I just started my sixth year in Biochemistry and Molecular Biology Ph.D. program and will graduate in October.
China Pharmaceutical University, B.S. in Pharmacy (Basic Pharmacy).
I have two research interests: 1) Discovery and optimization of novel inhibitors of clinically relevant targets 2) PROTAC and its applications. I have been working on multiple research projects within these research scopes.
I’m currently working on my dissertation thesis based on one of the projects, titled: Identification of Imidazo[1,2 a]pyridine pyridine derivatives as FLT3 kinase inhibitors for potential treatments of acute myeloid leukemia.
Acute myeloid leukemia (AML) is a hematologic cancer characterized by proliferative, clonal, abnormally differentiated, and occasionally poorly differentiated cells. Activating mutations in FMS-like tyrosine kinase 3 (FLT3) are the most frequent genetic alteration in AML, found in approximately 30% of newly diagnosed cases, most commonly consisting of internal tandem duplication (ITD) mutations in the juxtamembrane region. Recently, several FLT3 inhibitors have demonstrated clinical activity and three are currently approved – midostaurin, quizartinib, and gilteritinib. However, their clinical efficacies are limited in part due to the emergence of secondary clinical resistance, caused by multiple mechanism including on-target FLT3 secondary mutations – FLT3-ITD/D835Y and FLT3-ITD/F691L being the most common, as well as the off-target activation of alternative pathways including the BCR-ABL pathway. Therefore, in order to overcome drug resistance and further improve outcomes, new compounds targeting FLT3-ITD with secondary mutants are urgently needed. In my works, three compounds were identified with potent anti-leukemic effects, and may be further developed for treatment of AML.
Notable about his time as a Graduate
Throughout my Ph.D. periods, I got to know that research is never a solitary work. It requires frequent communication and close collaboration to get the work done.
I will seek postdoc training after my Ph.D. I have already accepted the postdoc offer at Dana-Farber Cancer Institute, Harvard Medical School, working with Dr. Jun Qi. My vision for my future career is to take on the academic path and be an independent principal investigator after the postdoc training.
Experiment or technique you would most like to do (could be something you enjoy doing or something you have never done but would like to get the opportunity to do)
I like the design and synthesis of new compounds because there is a sense of satisfaction in creating something new.
Fun Fact about Xiuqi
I like hiking and exploring nature.