Ph.D. – University of Hong Kong, Hong Kong
My primary research interest is to understand how endocrine status, diet and environment contribute to urological diseases encompassing prostate cancer, benign prostatic hyperplasia and lower urinary tract dysfunctions, with a focus on the role of physiological / dietary / environmental estrogens in uropathology. The knowledge gained from our research will foster development of better strategies for the urologic disease prevention, management and treatment. Our ongoing projects also focus on the impact of early-life exposure to environmental stressors on later-life health outcomes (e.g., cancer risks and fertility), inter-/trans-generational epigenetic inheritance via epitranscriptomic mechanisms, and environmentally induced stem cell carcinogenesis.
- Desai M, Tam NNC, Carraway R, Ho SM, Ferris C and King J. Novel Magnetic Resonance Imaging strategy targeting Neurotensin Receptors in detection of Prostate Cancer. BioRxiv, 2017; 180042.
- Ho SM, Cheong A, Adgent MA, Veevers J, Suen AA, Tam NNC, Leung YK, Jefferson WN, Williams CJ. Environmental factors, epigenetics, and developmental origin of reproductive disorders. Reproductive Toxicology, 2017; 68:85-104.
- Lam HM, Chen J, Medvedovic M, Ho SM and Tam NNC. Bisphenol A disrupts HNF4α-regulated gene networks linking to prostate preneoplasia in Noble rats. Endocrinology, 2016; 157:207-19.
- Ho SM and Tam NNC. Organoid model shows effect of BPA on prostate development. Nature Review Urology, 2015; 12: 658-9.
- Tam NNC, Xiang Z, Xiao H, Song D, Levin L, Meller J and Ho SM. Increased susceptibility of estrogen-induced bladder outlet obstruction in a novel mouse model. Laboratory Investigation, 2015; 95:546-60.
- Jin C, Chen J, Meng Q, Carreira V, Tam NNC, Geh E, Karyala S, Ho SM, Zhou X, Medvedovic M, and Xia Y. Deciphering Gene Expression Program of MAP3K1 in Mouse Eyelid Morphogenesis. Developmental Biology, 2013; 374:96-107.
- Tam NNC, Szeto CYY, Freudenberg J, Fullenkamp AN, Bakshi S, Medvedovic M and Ho SM (2010). Estrogen-driven prolactin-mediated gene expression networks in hormone-induced prostatic intraepithelial neoplasia. Molecular Endocrinology, 2010; 24:2207-17.
- Tam NNC, Sezto CYY, Sartor M, Medvedovic M and Ho SM. Gene expression profiling identifies lobe-specific and common disruptions of multiple gene networks in testosterone-supported, 17beta-estradiol- or diethylstilbestrol-induced prostate dysplasia in Noble rats. Neoplasia, 2008; 10: 20-40.
- Tam NNC, Leav I, Ho SM. Sex hormones induce direct epithelial and inflammation-mediated oxidative/nitrosative stress that favors prostatic carcinogenesis in the Noble rat. American Journal of Pathology, 2007; 171:1334-41.
- Tam NNC, Nyska A, Maronpot RR, Kissling G, Lomnitski L, Suttie A, Bakshi S, Bergman M, Grossman S, and Ho SM. Differential Attenuation of Oxidative/Nitrosative Injuries in Early Prostatic Neoplastic Lesions in TRAMP Mice by Dietary Antioxidants. Prostate, 2006; 66: 57-69.
- Tam NNC, Gao Y, Leung YK and Ho SM. Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth. American Journal of Pathology, 2003; 163:2513-22.