Dr. Holthoff completed the combined M.D./Ph.D. program at UAMS in 2014. He then completed a combined internal medicine and pediatrics residency at UAMS in 2018. He served as internal medicine chief resident from 2018-2019 and finished his nephrology clinical fellowship at UAMS in June 2021. He then joined the College of Medicine as an Assistant Professor in the Division of Nephrology. He is the recipient of a KL2 Mentored Research Career Development Award, which will support his efforts to identify novel therapeutic targets for acute kidney injury.
- Acute kidney injury
- IgA nephropathy
- Pathophysiology and biomarkers of AKI
- Development of pharmacological molecules for the treatment of AKI
- Enjoying time with my wife and toddler
- Classic cars
- World history
Becoming a father, followed by becoming a clinician scientist
What Do You Like About Nephrology?
I was first drawn to nephrology as a young college student because of the complex pathophysiology of acute kidney injury. My doctoral dissertation explored the use of resveratrol, an antioxidant found in red wine, to treat acute kidney injury in mice. It was during these three years of research that my desire to pursue a career in nephrology was established. Later, during my second year of residency, I was diagnosed with IgA nephropathy which has allowed me to relate to my patients on a more personable level.
Why Little Rock?
Arkansas has always been home for me and my family. I grew up in a small farming community of about 500 people in the Arkansas delta. My wife was born and raised about 60 miles north of Little Rock. We love Arkansas and hope that we never have to leave. The people are great, the outdoors and scenery are beautiful, and there is plenty of activities to keep you entertained.