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  1. University of Arkansas for Medical Sciences
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Journal Club

Fall 2022 Schedule

Spring 2022 Schedule

Fall 2021 Schedule

August 25 – Lance Benson

Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis

Watanabe, Hirofumi, Belyea, Brian C, Paxton, Robert L, Li, Minghong, Dzamba, Bette J, DeSimone, Douglas W, Gomez, R Ariel, Sequeira-Lopez, Maria Luisa S

September 1 – Francesca Lobianco

Hyperpolarized Metabolic Imaging Detects Latent Hepatocellular Carcinoma Domains Surviving Locoregional Therapy

Perkons, Nicholas R, Kiefer, Ryan M, Noji, Michael C, Pourfathi, Mehrdad, Ackerman, Daniel, Siddiqui, Sarmad, Tishchfield, David, Profka, Enri, Johnson, Omar, Pickup, Stephen, Mancuso, Anthony, Pantel, Austin, Denburg, Michelle R, Nadolski, Gregory J, Hunt, Stephen J, Furth, Emma E, Kadlecek, Stephen, Gade, Terence P F

September 8 – Joel Vazquez

Treatment of PD-1(-/-) mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

Metushi, IG, Hayes, M.A., Uetrecht J

September 15 – Brian Parks

Parental morphine exposure enhances morphine (but not methamphetamine) preference and increases monoamine oxidase-B level in the nucleus accumben

Sadat-Shirazi, Mitra-Sadat, Karimi, Forough, Kaka, Gholamreza, Ashabi, Ghorbangol, Ahmadi, Iraj, Akbarabadi, Ardeshir, Toolee, Heidar, Vousooghi, Nasim, Zarrindast, Mohammad-Reza

September 22 – Kalee Holloway

Acute oligodendrocyte loss with persistent white matter injury in a third trimester equivalent mouse model of fetal alcohol spectrum disorder

Newville, Jessie, Valenzuela, Carlos Fernando, Li, Lu, Jantzie, Lauren L, Cunningham, Lee Anna

September 29 – Ravi Sun

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation

Martinez-Corral, Ines, Zhang, Yan, Petkova, Milena, Ortsater, Henrik, Sjoberg, Sofie, Castillo, Sandra D., Brouillard, Pascal, Libbrecht, Louis, Saur, Dieter, Graupera, Mariona, Alitalo, Kari, Boo, Laurence, Vikkula, Miikka, Makinen, Taija

October 6 – Lance Benson

Posttranscriptional control of T cell effector function by aerobic glycolysis

Chang, Chih-Hao, Curtis, Johnathan D., Maggi, Jr., Leonard B., Faubert, Brandon, Villarino, Alejandro V., O’Sullivan, David, Ching-Cheng Huang, Stanley, van der Windt, Gerritje J.W., Blagih, Julianna, Qiu, Jing, Weber, Jason D., Pearce, Edward J. , Jones, Russell G., Pearce, Erika L.

October 13 – Francesca Lobianco

Sonodynamic therapy complements PD-L1 immune checkpoint inhibition in a murine model of pancreatic cancer

Nesbitt, Heather, Logan, Keiran, Thomas, Keith, Callan, Bridgeen, Gao, Jinhui, McKaig, Thomas, Taylor, Mark, Love, Mark, Stride, Eleanor, McHale, Anthony P., Callan, John F.

October 20 – Joel Vazquez

Black Patients With Cirrhosis Have Higher Mortality and Lower Transplant Rates: Results From a Metropolitan Cohort Study

Mazumder, Nikhilesh R., Simpson, Dinee, Atiemo, Kofi, Jackson, Kathryn, Zhao, Lihui, Daud, Amna, Kho, Abel, Gabra, Lauren G., Caicedo, Juan C., Levitsky, Josh, Ladner, Daniela P.

October 27 – Brian Parks

Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target

Egervari, Gabor, Landry, Joseph, Callens, James, Fullard, John F., Roussos, Panos, Keller, Eva, Hurd, Yasmin L.

November 3 – Kalee Holloway

TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders

Pascual, Maria, Montesinos, Jorge, Montagud-Romero, Sandra, Forteza, Jeronimo, Rodriguez-Arias, Marta, Minarro, Jose, Guerri, Consuelo

November 10 – Ravi Sun

TBD

Spring 2021 Schedule

January 27 – Lance Benson

Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19

Trump S, Lukassen S, Anker MS, Chua RL, Liebig J, Thürmann L, Corman VM, Binder M, Loske J, Klasa C, Krieger T, Hennig BP, Messingschlager M, Pott F, Kazmierski J, Twardziok S, Albrecht JP, Eils J, Hadzibegovic S, Lena A, Heidecker B, Bürgel T, Steinfeldt J, Goffinet C, Kurth F, Witzenrath M, Völker MT, Müller SD, Liebert UG, Ishaque N, Kaderali L, Sander LE, Drosten C, Laudi S, Eils R, Conrad C, Landmesser U, Lehmann I.

February 3 – Francesca Lobianco

Renin-angiotensin system blockers, risk of SARS-CoV-2 infection and outcomes from CoViD-19: systemic review and meta-analysis

Lee MMY, Docherty KF, Sattar N, Mehta N, Kalra A, Nowacki AS, Solomon SD, Vaduganathan M, Petrie MC, Jhund PS, McMurray JJV

February 10 –  Joel Vazquez

Development and evaluation of a rapid CRISPR-based diagnostic for COVID-19

Hou T, Zeng W, Yang M, Chen W, Ren L, Ai J, Wu J, Liao Y, Gou X, Li Y, Wang X, Su H, Gu B, Wang J, Xu T.

February 17 – Postponed due to Inclement Weather

February 24 – Brian Parks

Alcohol increases exosome release from microglia to promote Complement C1q-induced cellular death of proopiomelanocortin neurons in the hypothalamus in a rat model of fetal alcohol spectrum disorders

Mukherjee S, Cabrera MA, Boyadjieva NI, Berger G, Rousseau B, Sarkar DK.

March 3 – Soumiya Pal

Mast cell-mediated antigen presentation regulates CD8+T cell effector functions

Stelekati E, Bahr R, D’Orlando O, Orinska Z, Mittrücker HW, Langenhaun R, Glatzel M, Bollinger A, Paus R, Bulfone-Paus S

March 10 – Lance Benson

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Wang Z, Aguilar E, Luna J, Dunai C, Khuat L, Le C, Mirsoian A, Minnar C, Stoffel K, Sturgill I, Grossenbacher S, Withers S, Rebhun R, Hartigan-O’Connor D, Mendez-Lagares G, Tarantal A, Isseroff R, Griffith T, Schalper K, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely S, Longo D, Blazar B, Canter R, Murphy W, Monjazeb A

March 17 – Francesca Lobianco

Pharmacogenomics of intracellular methotrexate polyglutamates in patients’ leukemia cells in vivo

Lopez-Lopez E, Autry R, Smith C, Yang W, Paugh S, Panetta J,  Crews K, Bonten E, Smart B, Pei D, McCorkle R, Diouf B, Roberts K, Shi L, Pounds S, Cheng C, Mullighan C, Pui CH, Relling M, Evans W

March 24 – Spring Break

March 31 – Joel Vazquez

Acute liver failure is regulated by MYC- and microbiome-dependent programs

Kolodziejczyk A, Federici S, Zmora N, Mohapatra G, Dori-Bachash M, Hornstein S, Leshem A, Reuveni D, Zigmond E, Tobar A, Meir Salame T, Harmelin A, Shlomai A, Shapiro H, Amit I, Elinav E

April 7 – Brian Parks

Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference

Nam MH, Han KS, Lee J, Won W, Koh W, Bae JY, Woo J, Kim J, Kwong E, Choi TY, Chun H, Lee SE, Kim SB, Park KD, Choi SY, Bae YC, Lee CJ

April 14 – Soumiya Pal

Lymphatic drainage from bronchus-associated lymphoid tissue in tolerant lung allografts promotes peripheral tolerance

Li W, Gauthier J, Tong A, Terada Y, Higashikubo R, Frye C, Harrison M, Hashimoto K, Bery A, Ritter J, Nava R, Puri V, Wong B, Lavine K, Bharat A, Krupnick A, Gelman A, Kreisel D

Fall 2020 Schedule

September 2 –  Lauren Russell

Dissertation Defense Practice

September 9 –  Francesca Lobianco

COVID-19 vaccine development and a potential nanomaterial path forward.

Shin, M.D., Sourabh, S., Chung, Y.H., Beiss, V., Soo, K.C., Oscar, Ortega, O.A.O.,  Wirth, D.M. Chen, A., Sack, M., Pokorki, J.K., Steinmetz, N.F.

September 16 –  Amal Shoeib

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver.

Habib,  A., Chokr, D., Wan, J., Hedge, P., Mabire, M., Seibert, M., Ribeiro, M.P., Le Gall, M., Letteron, P., Pilard, N., Mansouri, A., Brouillet, A., Tardelli, M., Weiss, E., Le Faouder, P., Guillou, H., Cravatt, B.F., Moreau, R., Trauner, M., Lotersztajn, S.

September 23 – Cathryn Wilson

Cannabidiol improves survival and behaviroural co-morbidities of Dravet syndrom in mice .

Patra, H., P., Serafeimidou, P., E., Bazelot, M., Walley, B., J., Williams, C., M., McNeish, A., J.

October 7 –  Lance Benson and Soumiya Pal

L-type Ca 2+channel blockers promote vascular remodeling through activation of STIM proteins.

Johnson, M.T., Gudlur, A., Zhang, X., Xin, P., Emrich,  S. M., Yoast, R.E., Courjaret, R., Nwokonko, R.M., Li, W., Hempel, N., Machaca, K., Gill, D.L., Hogan, P., G., Trebak, M.

October 14 – Christian Cabanlong

The synthetic cannabinoid XLR-11 induces in vitro nephrotoxicity by impairment of endocannabinoid-mediated regulation of mitochondrial function homeostasis and triggering of apoptosis.

Silva, J.P., Carmo, H., Carvalho, F.

October 21 – Brian Parks and Lance Benson

Opioid presynaptic disinhibiton of the midbrian periaqueductal grey descending analgesic pathway.

Lau, B.K., Winters, B.L., Vaughn, C.W.

October 28 – Amal Shoeib and Joel Vazquez

Rotenone Increases Isoniazid Toxicity but Does Not Cause Significant Liver Injury: Implications for the Hypothesis that Inhibition of the Mitochondrial Electron Transport Chain Is a Common Mechanism of Idiosyncratic Drug-Induced Liver Injury

Cho, T., Wang, X., Uetrecht, J.

November 4 – Soumiya Pal and Brian Parks

Increased Blood Pressure Causes Lymphatic Endothelial Dysfunction via Oxidative Stress in Spontaneously Hyperetensive Rats.

Mukohda, M., Mizuno, R., Ozark, H.

November 18 – Francesca LoBianco

Efficacy and Safety of Transarterial Chemoembolization Plus External Beam Radiotherapy vs Sorafenib in Hepatocellular Carcinoma With Macroscopic Vascular Invasion. Yoon, S.M., Ryoo, B.Y., Lee, S.J., Kim, J.H., Shin, J.H., An, J.H., Lee, H.C., Lim, Y.K.

December 2 – Lance Benson and Brian Parks

The Purinergic Receptor P2RX7 directs Metabolic Fitness of Long-Lived Memory CD8+ T Cells da Silva, H.B., Beura, L.K., Wang, H., Hanse, E.A., Gore, R., Scott, M.C., Walsh, D.A., Block, K.E., Fonesca, R., Yan, Y., Hippen, K.L., Blazar, B.R., Masopust, D., Kelekar, A., Vulchanova, L., Hogquist, K.A., Jameson, S.C.

December 9 – Joel Vazquez and Soumiya Pal

Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lympathic System Burchill, M.A., Finlon, J.M., Goldberg, A.R., Gillen, A.E., Dahms, P.A., McMahan, R.H., Tye, A., Winter, A.B., Reisz, J.A., Bohrnsen, E., Schafer, J.B., D’Alessandro, A., Orlicky, D.J., Kriss, M.S., Rosen, H.R., McCullough, R.L., Tamburini, B.A.J.

Spring 2020 Schedule

January 26 –  Joel Vazquez and Melissa Clemens will present:

Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice.

Gluchowski, N.L., Gabriel, K.R., Chitraju, C., Bronson, R.T., Mejhert, N., Boland, S.,  Wang, K., Lai,  Z.W., Farese, R.V., Jr., Walther, T.C.,
Hepatology. 2019 Dec;70(6):1972-1985. doi: 10.1002/hep.30765. Epub 2019 Jun 26.  PMID 31081165, PMCID: PMC6893913

 February 5 – David Henry and Francesca Lobianco will present:

Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis.

Suchard, M.A., Schuemie, M.J., Krumholz, H.M., You, S.C., Chen, R., Pratt, N., Reich, C.G., Duke, J., Madigan, D., Hripcsak, G., Ryan, P.B.,
Lancet. 2019 Nov 16;394(10211):1816-1826. doi: 10.1016/S0140-6736(19)32317-7. Epub 2019 Oct 24.
PMID:  31668726, PMCID: PMC6924620

February 12 –   Amal Shoeib and Christian Cabanalong will present

Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse.

Ruehle, S., Wager-Miller, J., Straiker, A., Farnsworth, J. Murphy, M.N., Loch, S., Monory, K., Mackie, K., Lutz B.,
J Neurochem. 2017 Aug;142(4):521-533. doi: 10.1111/jnc.14099. Epub 2017 Jul 18. PMID: 28608535, PMCID: PMC5554085

February 19 – Melissa Clemens and David Henry

Cerebral collateral therapeutics in acute ischemic stroke: A randomized preclinical trial of four modulation strategies. 

Beretta, S., Versace, A., Carone, D., Riva,  M., Dell’Era,  V., Cuccione, E., Cai,  R., Monza, L., Pirovano, S., Padovano, G., Stiro, F., Presotto, L., Paternò, G., Rossi, E., Giussani, C., Sganzerla, E.P., Ferrarese, C.,

Feb. 26  –   Christian Cabanlong and Joel Vazquez will present:

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. 

Cai, B., Dongiovanni, P., Corey, K.E, Wang, X., Shmarakov, I.O., Zheng, Z., Kasikara, C., Davra, V., Meroni, M., Chung, R.T., Rothlin, C.V, Schwabe, R.F., Blaner, W.S., Birge, R.B., Valenti, L., Tabas, I. PMID: 31839486, PMCID: PMC7004886

March 4 –  Soumiya Pal and Lance Benson will present

Sympathetic enhancement of memory T cell homing and hypertension sensitization. 

Xiao, L., Do, Carmo, L., Foss, J.D., Chen, W., Harrison, D.G., PMID: 31928179

April 1 –  Brian Parks and Saki Fukuda to jointly present

In vivo brain GPCR signaling elucidated by phosphoproteomics. 

Liu, J.J., Sharma, K., Zangrandi, L., Chen, C., Humphrey, S.J., Chiu, Y.T., Spetea, M.,, Liu-Chen, L.Y., Schwarzer, C., Mann, M.,PMID: 29930108,
PMCID: PMC6527112

April 15 –  Lance Benson and Soumiya Pal will present

Epsin deficiency promotes lymphangiogenesis through regulation of VEGF3 degradation in diabetes. 

Wu, H., Rahman, H,N,A,  Dong,Y.,  Liu, X.,  Lee, Y., Wen, A., To,H.T., Xiao,L.,  Birsner, A.E., Bazinet, L., Wong,S., Song, K.,  Brophy, M.L., Mahamud, M.R., Baojun,C.,     Cai, X., Pasula, S.,  Kwak, S., Yang, W., Bischoff, J., Xu, J.,  Bielenberg, D.R., Dixon, J.B.,  J.D., Robert,  Srinivasan, S.R.,  and C, Hong, PMID: 30102256, PMCID: PMC6118634,

Fall 2019 Schedule

September 4, 2019 – Melissa Clemens will present:

Adipocyte Death Preferentially Induces Liver Injury and Inflammation Through the Activation of Chemokine (C-C Motif) Receptor 2-Positive Macrophages and Lipolysis.

Kim SJ, Feng D, Guillot A, Dai S, Liu F, Hwang S, Parker R, Seo W, He Y, Godlewski G, Jeong WI, Lin Y, Qin X, Kunos G, Gao B.
Hepatology. 2019 May;69(5):1965-1982. doi: 10.1002/hep.30525. Epub 2019 Mar 18.            PMID:   30681731

September 11, 2019 – David Henry will present:

Cerebral collateral flow defines topography and evolution of molecular penumbra in experimental ischemic stroke.

Beretta S, Cuccione E, Versace A, Carone D, Riva M, Padovano G, Dell’Era V, Cai R, Monza L, Presotto L, Rousseau D, Chauveau F, Paternò G, Pappadà GB, Giussani C, Sganzerla EP, Ferrarese C.
Neurobiol Dis. 2015 Feb;74:305-13. doi: 10.1016/j.nbd.2014.11.019. Epub 2014 Dec 5.           PMID:   25484287

September 18, 2019 – Joel Vazquez will present:

Arsenic May Act as a Pro-Metastatic Carcinogen Through Promoting Tumor Cell-Induced Platelet Aggregation.
Kim K, Heo YK, Chun S, Kim CH, Bian Y, Bae ON, Lee MY, Lim KM, Chung JH.
Toxicol Sci. 2019 Mar 1;168(1):18-27. doi: 10.1093/toxsci/kfy247.            PMID:  30428081

 September 25, 2019 – Amal Shoeib will present:

Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpesvirus-infected endothelium.

Maor Y, Yu J, Kuzontkoski PM, Dezube BJ, Zhang X, Groopman JE.
Genes Cancer. 2012 Jul;3(7-8):512-20. doi: 10.1177/1947601912466556.                      PMID:    23264851

October 2, 2019 – Christian Cabanalong will present:

Thermolytic Degradation of Synthetic Cannabinoids: Chemical Exposures and Pharmacological Consequences.

Thomas BF, Lefever TW, Cortes RA, Grabenauer M, Kovach AL, Cox AO, Patel PR, Pollard GT, Marusich JA, Kevin RC, Gamage TF, Wiley JL.
J Pharmacol Exp Ther. 2017 Apr;361(1):162-171. doi: 10.1124/jpet.116.238717. Epub 2017 Jan 13. Erratum in: J Pharmacol Exp Ther. 2017 May;361(2):245.    PMID:  28087785

October 16, 2019 – Francesca Lobianco will present:

DMAPT is an Effective Radioprotector from Long-Term Radiation-Induced Damage to Normal Mouse Tissues In Vivo.

Morel KL, Ormsby RJ, Klebe S, Sweeney CJ, Sykes PJ.
Radiat Res. 2019 Aug;192(2):231-239. doi: 10.1667/RR15404.1. Epub 2019 May 16.       PMID:    31095445

October 23, 2019 – David Henry & Laura Ewing will present:

Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration.

Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, Zhang L, Liu Q, Li Y, Li Y, Zhao H, Liu K, Lu J, Zhou Y, Huang P, Nie Y, Yan Y, Hui L, Lui KO, Zhou B.
Nat Commun. 2016 Nov 18;7:13369. doi: 10.1038/ncomms13369.      PMID:     27857132

October 30, 2019 – Laura Ewing & Francesca Lobianco will present:

Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice.

Zhu F, Guo R, Wang W, Ju Y, Wang Q, Ma Q, Sun Q, Fan Y, Xie Y, Yang Z, Jie Z, Zhao B, Xiao L, Yang L, Zhang T, Liu B, Guo L, He X, Chen Y, Chen C, Gao C, Xu X, Yang H, Wang J, Dang Y, Madsen L, Brix S, Kristiansen K, Jia H, Ma X.
Mol Psychiatry. 2019 Aug 7. doi: 10.1038/s41380-019-0475-4. [Epub ahead of print]    PMID:      31391545

November 6, 2019 – Amal Shoeib & Christian Cabanalong will present:

Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction.

Gao F, Kataoka M, Liu N, Liang T, Huang ZP, Gu F, Ding J, Liu J, Zhang F, Ma Q, Wang Y, Zhang M, Hu X, Kyselovic J, Hu X, Pu WT, Wang J, Chen J, Wang DZ.
Nat Commun. 2019 Apr 17;10(1):1802. doi: 10.1038/s41467-019-09530-1.        PMID:   30996254

November 13, 2019 –  Francesca Lobianco & Melissa Clemens will present:

Cardiac macrophages promote diastolic dysfunction.

Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR,  Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M.
J Exp Med. 2018 Feb 5;215(2):423-440. doi: 10.1084/jem.20171274. Epub 2018 Jan 16.    PMID:   29339450

November 20, 2019 – Melissa Clemens & Joel Vazquez will present:

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex.

Zeng WZ, Marshall KL, Min S, Daou I, Chapleau MW, Abboud FM, Liberles SD, Patapoutian A.
Science. 2018 Oct 26;362(6413):464-467. doi: 10.1126/science.aau6324.        PMID:      30361375

December 4, 2019 –  Christian Cabanalong & Amal Shoeib will present:

Systemic immunization with altered myelin basic protein peptide produces sustained antidepressant-like effects.

Han Y, Sun CY, Meng SQ, Tabarak S, Yuan K, Cao L, Yan W, Xu LZ, Deng JH, Zhu WL, Li JL, Lu L, Xue YX, Shi J.
Mol Psychiatry. 2019 Aug 2. doi: 10.1038/s41380-019-0470-9. [Epub ahead of print]    PMID:    31375779

December 11, 2019 – Joel Vazquez & David Henry will present:

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension.

Faraco G, Sugiyama Y, Lane D, Garcia-Bonilla L, Chang H, Santisteban MM, Racchumi G, Murphy M, Van Rooijen N, Anrather J, Iadecola C.
J Clin Invest. 2016 Dec 1;126(12):4674-4689. doi: 10.1172/JCI86950. Epub 2016 Nov 14.       PMID:  27841763

December 18, 2019 – Laura Ewing will present:

Radiosensitization In Vivo by Histone Deacetylase Inhibition with No Increase in Early Normal Tissue Radiation Toxicity.

Groselj B, Ruan JL, Scott H, Gorrill J, Nicholson J, Kelly J, Anbalagan S, Thompson J, Stratford MRL, Jevons SJ, Hammond EM, Scudamore CL, Kerr M, Kiltie AE.
Mol Cancer Ther. 2018 Feb;17(2):381-392. doi: 10.1158/1535-7163.MCT-17-0011. Epub 2017 Aug 24.               PMID:  28839000

Spring 2019 Schedule

January 9, 2019 – Samantha McClenahan & Laura Ewing

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.13030

Bosnano JS, Banks ML, Kolanos R, Sakloth F, Barnier ML, Glennon RA, Cozzi NV, Partilla JS, Baumann MH, Negus SS.  Quantitative structure-activity relationship analysis of the pharmacology of para-substituted methcathinone analogues. British Journal of Pharmacology. 2015, May; 172(10):2433-2444. PMID: 25438806.

January 16, 2019 – David Henry & Lauren Russell

http://stm.sciencemag.org/content/10/426/eaan4488.short

Sagiv-Barfi I, Czerwinkski DK, Levy S, Alam IS, Mayer AT, Gambhir SS, Levy R. Eradication of spontaneous malignancy by local immunotherapy. Science Translational Medicine. 2018, Jan 31; 10(426): eaan4488. PMID: 29386357

January 23, 2019 – Cancelled

January 30, 2019 – Julia Tobacyk & Amal Shoeib

https://www.nature.com/articles/s41598-017-13282-7

Carhart-Harris RL, Roseman L, Bolstridge M, Demetriou L, Pannekoek JN, Wall MB, Tanner M, Kaelen M, McGonigle J, Murphy K, Leech R, Curran HV, Nutt DJ.  Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms. Sci Rep. 2017, Oct 13; 7(1): 13187. PMID: 29030624

February 6, 2019 – Cancelled

February 13, 2019 – Kyle Urquhart & Julia Tobacyk

http://molpharm.aspetjournals.org/content/88/2/335.long

Thompson GL, Lane JR, Coudrat T, Sexton PM, Christopoulos A, Canals M.  Biased Agonism of Endogenous Opioid Peptides at the μ-Opioid Receptor. Mol Pharmacol. 2015 Aug; 88(2): 335-46. PMID: 2601354

February 20, 2019 – Brittney Garner & David Henry

https://www.sciencedirect.com/science/article/pii/S2211124718315031?via%3Dihub

Chakraborty S, Galla S, Cheng X, Yeo J-Y, Mell B, Singh V, Yeoh B, Saha P, Mathew AV, Vijay-Kumar M, Joe B. Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension. Cell Rep. 2018 Oct 16;25(3):677-689.e4. PMID: 30332647

February 27, 2019 – Christian Cabanlong & Brittney Garner

http://molpharm.aspetjournals.org/content/88/2/368.long

Khajehali E, Malone DT, Glass M, Sexton PM, Christopoulos A, Leach K. Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor. Mol Pharmacol. 2015 Aug; 88(2): 368-379. PMID: 26044547

March 6, 2019 – Stephen Shrum & Kyle Urquhart

https://onlinelibrary.wiley.com/doi/full/10.1111/adb.12639

Hemby SE, McIntosh S, Leon F, Cutler SJ, McCurdy CR.  Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.  Addict Biol. 2018 Jun 27. doi: 10.1111/adb.12639. PMID: 29949228

March 13, 2019 – Cancelled

March 20, 2019 – Spring Break

March 27, 2019 – Allie Davis & Stephen Shrum

https://www.nature.com/articles/nature18928

Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Changhong X, Ji X, Lo EH. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 Jul 28; 535(7613):551-555. PMID: 27466127

April 3, 2019 – Laura Ewing & Allie Davis

https://www.pnas.org/content/112/51/E7138.long

Wheeler DS, Underhill SM, Stolz DB, Murdoch GH, Thiels E, Romero G, Amara SG. Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine.  Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51): E7138-47. PMID: 26553986

April 17, 2019 – Melissa Clemens & Christian Cabanlong

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191299

Barry RL, Byun NE, Williams JM, Siuta MA, Tantawy MN, Speed NK, Saunders C, Galli A, Niswender KD, Avison MJ. Brief exposure to obesogenic diet disrupts brain dopamine networks.  PLoS One. 2018 Apr 26;13(4):e0191299. PMID: 29698491

April 24, 2019 – Amal Shoeib & Melissa Clemens

https://www.pnas.org/content/115/50/12616.long

Milojevic S, Radicchi F, Walsh JP. Changing demographics of scientific careers: the rise of the temporary workforce. PNAS.  2018, Dec 11; 115(50): 12616-12623. PMID: 3053069

Fall 2018 Schedule

September 5, 2018 – Julia Tobacyk & Samantha McClenahan

http://journals.sagepub.com/doi/abs/10.1177/0269881114565144?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&
Bogenschutz MP, Forcehimes AA, Pommy JA, Wilcox CE, Barbosa PC, Strassman RJ. Psilocybin-assisted treatment for alcohol dependence: a proof-of-concept study. J Psychopharmacol. 2015 Mar;29(3):289-99. doi: 10.1177/0269881114565144. Epub 2015 Jan 13. PMID: 25586396

September 12, 2018 – Chris Bolden & Lauren Russell

http://jpet.aspetjournals.org/content/344/3/708.long

DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD. A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17. doi: 10.1124/jpet.112.201616. Epub 2013 Jan 8. PMID: 23300227

September 19, 2018 – Christian Cabanlong & David Henry

https://www.sciencedirect.com/science/article/pii/S0140673612620893?via%3Dihub

2021-2022 Seminar Series

Seminars are held virtually on Wednesdays at 3:30 p.m. Please contact Cheryl Shelton to register.

September 22, 2021 – Special Session
Jason Paris, Ph.D. (Director, Neuropharmacology Core, University of Mississippi)
“HIV Proteins Disrupt Steroidogenesis: Implications for Stress and Reward”

October 6, 2021 – NCTR Series
Dr. Dayton Petibone, Division of Genetic and Molecular Toxicology
“Development of Microphysiological Systems for Evaluating Anti-Zika Virus Therapies”

Dr. Xilin Li, Division of Genetic and Molecular Toxicology
“The Development and Application of Metabolically Competent TK6 Cell Lines for Genotoxicity Testing”

October 13, 2021 – NCTR Series
Dr. Weida Tong, Division of Bioinformatics and Biostatistics
“Three Things You Need to Know About AI”

Dr. Wenjing Guo, Division of Bioinformatics and Biostatistics
“Informing Selection of Drugs for COVID-19 Treatment by Big Data Analytics”

October 20, 2021 – NCTR Series
Dr. Sangeeta Khare, Division of Microbiology
“Gastrointestinal Microbiome: Translational and Regulatory Sciences Research”

Dr. Kidon Sung, Division of Microbiology
“Dynamic Adaptive Response of Pseudomonas aeruginosa to Antibiotic-Coated Catheters”

October 27, 2021 – NCTR Series
Dr. Serguei Liachenko, Division of Neurotoxicology
“MRI Biomarkers of Neurotoxicity”

Dr. Andrew Shen, Division of Neurotoxicology
“The Importance of CBD Research at FDA”

November 3, 2021 – NCTR Series
Dr. Ellen Jones, Division of Systems Biology
“MALDI Imaging Mass Spectrometry: A New Tool Imaging Modality for Use in Toxicological Studies”

Dr. Li Pang, Division of Systems Biology
“Evaluation of Oncology Drug-Induced Cardiotoxicity with Patient-Specific iPSC-CMs”

November 10, 2021 – NCTR Series
Dr. Camila Silva, Division of Biochemical Toxicology
“Wastewater Surveillance as a Complementary Tool to Monitor COVID-19 Spread in Arkansas”

Dr. Yuxi Li, Division of Biochemical Toxicology
“Identify Male Reproductive Toxicities of Chemicals Using In Vitro Cell Models”

November 17, 2021
Brian Parks
Title TBD

November 25, 2021
No Seminar – Thanksgiving

December 1, 2021
Lance Benson
Title TBD

December 8, 2021

December 15, 2021

December 22, 2021
No Seminar – Winter Break

December 29, 2021
No Seminar – Winter Break

January 6, 2022
Benjamin Humphreys, M.D., Ph.D.

January 12, 2022
Julia Tobacyk, Ph.D.
Title TBD

January 19, 2022

January 26, 2022

February 2, 2022

February 9, 2022
Hui-Ming Chang, M.D., M.P.H. (Professor, Dept of Pharmacology & Toxicology, UAMS)
“Phoenix trials : Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane”

February 16, 2022

February 23, 2022

March 2, 2022

March 9, 2022

March 16, 2022

March 21-25, 2022
No Seminar – Spring Break

March 30, 2022

April 6, 2022
No Seminar – EB 2022 Conference April 2-5

April 13, 2022

April 20, 2022
Robert Nickells, Ph.D. (Professor and Frederick A. Davis Chair of Ophthalmology, University of Wisconsin-Madison)

April 27, 2022
Parajuli Lab (TBD)
Title TBD

May 4, 2022

May 11, 2022

2020-2021 Seminar Series

Seminars are held virtually on Wednesdays at 3:30 p.m. Please contact Pam Kahler to register.

November 4, 2020
Colleen Urban (Specialist, Nanostring Technologies)
“GeoMx Digital Spatial Profiling: Morphology Driven, High-Plex Spatial Analysis of Tissue Microenvironments”

November 11, 2020
No Seminar – Veterans Day

November 18, 2020
Lian Leng, Ph.D. (Associate Director, Emulate, Inc)
“Recreating Key Features of the Human Body using “Organs-on-a-Chip””

November 25, 2020
No Seminar – Thanksgiving

December 2, 2020
Adam Brown, Ph.D. (Field Application Specialist, BioRad Laboratories)
“Power of Partitioning: The QX200 Droplet Digital PCR System”

December 9, 2020
Neil Detweiler, Ph.D. (Assistant Professor, Goshen College)
“Control of Ventilation and Ventilation-Perfusion Matching: from Mice to Yaks”

December 16, 2020
Samantha McClenahan, Ph.D. (Postdoctoral Fellow, Vanderbilt University)
“Tools for Tubules: Development of Kir4.1/5.1 Potassium Channel Modulators for Controlling Sodium Reabsorption in the Distal Nephron”

December 23, 2020
No Seminar – Winter Break

December 30, 2020
No Seminar – Winter Break

January 6, 2021
Stephanie Byrum, Ph.D. (Assistant Professor, Dept of Biochemistry and Molecular Biology, UAMS)
“Exploring Gene Expression in the Context of the Tissue Microenvironment using 10x Spatial Gene Expression”

January 13, 2021
Benjamin J. Lieblong, Ph.D. (Study Coordinator, Dept of Pathology, UAMS)
“Immunomechanisms of Cervical Precancerous Lesion Regression with PepCan, a Therapeutic Human Papillomavirus Vaccine”

January 20, 2021
Dr. Nancy Rusch, Department Town Hall Meeting

January 27, 2021
Donald Johann, Ph.D. (Professor, Dept of Biomedical Informatics, UAMS)
“The ABC’s of Next Generation Sequencing”

February 3, 2021
Galen Wenger, Ph.D. (Emeritus Professor, Dept of Pharmacology and Toxicology, UAMS)
“Behavioral Pharmacology and Its History at UAMS”

February 10, 2021
Anatoliy Gashev, M.D., Ph.D. (Associate Professor, Texas A & M University)
“Mast Cells and Lymphatic Vessels: Bidirectional Regulatory Interactions”

February 17, 2021
Qinghua Zhou, Ph.D. (Professor, Jinan University, Guangzhou, China)
“Molecular Mechanisms of Autophagy Promotion by Mitochondrial Endonuclease G”

February 24, 2021
Zufeng Ding, Ph.D. (Assistant Professor Cardiology, Dept of Internal Medicine, UAMS)
“PCSK9 and Myocardial Infarction”

March 3, 2021
Timothy Haystead, Ph.D. (Professor, Duke University)
“Adventures in Targeting the Chaperone Machinery in Eukaryotes and Prokaryotes- from the Bench to Clinical Trials“

March 10, 2021
J. Christopher States, Ph.D. (Professor, Vice Chair, Research Dept of Pharmacology and Toxicology, University of Louisville)
“MicroRNA Dysregulation and Aneuploidy in Arsenic-induced Skin Carcinogenesis”

March 17, 2021
Nabil Alkayed, Ph.D. (Director, Cardiovascular Research, OHSU)
“GPR39 As a Therapeutic Target in Vascular Cognitive Impairment and Dementia“

March 24, 2021
No Seminar – Spring Break

March 31, 2021
Edward T. Yeh, Ph.D. (Chair of Department of Internal Medicine, UAMS)
“SUMO/Sentrin, From Bench to Bedside”

April 7, 2021
Martin Gallagher, M.D., Ph.D. (Associate Professor, Vanderbilt University)
“High Density EEG and Network Analysis in Rodent Models of Neurological Disease“

April 14, 2021
Sharda Singh, Ph.D. (Associate Professor, Texas Tech University)
“Sulforaphane Use in Cancer Chemotherapy to Protect Against Doxorubicin Cardiotoxicity”

April 21, 2021
Tanecia Mitchell, Ph.D. (Assistant Professor, University of Alabama at Birmingham )
“The Role of Diet and Immunity in Kidney Stone Disease”

April 28, 2021
No Seminar – EB 2021 Conference

May 5, 2021
Elizabeth Byrnes, Ph.D. (Professor, Tufts University)
“Is It Really All Your Mother’s Fault? Opioids, Transgenerational Epigenetics, and Metabolism“

May 12, 2021
Steve Crowley, M.D., Ph.D. (Professor of Nephrology, Duke University)
“Regulators of Dendritic Cell-Mediated T Cell Activation in Salt-Sensitive Hypertension”

May 19, 2021
Theresa M. Carbonaro, Ph.D. (Pharmacologist, US Dept of Justice, Drug Enforcement Administration)
“Evaluating Drug Abuse Liability: Applying Pharmacology Data to Drug Scheduling Actions”

May 26, 2021
Marco Pravetoni, Ph.D. (Associate Professor, University of Minnesota)
“Vaccines and Antibody-based Strategies to Counteract Opioid Use Disorders and Overdose”

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Mailing Address: 4301 West Markham Street, Little Rock, AR 72205
Phone: (501) 686-7000
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