• Skip to main content
  • Skip to main content
Choose which site to search.
University of Arkansas for Medical Sciences Logo University of Arkansas for Medical Sciences
College of Medicine: Department of Biochemistry and Molecular Biology
  • UAMS Health
  • Jobs
  • Giving
  • About Us
    • News
  • Faculty/Staff
    • Primary Faculty
    • Secondary Faculty
    • Adjunct Faculty
    • Professor Emeritus
    • Track Members
    • Research and Administrative Staff
  • Research Areas
    • Cancer Biology
    • Experimental Therapeutics
    • Systems Biology and Bioinformatics
      • Systems Biology News
    • Structural Biology and Enzymology
    • Nutrition and Metabolism
    • Chromatin Biology, Nucleic Acid Chemistry, and Genetics
    • Neurobiology and Neurobiochemistry
  • Students
    • Graduate Program
    • Integrative Biomedical and Data Science
    • Elective Courses
    • Student Highlight
    • Alumni
      • Graduates
      • Where Are They Now?
    • Grant Opportunities
    • Career Information
    • Resources for Current Students
    • Resilience
    • About the Area
  • Seminars
    • Faculty Seminars
    • Student Seminars
    • Webinars and Conferences
  • Undergraduate Programs
    • Summer Research
      • Program Details
      • Application Materials
      • Research Opportunities
      • Information for Participants
      • Prior Participants
      • SURF Related Publications
      • Contact Information
      • Frequently Asked Questions
    • Central Arkansas Undergraduate Summer Research Symposium
      • Details
      • Registration
      • Directions and Parking
      • Top Presentations
      • Contact
  • Research Resources
  1. University of Arkansas for Medical Sciences
  2. College of Medicine
  3. Department of Biochemistry and Molecular Biology
  4. Faculty/Staff
  5. Primary Faculty
  6. Alan J. Tackett, Ph.D.

Alan J. Tackett, Ph.D.

Alan J. Tackett, Ph.D.

Alan J. Tackett, Ph.D.Professor

Professor of Biochemistry and Molecular Biology
Deputy Director of Winthrop P. Rockefeller Cancer Institute
Scharlau Family Endowed Chair for Cancer Research

Ph.D. University of Arkansas for Medical Science

Email: AJTackett@uams.edu
Office: 501-686-8152 – Winthrop P. Rockefeller Cancer Institute 9-119
Lab: 501-686-5954 – Winthrop P. Rockefeller Cancer Institute 9-158
Fax: 501-686-8169

Research Interests

In recent years, new immunotherapy drugs have revolutionized how clinicians treat patients with certain cancers like melanoma. For some patients, immunotherapy can effectively eliminate cancer from the body – unfortunately in other patients these drugs show little benefit. Dr. Alan Tackett is interested in understanding why some patients show limited response to immunotherapies and then leveraging this information to design new cancer therapies to help all patients realize the lifesaving benefits of immunotherapy. His work is specifically focused on immunotherapy treatment of patients with metastatic melanoma. Towards these efforts, Dr. Tackett leads a translational team of researchers, oncologists, surgeons, and pathologists at the UAMS Winthrop P. Rockefeller Cancer Institute.

Research Projects Video

Alan Tackett, Ph.D. – Chromatin Biology

Selected Publications

Shields BD, Mahmoud F, Taylor EM, Byrum SD, Sengupta D, Koss B, Baldini G, Ransom S, Cline K, Mackintosh SG, Edmondson RD, Shalin S, Tackett AJ. Indicators of responsiveness to immune checkpoint inhibitors. Nature Sci Rep. 2017 Apr 11;7(1):807.

Sengupta D, Byrum SD, Avaritt NL, Davis L, Shields B, Mahmoud F, Reynolds M, Orr LM, Mackintosh SG, Shalin SC, Tackett AJ. Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma. Mol Cell Proteomics. 2016 Mar;15(3):765-75.

Shields BD, Tackett AJ, Shalin SC. Proteomics and melanoma: a current perspective. Glob Dermatol. 2016 Aug;3(4):366-370.

Byrum SD, Larson SK, Avaritt NL, Moreland LE, Mackintosh SG, Cheung WL, Tackett AJ. Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma. J Proteomics Bioinform. 2013 Mar 1;6(3):43-50.

Research Program Coordinator

Sonet WeedSonet Weed

Email: SMWeed@uams.edu
Phone: 501-686-6181

More Information

  • Pubmed link to additional publications
  • IDeA National Resource for Proteomics
  • Center for Translational Pediatric Research
UAMS College of Medicine LogoUAMS College of MedicineUniversity of Arkansas for Medical Sciences
Mailing Address: 4301 West Markham Street, Little Rock, AR 72205
Phone: (501) 686-7000
  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • LinkedIn
  • Pinterest
  • Disclaimer
  • Terms of Use
  • Privacy Statement

© 2023 University of Arkansas for Medical Sciences