Systems Pharmacology and Toxicology (SPaT) Ninth Annual Symposium
August 12, 2022
9:00 a.m. – 2:15 p.m.
The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its ninth annual symposium featuring presentations by SPaT trainees. The keynote presentation was given by David Mattson, Ph.D (Medical College of Georgia at Augusta University).
9:00-9:10 a.m.
Introductory Remarks
Paul Prather, Ph.D., Director, SPaT T32 Training Grant
9:10-9:35 a.m.
“Exploring the use of senolytics to mitigate cartilage degeneration and improve healing”
Luke Childress, SPaT T32 Trainee
9:35-10:00 a.m.
“Assessing the role of VEGF-A/VEGFR signaling through host macrophages during Leishmania major infection”
Lucy Fry, SPaT T32 Trainee
10:00-10:25 a.m.
“The role of ATF6 signaling in the immune recognition of the metastatic melanoma”
Jacob Edmondson, SPaT COM/ABI Supported Trainee
10:40-11:05 a.m.
“The IFNy-PDL1 pathway contributes to the pathogenesis of hypertension”
Lance Benson, SPaT T32 Trainee
11:05-11:30 a.m.
“Cerebellar and hippocampal transcriptomic changes induced in a chronic binge model of alcohol use disorder”
Kalee Holloway, SPaT T32 Trainee
11:30-11:55 a.m.
“Altered miRNA expression drive proliferation of lymphatic malformation by activating pro-growth signaling cascades”
Ravi Sun, SPaT COM/ABI Supported Trainee
12:00-1:00 p.m.
Trainee Luncheon with Dr. David Mattson
1:00-2:00 p.m.
Keynote Presentation- David Mattson, PhD
Professor and Chair of Physiology
Georgia Research Alliance Eminent Scholar in Hypertension
Medical College of Georgia at Augusta University
“The gut-immune kidney axis: Influence of dietary protein in salt sensitive hypertension”
2:00-2:15 p.m.
Closing Remarks
Systems Pharmacology and Toxicology (SPaT) Eighth Annual Symposium
August 13, 2021
9:00 a.m. – 2:15 p.m.
The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its eighth annual symposium featuring presentations by SPaT trainees. The keynote presentation was given by Christopher McCurdy, Ph.D (University of Florida). The morning session was held in-person and the afternoon keynote session was held virtually.
9:00-9:10 a.m.
Introductory Remarks
Paul Prather, Ph.D., Director, SPaT T32 Training Grant
9:10-9:35 a.m.
“Inappropriate activation of CD8+ T cells contributes to the pathogenesis of hypertension”
Lance Benson, SPaT T32 Trainee
9:35-10:00 a.m.
“Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period”
Kalee Holloway, SPaT T32 Trainee
10:05-10:30 a.m.
“Identification and characterizations of the microRNA networks driving lymphatic malformation growth”
Ravi Sun, SPaT COM/TRI Trainee
10:40-11:05 a.m.
“Molecular mechaisms of glucocorticoid-induced bone loss”
Anveshi Guha, SPaT Com/TRI Trainee
11:05-11:30 a.m.
“Novel regeneration-associated biomarkers to predict death in acute liver failure”
Joel Vazquez, SPaT T32 Trainee
11:30-11:55 a.m.
“Parthenolide induces thiol oxidation leading to ferroptosis in human hepatocellular carcinoma cells”
Francesca Lobianco, SPaT T32 Trainee
12:00-12:45 p.m.
Trainee Virtual Luncheon with Dr. Christopher McCurdy
1:00-2:00 p.m.
Keynote Presentation- Christopher McCurdy, PhD
Professor of Medicinal Chemistry and Pharmaceutics
Director, University of Florida Translational Drug Development Core
College of Pharmacy, University of Florida
“Can a Controversial Dietary Supplement End the Opioid Crisis?”
2:00-2:15 p.m.
Closing Remarks
Systems Pharmacology and Toxicology (SPaT) Seventh Annual Symposium (Virtual)
August 7, 2020
9:00 a.m. – 2:15 p.m.
The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its seventh annual symposium featuring presentations by SPaT trainees. The keynote presentation was given by S. Cyrus Khojasteh, Ph.D., (Genetech, Inc., South San Francisco, CA).
9:00-9:15 AM
Introductory Remarks
Paul Prather, Ph.D., Director, SPaT T32 Training Grant
9:10-9:40 AM
“Identification of serum biomarkers to distinguish hazardous and benign aminotransferase elevations”
Joel Vazquez, SPaT T32 Trainee
9:40-10:05 AM
“Diphenylamine NSAIDs are bioactivated into hepatotoxicants through multiple metabolic mechanisms”
Mary “Allie” Schleiff, SPaT T32 Trainee
10:05-10:30 AM
“The role of osteoprotein in glucocorticoid-induced bone loss”
Anveshi Guha, SPaT COM/TRI Trainee
10:30-10:55 AM
“Parthenolide induces thiol oxidation mediated cytotoxicity in human hepatocellular carcinoma cell lines”
Francesca Lobianco, SPaT T32 Trainee
10:55-11:20 PM
“Examining the role of macrophages in follicular thyroid cancer tumorigenesis”
Caitlin Caperton, SPaT COM/TRI Trainee
11:45-12:45 PM
Trainee Virtual Luncheon with Dr. S. Cyrus Khojasteh
1:00-2:00 PM
Keynote Presentation- S. Cyrus Khojasteh, Ph.D.
Principal Scientist and Associate Director
Genetech, Inc., South San Francisco, CA
“How Data-Rich Science Drives Drug Discovery”
2:00-2:15 PM
Closing Remarks
Systems Pharmacology and Toxicology (SPaT) Sixth Annual Symposium
May 9, 2019
9:00 a.m. – 2:30 p.m.
Walton Auditorium, Winthrop P. Rockefeller Cancer Institute
The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its sixth annual symposium featuring presentations by SPaT trainees and students and postdocs from various graduate programs presented posters. The keynote presentation was given by Susan B. Horwitz, Ph.D., (Albert Einstein College of Medicine).
9:00-9:10 AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Training Grant
9:10-9:35 AM
“Phosphatidic acid enhances liver regeneration after acetaminophen hepatotoxicity by promoting phosphorylation and inhibition of GSK3β”
Melissa Clemens, SPaT T32 Trainee, Pharmacology, Toxicology and Experimental Therapeutics GPIBS Track
9:35-10:00 AM
“Bioactivation of halogenated aromatic drugs as a precursor to drug-induced hepatotoxicity”
Mary “Allie” Davis, SPaT T32 Trainee, Biochemistry and Molecular Biology GPIBS Track
10:00-10:25 AM
“Exploring the tumor microenvironment of follicular thyroid cancer””
Caitlin Caperton, SPaT COM/TRI Trainee, Physiology and Biophysics GPIBS Track
10:25-10:40 AM
Break/Poster Viewing
10:40-11:05 AM
“The Role of Dietary Methionine in Acute Radiation-Induced Gastrointestinal Injury”
Laura Ewing, SPaT T32 Trainee, Pharmacology, Toxicology and Experimental Therapeutics GPIBS Track
11:05-11:30 PM
“In vivo abuse liability assessment of novel fentanyl analogues”
Kyle Urquhart, SPaT T32 Trainee, Pharmacology, Toxicology and Experimental Therapeutics GPIBS Track
11:30-11:55 PM
“EZH2 protects tumor-infiltrating lymphocytes from metabolic exhaustion”
Brian Koss, SPaT COM/TRI Trainee, Biochemistry and Molecular Biology Track
12:00-12:30 PM
Luncheon
12:30-1:00 PM
Poster Viewing
1:00-2:00 PM
Keynote Presentation- Susan B. Horwitz, Ph.D.
Distinguished Professor, Department of Molecular Pharmacology
Rose C. Falkenstein Chair in Cancer Research
Albert Einstein College of Medicine
“Taxol, Tubulin and Tumors: A Story of Drug Development”
2:00-2:30 PM
Closing Remarks and Final Poster Viewing
Systems Pharmacology and Toxicology (SPaT) Fifth Annual Symposium
May 10, 2018
9:00 a.m. – 3:00 p.m.
Walton Auditorium, Winthrop P. Rockefeller Cancer Institute
The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its fifth annual symposium featuring presentations by SPaT trainees and students and postdocs from various graduate programs presented posters. The keynote presentation was given by Sarah England, Ph.D. (Washington University School of Medicine).
8:00-9:00 AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Training Grant
9:10-9:35 AM
“In vivo and computational modeling of methionine disposition and interactions effects with radiation-induced toxicity”
Laura Ewing, SPaT T32 Trainee, Pharmacology, Toxicology and Experimental Therapeutics GPIBS Track
9:35-10:00 AM
“Inhibiting PARP-1 signaling of DNA repair by decoy G4 DNA activation”
Lucas DeYoung, SPaT T32 Trainee, Biochemistry and Molecular Biology Graduate Track
10:00-10:25 AM
“Histone H3 epigenetic switch drives metabolic reprogramming in tumor-infiltrating lymphocytes”
Brian Koss, SPaT COM/TRI Trainee, Biochemistry and Molecular Biology Graduate Track
10:25-10:50 AM
“ATP-sensitive potassium channel openers inhibit the rhythmic contractions of rat mesenteric lymph vessels and attenuate lymph flow”
Brittney Garner, SPaT T32 Trainee, Interdisciplinary Toxicology Graduate Program
10:50-11:00 AM
Break/Poster Viewing
11:00-11:25 AM
“Modeling barrier dysfunction relevant to eosinophilic esophagitis (EOE) in human esophageal explant cultures”
Dolapo Adejumobi, SPaT T32 Trainee, Interdisciplinary Toxicology Graduate Program
11:50-12:15 PM
“Use of CRISPR/Cas9 system to modulate endogenous gene transcriptional activity”
Ryan MacLeod, SPaT COM/TRI Trainee, Interdisciplinary Biomedical Sciences Graduate Program
12:15-12:45 PM
Luncheon
12:45-1:30 PM
Poster Viewing
1:30-2:30 PM
Keynote Presentation- Sarah England, Ph.D.
Professor Obstetrics and Gynecology
Alan A. and Edity L. Wolff Professor of Medicine
Associate Director, Center for Reproductive Health Services
Washington University school of Medicine in St. Louis
“Translational Studies on the Oxytocin Receptor: A Personalized Medicine Approach”
2:30-3:00 PM
Closing Remarks and Final Poster Viewing
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Systems Pharmacology and Toxicology (SPaT) Fourth Annual Symposium
May 9, 2017
9:00 a.m. – 3:00 p.m.
Walton Auditorium, Winthrop P. Rockefeller Cancer Institute
The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its fourth annual symposium featuring presentations by SPaT trainees and students from PCOL, INTX and IBS programs. The keynote presentation was given by James H. Woods, Ph.D. (University of Texas Health Science Center at San Antonio)
9:00-9:10 AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Training Grant
9:10–9:35 AM
“Cardiovascular and locomotor effects of 3/4-methylenedioxypyrovalerone (MDPV)
in male and female Sprague-Dawley (SD) rats”
Samantha McClenahan, SPaT Trainee, Interdisciplinary Toxicology Graduate Program
9:35—10:00 AM
“Measuring barrier function in human esophageal mucosa”
Dolapo Adejumobi, SPaT Trainee, IBS Graduate Program
10:00 ‐10:25 AM
“Influence of KATP Channels on the Contractile Properties of Rat Mesenteric Lymph Vessels”
Brittney Garner, SPaT Trainee, Interdisciplinary Toxicology Graduate Program
10:25 ‐10:50 AM
“Use of the CRISPRi/dCas9::KRAB system to suppress gene expression”
Ryan MacLeod, COM/TRI Trainee, IBS Graduate Program
10:50-11:00 AM
Break/Poster Viewing
11:00 ‐11:25 AM
“Novel interaction between a mitochondrial chaperone and protease during renal transplantation”
Julia Tobacyk, SPaT Trainee, Pharmacology Graduate Program
11:25 ‐11:50 AM
“The role of MitoBK channels in renal cold preservation”
Stephen Shrum, Former SPaT Trainee, IBS Graduate Program
11:50 ‐12:15 AM
“Training and development: Impulsive choice for milk reinforcement to predict drug abuse liability in rats”
Bill Hyatt, Former COM/TRI Trainee, IBS Graduate Program
12:15 – 12:45 PM
Luncheon
12:45 – 1:30 PM
Poster Viewing
1:30 – 2:30 PM
Keynote Presentation – James H. Woods, Ph.D.
Research Professor, Department of Pharmacology
University of Texas Health Science Center at San Antonio
“Behavioral discoveries related to cholinergic pharmacology”
2:30 – 3:00 PM
Closing Remarks and Final Poster Viewing
Systems Pharmacology and Toxicology (SPaT) Third Annual Symposium
May 10, 2016
9:00 a.m. – 2:30 p.m.
Walton Auditorium, Winthrop P. Rockefeller Cancer Institute
The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its third annual symposium featuring presentations by the six 2015-2016 SPaT trainees, poster presentations by the three previous trainees and students from PCOL, INTX and IBS programs, as well as graduate students of SPaT Training Faculty. The keynote presentation was given by Vishal Vaidya, Ph.D. (Harvard Medical School)
9:00-9:10 AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Training Grant
9:10–9:35 AM
“Population variability in cisplatin-induced kidney injury outcomes are modeled using diversity outbred mice”
Julia Tobacyk, SPaT Trainee, Pharmacology Graduate Program
9:35—10:00 AM
“The role of mitoBK channels in renal cold preservation”
Stephen Shrum, SPaT Trainee, IBS Graduate Program
10:00 ‐10:25 AM
“The development of Anti-METH immunotherapies using adeno-associated viruses”
Chuck Hay, SPaT Trainee, Interdisciplinary Toxicology Graduate Program
10:25-10:40 AM
Break/Poster Viewing
10:40 ‐11:05 AM
“Effects of synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and
α-pyrrolidinovalerophenone (α-PVP) on impulsivity and vulnerability to psychostimulant abuse”
Bill Hyatt, COM/TRI Trainee, IBS Graduate Program
11:05 ‐11:30 AM
“Genetic background plays a role in risk of zileuton-induced liver injury in diversity outbred mice”
Lascelles Lyn-Cook Jr., SPaT Trainee, IBS Graduate Program
11:30 ‐11:55 AM
“Photoactivation of targeted “nanodrugs” for the eradication of Staphylococcus aureus biofilms”
Daniel Meeker, Former SPaT Trainee, IBS Graduate Program
12:00 – 1:30 PM
Luncheon/Poster Viewing
1:30 – 2:30 PM
Keynote Presentation – Vishal Vaidya, PhD
Associate Professor of Medicine & Environmental Health
Harvard Medical School, Harvard T.H. Chan School of Public Health, Brigham and Women’s Hospital
“Systems and Translational Approach to Understand Toxicology”
2:30 – 3:00 PM
Closing Remarks and Final Poster Viewing
Systems Pharmacology and Toxicology (SPaT) Second Annual Symposium
May 7, 2015
10:00 a.m. – 2:30 p.m.
IDW Building, 2nd Floor
The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its second annual symposium featuring presentations by the four 2014-2015 SPaT trainees, plus two previous trainees, poster presentations by students from PCOL, INTX and IBS programs, as well as graduate students of SPaT Training Faculty, and a keynote presentation by Gary Petlz M.D., Ph.D. (Stanford University).
9:00—10:00AM
Registration and Poster Set Up
10:00—10:15AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Trainin gGrant
10:15–10:35AM
“Design and Testing of Long Acting Viral Mediated Anti-METH Immunotherapies”
Chuck Hay, SPaT Trainee, Interdisciplinary Toxicology Graduate Program
10:35—10:55AM
“Diversity Outbred Mice May Improve Preclinical Screening for Drug-Induced Liver Injury”
Lascelles Lyn-cook, SPaT Trainee, IBS Graduate Program
10:55 – 11:15 AM
“A Tiny Solution to a Huge Problem: Employing Antibiotic-Loaded Gold Nanocages to Kill Staphylococcus aureus”
Daniel Meeker, SPaT Trainee, IBS Graduate Program
11:15 – 11:35 AM
“ROS Signaling Differentially Regulates Bone Turnover in an Age-Specific Manner in Female Mice”
Alex Alund, SPaT Trainee, IBS Graduate Program
11:35 – 11:55 AM
“Targeting Oxidants in an Infant Model of Sepsis-Induced Cardiorenal Syndrome”
Clark Sims, Past SPaT Trainee, Pharmacology Graduate Program
11:55 – 12:15 AM
“Understanding the Role of Invasive Patterns and Stromal Response in the Development of Aggressive Vulvar Squamous Cell Carcinoma”
Emily Coffman Holthoff, Past SPaT Trainee,IBS Graduate Program
12:15 – 1:30 PM
Luncheon/Poster Viewing
1:30 – 2:30 PM
KeynotePresentation
“Computational Genetics and Translational Discovery”
Gary Peltz, M.D., Ph.D., Professor of Anesthesiology
Perioperative and Pain Medicine, Stanford University
2:00 – 2:30 PM
Closing Remarks and Final Poster Viewing
Systems Pharmacology and Toxicology (SPaT) First Annual Symposium
May 12, 2014
10:00 a.m. – 2:30 p.m.
IDW Building, 2nd Floor
The Systems Pharmacology and Toxicology (SPaT) Annual Symposium (associated with the SPaT T32 training grant) held its first annual symposium featuring presentations by the three 2013-2014 SPaT trainees, poster presentations by students from PCOL, INTX and IBS programs, as well as graduate students of SPaT Training Faculty, and a keynote presentation by Edward Sherwood MD, Ph.D. (Vanderbilt University).
Program Agenda
9:00 – 10:00 AM
Registration and Poster Set Up
10:00 – 10:15 AM
Introductory Remarks
Philip R. Mayeux, Ph.D., Director, SPaT T32 Training Grant
10:15 – 10:45 AM
“Targeting Renal Perfusion and Mitochondrial Oxidants in a Model of Infant Sepsis”
Clark Sims, SPaT Trainee, Pharmacology Graduate Program
10:45 – 11:15 AM
“Protection Against Ethanol-Induced Osteopenia in Female Mice by Dietary Antioxidants’”
Alex Alund, SPaT Trainee, IBS Graduate Program
11:15 – 11:45 AM
“Perineural Invasion as an Indicator of Clinical Outcome in Vulvar Carcinoma”
Emily Coffman Holthoff, SPaT Trainee, IBS Graduate Program
11:45 AM – 1:00 PM
Luncheon and Poster Viewing
1:00 – 2:00 PM
Keynote Presentation: Edward Sherwood, M.D., Ph.D.
Professor of Anesthesiology, Vice Chair for Research, Vanderbilt University
“Augmentation of antimicrobial immunity by TLR4 agonists”
2:00 – 2:30 PM
Closing Remarks and Final Poster Viewing