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Department of Pediatrics: Section of Emergency Medicine, Pharmacology and Toxicology
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  7. Research

Research

The PEM section is committed to research and collaborates on several projects with multiple pediatric subspecialties. Our faculty and fellows collaborate to drive research and innovation across all areas of emergency medicine.

Pediatric Emergency Medicine Research

Pediatric medicine is about improving the lives of children on a daily basis. This extends to our mission of treating patients in the best way possible to drive superior outcomes. Our faculty are dedicated and driven to advance the science of emergency care.

Dr. Hannah Wilkins, Dr. Renita Pushparajah, and Dr. Lauren Howard presenting at PAS in Toronto, ON. 2024
Dr. Hannah Wilkins, Dr. Renita Pushparajah, and Dr. Lauren Howard presenting at PAS in Toronto, ON. 2024

Trainees and faculty members present at the premier national and international pediatric conferences.

Research Opportunities During Fellowship

A great deal of emphasis and protected time is given to fellow’s research. Fellows are allocated 12 months throughout their three years for research. A dedicated research assistant works with the fellows throughout their training and assists with project design, IRB and grant submission, data collection and recruitment, conference presentations, and maintains a research binder for each fellow.

Dr. Lyndsay Fisher presents her research poster during Fellows' Research Forum 2024
Dr. Lyndsay Fisher presents her research poster during Fellows’ Research Forum 2024 on the campus of Arkansas Children’s Hospital.

Each fellow has an individual mentor, as well as a Scholarship Oversight Committee, to provide guidance and feedback throughout the fellowship. The expectations for fellow research are as follows:

  • An independent research project that culminates in a first author paper ready for journal submission prior to graduation
  • A smaller administrative project involving some aspect of QA/QI for the hospital or department
  • Each of our fellows participates in writing a review article on a wide variety of topics that results in a publication
  • Fellows submit a case for Emergiquiz or PemPix during the fellowship
  • National Fellows Conference – Held in the spring of each year, first-year fellows attend this conference where they get an opportunity to present their research ideas to leaders in the field of PEM and receive feedback and guidance
  • Presentation at the department’s annual fellows research day
  • Presentation at national meetings and conferences is encouraged and supported with funding

Recent Peer-Reviewed Publications

  • Medical and Socioeconomic Risk Factors for Academic and Psychological Outcomes in Pediatric Sickle Cell Disease
    May 24, 2025
    Risk factors for poor neuropsychological outcomes are not fully understood in youth with sickle cell disease (SCD). We examined the associations between medical factors (SCD genotype, silent infarct/stroke, etc), socioeconomic factors (insurance type), and neuropsychological outcomes (reading and math achievement, psychological symptoms) in youth with SCD. A chart review was conducted for 108 Black/African American youth with SCD (M(age) = 10.80, SD = 3.53, 54.6% males) referred for…
  • Perinatal Stroke Presenting as Arm Swelling: A Case Report
    May 22, 2025
    CONCLUSION: Through this case report, we aimed to increase awareness of perinatal stroke among healthcare professionals and highlight the importance of prompt recognition and appropriate management in optimizing outcomes for affected infants.
  • Impact of the Coronavirus Disease 2019 Pandemic on Clinical Trends in Pediatric Intentional Self-Poisonings
    March 20, 2025
    CONCLUSIONS: The demographic differences between time periods suggest the pandemic may have had a disparate impact on these vulnerable populations. Identifying trends in pediatric self-poisonings may help guide public health strategies and resources for prevention and harm reduction.
  • NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen
    March 11, 2025
    Acetaminophen (APAP) is the most-used over-the-counter analgesic among pregnant women. However, concerns have arisen over the safety of APAP exposure during gestation. In particular, it's been speculated that the hepatotoxic metabolite of APAP, N-acetyl-p-benzoquinone imine (NAPQI), forms in the brain after maternal use of therapeutic APAP doses and leads to neurodevelopmental disorders (NDDs). However, APAP metabolism in the brain is understudied. Here, we tested the hypothesis that NAPQI can…
  • Emergence of Invasive Group A Streptococcus Infection in an Infant: A Case Report
    February 4, 2025
    CONCLUSION: This case serves as a reminder of the critical importance of vigilance, prompt recognition, and aggressive intervention in the management of invasive GAS infections in infants.
  • Racial Disparity in Adherence to Endocrine Therapy among Women with Early-Stage Hormone Receptor Positive Breast Cancer: An Analysis of Arkansas All-Payers Claims Database
    August 17, 2024
    CONCLUSION: After adjusting for patients' and tumor characteristics, there were no racial/ethnic differences in ET initiation within 1 year of diagnosis and ET compliance within first year of ET use. However, NHB women were less likely to discontinue ET within 5 years of initiation.
  • Advances and ongoing challenges in eosinophilic gastrointestinal disorders presented at the CEGIR/TIGERs Symposium at the 2024 American Academy of Allergy, Asthma & Immunology meeting
    August 7, 2024
    The Consortium of Eosinophilic Gastrointestinal disease Researchers (CEGIR) and The International Gastrointestinal Eosinophil Researchers (TIGERs) organized a daylong symposium at the 2024 annual meeting of the American Academy of Allergy, Asthma & Immunology. The symposium featured new discoveries in basic and translational research as well as debates on the mechanisms and management of eosinophilic gastrointestinal diseases. Updates on recent clinical trials and consensus guidelines were also…
  • Physiologically-based pharmacokinetic modeling of pantoprazole to evaluate the role of CYP2C19 genetic variation and obesity in the pediatric population
    June 5, 2024
    Pantoprazole is a proton pump inhibitor indicated for the treatment of gastroesophageal reflux disease, a condition that disproportionately affects children with obesity. Appropriately dosing pantoprazole in children with obesity requires understanding the body size metric that best guides dosing, but pharmacokinetic (PK) trials using traditional techniques are limited by the need for larger sample sizes and frequent blood sampling. Physiologically-based PK (PBPK) models are an attractive…
  • The importance of peer review skills: Value and necessity of training residents to ensure continued scientific excellence
    May 22, 2024
    No abstract
  • Changes in Residency Applicant Cancellation Patterns with Virtual Interviews: A Single-site Analysis
    April 10, 2024
    CONCLUSION: While limited, at our site, changing to a virtual interview format correlated with fewer cancellations overall. The proportion of cancellations within 14 days was much higher during virtual interview seasons, with most cancellations occurring during that time frame. Additional studies are needed to determine the effects of cancellation patterns on emergency medicine recruitment.
  • Considerations for instituting pediatric pulmonary embolism response teams: A tool kit
    February 28, 2024
    The incidence of pediatric pulmonary embolism (PE) has increased by 200 % in the last decade, but at a single center, it is still infrequent. Given the unique epidemiologic features of pediatric PE, diagnosis is often delayed, and the management is empiric, based on individual physician experience or preference. Thus, there is a strong need for center-specific uniform management of pediatric PE patients. In adults, the development of pulmonary embolism response teams (PERTs) or PE […]
  • Unusual Pediatric Red Eye
    January 25, 2024
    No abstract
  • Massive Subcutaneous Emphysema after Hydrogen Peroxide Irrigation of a Penetrating Facial Injury
    December 27, 2023
    We present the case of a child impaled in the face by a meat thermometer who subsequently suffered a significant complication due to the administration of hydrogen peroxide to the wound. The soft tissues of the face rapidly expanded and blanched, the child experienced mental status changes, and imaging revealed massive subcutaneous emphysema, pneumomediastinum, and pneumo-orbit. Herein we review the literature on this rare complication and provide photodocumentation in the hopes that other…
  • A multicenter evaluation of pediatric emergency department injury visits during the COVID-19 pandemic
    December 14, 2023
    CONCLUSIONS: The proportion of PED injury-related visits in March through December 2020 increased compared to the same months in 2019. Racial and payor differences were noted. Mechanisms of injury seen in the PED during 2020 changed compared to 2019, and this can inform injury prevention initiatives.
  • Droperidol undermining gastroparesis symptoms (DRUGS) in the emergency department
    October 28, 2023
    CONCLUSION: In patients with gastroparesis presenting to the ED, droperidol reduced opioid use, improved pain control, and decreased antiemetic use without any differences in MME per dose, length of stay, hospital admission rate, or cost.
  • Disseminated Tuberculosis with Cutaneous Findings in an Immunocompetent Patient: A Case Report
    October 27, 2023
    BACKGROUND: Tuberculosis (TB) is one of the leading causes of infectious disease, and emergency medicine providers are often the first physicians to encounter patients with untreated or undiagnosed disease.
  • What is the Optimal Treatment Duration for Outpatient Pediatric Community-Acquired Pneumonia?
    October 19, 2023
    No abstract
  • Pharmacokinetics and safety of a single dose of telavancin in pediatric subjects 2-17 years of age
    October 10, 2023
    Antimicrobial resistance increases infection morbidity in both adults and children, necessitating the development of new therapeutic options. Telavancin, an antibiotic approved in the United States for certain bacterial infections in adults, has not been examined in pediatric patients. The objectives of this study were to evaluate the short-term safety and pharmacokinetics (PK) of a single intravenous infusion of telavancin in pediatric patients. Single-dose safety and PK of 10 mg/kg telavancin…
  • Improvement in Resident Scholarly Output with Implementation of a Scholarly Activity Guideline and Point System
    October 3, 2023
    Introduction: Ensuring high-quality scholarly output by graduate medical trainees can be a challenge. Within many specialties, including emergency medicine (EM), it is unclear what constitutes appropriate resident scholarly activity. We hypothesized that the quantity and quality of scholarly activity would improve with a clearer guideline, including a point system for eligible scholarly activities. Methods: A resident Scholarly Activity Guideline was implemented for EM residents in a university…
  • A Commitment to Making Health Care Personal
    September 27, 2023
    No abstract

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