Overview
With a 2,200 square-foot laboratory dedicated to the chemical analysis of biological samples and diets, the Arkansas Children’s Nutrition Center Metabolomics and Analytical Chemistry Core, directed by Colin Kay, Ph.D. (Scientific Director) and Renny Lan, Ph.D. (Operations Director), as well as a full-time chemist and several affiliated post-doctoral trainees responsible for operation and maintenance the LC-MS systems, and work closely with the Arkansas Children’s Nutrition Center Biostatistics and Data Innovation Core to analyze and process metabolomic, lipidomic, and targeted assay data (targeted and untargeted) from a variety of human and animal samples including plasma, serum, tissues, urine, milk, and fecal/intestinal contents. Learn more about the core capabilities

Assays
Using chromatography and various mass spectrometry platforms to describe metabolites – proteins, lipids, phytochemicals, and other small molecules from a variety of human/animal and plant/food samples.
- Untargeted Metabolomics
- Lipidomics
- Bile acids
- Tryptophen pathway metabolites
- Short Chain Faty Acids (SCFA)
- Amino acids
- Phytochemical and Microbial Metabolomics
- Acylcartinines
- Phytochemicals
- Carotenoids and lipid soluble vitamins
Powerful analytical capabilities for the systematic analysis of metabolites in biological specimens — found at a certain time, under defined conditions

Thermo Q-Exactive Mass Spectrometer
Thermo Q-Exactive hybrid quadrupole-orbitrap MS, with a Thermo/Dionex UltiMate 3000 UHPLC chromatography system
Learn more
Thermo Orbitrap Exploris 480 Mass Spectrometer
Thermo Orbitrap Exploris 480 MS coupled with a Vanquish Horizon UHPLC, using AcquireX data acquisition
Find out about specific analyses
SCIEX 7500+ QqQ Mass Spectrometer
Exion High performance UHPLC coupled electrospray 7500+ QqQ MS (SCIEX), using SCIEX OS operational and data acquisition software
Check out how we use it
Waters Cyclic Ion Mobility Quadrupole Time of Flight Mass Spectrometer
Waters Cyclic Ion Mobility Quadrupole Time of Flight MS (cIMS) interfaced with a Waters ACQUITY Premier UPLC system running Masslynx software
Delivering cutting-edge analysis
Waters Xevo TQ-S micro QqQ Mass Spectrometer
Waters Xevo TQ-S micro Triple Quadrupole MS running MassLynx Software, integrated with ACQUITY Premier UPLC
See how it works
Waters QDa Mass Spectrometer
Waters PDa system, coupled with an H-class ACQUITY UPLC with a QDa mass detector running Empower software
This is how we use itAdditional Information
Within the Metabolomics and Analytical Chemistry Core, the lab of Sree Chintapalli, Ph.D., has an advanced isothermal titration calorimeter (Microcal PEAQ-ITC, Malvern USA), Circular Dichroism (CD spectropolarimeter, J-1500 model, Jasco instruments, USA) and Oxytherm+ respirometer (Hansatech USA), ACTA Purification (GE USA) instruments for conducting biochemical and biophysical research in the fields of protein-ligand interactions and mitochondrial oxidative phosphorylation studies.