Researchers at the University of Arkansas for Medical Sciences (UAMS) have received a $604,208 grant to study how an abnormal protein found in ovarian cancer and some brain tumors helps tumors grow.

The National Institutes of Health (NIH) awarded the three-year grant to Karen Abbott, Ph.D., assistant professor in the UAMS College of Medicine’s Department of Biochemistry and Molecular Biology, and Analiz Rodriguez, M.D., Ph.D., assistant professor in the UAMS College of Medicine’s
Department of Neurosurgery. Abbott is principal investigator for the grant, and Rodriguez is co-investigator.

The pair are researching glycosylation changes, which are found in both ovarian cancer and glioblastoma, an aggressive brain tumor. Glycosylation is the enzymatic process that attaches glycans (a series of carbohydrates, including the sugars) to proteins, or other organic molecules.

In her previous research, Abbott developed an antibody that targets glycosylation on proteins covering the surface of ovarian cancer cells. The new project involves adapting that protein into a new type of therapy for the disease and examining if it also could serve as an effective therapy for glioblastoma, which shares the same type of glycosylation.

“This research can help us understand the proteins that carry this glycosylation change and how this change promotes signals to keep cancer cells alive. Studying those pathways may lead to new methods to kill the cancer cells but leave the normal ones alone,” said Rodriguez, a neurosurgeon
and researcher.

“With this grant, we will be developing a new type of therapeutic by modifying the current antibody to allow destruction of the cancer cells,” Abbott said.

In their work, Rodriguez’s lab, which focuses on glioblastoma, will provide tumor samples from patients to test this novel therapy.

Rodriguez and Abbott, whose labs are next door to each other, decided to team up after learning of each other’s research and discovering it intersected.

“We decided it would be a good idea to join forces and work on something together,” Rodriguez said.

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Congratulations to the Wahls lab for their recent publication in Epigenetics & Chromatin.

Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot

Congratulations to Binyam Balachew on winning first place in the Graduate Student Association Research Symposium Poster presentation!

Dr. Wayne Wahls’ study on disparities in NIH funding is featured in the Nature Daily Briefing today.

Andrea Edwards recently present her work at a conference on Molecular Biology & Nucleic Acids in Toronto Canada.  Andrea presented a poster entitled “G-Quadruplex in PARP1-Mediated DNA Damage Response”.  Her work is aimed at addressing the role of PARP-1 in DNA damage repair, in particular with regards to G-quadruplex DNA.  Andrea earned first prize in the poster competition and was chosen to present her work to the conference attendees as a short talk.  Her talk was well-received by the audience.  Congratulations Andrea!!

Two graduate students in the Raney lab, Andrea Edwards and Binyam Belachew, attended a Molecular Biology & Nucleic Acids meeting in Toronto, Canada. Andrea presented a poster entitled “G-Quadruplex in PARP1-Mediated DNA Damage Response.”  Binyam presented a poster entitled “Function and Mechanism of Hepatitis C Virus Non-structural Protein 3 (HCV NS3) Unfolding of Viral  G-quadruplex RNA Structures.”

Congratulations to the Chambers lab for their recent publication of two manuscripts.

Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes
U Majcher, A Urbaniak, E May, M Moshari, M Delgado, J Wietrzyk, F Barti, T Chambers, J Tuszynski, A Huczynski

Microtubules play an essential role in the survival of primary acute lymphoblastic leukemia cells advancing through G1 phase
Magdalena Delgado & Timothy C. Chambers

 

Congratulations to the Miller lab  on their recent publication.

Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches.  

Dustyn A. Barnette, Mary A. Davis, Na L. Dang, Anirudh S. Pidugu, Tyler Hughes, S. Joshua Swamidass, Gunnar Boysen, and Grover P. Miller

Congratulations to the Raney lab on their recent manuscript.

Pif1 helicase unfolding of G-quadruplex DNA is highly dependent on sequence and reaction conditions.

Alicia K. Byrd, Matthew R. Bell, and Kevin D. Raney

Karen Abbott has been awarded a new NIH grant totaling over 3 million dollars to translate new glycan biomarkers to the clinic for ovarian cancer.

Isabelle Racine Miousse, Ph.D., has joined the Department of Biochemistry and Molecular Biology as an Assistant Professor. Dr. Miousse received her doctorate from McGill University in Montreal, Canada. She completed a postdoctoral fellowship in cancer epigenetics in the Department of Environmental and Occupational Health at UAMS. Dr. Miousse’s research focuses on methyl donors during cancer progression and treatment.