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  1. University of Arkansas for Medical Sciences
  2. College of Medicine
  3. Department of Biochemistry and Molecular Biology
  4. News
  5. Page 5

News

UAMS Establishes Proteomics Center of Excellence in Little Rock with Thermo Fisher Scientific

Picture of scientist working at the lab bench
The University of Arkansas for Medical Sciences (UAMS) announced the launch of the Thermo Fisher Scientific Center of Excellence for Proteomics at UAMS — the first and only academic-industry partnership of its kind in the United States. Image by Bryan Clifton

By Marty Trieschmann

Oct. 15, 2024 | The University of Arkansas for Medical Sciences (UAMS) announced the launch of the Thermo Fisher Scientific Center of Excellence for Proteomics at UAMS — the first and only academic-industry partnership of its kind in the United States.

The world leader in serving science, Thermo Fisher Scientific, entered into a formal agreement with the IDeA National Resource for Quantitative Proteomics, which was founded in 2020 with a $11 million grant from the National Institutes of Health (NIH) as the only NIH-funded proteomics service provider in the United States, providing the most cost-effective access to proteomics for any researcher in the U.S. performing biomedical research.

Proteomics allows researchers and clinicians to rapidly identify novel disease biomarkers, new drug targets and unique mechanisms driving human diseases. IDeA National Resource for Quantitative Proteomics is equipped with multiple Thermo Fisher advanced Thermo Scientific™ Orbitrap™ mass spectrometers, including the most recent installed state-of-the-art mass spectrometry technology, Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer, to provide premium quantitative proteomics services to researchers.

“The Thermo Fisher Scientific Center of Excellence for Proteomics at UAMS will be a first-in-class partnership that will support research, education and outreach in proteomics not only in Arkansas but across the entire United States,” said Pushkin Pant, vice president/general manager, Life Science Mass Spectrometry at Thermo Fisher. “We will provide access to the latest and next generation technology at this site to support scientists in the United States performing biomedical research.”

“The study of proteins using proteomics is at the core of nearly all biomedical research and often serves as step one in the disease biomarker or drug discovery process,” said Alan Tackett, Ph.D., distinguished professor of biochemistry and molecular biology in the UAMS College of Medicine who directs the UAMS proteomics program.

As part of the agreement, Thermo Fisher will support annual proteomics educational workshops, and serve as a partner to provide on-site mass spectrometry technology for the NIH proteomics trainee program.

“The primary benefit of this unique academic-industry partnership is to bring the current and next-generation technology in proteomics to the UAMS campus to create a unique environment with world-class infrastructure to support biomedical researchers across the United States,” said Tackett, the inaugural recipient of the Scharlau Family Endowed Chair in Cancer Research at UAMS.

“In the past few years, we have provided proteomics access to more than 1,500 researchers across every state in the United States plus Puerto Rico and supported educational activities for over 500 faculty, students and support staff,” Tackett added. “The scope of our operation at UAMS is unmatched across academic institutions in the United States and recognized at the highest leadership levels of the National Institutes of Health.”

This first-in-kind partnership unites the industry leader in proteomics technology and solutions, Thermo Fisher, with the only academic national proteomics service provider at UAMS. This academic-industry partnership is designed to create an environment of creativity and innovation that will support discovery and development of new approaches and therapies to tackle the most challenging human diseases including cancer.

Filed Under: Department News

September 2024 publications

Picture of the authors

Agar lot-specific inhibition in the plating efficiency of yeast spores and cells
Protacio RU, Davidson MK, Malone EG, Helmlinger D, Smith JR, Gibney, PA, Wahls WP.

G3: Genes / Genomes / Genetics 2024


Picture of Kendrick lab members on a patio

Development of New Diffuse Large B Cell Lymphoma Mouse Models.
Mehdi SH, Xu YZ, Shultz LD, Kim E, Lee YG, Kendrick S, Yoon D.
Cancers (Basel). 2024


Members of the Byrd lab

Untargeted CUT&Tag and BG4 CUT&Tag are both enriched at G-quadruplexes and accessible chromatin.
Thompson MD, Byrd AK.
bioRxiv [Preprint]. 2024


Byrum lab

HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection.
Fry LG, Washam CL, Roys H, Bowlin AK, Venugopal G, Bird JT, Byrum SD, Weinkopff T.
bioRxiv [Preprint]. 2024

Filed Under: Department News

Alan Tackett receives Odyssey Medal

Pictures of Odyssey Medal recipients

Alan Tackett, Ph.D., Distinguished Professor of Biochemistry, received an Odyssey Medal for Research from Hendrix College. The Odyssey Medal is presented to alumni whose life achievements exemplify the ideals of the Hendrix Odyssey Program. Medalists are selected by the Hendrix Board of Trustees for their accomplishments in one of the six Odyssey categories: Artistic Creativity, Global Awareness, Professional and Leadership Development, Research, Service to the World, or Special Projects.

Alan Tackett, Ph.D., earned a degree in chemistry with distinction from Hendrix College in 1998, and received his Doctor of Philosophy degree in biochemistry and molecular biology from the University of Arkansas for Medical Sciences (UAMS) in 2002. He performed postdoctoral training in cancer epigenetics and proteomics at The Rockefeller University in New York City from 2002-2005. He joined the faculty at UAMS in 2005 and has risen in the ranks to a tenured distinguished professor of biochemistry and molecular biology. Tackett received the Sharlau Family Endowed Chair for Cancer Research in 2016 and was nominated into the Arkansas Research Alliance in 2021. He currently serves as Deputy Director of the Winthrop P. Rockefeller Cancer Institute at UAMS.

As a UAMS faculty member, Tackett has built an internationally recognized research team focused on uncovering new therapeutic strategies to treat metastatic melanoma and developing the next generation of molecular profiling technologies to identify cancer biomarkers. He has published more than 150 scientific articles and holds multiple patents in these areas; and has received more than $40 million in government funding to support his research endeavors.

Tackett serves as director of two National Institutes of Health (NIH) research centers in Arkansas: a NIH Center of Biomedical Research Excellence in systems biology that has enabled critical infrastructure development for large data generating technologies and has provided tailored mentoring to numerous early career faculty resulting in their acquisition of over $25 million in government research funding; and a NIH National Resource for Quantitative Proteomics that has supported biomedical research in over 1,500 laboratories across every state in the U.S. and has provided training and workforce development to over 500 faculty and students, including many who are underrepresented in the biomedical research workforce.

Filed Under: Department News

Stephanie Byrum named Distinguished Alumna

Photo of honored alumni

Congratulations to Stephanie Byrum, Ph.D. who was honored as Distinguished Alumni by Atlanta High School in Atlanta, Texas.

Filed Under: Department News

August 2024 Publications

Members of the Baldini lab

MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture.
Griffin H, Hanson J, Phelan KD, Baldini G.
Cells. 2024


Picture of the authors

Creating meiotic recombination-regulating DNA sites by SpEDIT in fission yeast reveals inefficiencies, target-site duplications, and ectopic insertions
Protacio RU, Dixon S, Davidson MK, Wahls WP
biomolecules 2024


Marie Burdine

Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441.
Waldrip ZJ, Acharya B, Armstrong D, Hanafi M, Rainwater RR, Amole S, Fulmer M, Azevedo-Pouly AC, Burns A, Burdine L, Frett B, Burdine MS.
Sci Rep. 2024


Picture of Kendrick lab members on a patio

Development of New Diffuse Large B Cell Lymphoma Mouse Models.
Mehdi SH, Xu Y-Z, Schultz LD, Kim E, Lee YG Kendrick S, Yoon D.
cancers. 2024


Members of the Wahls lab

Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles.
Protacio RU, Malone EG, Wahls WP.
MicroPubl Biol. 2024


Miousse lab

Climate Change and New Challenges for Rural Communities: Particulate Matter Matters.
Miousse IR, Hale RB, Alsbrook S, Boysen G, Broadnax T, Murry C, Williams C, Park CH, Richards R, Reedy J, Chalbot MC, Kavouras IG, Koturbash I.
Sustainability. 2023


Byrum lab

Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis.
Fry L, Roys H, Bowlin A, Venugopal G, Bird JT, Weaver A, Byrum SD, Weinkopff T.
bioRxiv [Preprint]. 2024

Filed Under: Department News

Research Milestone for Kevin Raney

Picture of Kevin Raney in front of a word collage of his publication topics
Professor Kevin Raney with word cloud of terms from his scientific publications and covers of scientific journals related to his research

Congratulations to Dr. Kevin Raney, Ph.D., Professor and Chair of the Department of Biochemistry and Molecular Biology.  He has now published more than 100 scientific papers that are indexed by PubMed at the National Library of Medicine.

Filed Under: Department News

Congratulations to Reine Protacio and Colleagues — In the NEWS at Science

Image of the feature in Science and the authors
Scientists Reine Protacio, Wayne Wahls, Emory Malone and Mari Davidson are members of the Department of Biochemistry and Molecular Biology at UAMS

Research spearheaded by Dr. Reine Protacio, Staff Scientist in the Department of Biochemistry and Molecular Biology at UAMS, was recently highlighted in the journal Science.  A full-length NEWS article describes how Protacio discovered that some batches of Agar—which is used to solidify solutions of nutrients in petri plates—were killing the fission yeast cells that the laboratory uses to study how chromosomes behave during cell divisions.

The original research article, published as a preprint in bioRxiv, was co-authored by Drs. Mari Davidson (UAMS), Wayne Wahls (UAMS) and Dominique Helmlinger (University of Montpellier in France).

Filed Under: Department News

July 2024 Publications

Contour image of Wayne Wahls, Reine Protacio, and Emory Malone.

Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles
Protacio RU, Malone EG, Wahls WP
MicroPubl Biol. 2024


Byrum lab

Understanding proteome quantification in an interactive learning module on Google Cloud Platform.
O’Connell KA, Kopchick B, Carlson T, Belardo D, Byrum SD.
Brief Bioinform. 2024


Members of the Raney lab

Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge.
Hong Z, Byrd AK, Gao J, Das P, Tan VQ, Malone EG, Osei B, Marecki JC, Protacio RU, Wahls WP, Raney KD, Song H.
Nat Commun. 2024


Byrum lab

Understanding PTM Cross Talk Through a Visualization Tool, PTMViz.
Chappell K, Byrum SD.
Methods Mol Biol. 2024


Alicja Urbaniak

Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer.
Ferdous KU, Tesfay MZ, Cios A, Shelton RS, Hartupee C, Urbaniak A, Chamcheu JC, Mavros MN, Giorgakis E, Mustafa B, Simoes CC, Miousse IR, Basnakian AG, Moaven O, Post SR, Cannon MJ, Kelly T, Nagalo BM.
Biomedicines. 2024


picture of Miller lab members

Bioactivation and reactivity research advances – 2023 year in review.
Wang S, Argikar UA, Chatzopoulou M, Cho S, Crouch RD, Dhaware D, Gu TJ, Heck CJS, Johnson KM, Kalgutkar AS, Liu J, Ma B, Miller GP, Rowley JA, Seneviratne HK, Zhang D, Khojasteh SC.
Drug Metab Rev. 2024

Filed Under: Department News

June 2024 publications

Picture of the authors

Laboratory horror stories: Poison in the agars.
Davidson MK, Protacio RU, Helmlinger D, Wahls WP.
bioRxiv [Preprint]. 2024


Ryan lab

Long-read sequencing for brain tumors.
Shelton WJ, Zandpazandi S, Nix JS, Gokden M, Bauer M, Ryan KR, Wardell CP, Vaske OM, Rodriguez A.
Front Oncol. 2024


Sean Taverna

Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex.
Nguyen MC, Rostamian H, Raman A, Wei P, Becht DC, Erbse AH, Klein BJ, Gilbert TM, Zhang G, Blanco MA, Strahl BD, Taverna SD, Kutateladze TG.
Nat Commun. 2024


Michael Birrer

Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis.
Tucker Andrews J, Zhang Z, Krishna Prasad GVR, Huey F, Nazarova EV, Wang J, Ranaraja A, Weinkopff T, Li LX, Mu S, Birrer MJ, Ching-Cheng Huang S, Zhang N, Argüello RJ, Philips JA, Mattila JT, Huang L.
Mucosal Immunol. 2024


Stephanie Byrum, Ph.D.

An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy.
Pechous RD, Malaviarachchi PA, Banerjee SK, Byrum SD, Alkam DH, Ghaffarieh A, Kurten RC, Kennedy JL, Zhang X.
J Virol. 2024

Filed Under: Department News

May 2024 Publications

Members of the Raney lab

Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth.
Gao J, Proffitt DR, Marecki JC, Protacio RU, Wahls WP, Byrd AK, Raney KD.
Nucleic Acids Res. 2024


Ryan lab

Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors.
Acharya B, Saha D, Garcia Garcia N, Armstrong D, Jabali B, Hanafi M, Frett B, Ryan KR.
Bioorg Med Chem. 2024

Filed Under: Department News

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