Jacy Wagnon, who earned her Ph.D. in Dr. Wayne Wahls’ laboratory, has now obtained a tenure-track faculty position at The Ohio State University. Doctor Wagnon is an Assistant Professor in the Department of Neuroscience, with research interests in epilepsy, neurodegenerative disorders, and genetics of neurological diseases.
Department News
November publications
Structural basis for DNA unwinding at forked dsDNA by two coordinating Pif1 helicases.
Su N, Byrd AK, Bharath SR, Yang O, Jia Y, Tang X, Ha T, Raney KD, Song H.
Nat Commun. 2019
Ramirez AM, Byrum SD, Beenken KE, Washam C, Edmondson RD, Mackintosh SG, Spencer HJ, Tackett AJ, Smeltzer MS. ACS Infect Dis. 2019
Synthesis and Anticancer Activity of Tertiary Amides of Salinomycin and Their C20-oxo Analogues.
Czerwonka D, Urbaniak A, Sobczak S, Piña-Oviedo S, Chambers TC, Antoszczak M, Huczyński A.
ChemMedChem. 2019
Integration of Flow Cytometry and Single Cell Sequencing.
Andreyev DS, Zybailov BL.
Trends Biotechnol. 2019
Cancer Research Highlights Largest-Ever Showcase of Medical Discoveries
Nov. 27, 2019 | Scientists conducting cancer research in the lab, clinic and community gathered Nov. 20 at the 26th UAMS Showcase of Medical Discoveries to share their projects and discuss ways to work together.
A quarterly event, the showcase is designed to highlight research areas across UAMS and encourage collaboration among scientists. Cancer research served as the focus of the event held at the UAMS Winthrop P. Rockefeller Cancer Institute. It attracted about 170 attendees from research and clinical areas to learn about the university’s wide scope of cancer research projects.
The showcase was co-sponsored by the UAMS Office of Research in conjunction the Cancer Institute, College of Medicine and Office of Institutional Advancement.
“This is an excellent time to highlight our cancer research programs, as we focus our efforts on attaining National Cancer Institute Designation and transition to new Cancer Institute leadership under director Dr. Michael Birrer. As we take stock of our strengths, we look forward to advancing our research programs on a strong new trajectory in the upcoming decade,” said Shuk-Mei Ho, Ph.D., vice chancellor of research.
Birrer, a medical oncologist who specializes in gynecologic cancers, joined the Cancer Institute as vice chancellor and director in late 2019.
In early 2019, the UAMS Cancer Institute received unanimous support in both the Arkansas Senate and House for its quest to achieve designation by the National Cancer Institute. An annual state allocation of $10 million will support this effort.
Ho stressed that the allocation designated by the Legislature is essential and illustrates the overarching support for designation among leaders and citizens in Arkansas.
“We have established a good foundation at UAMS toward achieving NCI Designation. The state’s support and enthusiasm for this important goal is a vital part of that,” Ho said.
To achieve designation, cancer centers undergo a highly competitive assessment process that demonstrates an outstanding depth and breadth of basic laboratory, patient/clinical and population-based research. The designation brings with it many benefits, including expanded access to federal funding for researchers and improved access to clinical trials for patients.
At the showcase, researchers displayed 40 scientific posters representing Cancer Institute programs and numerous UAMS colleges and academic departments. Together with their colleagues, the scientists joined in lively discussions about the implications and goals of their research. Of the 26 showcases the UAMS Office of Research and Innovation has presented, this one was by far the largest, Ho said.
Genetic counselor Mindy Simonson and Kristin Zorn, M.D., chair of the Division of Gynecologic Oncology, shared a poster they recently presented at the National Society of Genetic Counselors Annual Meeting in Salt Lake City.
Their project examines how better to identify and streamline the referral process for patients with hereditary cancers.
“We are working to build an adaptive questionnaire using electronic medical records to automatically generate a referral for patients who meet certain qualifications related to hereditary cancers,” Simonson said.
Although the process has presented technological challenges, the idea generated much excitement among participants at the Utah conference.
“A lot of people are interested in this concept and have talked to us about how it could work in various settings,” Simonson said.
Other scientists shared information related to their laboratory research, including Samantha Kendrick, Ph.D., assistant professor in the UAMS College of Medicine Department of Biochemistry and Molecular Biology.
Kendrick’s research focuses on treatment resistance in aggressive diffuse large B-cell lymphoma.
“We are working to find a way to shut off B-cell receptor signaling pathways at the DNA level. If we can develop a drug to target these genes, the disease could become more sensitive to chemotherapy and lead to better outcomes for patients,” Kendrick said.
In addition to viewing the wide range of cancer research programs and gathering information about potential collaborations, attendees also learned about the Cancer Institute’s infrastructure and research core facilities available to support their work.
In a brief presentation, Ho recognized Laura Hutchins, M.D., for her more than 30 years of service to UAMS and its cancer programs. Hutchins served in multiple roles at UAMS, including division director of the UAMS Division of Hematology/Oncology for 15 years and program director of the UAMS Hematology/Oncology Fellowship Program for 10 years.
She held the prestigious Virginia Clinton Kelley Endowed Chair for Clinical Research from March 2007-December 2018 and was associate director for clinical research in the Cancer Institute for 20 years. For 18 months, she served as Cancer Institute interim director while the search for the new director was underway.
“Dr. Hutchins is one the strongest friends of research we have at UAMS. She champions this place in many ways and we are so thankful for her contributions,” Ho said. Hutchins plans to retire in early 2020.
Women in Research Poster Session
Nov. 15, 2019 | By Amy Widner
The Women’s Faculty Development Caucus celebrated 30 years by turning a spotlight on women in research at UAMS, while also setting new goals to ensure that progress continues.
The Women in Research Poster Showcase was held Nov. 7 in the Fred W. Smith Conference Center on the 12th floor of the Jackson T. Stephens Spine & Neurosciences Institute. All women researchers on campus were invited to present posters. The presenters went in groups, allowing participants to visit other posters and network.
The format enabled visitors to see that women are advancing research in all aspects of health care and in all colleges and departments on campus.
“I am really impressed by the wide range of projects that I see around the room,” said Mari K. Davidson, Ph.D., an associate professor in the Department of Biochemistry and Molecular Biology in the College of Medicine. “I just talked to one person about safe sleep for babies, another about Stop the Bleed. We can get caught in a place where we just stick to our own area, so it’s really fun to see what’s going on.”
The Women’s Caucus was founded in 1989 at UAMS as a professional development and mentoring program to help women advance their careers and assume leadership positions. Its professional development efforts have resulted in an expanding organization that addresses the needs of all UAMS faculty members and trainees. The caucus provides leadership training, mentoring/advising, faculty handbook publications, faculty development, and networking opportunities.
The caucus is structured around faculty-led committees with rotating leadership, which simultaneously gives women leadership opportunities and provides new ideas and energy behind caucus activities.
Research Committee Chair Taren Swindle, Ph.D., assistant professor in the Department of Family and Preventive Medicine Research and Evaluation Division, welcomed the crowd with information on caucus history and inspiration for its future.
“For women in science, we have made some progress,” Swindle said. “The National Institutes of Health, for example, just announced last week they are extending early career status for career development applications after childbirth. Another example is here at UAMS, promotion and tenure guidelines have been changed to accommodate familial needs for men and for women. These are wonderful areas of progress, but we still have work to do.”
Swindle shared statistics that paint a picture of the remaining gender gaps:
- Only 32% of scientists in North America are women, according to a UNESCO report.
- While there is no difference in productivity between young male and female scientists, the first grant given to female scientists is $40,000 less on average, and that gap increases to almost double at Big 10 universities, according to a report published in JAMA.
- Women scientists are 20% less likely than men to come back to work after starting a family, according to an article in Nature.
- Only 21% of full professors are women, according to the American Medical Association.
Swindle pointed to a poster near the entrance which provided attendees an opportunity to list strengths, weaknesses, opportunities and challenges facing women faculty at UAMS. The committee supplied a few bullet points in each category, and the participants were encouraged to use sticky notes to provide their own insights.
“We’re really seeking your perspective on this,” Swindle said. “The Women’s Faculty Development Caucus has decided to broaden the research committee. In the past, the committee has focused on promoting students. These statistics and others show us that not only do students and young researchers need help, mid-career faculty face challenges too. There is a gap to bridge between young, promising researchers and full tenured professors, so we’re looking at how we can address that issue. This will also result in serving the faculty more broadly and better promoting all women in science.”
Eva Woodward, Ph.D., an assistant professor in the Department of Psychiatry in the College of Medicine, was swarmed by interest in her recent publication about ways to address health inequity using the tools of implementation science. Between interested visitors, she paused to say that the points made by Swindle were exactly why she welcomed the opportunity to take part in the research showcase.“While men and women start out even at the assistant professor level, by the time you’re talking about full professor, the women fall out and the men dominate those positions, and we still have huge disparities to address,” Woodward said. “I’m taking time out of my schedule for this because it’s one way in which I can provide witness to the work of other women scientists who aren’t necessarily underrepresented in their field, but are underrepresented in positions of leadership, and also to be seen as well. It seems simple, but it’s important.”
On the cover
Congratulations to graduate student Tresor Mukiza and his co-authors, Reine Protacio, Mari Davidson, Walter Steiner and Wayne Wahls. Cover art for their new article on chromosome dynamics is featured on the home page of Genetics for November, 2019. The editors also selected this paper to be featured in a highlight in Genetics.
October publications
Urbaniak A, Jousheghany F, Yuan Y, Piña-Oviedo S, Huczyński A, Delgado M, Kieber-Emmons T, Monzavi-Karbassi B, Chambers TC.
Oncol Lett.
Barnette DA, Davis MA, Flynn N, Pidugu AS, Joshua Swamidass S, Miller GP.
Biochem Pharmacol.
Storey AJ, Wang HP, Protacio RU, Davidson MK, Wahls WP.
G3 (Bethesda).
Klejborowska G, Urbaniak A, Preto J, Maj E, Moshari M, Wietrzyk J, Tuszynski JA, Chambers TC, Huczyński A.
Bioorg Med Chem.
Allie Davis and Dusty Barnette win at GSA Research Symposium
Dusty Barnette won third in the poster presentations, and Allie Davis won first in the oral presentations at the GSA Research Symposium. Dusty and Allie are both students in Dr. Grover Paul Miller‘s lab. Congratulations!
Miller lab attends Society of Toxicology meeting
Graduate students Dusty Barnette and Allie Davis, along with Laura Osborn (SURF student), Sasin (Copter) Payakachat (SURF student), and Anna Pinson (INBRE student) attended the Society of Toxicology – South Central Chapter Conference at Louisiana State University Health Sciences Center October 17-18. They are all students in Paul Miller‘s lab. Allie, Laura, and Sasin received travel awards.
Dusty presented a poster entitled “C5 Methyl Substituent Alters Which Enzymes Bioactivate Meloxicam Compared to Sudoxicam”. Laura presented a poster entitled “Multiple Metabolic Pathways Decrease Meloxicam Toxicity Relative to Analog, Sudoxicam”. Sasin presented a poster entitled “Identifying How Halogens Impact Bioactivation of Aryl Acetic Acid Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)”. Anna presented a poster entitled “Highly Efficient and Extensive Metabolism of Synthetic Cannabinoid 5F-APINACA Experiences Substrate Inhibition at High Concentrations”. Allie presented a talk entitled “Bioactivation of Halogenated Aromatic Drugs as a Precursor to Drug-Induced Hepatotoxicity”.
Happy Birthday Dr. Raney!
We had an impromptu celebration for Dr. Raney’s birthday. Thanks Sharon and Kahla for the birthday treats.
September publications
The response of phyllodes tumor of the breast to anticancer therapy: An in vitro and ex vivo study
Alicja Urbaniak, Fariba Jousheghany, Youzhong Yuan, Sergio Piña‑Oviedo, Adam Huczyński, Magdalena Delgado, Thomas Kieber‑Emmons, Behjatolah Monzavi‑Karbassi, Timothy C. Chambers
Oncology Letters
Mukiza TO, Protacio RU, Davidson MK, Steiner WW, Wahls WP.
Genetics.
Histone Modifications as Biomarkers for Immunotherapy.
Taylor EM, Koss B, Davis LE, Tackett AJ.
Methods Mol Biol