Supported by funds from the UAMS College of Medicine, the CMIC Pilot Project Program continues to identify researchers with ideas that align with the mission of the center and that could serve as a foundation for a full-fledged COBRE research project. To help these ideas mature and obtain key preliminary results, the CMIC funds up to two $75,000 Pilot Project awards annually.
In 2024, two projects were selected for Pilot Project funding.
The Pilot Award for the proposal entitled “Biophysical insights into AID mutagenic activity at DNA secondary structure hotspots” will support work on understanding the molecular mechanisms behind the genomic instability in diffuse large B-cell lymphoma. Her proposal incorporates elements from the CMIC mission and the Core facilities to define and exploit the molecular interactions between a mis-regulated mutagenic protein and the nuclear genome to minimize the risk associated with resistance to chemotherapy.
Kirk West, PhD is an Assistant Professor in the Department of Biochemistry and Molecular Biology. His COBRE-sponsored research program aims to delineate the mechanistic role of TLKs in pathways of genomic nucleotide excision repair. Dr. West was a CMIC Pilot Project Awardee and prior to that, he was supported by a postdoctoral fellowship from the American Cancer Society. Dr. West’s mentors are Dr. Eric Enemark and Dr. Wayne Wahls.
How to Acknowledge the CMIC
“Research reported in this [publication, release] was supported (in whole or in part) by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number P20GM152281. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.”
For abstracts, a short note “Supported by a grant from the NIH/NIGMS – 1P20GM152281” will suffice.
Contact
Robert L. Eoff, Ph.D.
Biomedical Research Center 1
325 Jack Stephens Drive
Little Rock, AR 72210
Telephone: 501-686-8343
Email: rleoff@uams.edu