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Department of Pharmacology and Toxicology: SPaT

SPaT Trainee Publications

2022 Publications

  • Benson, L.N., Liu, Y., Wang, X., Xiong, Y., Rhee, S.W., Guo, Y., Deck, K.S., Mora, C.J., Li, Lin-Xi, Huang, L., Andrews, J.T., Qin, Z., Hoover, R.S., Ko, B., Williams, R.M., Heller, D.A., Jaimes, E.A. and Mu, S. (2022) The IFNγ-PDL1 pathway enhances CD8T-DCT interaction to promote hypertension. Circ Res, 130, 1550-1564.  PMCID: PMC9106883
  • Benson, L.N., Liu, Y., Guo, Y., Xiong, Y. and Mu, S. (2022) The IFNγ-PDL1 pathway enhances the interaction between CD8+T-cells and distal convoluted tubules to promote salt-sensitive hypertension.  FASEB J, 36 Suppl 1, doi: 10.1096/fasebj.2022.36.S1.)R513. PMID: 35553164
  • Ewing, L.E., Biju, P.G., Pathak, R., Melnyk, S. Hauer-Jensen, M. and Koturbash, I. (2022) Methods for induction and assessment of intestinal permeability in rodent models of radiation injury, Methods Cell Biol, 168, 235-247. PMID: 3536698
  • McGill, M.R., James, L.P., McCullough, S.S., Moran, J.H., Mathews, S.E., Peterson, E.C., Fleming, D.P., Tripod, M.E., Vazquez, J.H., Kennon-McGill, S., Spencer, H.J. and Dranoff, J.A. (2022) Short-term safety of repeated acetaminophen use in patients with compensated cirrhosis.  Hepatol Commun, 6(2), 361-373.  PMCID: PMC87939895
  • Shoeib, A.M., Benson, L.N., Mu, S., MacMillan-Crow, L.A. and Prather, P.L. (2022) Non-canonical cannabinoid receptors with distinct binding and signaling properties in prostate and other cancer cell types mediate cell death. Int J Mol Sci, 23(6), 3049.  PMCID: PMC8954350
  • Vazquez, J.H., Kennon-McGill, S., Byrum, S.D., Mackintosh, S.G., Jaeschke, H., Williams, D.K., Lee, W.M., Dranoff, J.A., McGill, M.R. and Acute Liver Failure Study Group (2022) Proteomics indicates lactate dehydrogenase is prognostic in acetaminophen-induced acute liver failure patients and reveals altered signaling pathways. Toxicol Sci, 187(1), 25-34.  PMID: 35172013
  • Yee, A., Navulur, S., Sun, R., Lindsey, M., Gonzalez-Krellwitz and Strub, G. (2022) Bronchogenic cyst of posterior neck mimicking lymphatic malformation. Clin Case Rep, 10(3), e05210. PMCID: PMC8898750

2021 Publications

  • Barnette, D.A., Schleiff, M.A., Datta, A., Flynn, N., Swamidass, S.J. and Miller, G.P. (2021) Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam. Toxicol Lett,  338, 10-20. PMCID: PMC7807415
  • Bettadapura, M., Roys, H., Bowlin, A., Venugopal, G., Washam, C.L.,Fry, L., Murdock, S., Wanjala, H., Byrum, S.D. and Weinkopff, T. (2021) HIF-α activation impacts macrophage function during Murine Leishmania major Infection Pathogens, 10(12), 1584. PMCID: PMC8706659
  • Caperton, C.O., Jolly, L.A. Massoll, N., Bauer, A.J. and Franco, A.T. (2021) Development of novel follicular thyroid cancer models which progress to poorly differentiated and anaplastic thyroid cancer, Cancers (Basel), 13(5), 1094.  PMCID: PMC7961488
  • Clemens, M.M., Kennon-McGill, S., Vazquez, J.H., Stephens, O.W., Peterson, E.A., Johann, D.J., Allard, F.D., Yee, E.U., McCullough, S.S., James, L.P., Finck, B.N. and McGill, M.R. (2021) Exogenous phosphatidic acid reduce acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk. Acta Pharm Sin B, 11(12), 3836-3846. PMCID: PMC8727922
  • Cui, H., Carlson, A.S., Schleiff, M.A., Divakaran, A., Johnson, J.A., Buchholz, C.R., Zahid, H., Vail, N.R., Shi, K., Aihara, H., Miller, G.P., Topczewski, J.J., Pomerantz, W.C.K. (2021) 4-methyl-1,2,3-triazoles as N-acetyl-lysine mimics afford potent BET bromodomain inhibitors with improved selectivity.  J Med Chem, 64(14), 10497-10511.  PMCID: PMC8491147
  • Dhuria, N.V., Haro, B., Kapadia, A., Lobo, K.A., Matusow, B., Schleiff, M.A., Tantoy, C., Sodhi, J.K. (2021). Recent developments in predicting CYP-independent metabolism. Drug Metab Rev, 53(2), 188-206.
  • Ewing, L.E., Skinner, C.M., Pathak, R., Yee, E.U., Krager, K., Gurley, P.C., Melnyk, S., Boerma, M., Hauer-Jensen, M. and Korturbash, I. (2021) Dietary methionine supplementation exacerbates gastrointestinal toxicity in a mouse model of abdominal irradiation. Int J Radiat Oncol Biol Phys, 109(2), 581-593.  PMCID: PMC7855316
  • Ferreira, E., Gatrell, L.B., Childress, L., Wu, H. and Porter, R.M. (2021) A transgenic rat for noninvasive assessment of chondrogeneiss in vivo. Cartilage, 13(2-suppl), 1720S-1733S. PMCID: PMC8804729
  • Flynn, N.R., Ward, M.D., Schleiff, M.A., Laurin, C.M.C., Farmer, R., Conway, S.J., Boysen, G., Swamidass J.S. and Miller, G.P. (2021) Bioactivation of isoxazole-containing bromodomain and extra-terminal domain (BET) inhibitors. Metabolites, 11(6), 390. PMCID: PMC823221
  • MacLeod, R.S., Meyer, M.B., Xiong, J., Cawley, K.M., Liu, Y., Onal, M., Benkusky, N.A., Thostenson, J.D., Pike, J.W. and O’Brien, C.A. (2021) Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo. PLoS One, 16(5), eo2500974. PMCID: PMC8109787
  • McClenahan, S.J., Gunnell, M. and Owens, S.M. (2021) Pharmacokinetics of α-pyrrolidinovalerophenone in male rats with and without vaccination with an α-pyrrolidinovalerophenone vaccine. J Pharm Pharm Sci, 24, 267-276. PMCID: PMC8604100
  • Pinson, M.R*., Holloway, K.N.*, Douglas, J.C., Kane, C.J.M., Miranda, R.C. and Drew, P.D. (2021) Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period.  Alcohol Clin Exp Res, 45(7), 1408-1423.  PMCID: PMC8312515 (*co-first authors)
  • Schleiff, M.A., Flynn, N.R., Payakachat, S., Schleiff, B.M., Pinson, A.O., Province, D.W., Swamidass, S.J., Boysen, G. and Miller, G.P. (2021)  Significance of multiple bioactivation pathways for meclofenamate as revealed through modeling and reaction kinetics. Drug Metab Dispos, 49, 133-141. PMCID: PMC841419
  • Schlieff, M.A., Crosby, S., Blue, M., Schleiff, B.M., Boysen, G. and Miller, G.P. (2021) CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs, Biochem Pharmcol, 194, 114824. PMCID: PMC8710044
  • Schleiff, M.A., Payakachat, S., Schleiff, B.M., Swamidass, S.J., Boysen, G. and Miller, G.P. (2021) Impacts of diphenylamine NSAID halogenation on bioactivation risks. Toxicology, 458, 152832. PMCID: PMC8513111
  • Schonning, M.J., Koh, S., Sun, R.W., Richter, G.T., Edwards, A.K., Shawber, C.J. and Wu, J.K. (2021) Venous malformation vessels are improperly specified and hyperproliferative. PLoS One, 16(5), e0252342. PMCID: PMC8158993
  • Shoeib, A.M., Yarbrough, A.L., Ford, B.M., Franks, L.N., Urbaniak, A., Hensley, L.L., Benson, L.N., Mu, S., Radominska-Pandya, A., and Prather, P.L. (2021) Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development. Life Sci, 285, 119993.  PMID: 34592231
  • Tobacyk, J. and MacMillan-Crow, L.A. (2021) Fluorescence-based assay for measuring OMA1 activity, Methods Mol Biol, 2276, 325-332. PMID: 34060052
  • Tobacyk, J., Grishma, K. and MacMillan-Crow, L.A. (2021) Overexpression of MnSOD protects against cold storage-induced mitochondrial injury but not against OMA1-dependent OPA1 proteolytic processing in rat renal proximal tubular cells, Antioxidants, 10(8), 1272. PMCID: PMC8389209
  • Vazquez, J.H. and McGill, M.R. (2021) Redrawing the map to novel DILI biomarkers in circulation: Where are we, where should we go, and how can we get there?  Livers, 1(4), 286-293.  PMCID: PMC8713950
  • Zhang, H., Wei, T., Johnson, A., Sun, R., Richter, G. and Strub, G. (2021) NOTCH pathway activation in infantile hemangiomas. J Vasc Surg Venous Lympath Disord, 9(2), 489-496. PMID: 32763337

2020 Publications

  • Barnette, D.A., Schleiff, M.A., Osborn, L.R., Flynn, N., Matlock, M., Swamidass, S.J. and Miller, G.P. (2020) Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam. Toxicology, 440,152478. PMCID: PMC8716319
  • Cawley, K.M., Bustamante-Gomez, N.C., Guha, A.G, MacLeod, R.S., Xiong, J., Gubrij, I., Liu, Y., Mulkey, R., Palmieri, M., Thostenson J.D., Goellner, J.J. and O’Brien, C.A. (2020) Local production of osteoprotegerin by osteoblasts suppresses bone resorption. Cell Rep, 32(10), 108052.  PMCID: PMC7493998
  • Clemens, M.M., Vazquez, J.H., Kennon-McGill, S., McCullough, S.S., James, L.P. and McGill, M.R. (2020) Pre-treatment twice with liposomal clodronate protects against  acetaminophen hepatotoxicity through a pre-conditioning effect. Liver Res, 4(3), 145-152. PMCID: PMC7544241
  • Ewing L.E., Miousse, I.R., Pathak, R., Skinner, C.M., Kosanke, S., Boerma, M., Hauer-Jensen, M. and Kortubash, I. (2020) NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. Int J Radiat Biol, 96, 93-99.  PMCID: PMC6581619
  • Gaba, R.C., Elkhadragy, L., Boas, F.E., Chaki, S., Chen, H.H., El-Kebir, M., Garcia, K.D., Guirini, E.F., Guzman, G., Lobianco, F.V., Neto, M.F., Newsom, J.L., Qazi, A., Regan, M., Rund, L.A., Schwind, R.M., Stewart, M.C., Thomas, F.M., Whitely, H.E., Wu, J., Schook, L.B. and Schachtschneider, K.M. (2020) Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation. Oncotarget, 11(28), 2686-2701. PMCID: PMC7367657
  • Hay, C.E., Ewing, L.E., Hambuchen, M.D., Zintner, S.M., Small, J.C., Bolden, C.T., Fantegrossi, W.E., Margaritis, P., Owens, S.M. and Peterson, E.C. (2020) The development and characterization of an scFv-Fc fusion-based gene therapy to reduce the psychostimulant effects of methamphetamine abuse.  J Pharmcol Exp Ther, 374(1), 16-23.  PMCID: PMC7289050
  • Hyatt, W.S., Hirsh, C.E., Russell, L.N., Chitre, N.M., Murnane, K.S., Rice, K.C. and Fantegrossi, W.E. (2020) The synthetic cathinone 3,4-methylenedioxypyrovalerone increases impulsive action in rats, Behav Pharmcol, 31(4), 309-321. PMID: 32101987
  • Kim, H-N., Xiong, J., MacLeod, R.S., Iyer, S., Fujiwara, Y., Cawley, K.M., Han, L., He, Y., Thostenson, J.D., Ferreira, E., Jilka, R.L., Zhou, D., Almeida, M. and O’Brien, C.A. (2020) Osteocyte RANKL is required for corticol bone loss with age and is induced by senescence. JCI Insight, 5(19), e138815.  PMCID: PMC7566701
  • Koss, B., Shields, B.D., Taylor, E.M., Storey, A.J., Byrum, S.D., Gies, A.J., Washam, C.L., Choudhury, S.R., Ahn, J.H., Uryu, H., Williams, J.B., Krager, K.J., Chiang, T-C., Mackintosh, S.G., Edmondson, R.D., Aykin-Burns, N., Gajewski, T.F., Wang, G.G. and Tackett, A.J. (2020) Epigenetic control of Cdkn2a.Arf protects tumor infiltrating lymphocytes from metabolic exhaustion.  Cancer Res, 80(21), 4707-4719.  PMCID: PMC642172
  • Kutanzi, K.R., Ewing, L.E., Skinner, C.M., Quick, C.M., Kennon-McGill, S., McGill, M.R., Walker, L.A., ElSohly, M.A., Gurley, B.J. amd Kortubash, I. (2020) Safety and molecular-toxicological implications of cannabidiol-rich cannabis extract and methylsulfonylmethane co-administration. Int J Mol Sci, 21(20), 7808. PMCID: PMC7656295
  • Lobianco, F.V., Krager, K.J., Carter, G.S., Alam, S., Yuan, Y., Lavoie, E.G., Dranoff, J.A. and Aykin-Burns, N. (2020) The role of sirtuin 3 in radiation-induced long-term persistent liver injury. Antioxidants (Basel), 9(5), 409.  PMCID: PMC7278565
  • McClenahan, S.J., Kormos, C.M., Gunnell, M, Hambuchen, M.D., Lamb, P., Carroll, F.I., Lewin, A.H., Peterson, E.C. and Owens, S.M. (2020) Design, synthesis and biological evaluation of bi-specifc vaccine against α-pyrrolidinovalerophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats. Vaccine, 38(2), 336-344. PMCID: PMC6938543
  • McClenahan, S.J., Gunnell, M.G., Owens, S.M. and Fantegrossi, W.E. (2020) Active vaccination reduces reinforcing effects of MDPV in male Sprague-Dawley rats trained to self-administer cocaine. Psychopharmacology (Berl), 237(9), 2613-2620. PMCID: PMC7502518
  • Miousse, I.R., Ewing, L.E., Skinner, C.M., Pathak, R., Garg, S., Kutanzi, K.R., Melnyk, S., Hauer-Jensen, M., and Kortubash, I. (2020) Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. Am J Physiol Gastrointest Liver Physiol, 318, G439-G450. PMCID: PMC7099489
  • Pinson, A.O., Pouncey, D.L., Schleiff, M.A., Fantegrossi, W.E., Prather, P.L., Radominska-Pandya, A., Boysen, G. and Miller, G.P. (2020) Significance of competing metabolic pathways for 5F-APINACA based on quantitative kinetics. Molecules, 25(20), 4820. PMCID: PMC7587938
  • Ronis, M.J., Watt, J., Pulliam, C.F., Williams, A.E., Alund, A.W., Haque, E., Gadupudi, G.S., and Robertson, L.W. (2020) Skeletal toxicity resulting from exposure of growing male rats to coplanar PCB 126 is associated with disruption of calcium homeostasis and the GH-IGF-1 axis and direct effects on bone formation. Arch Toxicol, 94(2), 389-399.  PMCID: PMC7047627
  • Russell, L.E., Schleiff, M.A., Gonzalez, E., Bart, A.G., Broccatelli, F., Hartman, J.H., Humphreys, W.G., Lauschke, V.M., Martin, I., Nwabufo, C., Prasad, B., Scott, E.E., Segall, M., Takahashi, R., Taub, M.E. and Sodhi, J.K. (2020) Advances in the study of drug metabolism – symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX), Drug Metab Rev, 52(3), 395-407. PMCID: PMC7466845
  • Shrum, S., Tobacyk, J., Lo, S., Parajuli, N. and MacMillan-Crow, L.A. (2020) The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury, Arch Biochem Biophys, 688, 108410. PMCID: PMC7322695
  • Skinner, C.M., Nookaew, I., Ewing, L.E., Wongsurawat, T., Jenjaroenpun, P., Quick, C.M., Yee, E.U., Piccolo, B.D., ElSohly, M., Walker, L.A., Gurley, B. and Kortubash, I. (2020) Potential probiotic or trigger of gut inflammation – the Janus-faced nature of cannabidiol-rich cannabis extract. J Diet Suppl, 17, 543-560. PMCID: PMC7470626
  • Tascoiglu, A.A., Lobianco, F., Krager, K.J. and Aykin-Burns, N. (2020) Assessment of cellular oxidation using a subcellular compartment-specific redox-sensitive green fluoresecent protein. J Vis Exp, 160, 10.3791/61229. PMCID: PMC7725482
  • Taylor, E.M., Koss, B., Davis, L.E. and Tackett, A.J. (2020) Histone modifications as biomarkers for immunotherapy. Methods Mol Biol, 2055, 213-228.  PMID: 31502154
  • Taylor, E.M., Byrum, S.D., Edmondson, J.L., Wardell, C.P., Griffin, B.G., Shalin, S.G., Gokden, M., Makhoul, I. and Tackett, A.J. (2020)  Proteogenomic analysis of melanoma brain metastes from distinct anatomical sites identifies pathways of metastatic progression, Acta Neuropathol Commun, 8(1), 157. PMCID: PMC7487560
  • Trentzch, M., Nyamugenda, E., Miles, T.K., Griffin, H., Russell, S., Koss, B., Cooney, K.A., Phelan, K.D., Tackett, A.J., Iyer, S., Boysen, G. and Baldini, G. (2020) Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum.  Cell Death Discov, 6, 8. PMCID: PMC7028721
  • Vazquez, J.H., Clemens, M.M., Allard, F.D., Yee, E.U., Kennon-McGill, S., Mackintosh, S.G., Jaeschke, H., Hambuchen, M.D. and McGill, M.R. (2020) Identification of serum biomarkers to distinguish hazardous and benign aminotransferase elevations. Toxicol Sci, 173(2), 244-254. PMCID: PMC8445665
  • You, D., Lyn-Cook, L.E., Gatti, D.M., Bell, N., Mayeux, P.R., James, L.P., Mattes, W.B., Larson, G.J. and Harrill, A.H. (2020) Nitrosative stress and lipid homeostasis as a mechanism for zileuton hepatotoxicity and resistence in genetically sensitive mice, Toxicol Sci, 175(2), 220-235. PMCID: PMC7253212

2019 Publications

  • Barnette, D.A., Davis, M.A., Flynn, N., Pidugu, A.S., Swamidass, S.J. and  Miller, G.P. (2019) Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation. Biochem Pharmacol, 170, 113661. PMCID: PMC6905088
  • Chiang, T-C., Koss, B., Su, L.J., Washam, C.L., Byrum, S.D., Storey, A. and Tackett, A.J. (2019) Effect of sulforaphane and 5-Aza-2-deoxycytidine on melanoma cell growth.  Medicines (Basel), 6(3), 71. PMCID: PMC6789461
  • Clemens, M.M., McGill, M.R. and Apte, U. (2019) Mechanisms and biomarkers of liver regeneration after drug-induced liver injury. Adv Pharmacol, 85, 241-262. PMCID: PMC7641498
  • Clemens, M.M., Kennon-McGill, S., Apte, U., James, L.P., Finck, B.N. and McGill, M.R. (2019) The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling. Food Chem Toxicol, 12, :279-288.  PMCID: PMC6443093
  • Davis, M.A., Barnette, D.A., Flynn, N.R., Pidugu, A.S., Swamidass, S.J., Boysen, G. and Miller, G.P. (2019) CYP2C19 and 3A4 dominate metabolic clearance and bioactivation of terbinafine based on computational and experimental approaches. Chem Res Toxicol, 32, 1151-1164.
  • Ewing, L.E., Skinner, C.M., Quick, C.M., Kennon-McGill, S., McGill, M.R., Walker, L.A., ElSohly, M.A., Gurley, B.J. and Korturbash, I. (2019) Hepatotoxicity of a cannabidiol-rich cannabis extract in the mouse model. Molecules, 24(9), 1694. PMCID: PMC6539990
  • Ewing, L.E., McGill, M.R., Yee, E.U., Quick, C.M., Skinner, C.M., Kennon-McGill, S., Clemens, M.M., Vazquez, J.H., McCullough, S.S., Williams, D.K., Kutanzi, K.R., Walker, L.A., ElSohly, M.A., James, L.P., Gurley, B.J. and Korturbash, I. (2019) Paradoxical patterns of sinusoidal obstruction syndrome-like liver injury in aged female CD-1 mice triggered by cannabidiol-rich cannabis extract and acetaminophen co-administration. Molecules, 24(12), 2256.  PMCID: PMC6630875
  • Griffin, B.A., Caperton, C.O., Russell, L.N., Cabanlong, C.V., Wilson, C.D., Urquhart, K.R., Martins, B.S., Dina Zita, M., Patton, A.L., Alund, A.W., Owens, S.M., Fantegrossi, W.E., Moran, J.H., Brents, L.K. (2019) In utero exposure to norbuprenorphine, a major metabolite of buprenorphine, induces fetal opioid dependence and leads to neonatal opioid withdrawal syndrome. J Pharmcol Exp Ther, 370(1), 9-17. PMCID: PMC6538887
  • Hyatt, W.S., Berquist, M.D., Chitre, N.M., Russell, L.N., Rice, K.C., Murnane, K.S. and Fantegrossi, W.E. (2019) Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats, Behav Pharmacol, 30(7), 555-565. PMID: 31211703
  • Kennon-McGill, S., Clemens, M.M. and McGill, M.R. (2019) Expression of drug metabolizing enzymes and transporters in the cochlea: implications for drug delivery and ototoxicity. Hear Res, 379, 98-102. PMCID: PMC6590996
  • Kurten, R., Rawson, R., Shoda, T., Duong, L.D., Adejumobi, D., Levy, R., Newbury, R.O., Rothenberg, M.E., Akuthota, P., Wright, B.L., Dohil, R., Jones, S.M. and Aceves, S.S. (2019) Development and application of a functional human esophageal mucosa explant platform to eosinophilic esophagitis, Sci Rep, 9(1), 6206. PMCID: PMC6470157
  • Lee, T., Christov, P.P., Shaw, S., Tarr, J.C., Zhao, B., Veerasamy, N., Jeon, K.O., Mills, J.J., Bian, Z., Sensintaffar, J.L., Arnold, A.L., Fogarty, S.A., Perry, E., Ramsey, H.E., Cook, R.S., Hollingshead, M., Millin, M.D., Lee, K-M., Koss, B., Budhraja, A., Opferman, J.T., Kim, K., Arteaga, C.L., Moore, W.J., Olejniczak, E.T., Savona, M.R. and Fesik, S.W. (2019) Discovery of potent myeloid cell leukemia-1 (Mcl-1) inhibitors that demonstrate in vivo activity in mouse xenograft models of human cancer.  J Med Chem, 62(8), 3971-3988.  PMID: 30929420
  • McClenahan, S.J., Hambuchen, M.D., Simecka, C.M., Gunnell, M.G., Berquist, M.D and Owens, S.M. (2019) Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats.  Drug Alcohol Depend, 195, 140-147. PMCID: PMC6915966
  • Post, G.R., Yuan, Y., Holthoff, E.R., Quick, C.M. and Post, S.R. (2019) Identification of a novel monocytic phenotype in classic Hodgkin Lymphoma tumor microenvironment. PLoS One, 14(11), e0224621.  PMCID: PMC6850552
  • Ren, Z., Ahn, J.H., Liu, H., Tsai, Y-H., Bhanu, N.V., Koss, B., Allison, D.F., Ma, A., Storey, A.J., Wang, P., Mackintosh, S.G., Edmondson, R.D., Groen, R.W.J., Martens, A.C., Garcia, B.A., Tackett, A.J., Jin, J., Cai, L., Zheng, D. and Wang, G.G. (2019) PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Blood, 134(14), 1176-1189.  PMCID: PMC6776795
  • Shields, B.D., Koss, B., Taylor, E.M., Storey, A.J., West, K.L., Byrum, S.D., Mackintosh, S.G., Edmondson, R., Mahmoud, F., Shalin, S.C. and Tackett, A.J. (2019) Loss of E-cadherin inhibits CD103 antitumor activity and reduces checkpoint blockage responsiveness in melanoma.  Cancer Res, 79(6), 1113-1123. PMCID: PMC6420873
  • Shrum, S., Rusch, N.J. and MacMillan-Crow, L.A. (2019) Specific BK channel activator NS11021 protects rat renal proximal tubular cells from cold-storage induced mitochondrial injury in vitro, Biomolecules, 9(12), 825. PMCID: PMC6995623
  • Tobacyk, J., Parajuli, N., Shrum, S., Crow, J.P. and MacMillan-Crow, L.A. (2019) The first direct activity assay for the mitochondrial protease OMA1, Mitochondrian, 46, 1-5. PMCID: PMC6487223

2018 Publications

  • Barnette, D.A., Davis, M.A., Dang, N.L., Pidugu, A.S., Hughes, T., Swamidass, S.J., Boysen, G. and Miller, G.P. (2018)  Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches. Biochem Pharmacol, 156, 10-21. PMCID: PMC6188815
  • Berquist, M.D., Hyatt, W.S., Bauer-Erickson, J., Gannon, B.M., Norwood, A.P. and Fantegrossi, W.E. (2018) Phencyclidine-like in vivo effects of methoxetamine in mice and rats, Neuropharmacology, 134(Pt A), 158-166. PMCID: PMC5818319
  • Chen, J-R, Lazarenko, O.P., Zhao, H., Alund, A.W., Shankar, K. (2018) Maternal obesity impairs skeletal development in adult offspring. J Endocrinol, 239(1), 33-47. PMCID: PMC6145139
  • Garner, B.R., Stolarz, A.J., Stuckey, D., Sarimollaoglu, M., Liu, Y., Palade, P.T., Rusch, N.J. and Mu, S. (2021) K ATP channel openers inhibit lymphatic contractions and lymph flow as a possible mechanism of peripheral edema, J Pharmcol Exp Ther, 376(1), 40-50. PMCID: PMC7745085
  • Hay, C.E., Gonzalez 3rd, G.A., Ewing, L.E., Reichard, E.E., Hambuchen, M.D., Nanaware-Kharade, N., Alam, S., Bolden, C.T., Owens, S.M., Margaritis, P. and Peterson, E.C. (2018) Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse. PLoS One, 13(6), e0200060. PMCID: PMC6025879
  • Lutkewitte, A.J., Schweitzer, G.G., Kennon-McGill, S., Clemens, M.M., James, L.P., Jaeschke, H., Finck, B.N. and McGill, M.R. (2018) Lipin deactivation after acetaminophen overdose causes phosphatidic acid acculumation in liver and plasma in mice and humans and enhances liver regeneration. Food Chem Toxicol, 115, 273-283. PMCID: PMC5935563
  • Meeker, D.G., Wang, T., Harrington, W.N., Zharov, V.P., Johnson, S.A., Jenkins, S.V., Oyibo, S.E., Walker, C.M., Mills, W.B., Shirtliff, M.E., Beenken, K.E., Chen, J., Smeltzer, M.S. (2018) Versatility of targeted antibiotic-loaded gold nanoconstructs for the treatment of biofilm-associated bacterial infections.  Int J Hyperthermia, 34(2), 209-2019.  PMCID: PMC6095133
  • Miousse, I.R., Ewing, L.E., Kutanzi, K.R., Griffin, R.J. and Koturbash, I. (2018) DNA methylation in radiation-induced carcinogenesis: experimental evidence and Ccinical perspectives. Crit Rev Oncog, 23, 1-11. PMCID: PMC6369919
  • Sarimollaoglu, M., Stolarz, A.J., Nedosekin, D.A., Garner, B.R., Fletcher, T.W., Galanzha, E.I., Rusch, N.J. and Zharov, V.P. (2018) High-speed microscopy for in vivo monitoring of lymph dynamics. J Biophotonics, 11(8), e201700126. PMCID: PMC6314807
  • Skinner, C.M., Miousse, I.R., Ewing, L.E., Sridharan, V., Cao, M., Lin, H., Williams, D.K., Avula, B., Haider, S., Chittiboyina, A.G., Khan, I.A., ElSohly, M.A., Boerma, M., Gurley, B.J and Kortubash, I. (2018) Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol, 122, 21-32. PMCID: PMC6219625
  • Van, S., Pal, S., Garner, B.R., Steed, K., Sridharan, V., Mu, S., Rusch, N.J. and Stolarz, A.J. (2021) Dantrolene prevents the lymphostasis caused by doxorubicin in the rat mesenteric circulation.  Front Pharmcol, 12, 727526. PMCID: PMC8415554
  • Watt, J., Alund, A.W., Pulliam, C.F., Mercer, K.E., Suva, L.J., Chen, J-R. and Ronis, M.J.J. (2018) NOX4 deletion in male mice exacerbates the effect of ethanol on trabecular bone and osteoblastogenesis. J Pharmcol Exp Ther, 366(1), 46-57. PMCID: PMC5988025

2017 Publications

  • Hambuchen, M.D., Hendrickson, H.P., Gunnell, M.G., McClenahan, S.J., Ewing, L.E., Gibson, D.M., Berquist, M.D. and Owens, S.M. (2017) The pharmacokinetics of racemic MDPV and its (R ) and (S ) enantiomers in female and male rats. Drug Alcohol Depend, 179, 347-354.  PMCID: PMC5600196
  • Harrill, A.H., Lin, H., Tobacyk, J., Seely, J.C. (2017) Mouse population-based evaluation of urinary protein and miRNA biomarker performance associated with cisplatin renal injury. Exp Biol Med (Maywood), 243(3), 237-247. PMCID: PMC5813868
  • Holthoff, E.R., Byrum, S.D., Mackintosh, S.G., Kelly, T., Tackett, A.J., Quick, C.M and Post, S.R. (2017) Vulvar squamous cell carcinoma aggressiveness in associated with differential expression of collagen and STAT1. Clin Proteomics, 14, 40. PMCID: PMC5717999
  • Lin, H., Ewing, L.E., Koturbash, I., Gurley, B.J. and Miousse, I.R. (2017) MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects. Food Chem Toxicol, 110, 229-239. PMCID: PMC6693868
  • Mazur, A., Holthoff, E.R., Vadali, S., Kelly, T. and Post, S.R. (2016) Cleavage of type I collagen by fibroblast activation protein- enhances class A scavenger receptor mediated macrophage adhesion. PLoS One, e0150287. PMCID: PMC4774960
  • Miousse, I.R., Skinner, C.M., Lin, H., Ewing, L.E., Kosanke, S.D., Williams, D.K., Avula, B., Khan, I.A., ElSohly, M.A., Gurley, B.J. and Kortubash, I. (2017) Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains. Food Chem Toxicol, 109, 194-209. PMCID: PMC6756457
  • Parajuli, N., Shrum, S., Tobacyk, J., Harb, A., Arthur, J.M. and MacMillan-Crow, L.A. (2017) Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins, PLoS One, 12(10), e0185542. PMCID: PMC5627902
  • Sims, C.R., Singh, S.P., Mu, S.., Gokden, N., Zakaria, D., Nguyen, T.C. and Mayeux, P.R., (2017) Rolipam improves outcome in a rat model of infant sepsis-induced cardiorenal syndrome, Front Pharmcol, 8, 237. PMCID: PMC5413568
  • Shields, B.D., Mahmoud, F., Taylor, E.M., Byrum, S.D., Sengupta, D., Koss, B., Baldini, G., Ransom, S., Cline, K., Mackintosh, S.G., Edmondson, R.D., Shalin, S. and Tackett, A.J. (2017) Indicators of responsiveness to immune checkpoint inhibitors. Sci Rep, 7(1), 807. PMCID: PMC5429745

2016 Publications

  • Alund, A.W., Mercer, K.E., Suva, L.J., Pulliam, C.F., Chen, J.R., Badger, T.M., Van Remmen, H. and Ronis, M,J. (2016) Reactive oxygen species differentially regulate bone turnover in an age-specific manner in catalase transgenic female mice. J Pharmacol Exp Ther, 358, 50-60.  PMCID: PMC4931876
  • Alund, A.W., Mercer, K.E., Suva, L.J., Pulliam, C.F., Chen, J-R., Badger, T.M. and Ronis, M.J. (2016) Patrial protection by dietary antioxidants against ethanol-induced osteopenia and changes in bone morphology in female mice. Alcoholism: Clin Exp Res., 41(1), 46-56. PMCID: PMC5521216
  • Atwood, D.N., Beenken, K.E., Lantz, T.L., Meeker, D.G., Lynn, W.B., Mills, W.B., Spencer, H.J. and Smeltzer, M.S. (2016) Regulatory mutations impacting antibiotic susceptibility in an established Staphylococcus aureus biofilm. Antimicrob Agents Chemother, 60, 1826-1829. PMCID: PMC4775981
  • Atwood, D.N., Beenken, K.E., Loughran, A.J., Meeker, D.G., Lantz, T.L., Graham, J.W., Spencer, H.J., and Smeltzer, M.S. (2016) XerC contributes to diverse forms of Staphylococcus aureus infection via agr-dependent and agr-independent pathways. Infect Immun, 84,1214-25. PMCID: PMC4807471
  • Holthoff, E., Spencer, H., Kelly, T., Post, S.R. and Quick, C.M. (2016) Pathologic features of aggressive vulvar squamous cell carcinoma are associated with an epithelial-mesenchymal transition. Hum Pathol. 56, 22-30. PMCID: PMC5021565
  • Jennings, J.A., Beenken, K.E., Skinner, R.A., Meeker, D.G., Smeltzer, M.S., Haggard, W.O. and Troxel, K.S. (2016) Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection. World J Orthop. 2016, 7(8), 467-474. PMCID: PMC4990767
  • Loughran, A.J., Gaddy, D., Beenken, K.E., Meeker, D.G., Morello, R., Zhao, H., Byrum, S.D, Tackett, A.J., Cassat, J.E. and Smeltzer, M.S. (2016) Impact of sarA and phenol-soluble modulins in the pathogenesis of osteomyelitis in diverse clinical isolates of Staphylococcus aureus. Infect Immun, 84(9), 2586-2594.  PMCID: PMC4995912
  • Meeker, D.G., Chen, J. and  MS. (2016) Could targeted, antibiotic-loaded gold nanoconstructs be a new magic bullet to fight infection? Nanomedicine (Lond), 11, 2379-2382. PMCID: PMC27529572
  • Meeker, D.G., Jenkins, S.V., Miller, E.K., Beenken, K.E., Loughran, A.J., Powless, A., Muldoon, T.J., Galanzha, E.I., Zharov, V.P., Smeltzer, M.S., and Chen, J. (2016) Synergistic photothermal and antibiotic killing of biofilm-associated Staphylococcus aureus using targeted antibiotic-loaded gold nanoconstructs. ACS Infectious Diseases, 2(4), 241-250.  PMCID: PMC4945994
  • Meeker, D.G., Chen, J. and Smeltzer, M.S. (2016) Could targeted, antibiotic-loaded gold nanoconstructs be a new magic bullet to fight infection? Nanomedicine (Lond), 11(18), 2379-2382. PMCID: PMC5561798
  • Meeker, D.G., Beenken, K.E., Mills, W.B., Loughran, A.J., Spencer, H.J., Lynn, W.B. and Smeltzer, M.S. (2016) Evaluation of antibiotics active against methicillin-resistant Staphylococcus aureus based on activity in an established biofilm. Antimicrob Agents Chemother, 60(10), 5688-5694.   PMCID: PMC5038242
  • Sims, C.R., Nguyen, T.C. and Mayeux, P.R. (2016) Could biomarkers direct therapy for the septic patient? J Pharmacol Exp Ther, 357, 228-239. PMCID: PMC4851319
  • Shrum, S., MacMillan-Crow, L.A. and Parajuli, N. (2016) Cold storage exacerbates renal and mitochondrial dysfunction following transplantation. J Kidney,  (2)1, 114.PMCID: PMC4825688

2015 Publications

  • Atwood, D.N., Loughran, A.J., Courtney, A., Spencer, H.J., Anthony, A.C., Meeker, D.G., Gupta, R.K., Lee, C.Y., Beenken, K.E. and Smeltzer, M.S. (2015) Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiology Open, 4,436-451, PMCID:  PMC4475386
  • Holthoff, E.R., Jeffus, S.K., Gehlot, A., Stone, R., Erickson, S.W., Kelly, T., Quick, C.M. and Post, S.R. (2015) Perineural invasion is an independent pathologic indicator of recurrence in vulvar squamous cell carcinoma. Am J Surg Pathol, 39, 1070-1074. PMCID: PMC4503485
  • Jeffus, S.K., Gehlot, A., Holthoff, E., Stone, R., Spencer, H., Kelly, T., Post, S.R. and Quick, C.M. (2015) A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva. Am J Surg Pathol, 39,1226-1233. PMCID: PMC4538995
  • Tai, S., Hyatt, W.S., Gu, C., Franks, L.N., Vasiljevik, T., Brents, L.K., Prather, P.L. and Fantegrossi, W.E. (2015) Repeated administration of phytocannabinoid delta(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner. Pharmacol Res, 102, 22-32. PMCID: PMC468444
  • Wang, Z., Sims, C.R., Patil, N.K., Gokden, N. and Mayeux, P.R.,(2015) Pharmacological targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. J Pharmacol Exp Ther, 352, 61-66. PMCID: PMC4279105

2014 Publications

  • Sims, C.R., MacMillan-Crow, L.A. and Mayeux, P.R. (2014) Targeting mitochondrial oxidants may facilitate recovery of renal function during infant sepsis. Clin Pharmacol Ther,  96, 662-664. PMCID: PMC4243161
  • Yang, C.S., Mercer, K.E., Alund, A.W., Suva, L.J., Badger, T.M. and Ronis. M.J. (2014) Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice. Exp Biol Med, 239, 1380-1389.  PMCID: PMC4263414