The Delgado-Calle laboratory investigates the mechanisms by which myeloma cancer cells alter the biology of other cells in the tumor/bone marrow microenvironment, particularly osteocytes, with the final goal of identifying targetable factors for the treatment of multiple myeloma and its associated bone disease. We employ a combination of in vitro, ex vivo and in vivo mouse models to study tumor biology and characterized the effects of tumor cells on bone remodeling. Current projects in the laboratory investigate the effects of Wnt and Notch signaling communication between myeloma cells and bone cells on tumor growth, cancer cell dormancy, and bone destruction. Other projects in the laboratory investigate the crosstalk between bone and adipose tissues that regulates body fat and whole-body metabolism.