On July 12, 2021, Mary “Allie” Schleiff successfully defended her dissertation entitled “Diphenylamine NSAIDs are Bioactivated into Hepatotoxic Quinone-Species Metabolites”. Dr. Schleiff was mentored by Dr. Grover Paul Miller and was a trainee of the Systems Pharmacology and Toxicology (SPaT) T32 program. As a graduate student, she was an author on 15 publications, 6 of them first author. Moreover, she gave 24 oral and poster presentations, including invited talks. Based on her research efforts, she received 11 awards including Top 10 Finalist for the Sternfels Prize in Drug Safety Discoveries (2020), Third Place for the Bhuvan Award for Excellence in Biochemistry Graduate Research at UAMS (2021), and the Drug Metabolism and Disposition Highlighted Trainee Author by the American Society for Pharmacology and Experimental Therapeutics (2021). Allie has since taken a position as a postdoctoral fellow with Drs. Qin Shu and Daniel Willett at the FDA Center for Drug Evaluation and Research in St Louis, MO.
June 2021 publications
Phase separation drives aberrant chromatin looping and cancer development.
Ahn JH, Davis ES, Daugird TA, Zhao S, Quiroga IY, Uryu H, Li J, Storey AJ, Tsai YH, Keeley DP, Mackintosh SG, Edmondson RD, Byrum SD, Cai L, Tackett AJ, Zheng D, Legant WR, Phanstiel DH, Wang GG.
Nature. 2021
Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer.
Chappell K, Manna K, Washam CL, Graw S, Alkam D, Thompson MD, Zafar MK, Hazeslip L, Randolph C, Gies A, Bird JT, Byrd AK, Miah S, Byrum SD.
Mol Omics. 2021
Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.
Urbaniak A, Reed MR, Fil D, Moorjani A, Heflin S, Antoszczak M, Sulik M, Huczyński A, Kupsik M, Eoff RL, MacNicol MC, Chambers TC, MacNicol AM.
Biomed Pharmacother. 2021
Impacts of diphenylamine NSAID halogenation on bioactivation risks.
Schleiff MA, Payakachat S, Schleiff BM, Swamidass SJ, Boysen G, Miller GP.
Toxicology. 2021
Structure of a dimer of the Sulfolobus solfataricus MCM N-terminal domain reveals a potential role in MCM ring opening.
Meagher M, Spence MN, Enemark EJ.
Acta Crystallogr F Struct Biol Commun. 2021