Swaminathan A, Acharya P, Cheungpasitporn W, Gupta S, Samanta D, Mahfooz N, Mainali G, Carney PR, Naik S. A Review of the Multi-Systemic Complications of a Ketogenic Diet in Children and Infants with Epilepsy. Children (Basel). 2022 Sep 10;9(9):1372. doi: 10.3390/children9091372. PMID: 36138681; PMCID: PMC9498174.
- Samanta D, Ostendorf AP, Singh R, Gedela S, Elumalai V, Hoyt ML, Perry MS, Bartolini L, Curran GM. Physicians’ Perspectives on Presurgical Discussion and Shared Decision-Making in Pediatric Epilepsy Surgery. J Child Neurol. 2022 Apr;37(5):416-425. doi: 10.1177/08830738221089472. Epub 2022 Mar 21. PMID: 35312338; PMCID: PMC9086119.
- Samanta D. A scoping review on cannabidiol therapy in tuberous sclerosis: Current evidence and perspectives for future development. Epilepsy Behav. 2022 Mar;128:108577. doi: 10.1016/j.yebeh.2022.108577. Epub 2022 Feb 9. PMID: 35151190.
- Veerapandiyan A, Rao VK. Palliative care in Duchenne muscular dystrophy: Goals of care discussions and beyond. Muscle Nerve. 2022 Jun;65(6):627-629. doi: 10.1002/mus.27544. Epub 2022 Apr 13. PMID: 35362613.
- Kwon JM, Arya K, Kuntz N, Phan HC, Sieburg C, Swoboda KJ, Veerapandiyan A, Assman B, Bader-Weder S, Dickendesher TL, Hansen J, Lin H, Yan Y, Rao VK. An expanded access program of risdiplam for patients with Type 1 or 2 spinal muscular atrophy. Ann Clin Transl Neurol. 2022 06; 9(6):810-818. PMID: 35567422.
- Willis E, Moore SA, Cox MO, Stefans V, Aravindhan A, Gokden M, Veerapandiyan A. Limb-Girdle Muscular Dystrophy R9 due to a Novel Complex Insertion/Duplication Variant in FKRP Child Neurol Open. 2022 Apr 28;9:2329048X221097518. doi: 10.1177/2329048X221097518. PMID: 35557983; PMCID: PMC9087226.
- Karakas C, Fidan E, Arya K, Webber T, Cracco JB. Frequency, Predictors, and Outcome of Seizures in Patients With Myelomeningocele: Single-Center Retrospective Cohort Study. J Child Neurol. 2022 Jan;37(1):80-88. doi: 10.1177/08830738211053132. Epub 2021 Nov 24. PMID: 34817276.
- ElSheikh RH, Aravindhan A, Boysen S, Veerapandiyan A. Infantile-Onset Complex Hereditary Spastic Paraplegia Due to a Novel Mutation in SPAST Gene. Pediatr Neurol. 2022 Sep;134:71. doi: 10.1016/j.pediatrneurol.2022.06.020. Epub 2022 Jun 30. PMID: 35841713.
- Bolin EH, Whittington JR, Mehl ST, Escalona-Vargas D, Eswaran H. Fetal Magnetocardiography for the Diagnosis of Fetal Dysrhythmias: Single-Center Experience Over 8 Years. JACC Clin Electrophysiol. 2022 Sep;8(9):1161-1163. doi: 10.1016/j.jacep.2022.05.011. Epub 2022 Jul 27. PMID: 35907757.
- Raghuram A, Sanchez S, Wendt L, Cochran S, Ishii D, Osorno C, Bathla G, Koscik TR, Torner J, Hasan D, Samaniego EA. 3D aneurysm wall enhancement is associated with symptomatic presentation. J Neurointerv Surg. 2022 Jul 19:neurintsurg-2022-019125. doi: 10.1136/jnis-2022-019125. Epub ahead of print. PMID: 35853699.
- Hamilton MJ, Atalaia A, McLean J, Cumming SA, Evans JJ, Ballantyne B, Jampana R, The Scottish Myotonic Dystrophy Consortium, Longman C, Livingston E, van der Plas E, Koscik T, Nopoulos P, Farrugia ME, Monckton DG. Clinical and neuroradiological correlates of sleep in myotonic dystrophy type 1. Neuromuscul Disord. 2022 May;32(5):377-389. doi: 10.1016/j.nmd.2022.02.003. Epub 2022 Feb 14. PMID: 35361525.
- Raghuram A, Varon A, Sanchez S, Ishii D, Wu C, Magnotta VA, Hasan DM, Raghuram A, Varon A, Sanchez S, Ishii D, Wu C, Magnotta VA, Hasan DM, Koscik TR, Samaniego EA. Topographical Analysis of Aneurysm Wall Enhancement With 3-Dimensional Mapping. Stroke Vasc Interv Neurol. 2022 Jul;2(4):e000309. doi: 10.1161/svin.121.000309. Epub 2022 May 8. PMID: 36061513; PMCID: PMC9432773.
- Gill PS, Elchynski AL, Porter-Gill PA, Goodson BG, Scott MA, Lipinski D, Seay A, Kehn C, Balmakund T, Schaefer GB. Multidisciplinary Consulting Team for Complicated Cases of Neurodevelopmental and Neurobehavioral Disorders: Assessing the Opportunities and Challenges of Integrating Pharmacogenomics into a Team Setting. J Pers Med. 2022 Apr 8;12(4):599. doi: 10.3390/jpm12040599. PMID: 35455715; PMCID: PMC9024886.
- Benavides A, Bell EF, Conrad AL, Feldman HA, Georgieff MK, Josephson CD, Koscik TR, Stowell SR, Sola-Visner M, Nopoulos P. Sex Differences in the Association of Pretransfusion Hemoglobin Levels with Brain Structure and Function in the Preterm Infant. J Pediatr. 2022 Apr;243:78-84.e5. doi: 10.1016/j.jpeds.2021.12.051. Epub 2021 Dec 27. PMID: 34968498; PMCID: PMC9088851.
- Samanta D, Ostendorf AP, Willis E, Singh R, Gedela S, Arya R, Scott Perry M. Underutilization of epilepsy surgery: Part I: A scoping review of barriers. Epilepsy Behav. 2021 Apr;117:107837. doi: 10.1016/j.yebeh.2021.107837. Epub 2021 Feb 18. PMID: 33610461; PMCID: PMC8035287.
- Escalona-Vargas D, Siegel ER, Oliphant S, Eswaran H. Evaluation of Pelvic Floor Muscles in Pregnancy and Postpartum With Non-Invasive Magnetomyography. IEEE J Transl Eng Health Med. 2021 Nov 25;10:1800106. doi: 10.1109/JTEHM.2021.3130785. PMID: 34950538; PMCID: PMC8673696.
- Escalona-Vargas D, Bolin EH, Lowery CL, Siegel ER, Eswaran H. Recording and quantifying fetal magnetocardiography signals using a flexible array of optically-pumped magnetometers. Physiol Meas. 2021 Jan 1;41(12):125003. doi: 10.1088/1361-6579/abc353. PMID: 33086201; PMCID: PMC7875519.
- Chand DH, Zaidman C, Arya K, Millner R, Farrar MA, Mackie FE, Goedeker NL, Dharnidharka VR, Dandamudi R, Reyna SP. Thrombotic Microangiopathy Following Onasemnogene Abeparvovec for Spinal Muscular Atrophy: A Case Series. J Pediatr. 2021 Apr;231:265-268. doi: 10.1016/j.jpeds.2020.11.054. Epub 2020 Nov 28. PMID: 33259859.
- Clarke DF, Shah EG, Perkins FF. The Preoperative Evaluation of Drug-Resistant Epilepsy. Pediatr Neurol. 2020 Nov;112:78-83. doi: 10.1016/j.pediatrneurol.2020.05.010. Epub 2020 Jun 27. PMID: 32920308.
- Swafford C, Roach ES. Juvenile Dermatomyositis and the Inflammatory Myopathies. Semin Neurol. 2020 Jun;40(3):342-348. doi: 10.1055/s-0040-1705120. Epub 2020 Apr 6. PMID: 32252099.
- Samanta D, Willis E. KIAA2022-related disorders can cause Jeavons (eyelid myoclonia with absence) syndrome. Acta Neurol Belg. 2020 Feb;120(1):205-207. doi: 10.1007/s13760-018-0887-y. PMID: 29417424.
- Abramo TJ, McKinney S, Moore J, Jacobs R, Albert G, Meredith M, Porter NH, Storm E, Willis E, Gonzalez CV, Hargrave H, Schneider B, Sharp G. Hemispheric Cerebral Oximetry Monitoring During Pediatric Seizure Activity in a Pediatric Emergency Department. Pediatr Emerg Care. 2020 Sep;36(9):e513-e526. doi: 10.1097/PEC.0000000000001354. PMID: 29140931; PMCID: PMC7469875.
Recent Abstracts in Neurology
- S. Oliphant, L. Mercado, D. Escalona-Vargas, E. R. Siegel, H. Eswaran. 3rd Trimester Pelvic Floor Magnetomyography. AUGS Scientific Meeting, 2023.
- Eswaran, D. Escalona-Vargas, E. Bolin, H. Moody. A Non-Invasive Flexible Sensor Array for Fetal Heart Electrophysiology. 70th Annual Meeting of the Society for Reproductive Investigation, Brisbane, Australia, March 2023.
- Haley, D. Escalona-Vargas, X. Ou, D. Samanta, Sorensen, A. Veerapandiyan. Magnetoencephalography (MEG) Findings in Boys with Dystrophinopathy. MDA Clinical & Scientific Conference, March 2023.
- McManis M, Perkins F. AI Derived Seizure Detection in Neonates: A Comparison of Channel Sampling Montages. 76th Annual Meeting of the American Epilepsy Society. Nashville, TN, December 2022.
- Elumalai V, Veerapandiyan A. Diagnostic Dilemma in Pediatric CMT. Child Neurology Society Annual Meeting. Cincinnati, OH, Oct 2022.
- Eswaran, D. Escalona-Vargas, E. Bolin, H. Moody. Recording and Quantification of Fetal Magnetocardiography Using Optically-Pumped Magnetometers. 22nd International Conference on Biomagnetism, September 2022.
- Kapil N, Majmudar-Sheth B, Escapita A, Sivakumar S, Spray B, Ying J, Johnson T. Early clinical markers of cerebral palsy in former NICU infants. Poster Presented at: Implementation Of Early Detection And Intervention For Cerebral Palsy Conference; Atlanta, GA. August, 2022.
- Saylam E, Ramani P, James B, Savage M, Jambhekar S, Veerapandiyan A. Assessing sleep quality in children with Migraines: Implementation of electronic health record cue. American Academy of Neurology Annual Meeting. Seattle WA, Apr 2022.
- Flegal M, Bearden R, Haley B, Fawcett K, Sorensen S, Veerapandiyan A. Perceived attitudes, parenting practices, and beliefs of nutrition and psychosocial interplay in families of children with dystrophinopathy. MDA Clinical and Scientific Conference. Nashville TN, March 2022.
- Bearden R, Flegal M, Haley B, Fawcett K, Veerapandiyan A, Sorensen S. Assessment of cognitive and learning challenges in patients with dystrophinopathy via parent ratings of learning and executive functioning challenges. MDA Clinical and Scientific Conference. Nashville TN, Mar 2022.
- Haley B, Flegal M, Bearden R, Fawcett K, Veerapandiyan A, Sorensen S. Assessment of psychiatric symptoms in dystrophinopathy patients using the pediatric symptom checklist and revised child anxiety and depression scale. MDA Clinical and Scientific Conference. Nashville, TN, Mar 2022.
- Prabhu N, Arya K, Drake P, Arulprakash N, Cobb S, Manbeck P, Willis E, Burrow T, Fry D, Samanta D, Perkins P. A pathogenic variant of the DNM1L mitochondrial gene associated with super-refractory status epilepticus (SE) in a 15-year-old female. Child neurology Society annual meeting. Boston, MA, September 2022.
- Escapita AC, Lambou KR, Greiten L, Reemtsen B, Knecht K, Zakaria D, Raiees-Dana H, Johnson TL. Early neurodevelopmental outcomes of children with Single Ventricle Physiology. Oral Presentation presented at Additional Ventures Single Ventricle Investigator Meeting; Virtual Meeting, March 2021.
- P Ramani, K Arya. Clinical spectrum of GAD 65 associated syndrome in Pediatric population. Child neurology Society annual meeting 2021.
- Harada Y, Arya K, Rao V, Agarwal A, Stefans V, Veerapandiyan A. Combination therapy with nusinersen and AVXS-101: a real-world clinical experience. AAN Annual Conference (cancelled due to Covid-19). Toronto, Canada, April 2020.
- Prabhu N, Saylam E, Moss M, Douglass D, Millner R, Agarwal A, Stefans V, Veerapandiyan A, Arya K. Thrombotic Microangiopathy (TMA): A potential adverse reaction post Zolgensma (onasemnogene abeparvovec-xioi) therapy for Spinal Muscular Atrophy (SMA). AAN annual conference (cancelled due to Covid-19). Toronto, Canada, April 2020.
Recent Clinical Trials and Research Projects in Neurology
- A Phase 2, multicenter, open-label, long-term safety study of LP352 in subjects with developmental and epileptic encephalopathy.
- PI: Dr. Debopam Samanta
- A Phase 3, Open-label Study of Adjunctive Ganaxolone (GNX) Treatment in Children and Adults with Tuberous Sclerosis Complex (TSC)-related Epilepsy (TrustTSC OLE).
- PI: Dr. Debopam Samanta
- A Phase 4 Study of Nusinersen Among Patients with Spinal Muscular Atrophy Who Received Onasemnogene.
- PI: Dr. Kapil Arya
- A Phase 1b/2a randomized, double-blind, placebo-controlled, parallel-group, dose escalation study to investigate the safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of LP352 in subjects with developmental and epileptic encephalopathies.
- PI: Dr. Debopam Samanta
- Intrathecal Onasemnogene Abeparvovec for treatment naïve type 2 SMA patients > 2 y.o.
- PI: Dr. Kapil Arya
- Magnetoencephalography based tracking of fetal neurodevelopment in diabetic pregnancies.
- PI: Dr. Hari Eswaran (co-I: Dr. Debopam Samanta, Dr. Diana Escalona-Vargas)
- A Phase 3, Double-blind, Randomized, Placebo-controlled Trial of Adjunctive Ganaxolone (GNX) Treatment in Children and Adults with Tuberous Sclerosis Complex (TSC)-related Epilepsy.
- PI: Dr. Debopam Samanta
- Novel AI-Powered System for Detection of Cortical Dysplasia in Patients with Seizures.
- Co-Investigators Dr. Fred Perkins and Dr. Mark McManis
- A 2-year randomized, 3-arm, double-blind, non-inferiority study comparing the efficacy and safety of ofatumumab and siponimod versus fingolimod in pediatric patients with multiple sclerosis followed by an open-label extension.
- PI: Dr. Erin Willis
- Muscular Dystrophy Association Neuromuscular Observational Research (MOVR) Data Hub protocol.
- PI: Dr. Aravindhan Veerapandiyan
- A Phase 3b Study to Evaluate Higher Dose Nusinersen (BIIB058) in Patients with Spinal Muscular Atrophy Previously Treated with Risdiplam.
- PI: Dr. Kapil Arya
- A Long-term Observational Study Evaluating Eteplirsen in Patients with Duchenne Muscular Dystrophy under Conditions of Routine Clinical Practice.
- PI: Dr. Aravindhan Veerapandiyan
- A Multi-Center, Longitudinal Study of the Natural History of Subjects with Limb Girdle Muscular Dystrophy (LGMD) Type 2E (LGMD2E/R4), Type 2D (LGMD2D/R3), and Type 2C (LGMD2C/R5).
- PI: Dr. Aravindhan Veerapandiyan
- BioMarin international neuronal ceroid lipofuscinosis (CLN2) registry.
- PI: Dr. Kapil Arya
- Pediatric Language and Memory Mapping in Refractory Epilepsy using Magnetoencephalography.
- PI: Dr. Diana Escalona-Vargas
- Duchenne Outcomes Research Interchange Data Enrichment through EHR Extraction.
- PI: Dr. Aravindhan Veerapandiyan
- An Open-label, Randomized Trial to Assess the Safety, Pharmacokinetics, and Exploratory Efficacy of Adjunctive Cannabidiol Oral Solution (GWP42003-P) Compared with Standard of Care Antiepileptic Therapy, in Patients Age 1 Month to Less Than 12 Months of Age with Tuberous Sclerosis Complex Who Experience Inadequately controlled Seizures.
- PI: Dr. Erin Willis
- A 53 Week, Open-Label Study to evaluate the Long-Term Safety and Efficacy of Tideglusib for the treatment of congenital MD1.
- PI: Dr. Aravindhan Veerapandiyan
- Phase 2 Randomized, Double-Blind, Placebo-controlled Study to Evaluate the Effect of EDG-5506 on Safety, Biomarkers, PK and Functional Measures in Adults & Adolescents with BMD.
- PI: Dr. Aravindhan Veerapandiyan
- International Pediatric Stroke Study (IPSS).
- PI: Dr. Adrianne Parkey
- Identifying markers of abnormal neurocognitive trajectories during chemotherapy treatment of childhood acute lymphoblastic leukemia.
- PI: Dr. E. Van Der Plas (Co-I: Dr. Timothy Koscik)
- Brain Development and Pre-Speech Function in Infants with Isolated Oral Clefts: Relationship to Anesthesia Exposure and Oxygenation.
- PI: Dr. A. Conrad (Co-I: Dr. Timothy Koscik)
- Neuroimaging of food-related impulse control and stressors in childhood obesity.
- PI: Dr. Diana Escalona-Vargas