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Department of Microbiology and Immunology: Manzano Lab

Publications

Under Review

  1. Viswanathan P, Bersonda JR, Gill J, Navarro A, Farrar AC, Dunham D, Boehme KW, Mark Manzano. The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines. bioRxiv.
  2. Maddineni A, Liang Z, Jambardi S, Roy S, Tycko J, Patil A, Manzano M, Gottwein E. Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems. bioRxiv.
  3. Owens SM, Sifford JM, Li G, Murdock S, Salinas E, Manzano M, Ghosh D, Stumhofer J, Forrest JC. Intrinsic p53 Activation Restricts Gammaherpesvirus-Driven Germinal Center B Cell Expansion during Latency Establishment. bioRxiv. In revision for Nature Communications.

Publications

Google Scholar link

At UAMS

  1. Murdock SJ, Bersonda JR, Forrest JC, and Manzano M (Corresponding Author). Molecular Mechanisms of KSHV Latency Establishment and Maintenance. Current Clinical Microbiology Reports, 2024. PDF.
  2. Kuehnle N, Osborne SM, Liang Z, Manzano M, and Gottwein E. CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent TRAIL-R1-mediated cell death. Cell Death and Differentiation, doi.org/10.1038/s41418-023-01133-0. 2023.
  3. Dunham D*, Viswanathan P*, Gill J, Manzano M (Corresponding Author). Expression ratios of the antiapoptotic BCL2 family members dictate the selective addiction of Kaposi’s sarcoma-associated herpesvirus-transformed primary effusion lymphoma cell lines to MCL1. Journal of Virology. 96(23):e0136022, 2022. PMC9749474, PMID: 36416587. *Equal contributions.

Prior to UAMS

  1. Manzano M*, Gunther T*, Ju H, Nicholas J, Bartom ET, Grundhoff A, Gottwein E. KSHV drives a super-enhancer-mediated survival gene expression program in primary effusion lymphoma. mBio 11(4):e01457-20. 2020. PMID 32843547. (*Equal contributions.)
  2. Morrison K, Manzano M, Chung K, Schipma MJ, Bartom ET, Gottwein E. The oncogenic Kaposi’s sarcoma-associated herpesvirus encodes a mimic of the tumor suppressive miR-15/16 family. Cell Reports 29(10):2961-2969.e6. 2019. PMID 31801064.
  3. Patil A, Manzano M, Gottwein E. Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma. Blood Advances 3(14):2105-2117, 2019. PMID 31300418.
  4. Manzano M, Patil A, Waldrop A, Dave S, Behdad A, and Gottwein E. Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma. Nature Communications, 9(1):3263, 2018. PMID 30111820.
  5. Patil A, Manzano M, and Gottwein E. CK1α and IRF4 are essential and independent effectors of immunomodulatory drugs in primary effusion lymphoma. Blood 132:577-86, 2018. PMID 29954751.
  6. Balasubramanian A*, Manzano M*, Teramoto T, Pilankatta R, and Padmanabhan R. High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease. Antiviral Research 134:6-16, 2016. PMID 27539384 (*Equal contributions)
  7. Manzano M, Forte E, Raja AN, Schipma MJ, and Gottwein E. Divergent target recognition by coexpressed 5′-isomiRs of miR-142-3p and selective viral mimicry. RNA 21(9):1606-1620, 2015. PMID 26137849.
  8. Forte E, Raja AN, Shamulailatpam P, Manzano M, Schipma MJ, Casey JL, and Gottwein E. MicroRNA-mediated transformation by the Kaposi’s sarcoma-associated herpesvirus Kaposin locus. Journal of Virology. 89(4):2333-2341, 2015. PMID 25505059.
  9. Grosswendt S*, Filipchyk A*, Manzano M, Klironomos F, Schilling M, Herzog M, Gottwein E, and Rajewsky N. Unambiguous identification of miRNA:target site interactions by different types of ligation reactions. Molecular Cell. 54(6):1042-1054, 2014. PMID 24857550 (*Equal contributions)
  10. Zhang W, Nandakumar N, Shi Y, Manzano M, Smith A, Graham G, Gupta S, Vietsch EE, Laughlin SZ, Wadhwa M, Chetram M, Joshi M, Wang F, Kallakury B, Toretsky J, Wellstein A, and Yi C. Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Science Signaling 7(324):ra42, 2014. PMID 24803537
  11. Boonyasuppayakorn S, Reichert ED, Manzano M, Nagarajan K, Padmanabhan R. Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity. Antiviral Research 106:125-134, 2014. PMID 24680954
  12. Manzano M, Padia J, and Padmanabhan R. Small molecule inhibitor discovery for dengue virus protease using high-throughput screening. Methods in Molecular Biology 1138:331-344, 2014. PMID 24696346
  13. Manzano M and Padmanabhan R. Targeted mutagenesis of dengue virus type 2 replicon RNA by yeast in vivo recombination. Methods in Molecular Biology 1138:151-160, 2014. PMID 24696336
  14. Manzano M, Shamulailatpam P, Raja AN, Gottwein E. Kaposi’s sarcoma-associated herpesvirus encodes a mimic of cellular miR-23. Journal of Virology 87(21):11821-11830, 2013. PMID 23986579
  15. Teramoto T, Chiang HS, Takhampunya R, Manzano M, Padmanabhan R, and Maric M. Gamma interferon-inducible lysosomal thioreductase (GILT) ablation renders mouse fibroblasts sensitive to dengue virus replication. Virology 441(2):146-151, 2013. PMID 23642353
  16. Manzano M, Reichert ED, Polo S, Falgout B, Kasprzak W, Shapiro BA, and Padmanabhan R. Identification of cis-acting elements in the 3′-untranslated region of the dengue virus type 2 RNA that modulate translation and replication. Journal of Biological Chemistry 286(25):22521-22534, 2011. PMID 21515677
  17. Alcaraz-Estrada SL, Manzano MI, Del Angel RM, Levis R, and Padmanabhan R. Construction of a dengue virus type 4 reporter replicon and analysis of temperature-sensitive mutations in non-structural proteins 3 and 5. Journal of General Virology 91(Pt 11):2713-2718, 2010. PMID 20631089