News
Kirk West, Ph.D., Receives American Cancer Society Postdoctoral Fellowship
West ACS Fellowship
![Kirk West](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2022/01/West_Kirk-L_wide-2-2048x1152-1.jpg)
Kirk, West, Ph.D., is UAMS’ first recipient of the prestigious American Cancer Society’s three-year postdoctoral fellowship.
Only 18% of ACS fellowships are funded from a nationwide pool of applicants. The three-year fellowship will help fund West’s research on the role of LC8-TLK1/2 axis in the DNA repair pathway in the ACS-funded laboratory of his mentor, Justin Leung, Ph.D., an assistant professor in the College of Medicine’s Department of Radiation Oncology.
West is a graduate of Arkansas Tech University and completed his Ph.D. at UAMS in the Department of Biochemistry and Molecular Biology in 2018 under the mentorship of Alan Tackett, Ph.D. West is a native of Lamar, Arkansas.
“This prestigious award speaks volumes to the potential of Dr. West in cancer research and the cutting-edge research environment in Dr. Leung’s laboratory and the Winthrop P. Rockefeller Cancer Institute,” said Tackett, the Cancer Institute’s deputy director and director of the IDeA National Resource for Quantitative Proteomics at UAMS.
December 2021 Publications
![Megan Reed](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2021/08/Megan-Reed-copy-255x300.jpg)
A Functional Precision Medicine Pipeline Combines Comparative Transcriptomics and Tumor Organoid Modeling to Identify Bespoke Treatment Strategies for Glioblastoma.
Reed MR, Lyle AG, De Loose A, Maddukuri L, Learned K, Beale HC, Kephart ET, Cheney A, van den Bout A, Lee MP, Hundley KN, Smith AM, DesRochers TM, Vibat CRT, Gokden M, Salama S, Wardell CP, Eoff RL, Vaske OM, Rodriguez A.
Cells. 2021
![Wahls lab](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2019/01/2018-Wahls-lab-300x155.jpg)
Molecular mechanisms for environmentally induced and evolutionarily rapid redistribution (plasticity) of meiotic recombination.
Protacio RU, Mukiza TO, Davidson MK, Wahls WP.
Genetics. 2021
![Members of the Raney lab](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2022/01/2021-Raney-lab-300x225.jpg)
RNA helicases required for viral propagation in humans.
Marecki JC, Belachew B, Gao J, Raney KD.
Enzymes. 2021
![Robert Eoff, Ph.D.](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2017/05/Eoff_Robert-e1628102795420-254x300.jpg)
Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M1dG, the Genomic Metabolite of M1dG, and Liquid Chromatography-Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι.
Christov PP, Richie-Jannetta R, Kingsley PJ, Vemulapalli A, Kim K, Sulikowski GA, Rizzo CJ, Ketkar A, Eoff RL, Rouzer CA, Marnett LJ.
Chem Res Toxicol. 2021
![Dr. Michael Birrer](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2020/12/Dr.-Birrer-pic-e1624476331213-213x300.jpg)
Impact of homologous recombination status and responses with veliparib combined with first-line chemotherapy in ovarian cancer in the Phase 3 VELIA/GOG-3005 study.
Swisher EM, Aghajanian C, O’Malley DM, Fleming GF, Kaufmann SH, Levine DA, Birrer MJ, Moore KN, Spirtos NM, Shahin MS, Reid TJ, Friedlander M, Steffensen KD, Okamoto A, Sehgal V, Ansell PJ, Dinh MH, Bookman MA, Coleman RL.
Gynecol Oncol. 202
November 2021 Publications
![Members of the Miller lab](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2019/11/2019-miller-lab-300x225.jpg)
CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs.
Schleiff MA, Crosby S, Blue M, Schleiff BM, Boysen G, Miller GP.
Biochem Pharmacol. 2021
![Members of the Byrd lab](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2021/12/210630-lab-photo3-resized-300x169.jpg)
A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA.
Byrd AK, Malone EG, Hazeslip L, Zafar MK, Harrison DK, Thompson MD, Gao J, Perumal SK, Marecki JC, Raney KD.
Protein Sci. 2021
![Members of the Kendrick Lab](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2021/03/Kendrick-lab-2019-cropped-300x225.jpg)
Clinical implications of loss of bone marrow minimal residual disease negativity in multiple myeloma.
Mohan M, Kendrick S, Szabo A, Yarlagadda NK, Atwal D, Pandey Y, Roy AM, Parikh R, Lopez J, Thanendrarajan S, Schinke C, Alapat D, Sawyer JR, Tian E, Tricot G, van Rhee F, Zangari M.
Blood Adv. 2021
![Dr. Michael Birrer](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2020/12/Dr.-Birrer-pic-e1624476331213-213x300.jpg)
Utilization of a 3-D tissue engineered model to investigate the effects of perfusion on gynecologic cancer biology.
Martinez A, Buckley MS, Scalise CB, Wang D, Katre AA, Birrer MJ, Berry JL, Arend RC.
J Tissue Eng. 2021
Risk stratification after recurrence of human papillomavirus (HPV)-related and non-HPV-related oropharyngeal cancer: A secondary analysis of NRG Oncology RTOG 0129 and 0522.
Bigelow EO, Harris J, Fakhry C, Gillison ML, Nguyen-Tân PF, Rosenthal DI, Frank SJ, Nair SG, Bahig H, Ridge JA, Caudell J, Donaldson C, Clifford BT, Shenouda G, Birrer MJ, Chen Y, Le QT.
Head Neck. 2021
Milk Formula Diet Alters Bacterial and Host Protein Profile in Comparison to Human Milk Diet in Neonatal Piglet Model.
Rosa F, Zybailov BL, Glazko GV, Rahmatallah Y, Byrum S, Mackintosh SG, Bowlin AK, Yeruva L.
Nutrients. 2021
Popular Paper
![Duah Alkam](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2021/08/2019-Duah-Alkam_cropped-251x300.jpg)
An article by Dr. Duah Alkam, Assistant Staff Scientist in the Department of Biochemistry and Molecular Biology working in the Bioinformatics core, and colleagues has been one of the most popular articles in the journal Microbial Genomics this fall. The article – the journal’s third most read in both October and November – was part of her thesis project for her Ph.D. in the Graduate Program in Interdisciplinary Biomedical Sciences, which she completed earlier this year. As a graduate student, she worked with Dr. Mark Smeltzer, Professor of Microbiology and Immunology, and Dr. David Ussery, Professor of Biomedical Informatics. Great job!
Bethany Paxton Wins at AR-INBRE
AR-INBRE conference
![Bethany Paxton](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2021/11/2021-Bethany-INBRE-cropped.jpg)
Bethany Paxton won won 1st place in Biological Sciences at the 2021 AR-INBRE meeting. Bethany worked in Robert Eoff’s lab on their NSF-funded project investigating the role of human Rev1 in G4 replication. This was her first scientific conference. Great job Bethany!
October 2021 Publications
![Duah Alkam](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2021/08/2019-Duah-Alkam_cropped-251x300.jpg)
Is amplification bias consequential in transposon sequencing (TnSeq) assays? A case study with a Staphylococcus aureus TnSeq library subjected to PCR-based and amplification-free enrichment methods.
Alkam D, Wongsurawat T, Nookaew I, Richardson AR, Ussery D, Smeltzer MS, Jenjaroenpun P.
Microb Genom.
![Dr. Michael Birrer](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2020/12/Dr.-Birrer-pic-e1624476331213-213x300.jpg)
A highly annotated database of genes associated with platinum resistance in cancer.
Huang D, Savage SR, Calinawan AP, Lin C, Zhang B, Wang P, Starr TK, Birrer MJ, Paulovich AG.
Oncogene.
![Authors](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2020/05/ProteomicsCore-300x183.jpg)
Raman spectroscopy and machine learning reveals early tumor microenvironmental changes induced by immunotherapy.
Paidi SK, Troncoso JR, Raj P, Monterroso Diaz P, Ivers JD, Lee DE, Avaritt NL, Gies AJ, Quick CM, Byrum SD, Tackett AJ, Rajaram N, Barman I.
Cancer Res.
![Robert Eoff, Ph.D.](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2017/05/Eoff_Robert-e1628102795420-254x300.jpg)
Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion.
Darrigues E, Zhao EH, De Loose A, Lee MP, Borrelli MJ, Eoff RL, Galileo DS, Penthala NR, Crooks PA, Rodriguez A.
Int J Mol Sci.
UAMS Cancer Researcher Brian Koss, Ph.D., Is First in State to Earn Prestigious NIH Director’s Award
Koss award
Part of the High-Risk, High-Reward Research program, the Early Independence Award supports outstanding junior scientists with the intellect, scientific creativity, drive and maturity to bypass the traditional postdoctoral training period to launch independent research careers.
Koss joins an elite group of only 13 2021 NIH Director’s Early Independence Award recipients in the U.S. from such institutions as Stanford, Harvard, Johns Hopkins, Mount Sinai, Vanderbilt and Columbia. He will receive a five-year, nearly $1.9 million grant to fund his highly specialized cancer research at UAMS.
“This award provides a tremendous opportunity to expand my research on immune-based therapies for cancer,” said Koss. “I plan to use the Early Independence Award to build a team of researchers who will be crucial for establishing an innovative and collaborative research laboratory.”
In addition to being the first Arkansan to receive the award, Koss is only the second recipient from an NIH-designated Institutional Development Award (IDeA) state, a group of 23 states plus Puerto Rico that have historically received lower research funding.
“The NIH Director’s Early Independence Award is one of the most prestigious awards given by the NIH to the most promising young scientists across the country,” said Michael Birrer, M.D., Ph.D., UAMS vice chancellor and director of the Winthrop P. Rockefeller Cancer Institute. “Dr. Koss’ research will be a key supporting component of taking the Cancer Institute to NCI designation in the near future.”
“We are thrilled that Dr. Koss is Arkansas’ first recipient of this prestigious and transformative award,” said Susan Smyth, M.D., Ph.D., executive vice chancellor of UAMS and dean of the College of Medicine. “All of us at UAMS look forward to watching Dr. Koss’ ingenuity and hard work lead to meaningful advances in the understanding of the immune response to cancer, and potentially to effective new treatments for cancer patients.”
“This award demonstrates how exceptionally promising the NIH considers Dr. Koss, and how confident the NIH is in the supportive environment at UAMS and the Winthrop P. Rockefeller Cancer Institute,” Smyth said. “Dr. Koss has superb mentors in the Cancer Institute and College of Medicine.”
Unique to Koss’ research is the use of proteomics — powerful computing tools that help make sense of enormous amounts of biological data. This includes creating functional maps of cells and other techniques that lead to better understanding of the molecular pathways in cancer and other diseases. UAMS is home to the NIH’s only national proteomics resource, the IDeA National Resource for Quantitative Proteomics. Koss will use proteomics to study protein turnover rates on a massive scale.
“Dr. Koss performed his graduate work in my laboratory, building a program that focused on how the environment in solid tumors creates unique challenges for immunotherapies,” said Alan Tackett, Ph.D., deputy director of the Winthrop P. Rockefeller Cancer Institute and one of Koss’ mentors. “He will now translate his graduate work to build an independent research program at the Cancer Institute, focusing on how to better understand and engineer the immune system to recognize and eliminate tumors from the body.”
A Mountain Home native, Koss completed his undergraduate degree in biology at Hendrix College in Conway, where he got his first exposure to undergraduate research. Cancer became real to Koss when he worked as a research technician at St. Jude Children’s Hospital in Memphis after college. He returned to Arkansas in 2015 to begin graduate studies at UAMS and earned a Ph.D. in 2020.
In 2021, the National Institutes of Health awarded 106 grants through its High-Risk, High-Reward Research (HRHR) program. Examples of supported research include understanding how long-term memory might be encoded in the shape of folded DNA in our neurons, mining data from unconventional sources to reveal social determinants of suicide, establishing new paradigms to address the functional consequences of health disparities in drug development and looking at the impact of high school and collegiate athlete injuries on long-term health. The 106 awards total approximately $329 million over five years, pending available funds. Koss’ award is funded by NIH Grant DP5-OD031863.
September 2021 publications
![Members of the Chambers lab](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2018/09/2018-Chambers-lab-300x162.jpg)
Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle.
Delgado M, Washam CL, Urbaniak A, Heflin B, Storey AJ, Lan RS, Mackintosh SG, Tackett AJ, Byrum SD, Chambers TC.
ACS Omega. 2021
![Alicja Urbaniak](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2020/11/Alicja_August2020-17_cropped-281x300.jpg)
Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development.
Shoeib AM, Yarbrough AL, Ford BM, Franks LN, Urbaniak A, Hensley LL, Benson LN, Mu S, Radominska-Pandya A, Prather PL.
Life Sci. 2021
![Marie Burdine](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2019/03/Burdine_Marie-PhD-300x204.png)
DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells.
Waldrip ZJ, Burdine L, Harrison DK, Azevedo-Pouly AC, Storey AJ, Moffett OG, Mackintosh SG, Burdine MS.
J Biol Chem. 2021
![Authors](https://medicine.uams.edu/biochemistry/wp-content/uploads/sites/25/2020/05/ProteomicsCore-300x183.jpg)
A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells.
Xu C, Meng F, Park KS, Storey AJ, Gong W, Tsai YH, Gibson E, Byrum SD, Li D, Edmondson RD, Mackintosh SG, Vedadi M, Cai L, Tackett AJ, Kaniskan HÜ, Jin J, Wang GG.
Cell Chem Biol. 2021
Congratulations to our Ph.D. candidates
Research Induction Ceremony
September 13, 2021 – Four new Ph.D. candidates in the Department of Biochemistry and Molecular Biology received their white coats at the Graduate School’s Research Induction Ceremony. Each student was assisted in putting on their white coat by their dissertation advisor and the graduate program director. These students passed their qualifier exam within the last two years. Congratulations to Katherine “Katie” Bronson, mentored by Angus MacNicol, Ph.D., Susie Brown, mentored by Samantha Kendrick, Ph.D., Xuiqi “Michael” Wang, mentored by Hong-Yu Li, Ph.D., and Lauren “Clai” Morehead, mentored by Alan Tackett, Ph.D., and Isabelle Miousse, Ph.D.