Office: Biomed 1, B323G
Lab: Biomed 1, B316
Email: Dbhattarai@uams.edu
Phone: 501-526-7823
Education and Training
- DVM: Tribhuvan University, Institute of Agriculture and Animal Science, Nepal, (2010)
- M.V.Sc.: Tribhuvan University, Institute of Agriculture and Animal Science, Nepal, (2013)
- Ph.D.: Huazhong Agricultural University, Wuhan, China, (2017)
Post-Doctoral Training
- School of Veterinary Medicine, Louisiana State University (2019-2021)
- College of Medicine, University of Arkansas for Medical Science (2022-2024)
Research Interests
My research focused on understanding the mechanisms behind kidney injury during cold storage and transplantation. Then developing therapeutic strategies to improve transplant outcomes, particularly through better organ preservation techniques. I explored the roles of the proteasome and immunoproteasome in kidney cold storage and transplantation, yielding significant insights into the molecular processes involved. Currently, my research is centered on mitochondrial dysfunction and protein proteostasis within mitochondria during acute kidney injury. By identifying novel therapeutic interventions, I aim to enhance patient survival rates and improve outcomes for those affected by chronic kidney disease or end-stage kidney disease. I work closely with Dr. Nirmala Parajuli at UAMS and am always open to exploring new collaborations within and outside UAMS.
Areas of Research
- Kidney Injury (Acute Kidney Disease, Chronic Kidney Disease)
- Mitochondrial pathobiology
- Immunology and complement biology
Selected Publications
- Sharma A, Jun SR, Bhattarai D, Panday S, Venugopal G, Panawan O, Washam C, Mackingtosh S, Byrum S, Udaondo Z, Arthur JM, MacMillan-Crow LA, Parajuli N (2024). Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants. Transplantation. PMID: 30875082, PMCID: PMC6419919, DOI: 10.1002/14651858.CD011671.pub2
- Bhattarai D, Lee S, MacMillan-Crow LA, and Parajuli N (2024). Normal proteasome function is needed to prevent kidney graft injury during cold storage followed by transplantation. Int. J. Mol. Sci. 25(4), 2147 DOI: 10.3390/ijms25042147. PMCID: PMC10888692; PMID 38396827.
- Bhattarai D, Lee S, Jun S, Joshi N, Lo S, Jiang L, Gokden N, Parajuli N (2024). Cold storage followed by transplantation induces immunoproteasome in rat kidney allografts: Inhibition of immunoproteasome does not improve function. Kidney360. DOI: 10.34067/KID.0000000000000368. PMCID: PMC11146655; PMID 38303110.