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Department of Pharmacology and Toxicology: T-SPaT

T-SPaT Trainee Publications

2024 Publications

  • Azevdeo-Pouly, AC, Appell, LE, Burdine, L, Rogers, LJ, Morehead, LC, Fil, D., Barker, M., Rainwater, RR, Waldrip, ZJ, Koss, B., and Schluterman Burdine, M. (2023) Chemical inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4+ helper and CD8+ effective T cells. Immunol Cell Biol, 101(7), 6630671. PMCID: PMC10527493
  • Benson, LN, Deck, KS, Mora, CJ, Guo, Y, Rafferty, TM, Li, LX, Huang, L, Andrews, JT, Qin, Z, Trott, DW, Hoover, RS, Liu, Y, and Mu, S. (2024) “P2X7-Mediated Antigen-Independent Activation of CD8+ T Cells Promotes Salt-Sensitive Hypertension.” Hypertension. PMID: 38193292
  • Cole, S., Rainwater, RR, Mannen, E., Tait, MA, and Bracey, J.W. (2024) Microstructure of the radial head: Insights into anatomical variations and implications for advanced interventions. Clin Anat, doi: 10.1002/ca.24191.  PMID: 38984382
  • Parks BJ, Salazar P, Morrison L, McGraw MK, Gunnell M, Tobacyk J, Brents LK, and Berquist MD. (2024) Limited bedding and nesting increases ethanol drinking in female rats. Pharmacol Biochem Behav, 239, 173756.  PMCID: PMC11088506  
  • Sun, RW, Zhang, H, Mehdi, SJ, Richter, GT, Bowman, HH, Sifford, J., Smith, C., Burnett, AK, Layman, A., Washam, CL, Byrum, SD, Bennett, JT, Jensen, DM, Dmyterko, V., Perkins, JA, Shawber, CJ, Wu, JK and Strub, GM (2023) Upregulated microrna-21 drives the proliferation of lymphatic malformation endothelial cells by inhibiting PDCD4. J Invest Dermtal, 143(10), 2085-2089. PMCID: PMC10524134
  • Xia, J., Zhao, H., Edmondson, JL, Koss, B, and Zhan, F (2024) Role of NEK2 in tumorigenesis and tumor progression. Molecular Medicine (accepted but not yet published)

2023 Publications

  • Benson LN, Liu Y, Wang X, Xiong Y, Rhee SW, Guo Y, Deck KS, Mora C, Li L, Huang L, Andrews JT, Qin Z, Hoover RS, Ko B, Williams RM, Heller DA, Jaimes EA, Mu S (2022). The IFNγ-PDL1 pathway enhances CD8Ts-DCT ionteraction to promote hypertension. Circulation Research, 130(10), 1550-1564.
  • Benson LN, Liu Y, Deck KS, Mora C, Mu, S (2022). IFN-γ contributes to the immune mechanisms of hypertension.” Kidney360, 12,  2164-2173.
  • Benson LN, Guo Y, Deck KS, Mora C, Liu Y, Mu S (2023) The link between immunity and hypertension in the kidney and heart” Frontiers in Cardiovascular Medicine, 10: 1129384.
  • Deck KS, Mu S (2022). uEVs: A potential tool for examining renal epithelial cells. Kidney360, 3(5), 796-798.
  • Holloway, KN, Pinson, MR, Douglas, JC, Rafferty, TM, Kane, CJM, Miranda, RC, Drew, PD (2023) Cerebeller transcriptomic analysis in a chronic plus binge mouse model of alcohol use disorder demonstrates ethanol-induced neuroinflammation and altered glial gene expression.  Cells, 12(5), 745. 
  • Neidzwiedz-Massey, VM, Douglas JC, Rafferty T, Johnson JW, Holloway, KN, Berquist MD, Kane, CJM, Drew, PD (2023) Effects of chronic and binge ethanol administration on mouse cerebellar and hippocampal neuroinflammation. Am J Drug Alcohol Abuse, 49(3), 345-358.
  • Venugopal, G, Bird, JT, Roys, H, Bowlin, A, Fry, L, Byrum, SD, Weinkopff, T (2023). Both the infection status and inflammatory microenvironment induce transcriptional remodeling in macrophages in murine Leishmanial lesions. The Journal of Parasitology, 109(3), 200-210. 
  • Wanchai V, Jenjaroenpun P, Leangapichart, T, Arrey, G, Burnham, CM, Tümmler MC, et al. (2022). CReSIL: Accurate identification of extrachromosomal circular DNA from long-read sequences. Brief. Bioinformatics. 23(6), bbac422. doi: 10.1093/bib/bbac422
  • Wei T, Richter GT, Zhang H, Sun RW, Smith CH, Strub GM. (2022) Extracranial arteriovenous malformations demonstrate dysregulated TGF- β/BMP signaling and increased circulating TGF-β1. Sci Rep. 12(1):16612.

2022 Publications

  • Benson, L.N., Liu, Y., Wang, X., Xiong, Y., Rhee, S.W., Guo, Y., Deck, K.S., Mora, C.J., Li, Lin-Xi, Huang, L., Andrews, J.T., Qin, Z., Hoover, R.S., Ko, B., Williams, R.M., Heller, D.A., Jaimes, E.A. and Mu, S. (2022) The IFNγ-PDL1 pathway enhances CD8T-DCT interaction to promote hypertension. Circ Res, 130, 1550-1564.  PMCID: PMC9106883
  • Benson, L.N., Liu, Y., Guo, Y., Xiong, Y. and Mu, S. (2022) The IFNγ-PDL1 pathway enhances the interaction between CD8+T-cells and distal convoluted tubules to promote salt-sensitive hypertension.  FASEB J, 36 Suppl 1, doi: 10.1096/fasebj.2022.36.S1.)R513. PMID: 35553164
  • Ewing, L.E., Biju, P.G., Pathak, R., Melnyk, S. Hauer-Jensen, M. and Koturbash, I. (2022) Methods for induction and assessment of intestinal permeability in rodent models of radiation injury, Methods Cell Biol, 168, 235-247. PMID: 3536698
  • McGill, M.R., James, L.P., McCullough, S.S., Moran, J.H., Mathews, S.E., Peterson, E.C., Fleming, D.P., Tripod, M.E., Vazquez, J.H., Kennon-McGill, S., Spencer, H.J. and Dranoff, J.A. (2022) Short-term safety of repeated acetaminophen use in patients with compensated cirrhosis.  Hepatol Commun, 6(2), 361-373.  PMCID: PMC87939895
  • Shoeib, A.M., Benson, L.N., Mu, S., MacMillan-Crow, L.A. and Prather, P.L. (2022) Non-canonical cannabinoid receptors with distinct binding and signaling properties in prostate and other cancer cell types mediate cell death. Int J Mol Sci, 23(6), 3049.  PMCID: PMC8954350
  • Vazquez, J.H., Kennon-McGill, S., Byrum, S.D., Mackintosh, S.G., Jaeschke, H., Williams, D.K., Lee, W.M., Dranoff, J.A., McGill, M.R. and Acute Liver Failure Study Group (2022) Proteomics indicates lactate dehydrogenase is prognostic in acetaminophen-induced acute liver failure patients and reveals altered signaling pathways. Toxicol Sci, 187(1), 25-34.  PMID: 35172013
  • Yee, A., Navulur, S., Sun, R., Lindsey, M., Gonzalez-Krellwitz and Strub, G. (2022) Bronchogenic cyst of posterior neck mimicking lymphatic malformation. Clin Case Rep, 10(3), e05210. PMCID: PMC8898750

2021 Publications

  • Barnette, D.A., Schleiff, M.A., Datta, A., Flynn, N., Swamidass, S.J. and Miller, G.P. (2021) Meloxicam methyl group determines enzyme specificity for thiazole bioactivation compared to sudoxicam. Toxicol Lett,  338, 10-20. PMCID: PMC7807415
  • Bettadapura, M., Roys, H., Bowlin, A., Venugopal, G., Washam, C.L.,Fry, L., Murdock, S., Wanjala, H., Byrum, S.D. and Weinkopff, T. (2021) HIF-α activation impacts macrophage function during Murine Leishmania major Infection Pathogens, 10(12), 1584. PMCID: PMC8706659
  • Caperton, C.O., Jolly, L.A. Massoll, N., Bauer, A.J. and Franco, A.T. (2021) Development of novel follicular thyroid cancer models which progress to poorly differentiated and anaplastic thyroid cancer, Cancers (Basel), 13(5), 1094.  PMCID: PMC7961488
  • Clemens, M.M., Kennon-McGill, S., Vazquez, J.H., Stephens, O.W., Peterson, E.A., Johann, D.J., Allard, F.D., Yee, E.U., McCullough, S.S., James, L.P., Finck, B.N. and McGill, M.R. (2021) Exogenous phosphatidic acid reduce acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk. Acta Pharm Sin B, 11(12), 3836-3846. PMCID: PMC8727922
  • Cui, H., Carlson, A.S., Schleiff, M.A., Divakaran, A., Johnson, J.A., Buchholz, C.R., Zahid, H., Vail, N.R., Shi, K., Aihara, H., Miller, G.P., Topczewski, J.J., Pomerantz, W.C.K. (2021) 4-methyl-1,2,3-triazoles as N-acetyl-lysine mimics afford potent BET bromodomain inhibitors with improved selectivity.  J Med Chem, 64(14), 10497-10511.  PMCID: PMC8491147
  • Dhuria, N.V., Haro, B., Kapadia, A., Lobo, K.A., Matusow, B., Schleiff, M.A., Tantoy, C., Sodhi, J.K. (2021). Recent developments in predicting CYP-independent metabolism. Drug Metab Rev, 53(2), 188-206.
  • Ewing, L.E., Skinner, C.M., Pathak, R., Yee, E.U., Krager, K., Gurley, P.C., Melnyk, S., Boerma, M., Hauer-Jensen, M. and Korturbash, I. (2021) Dietary methionine supplementation exacerbates gastrointestinal toxicity in a mouse model of abdominal irradiation. Int J Radiat Oncol Biol Phys, 109(2), 581-593.  PMCID: PMC7855316
  • Ferreira, E., Gatrell, L.B., Childress, L., Wu, H. and Porter, R.M. (2021) A transgenic rat for noninvasive assessment of chondrogeneiss in vivo. Cartilage, 13(2-suppl), 1720S-1733S. PMCID: PMC8804729
  • Flynn, N.R., Ward, M.D., Schleiff, M.A., Laurin, C.M.C., Farmer, R., Conway, S.J., Boysen, G., Swamidass J.S. and Miller, G.P. (2021) Bioactivation of isoxazole-containing bromodomain and extra-terminal domain (BET) inhibitors. Metabolites, 11(6), 390. PMCID: PMC823221
  • MacLeod, R.S., Meyer, M.B., Xiong, J., Cawley, K.M., Liu, Y., Onal, M., Benkusky, N.A., Thostenson, J.D., Pike, J.W. and O’Brien, C.A. (2021) Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo. PLoS One, 16(5), eo2500974. PMCID: PMC8109787
  • McClenahan, S.J., Gunnell, M. and Owens, S.M. (2021) Pharmacokinetics of α-pyrrolidinovalerophenone in male rats with and without vaccination with an α-pyrrolidinovalerophenone vaccine. J Pharm Pharm Sci, 24, 267-276. PMCID: PMC8604100
  • Pinson, M.R*., Holloway, K.N.*, Douglas, J.C., Kane, C.J.M., Miranda, R.C. and Drew, P.D. (2021) Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period.  Alcohol Clin Exp Res, 45(7), 1408-1423.  PMCID: PMC8312515 (*co-first authors)
  • Schleiff, M.A., Flynn, N.R., Payakachat, S., Schleiff, B.M., Pinson, A.O., Province, D.W., Swamidass, S.J., Boysen, G. and Miller, G.P. (2021)  Significance of multiple bioactivation pathways for meclofenamate as revealed through modeling and reaction kinetics. Drug Metab Dispos, 49, 133-141. PMCID: PMC841419
  • Schlieff, M.A., Crosby, S., Blue, M., Schleiff, B.M., Boysen, G. and Miller, G.P. (2021) CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs, Biochem Pharmcol, 194, 114824. PMCID: PMC8710044
  • Schleiff, M.A., Payakachat, S., Schleiff, B.M., Swamidass, S.J., Boysen, G. and Miller, G.P. (2021) Impacts of diphenylamine NSAID halogenation on bioactivation risks. Toxicology, 458, 152832. PMCID: PMC8513111
  • Schonning, M.J., Koh, S., Sun, R.W., Richter, G.T., Edwards, A.K., Shawber, C.J. and Wu, J.K. (2021) Venous malformation vessels are improperly specified and hyperproliferative. PLoS One, 16(5), e0252342. PMCID: PMC8158993
  • Shoeib, A.M., Yarbrough, A.L., Ford, B.M., Franks, L.N., Urbaniak, A., Hensley, L.L., Benson, L.N., Mu, S., Radominska-Pandya, A., and Prather, P.L. (2021) Characterization of cannabinoid receptors expressed in Ewing sarcoma TC-71 and A-673 cells as potential targets for anti-cancer drug development. Life Sci, 285, 119993.  PMID: 34592231
  • Tobacyk, J. and MacMillan-Crow, L.A. (2021) Fluorescence-based assay for measuring OMA1 activity, Methods Mol Biol, 2276, 325-332. PMID: 34060052
  • Tobacyk, J., Grishma, K. and MacMillan-Crow, L.A. (2021) Overexpression of MnSOD protects against cold storage-induced mitochondrial injury but not against OMA1-dependent OPA1 proteolytic processing in rat renal proximal tubular cells, Antioxidants, 10(8), 1272. PMCID: PMC8389209
  • Vazquez, J.H. and McGill, M.R. (2021) Redrawing the map to novel DILI biomarkers in circulation: Where are we, where should we go, and how can we get there?  Livers, 1(4), 286-293.  PMCID: PMC8713950
  • Zhang, H., Wei, T., Johnson, A., Sun, R., Richter, G. and Strub, G. (2021) NOTCH pathway activation in infantile hemangiomas. J Vasc Surg Venous Lympath Disord, 9(2), 489-496. PMID: 32763337

2020 Publications

  • Barnette, D.A., Schleiff, M.A., Osborn, L.R., Flynn, N., Matlock, M., Swamidass, S.J. and Miller, G.P. (2020) Dual mechanisms suppress meloxicam bioactivation relative to sudoxicam. Toxicology, 440,152478. PMCID: PMC8716319
  • Cawley, K.M., Bustamante-Gomez, N.C., Guha, A.G, MacLeod, R.S., Xiong, J., Gubrij, I., Liu, Y., Mulkey, R., Palmieri, M., Thostenson J.D., Goellner, J.J. and O’Brien, C.A. (2020) Local production of osteoprotegerin by osteoblasts suppresses bone resorption. Cell Rep, 32(10), 108052.  PMCID: PMC7493998
  • Clemens, M.M., Vazquez, J.H., Kennon-McGill, S., McCullough, S.S., James, L.P. and McGill, M.R. (2020) Pre-treatment twice with liposomal clodronate protects against  acetaminophen hepatotoxicity through a pre-conditioning effect. Liver Res, 4(3), 145-152. PMCID: PMC7544241
  • Ewing L.E., Miousse, I.R., Pathak, R., Skinner, C.M., Kosanke, S., Boerma, M., Hauer-Jensen, M. and Kortubash, I. (2020) NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. Int J Radiat Biol, 96, 93-99.  PMCID: PMC6581619
  • Gaba, R.C., Elkhadragy, L., Boas, F.E., Chaki, S., Chen, H.H., El-Kebir, M., Garcia, K.D., Guirini, E.F., Guzman, G., Lobianco, F.V., Neto, M.F., Newsom, J.L., Qazi, A., Regan, M., Rund, L.A., Schwind, R.M., Stewart, M.C., Thomas, F.M., Whitely, H.E., Wu, J., Schook, L.B. and Schachtschneider, K.M. (2020) Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation. Oncotarget, 11(28), 2686-2701. PMCID: PMC7367657
  • Hay, C.E., Ewing, L.E., Hambuchen, M.D., Zintner, S.M., Small, J.C., Bolden, C.T., Fantegrossi, W.E., Margaritis, P., Owens, S.M. and Peterson, E.C. (2020) The development and characterization of an scFv-Fc fusion-based gene therapy to reduce the psychostimulant effects of methamphetamine abuse.  J Pharmcol Exp Ther, 374(1), 16-23.  PMCID: PMC7289050
  • Hyatt, W.S., Hirsh, C.E., Russell, L.N., Chitre, N.M., Murnane, K.S., Rice, K.C. and Fantegrossi, W.E. (2020) The synthetic cathinone 3,4-methylenedioxypyrovalerone increases impulsive action in rats, Behav Pharmcol, 31(4), 309-321. PMID: 32101987
  • Kim, H-N., Xiong, J., MacLeod, R.S., Iyer, S., Fujiwara, Y., Cawley, K.M., Han, L., He, Y., Thostenson, J.D., Ferreira, E., Jilka, R.L., Zhou, D., Almeida, M. and O’Brien, C.A. (2020) Osteocyte RANKL is required for corticol bone loss with age and is induced by senescence. JCI Insight, 5(19), e138815.  PMCID: PMC7566701
  • Koss, B., Shields, B.D., Taylor, E.M., Storey, A.J., Byrum, S.D., Gies, A.J., Washam, C.L., Choudhury, S.R., Ahn, J.H., Uryu, H., Williams, J.B., Krager, K.J., Chiang, T-C., Mackintosh, S.G., Edmondson, R.D., Aykin-Burns, N., Gajewski, T.F., Wang, G.G. and Tackett, A.J. (2020) Epigenetic control of Cdkn2a.Arf protects tumor infiltrating lymphocytes from metabolic exhaustion.  Cancer Res, 80(21), 4707-4719.  PMCID: PMC642172
  • Kutanzi, K.R., Ewing, L.E., Skinner, C.M., Quick, C.M., Kennon-McGill, S., McGill, M.R., Walker, L.A., ElSohly, M.A., Gurley, B.J. amd Kortubash, I. (2020) Safety and molecular-toxicological implications of cannabidiol-rich cannabis extract and methylsulfonylmethane co-administration. Int J Mol Sci, 21(20), 7808. PMCID: PMC7656295
  • Lobianco, F.V., Krager, K.J., Carter, G.S., Alam, S., Yuan, Y., Lavoie, E.G., Dranoff, J.A. and Aykin-Burns, N. (2020) The role of sirtuin 3 in radiation-induced long-term persistent liver injury. Antioxidants (Basel), 9(5), 409.  PMCID: PMC7278565
  • McClenahan, S.J., Kormos, C.M., Gunnell, M, Hambuchen, M.D., Lamb, P., Carroll, F.I., Lewin, A.H., Peterson, E.C. and Owens, S.M. (2020) Design, synthesis and biological evaluation of bi-specifc vaccine against α-pyrrolidinovalerophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats. Vaccine, 38(2), 336-344. PMCID: PMC6938543
  • McClenahan, S.J., Gunnell, M.G., Owens, S.M. and Fantegrossi, W.E. (2020) Active vaccination reduces reinforcing effects of MDPV in male Sprague-Dawley rats trained to self-administer cocaine. Psychopharmacology (Berl), 237(9), 2613-2620. PMCID: PMC7502518
  • Miousse, I.R., Ewing, L.E., Skinner, C.M., Pathak, R., Garg, S., Kutanzi, K.R., Melnyk, S., Hauer-Jensen, M., and Kortubash, I. (2020) Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. Am J Physiol Gastrointest Liver Physiol, 318, G439-G450. PMCID: PMC7099489
  • Pinson, A.O., Pouncey, D.L., Schleiff, M.A., Fantegrossi, W.E., Prather, P.L., Radominska-Pandya, A., Boysen, G. and Miller, G.P. (2020) Significance of competing metabolic pathways for 5F-APINACA based on quantitative kinetics. Molecules, 25(20), 4820. PMCID: PMC7587938
  • Ronis, M.J., Watt, J., Pulliam, C.F., Williams, A.E., Alund, A.W., Haque, E., Gadupudi, G.S., and Robertson, L.W. (2020) Skeletal toxicity resulting from exposure of growing male rats to coplanar PCB 126 is associated with disruption of calcium homeostasis and the GH-IGF-1 axis and direct effects on bone formation. Arch Toxicol, 94(2), 389-399.  PMCID: PMC7047627
  • Russell, L.E., Schleiff, M.A., Gonzalez, E., Bart, A.G., Broccatelli, F., Hartman, J.H., Humphreys, W.G., Lauschke, V.M., Martin, I., Nwabufo, C., Prasad, B., Scott, E.E., Segall, M., Takahashi, R., Taub, M.E. and Sodhi, J.K. (2020) Advances in the study of drug metabolism – symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX), Drug Metab Rev, 52(3), 395-407. PMCID: PMC7466845
  • Shrum, S., Tobacyk, J., Lo, S., Parajuli, N. and MacMillan-Crow, L.A. (2020) The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury, Arch Biochem Biophys, 688, 108410. PMCID: PMC7322695
  • Skinner, C.M., Nookaew, I., Ewing, L.E., Wongsurawat, T., Jenjaroenpun, P., Quick, C.M., Yee, E.U., Piccolo, B.D., ElSohly, M., Walker, L.A., Gurley, B. and Kortubash, I. (2020) Potential probiotic or trigger of gut inflammation – the Janus-faced nature of cannabidiol-rich cannabis extract. J Diet Suppl, 17, 543-560. PMCID: PMC7470626
  • Tascoiglu, A.A., Lobianco, F., Krager, K.J. and Aykin-Burns, N. (2020) Assessment of cellular oxidation using a subcellular compartment-specific redox-sensitive green fluoresecent protein. J Vis Exp, 160, 10.3791/61229. PMCID: PMC7725482
  • Taylor, E.M., Koss, B., Davis, L.E. and Tackett, A.J. (2020) Histone modifications as biomarkers for immunotherapy. Methods Mol Biol, 2055, 213-228.  PMID: 31502154
  • Taylor, E.M., Byrum, S.D., Edmondson, J.L., Wardell, C.P., Griffin, B.G., Shalin, S.G., Gokden, M., Makhoul, I. and Tackett, A.J. (2020)  Proteogenomic analysis of melanoma brain metastes from distinct anatomical sites identifies pathways of metastatic progression, Acta Neuropathol Commun, 8(1), 157. PMCID: PMC7487560
  • Trentzch, M., Nyamugenda, E., Miles, T.K., Griffin, H., Russell, S., Koss, B., Cooney, K.A., Phelan, K.D., Tackett, A.J., Iyer, S., Boysen, G. and Baldini, G. (2020) Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum.  Cell Death Discov, 6, 8. PMCID: PMC7028721
  • Vazquez, J.H., Clemens, M.M., Allard, F.D., Yee, E.U., Kennon-McGill, S., Mackintosh, S.G., Jaeschke, H., Hambuchen, M.D. and McGill, M.R. (2020) Identification of serum biomarkers to distinguish hazardous and benign aminotransferase elevations. Toxicol Sci, 173(2), 244-254. PMCID: PMC8445665
  • You, D., Lyn-Cook, L.E., Gatti, D.M., Bell, N., Mayeux, P.R., James, L.P., Mattes, W.B., Larson, G.J. and Harrill, A.H. (2020) Nitrosative stress and lipid homeostasis as a mechanism for zileuton hepatotoxicity and resistence in genetically sensitive mice, Toxicol Sci, 175(2), 220-235. PMCID: PMC7253212

2019 Publications

  • Barnette, D.A., Davis, M.A., Flynn, N., Pidugu, A.S., Swamidass, S.J. and  Miller, G.P. (2019) Comprehensive kinetic and modeling analyses revealed CYP2C9 and 3A4 determine terbinafine metabolic clearance and bioactivation. Biochem Pharmacol, 170, 113661. PMCID: PMC6905088
  • Chiang, T-C., Koss, B., Su, L.J., Washam, C.L., Byrum, S.D., Storey, A. and Tackett, A.J. (2019) Effect of sulforaphane and 5-Aza-2-deoxycytidine on melanoma cell growth.  Medicines (Basel), 6(3), 71. PMCID: PMC6789461
  • Clemens, M.M., McGill, M.R. and Apte, U. (2019) Mechanisms and biomarkers of liver regeneration after drug-induced liver injury. Adv Pharmacol, 85, 241-262. PMCID: PMC7641498
  • Clemens, M.M., Kennon-McGill, S., Apte, U., James, L.P., Finck, B.N. and McGill, M.R. (2019) The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling. Food Chem Toxicol, 12, :279-288.  PMCID: PMC6443093
  • Davis, M.A., Barnette, D.A., Flynn, N.R., Pidugu, A.S., Swamidass, S.J., Boysen, G. and Miller, G.P. (2019) CYP2C19 and 3A4 dominate metabolic clearance and bioactivation of terbinafine based on computational and experimental approaches. Chem Res Toxicol, 32, 1151-1164.
  • Ewing, L.E., Skinner, C.M., Quick, C.M., Kennon-McGill, S., McGill, M.R., Walker, L.A., ElSohly, M.A., Gurley, B.J. and Korturbash, I. (2019) Hepatotoxicity of a cannabidiol-rich cannabis extract in the mouse model. Molecules, 24(9), 1694. PMCID: PMC6539990
  • Ewing, L.E., McGill, M.R., Yee, E.U., Quick, C.M., Skinner, C.M., Kennon-McGill, S., Clemens, M.M., Vazquez, J.H., McCullough, S.S., Williams, D.K., Kutanzi, K.R., Walker, L.A., ElSohly, M.A., James, L.P., Gurley, B.J. and Korturbash, I. (2019) Paradoxical patterns of sinusoidal obstruction syndrome-like liver injury in aged female CD-1 mice triggered by cannabidiol-rich cannabis extract and acetaminophen co-administration. Molecules, 24(12), 2256.  PMCID: PMC6630875
  • Griffin, B.A., Caperton, C.O., Russell, L.N., Cabanlong, C.V., Wilson, C.D., Urquhart, K.R., Martins, B.S., Dina Zita, M., Patton, A.L., Alund, A.W., Owens, S.M., Fantegrossi, W.E., Moran, J.H., Brents, L.K. (2019) In utero exposure to norbuprenorphine, a major metabolite of buprenorphine, induces fetal opioid dependence and leads to neonatal opioid withdrawal syndrome. J Pharmcol Exp Ther, 370(1), 9-17. PMCID: PMC6538887
  • Hyatt, W.S., Berquist, M.D., Chitre, N.M., Russell, L.N., Rice, K.C., Murnane, K.S. and Fantegrossi, W.E. (2019) Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats, Behav Pharmacol, 30(7), 555-565. PMID: 31211703
  • Kennon-McGill, S., Clemens, M.M. and McGill, M.R. (2019) Expression of drug metabolizing enzymes and transporters in the cochlea: implications for drug delivery and ototoxicity. Hear Res, 379, 98-102. PMCID: PMC6590996
  • Kurten, R., Rawson, R., Shoda, T., Duong, L.D., Adejumobi, D., Levy, R., Newbury, R.O., Rothenberg, M.E., Akuthota, P., Wright, B.L., Dohil, R., Jones, S.M. and Aceves, S.S. (2019) Development and application of a functional human esophageal mucosa explant platform to eosinophilic esophagitis, Sci Rep, 9(1), 6206. PMCID: PMC6470157
  • Lee, T., Christov, P.P., Shaw, S., Tarr, J.C., Zhao, B., Veerasamy, N., Jeon, K.O., Mills, J.J., Bian, Z., Sensintaffar, J.L., Arnold, A.L., Fogarty, S.A., Perry, E., Ramsey, H.E., Cook, R.S., Hollingshead, M., Millin, M.D., Lee, K-M., Koss, B., Budhraja, A., Opferman, J.T., Kim, K., Arteaga, C.L., Moore, W.J., Olejniczak, E.T., Savona, M.R. and Fesik, S.W. (2019) Discovery of potent myeloid cell leukemia-1 (Mcl-1) inhibitors that demonstrate in vivo activity in mouse xenograft models of human cancer.  J Med Chem, 62(8), 3971-3988.  PMID: 30929420
  • McClenahan, S.J., Hambuchen, M.D., Simecka, C.M., Gunnell, M.G., Berquist, M.D and Owens, S.M. (2019) Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats.  Drug Alcohol Depend, 195, 140-147. PMCID: PMC6915966
  • Post, G.R., Yuan, Y., Holthoff, E.R., Quick, C.M. and Post, S.R. (2019) Identification of a novel monocytic phenotype in classic Hodgkin Lymphoma tumor microenvironment. PLoS One, 14(11), e0224621.  PMCID: PMC6850552
  • Ren, Z., Ahn, J.H., Liu, H., Tsai, Y-H., Bhanu, N.V., Koss, B., Allison, D.F., Ma, A., Storey, A.J., Wang, P., Mackintosh, S.G., Edmondson, R.D., Groen, R.W.J., Martens, A.C., Garcia, B.A., Tackett, A.J., Jin, J., Cai, L., Zheng, D. and Wang, G.G. (2019) PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Blood, 134(14), 1176-1189.  PMCID: PMC6776795
  • Shields, B.D., Koss, B., Taylor, E.M., Storey, A.J., West, K.L., Byrum, S.D., Mackintosh, S.G., Edmondson, R., Mahmoud, F., Shalin, S.C. and Tackett, A.J. (2019) Loss of E-cadherin inhibits CD103 antitumor activity and reduces checkpoint blockage responsiveness in melanoma.  Cancer Res, 79(6), 1113-1123. PMCID: PMC6420873
  • Shrum, S., Rusch, N.J. and MacMillan-Crow, L.A. (2019) Specific BK channel activator NS11021 protects rat renal proximal tubular cells from cold-storage induced mitochondrial injury in vitro, Biomolecules, 9(12), 825. PMCID: PMC6995623
  • Tobacyk, J., Parajuli, N., Shrum, S., Crow, J.P. and MacMillan-Crow, L.A. (2019) The first direct activity assay for the mitochondrial protease OMA1, Mitochondrian, 46, 1-5. PMCID: PMC6487223

2018 Publications

  • Barnette, D.A., Davis, M.A., Dang, N.L., Pidugu, A.S., Hughes, T., Swamidass, S.J., Boysen, G. and Miller, G.P. (2018)  Lamisil (terbinafine) toxicity: Determining pathways to bioactivation through computational and experimental approaches. Biochem Pharmacol, 156, 10-21. PMCID: PMC6188815
  • Berquist, M.D., Hyatt, W.S., Bauer-Erickson, J., Gannon, B.M., Norwood, A.P. and Fantegrossi, W.E. (2018) Phencyclidine-like in vivo effects of methoxetamine in mice and rats, Neuropharmacology, 134(Pt A), 158-166. PMCID: PMC5818319
  • Chen, J-R, Lazarenko, O.P., Zhao, H., Alund, A.W., Shankar, K. (2018) Maternal obesity impairs skeletal development in adult offspring. J Endocrinol, 239(1), 33-47. PMCID: PMC6145139
  • Garner, B.R., Stolarz, A.J., Stuckey, D., Sarimollaoglu, M., Liu, Y., Palade, P.T., Rusch, N.J. and Mu, S. (2021) K ATP channel openers inhibit lymphatic contractions and lymph flow as a possible mechanism of peripheral edema, J Pharmcol Exp Ther, 376(1), 40-50. PMCID: PMC7745085
  • Hay, C.E., Gonzalez 3rd, G.A., Ewing, L.E., Reichard, E.E., Hambuchen, M.D., Nanaware-Kharade, N., Alam, S., Bolden, C.T., Owens, S.M., Margaritis, P. and Peterson, E.C. (2018) Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse. PLoS One, 13(6), e0200060. PMCID: PMC6025879
  • Lutkewitte, A.J., Schweitzer, G.G., Kennon-McGill, S., Clemens, M.M., James, L.P., Jaeschke, H., Finck, B.N. and McGill, M.R. (2018) Lipin deactivation after acetaminophen overdose causes phosphatidic acid acculumation in liver and plasma in mice and humans and enhances liver regeneration. Food Chem Toxicol, 115, 273-283. PMCID: PMC5935563
  • Meeker, D.G., Wang, T., Harrington, W.N., Zharov, V.P., Johnson, S.A., Jenkins, S.V., Oyibo, S.E., Walker, C.M., Mills, W.B., Shirtliff, M.E., Beenken, K.E., Chen, J., Smeltzer, M.S. (2018) Versatility of targeted antibiotic-loaded gold nanoconstructs for the treatment of biofilm-associated bacterial infections.  Int J Hyperthermia, 34(2), 209-2019.  PMCID: PMC6095133
  • Miousse, I.R., Ewing, L.E., Kutanzi, K.R., Griffin, R.J. and Koturbash, I. (2018) DNA methylation in radiation-induced carcinogenesis: experimental evidence and Ccinical perspectives. Crit Rev Oncog, 23, 1-11. PMCID: PMC6369919
  • Sarimollaoglu, M., Stolarz, A.J., Nedosekin, D.A., Garner, B.R., Fletcher, T.W., Galanzha, E.I., Rusch, N.J. and Zharov, V.P. (2018) High-speed microscopy for in vivo monitoring of lymph dynamics. J Biophotonics, 11(8), e201700126. PMCID: PMC6314807
  • Skinner, C.M., Miousse, I.R., Ewing, L.E., Sridharan, V., Cao, M., Lin, H., Williams, D.K., Avula, B., Haider, S., Chittiboyina, A.G., Khan, I.A., ElSohly, M.A., Boerma, M., Gurley, B.J and Kortubash, I. (2018) Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro™ (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol, 122, 21-32. PMCID: PMC6219625
  • Van, S., Pal, S., Garner, B.R., Steed, K., Sridharan, V., Mu, S., Rusch, N.J. and Stolarz, A.J. (2021) Dantrolene prevents the lymphostasis caused by doxorubicin in the rat mesenteric circulation.  Front Pharmcol, 12, 727526. PMCID: PMC8415554
  • Watt, J., Alund, A.W., Pulliam, C.F., Mercer, K.E., Suva, L.J., Chen, J-R. and Ronis, M.J.J. (2018) NOX4 deletion in male mice exacerbates the effect of ethanol on trabecular bone and osteoblastogenesis. J Pharmcol Exp Ther, 366(1), 46-57. PMCID: PMC5988025

2017 Publications

  • Hambuchen, M.D., Hendrickson, H.P., Gunnell, M.G., McClenahan, S.J., Ewing, L.E., Gibson, D.M., Berquist, M.D. and Owens, S.M. (2017) The pharmacokinetics of racemic MDPV and its (R ) and (S ) enantiomers in female and male rats. Drug Alcohol Depend, 179, 347-354.  PMCID: PMC5600196
  • Harrill, A.H., Lin, H., Tobacyk, J., Seely, J.C. (2017) Mouse population-based evaluation of urinary protein and miRNA biomarker performance associated with cisplatin renal injury. Exp Biol Med (Maywood), 243(3), 237-247. PMCID: PMC5813868
  • Holthoff, E.R., Byrum, S.D., Mackintosh, S.G., Kelly, T., Tackett, A.J., Quick, C.M and Post, S.R. (2017) Vulvar squamous cell carcinoma aggressiveness in associated with differential expression of collagen and STAT1. Clin Proteomics, 14, 40. PMCID: PMC5717999
  • Lin, H., Ewing, L.E., Koturbash, I., Gurley, B.J. and Miousse, I.R. (2017) MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects. Food Chem Toxicol, 110, 229-239. PMCID: PMC6693868
  • Mazur, A., Holthoff, E.R., Vadali, S., Kelly, T. and Post, S.R. (2016) Cleavage of type I collagen by fibroblast activation protein- enhances class A scavenger receptor mediated macrophage adhesion. PLoS One, e0150287. PMCID: PMC4774960
  • Miousse, I.R., Skinner, C.M., Lin, H., Ewing, L.E., Kosanke, S.D., Williams, D.K., Avula, B., Khan, I.A., ElSohly, M.A., Gurley, B.J. and Kortubash, I. (2017) Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains. Food Chem Toxicol, 109, 194-209. PMCID: PMC6756457
  • Parajuli, N., Shrum, S., Tobacyk, J., Harb, A., Arthur, J.M. and MacMillan-Crow, L.A. (2017) Renal cold storage followed by transplantation impairs expression of key mitochondrial fission and fusion proteins, PLoS One, 12(10), e0185542. PMCID: PMC5627902
  • Sims, C.R., Singh, S.P., Mu, S.., Gokden, N., Zakaria, D., Nguyen, T.C. and Mayeux, P.R., (2017) Rolipam improves outcome in a rat model of infant sepsis-induced cardiorenal syndrome, Front Pharmcol, 8, 237. PMCID: PMC5413568
  • Shields, B.D., Mahmoud, F., Taylor, E.M., Byrum, S.D., Sengupta, D., Koss, B., Baldini, G., Ransom, S., Cline, K., Mackintosh, S.G., Edmondson, R.D., Shalin, S. and Tackett, A.J. (2017) Indicators of responsiveness to immune checkpoint inhibitors. Sci Rep, 7(1), 807. PMCID: PMC5429745

2016 Publications

  • Alund, A.W., Mercer, K.E., Suva, L.J., Pulliam, C.F., Chen, J.R., Badger, T.M., Van Remmen, H. and Ronis, M,J. (2016) Reactive oxygen species differentially regulate bone turnover in an age-specific manner in catalase transgenic female mice. J Pharmacol Exp Ther, 358, 50-60.  PMCID: PMC4931876
  • Alund, A.W., Mercer, K.E., Suva, L.J., Pulliam, C.F., Chen, J-R., Badger, T.M. and Ronis, M.J. (2016) Patrial protection by dietary antioxidants against ethanol-induced osteopenia and changes in bone morphology in female mice. Alcoholism: Clin Exp Res., 41(1), 46-56. PMCID: PMC5521216
  • Atwood, D.N., Beenken, K.E., Lantz, T.L., Meeker, D.G., Lynn, W.B., Mills, W.B., Spencer, H.J. and Smeltzer, M.S. (2016) Regulatory mutations impacting antibiotic susceptibility in an established Staphylococcus aureus biofilm. Antimicrob Agents Chemother, 60, 1826-1829. PMCID: PMC4775981
  • Atwood, D.N., Beenken, K.E., Loughran, A.J., Meeker, D.G., Lantz, T.L., Graham, J.W., Spencer, H.J., and Smeltzer, M.S. (2016) XerC contributes to diverse forms of Staphylococcus aureus infection via agr-dependent and agr-independent pathways. Infect Immun, 84,1214-25. PMCID: PMC4807471
  • Holthoff, E., Spencer, H., Kelly, T., Post, S.R. and Quick, C.M. (2016) Pathologic features of aggressive vulvar squamous cell carcinoma are associated with an epithelial-mesenchymal transition. Hum Pathol. 56, 22-30. PMCID: PMC5021565
  • Jennings, J.A., Beenken, K.E., Skinner, R.A., Meeker, D.G., Smeltzer, M.S., Haggard, W.O. and Troxel, K.S. (2016) Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection. World J Orthop. 2016, 7(8), 467-474. PMCID: PMC4990767
  • Loughran, A.J., Gaddy, D., Beenken, K.E., Meeker, D.G., Morello, R., Zhao, H., Byrum, S.D, Tackett, A.J., Cassat, J.E. and Smeltzer, M.S. (2016) Impact of sarA and phenol-soluble modulins in the pathogenesis of osteomyelitis in diverse clinical isolates of Staphylococcus aureus. Infect Immun, 84(9), 2586-2594.  PMCID: PMC4995912
  • Meeker, D.G., Chen, J. and  MS. (2016) Could targeted, antibiotic-loaded gold nanoconstructs be a new magic bullet to fight infection? Nanomedicine (Lond), 11, 2379-2382. PMCID: PMC27529572
  • Meeker, D.G., Jenkins, S.V., Miller, E.K., Beenken, K.E., Loughran, A.J., Powless, A., Muldoon, T.J., Galanzha, E.I., Zharov, V.P., Smeltzer, M.S., and Chen, J. (2016) Synergistic photothermal and antibiotic killing of biofilm-associated Staphylococcus aureus using targeted antibiotic-loaded gold nanoconstructs. ACS Infectious Diseases, 2(4), 241-250.  PMCID: PMC4945994
  • Meeker, D.G., Chen, J. and Smeltzer, M.S. (2016) Could targeted, antibiotic-loaded gold nanoconstructs be a new magic bullet to fight infection? Nanomedicine (Lond), 11(18), 2379-2382. PMCID: PMC5561798
  • Meeker, D.G., Beenken, K.E., Mills, W.B., Loughran, A.J., Spencer, H.J., Lynn, W.B. and Smeltzer, M.S. (2016) Evaluation of antibiotics active against methicillin-resistant Staphylococcus aureus based on activity in an established biofilm. Antimicrob Agents Chemother, 60(10), 5688-5694.   PMCID: PMC5038242
  • Sims, C.R., Nguyen, T.C. and Mayeux, P.R. (2016) Could biomarkers direct therapy for the septic patient? J Pharmacol Exp Ther, 357, 228-239. PMCID: PMC4851319
  • Shrum, S., MacMillan-Crow, L.A. and Parajuli, N. (2016) Cold storage exacerbates renal and mitochondrial dysfunction following transplantation. J Kidney,  (2)1, 114.PMCID: PMC4825688

2015 Publications

  • Atwood, D.N., Loughran, A.J., Courtney, A., Spencer, H.J., Anthony, A.C., Meeker, D.G., Gupta, R.K., Lee, C.Y., Beenken, K.E. and Smeltzer, M.S. (2015) Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiology Open, 4,436-451, PMCID:  PMC4475386
  • Holthoff, E.R., Jeffus, S.K., Gehlot, A., Stone, R., Erickson, S.W., Kelly, T., Quick, C.M. and Post, S.R. (2015) Perineural invasion is an independent pathologic indicator of recurrence in vulvar squamous cell carcinoma. Am J Surg Pathol, 39, 1070-1074. PMCID: PMC4503485
  • Jeffus, S.K., Gehlot, A., Holthoff, E., Stone, R., Spencer, H., Kelly, T., Post, S.R. and Quick, C.M. (2015) A fibromyxoid stromal response is associated with an infiltrative tumor morphology, perineural invasion, and lymph node metastasis in squamous cell carcinoma of the vulva. Am J Surg Pathol, 39,1226-1233. PMCID: PMC4538995
  • Tai, S., Hyatt, W.S., Gu, C., Franks, L.N., Vasiljevik, T., Brents, L.K., Prather, P.L. and Fantegrossi, W.E. (2015) Repeated administration of phytocannabinoid delta(9)-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner. Pharmacol Res, 102, 22-32. PMCID: PMC468444
  • Wang, Z., Sims, C.R., Patil, N.K., Gokden, N. and Mayeux, P.R.,(2015) Pharmacological targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse. J Pharmacol Exp Ther, 352, 61-66. PMCID: PMC4279105

2014 Publications

  • Sims, C.R., MacMillan-Crow, L.A. and Mayeux, P.R. (2014) Targeting mitochondrial oxidants may facilitate recovery of renal function during infant sepsis. Clin Pharmacol Ther,  96, 662-664. PMCID: PMC4243161
  • Yang, C.S., Mercer, K.E., Alund, A.W., Suva, L.J., Badger, T.M. and Ronis. M.J. (2014) Genistein supplementation increases bone turnover but does not prevent alcohol-induced bone loss in male mice. Exp Biol Med, 239, 1380-1389.  PMCID: PMC4263414