College of Medicine
Core Facilities
College of Medicine Subsidized Core Facilities that use recharge to enable basic, clinical, and translational research at UAMS.
- Digital Microscopy Core Fcility
- Flow Cytometry Core Facility
- Experimental Pathology Core Facility
- DNA and Next Generation Sequencing Core Facility
Shared Resources
College of Medicine subsidized shared resources that use recharge to enable basic, clinical, and translational research at UAMS.
- Brain Imaging Research Center Shared Resource
- Histology, Biomechanics, and Human Tissue Core Shared Resource
- Bone Imaging Core Shared Resource
- Comprehensive Informatics Resource Core Shared Resource
- DNA Damage and Toxicology Shared Resource
- Genetic Models Shared Resource
- Bioinformatics Collaborative Resource Center
- Genomics Shared Resource
- IDeA National Resource for Quantitative Proteomics
Brain Imaging Research Center Shared Resource
Magnetic resonance imaging
Details
Summary: State-of-the-art facility magnetic resonance imaging facility with a research focus related to human neuroscience
| Contact Email | GAJames@uams.edu |
| Key resources | Philips Achieva 3 Tesla magnetic resonance imaging (MRI) instrument |
| Director | Andy James, Ph.D. |
| Location | Psychiatric Research Institute |
| Further detail | https://psychiatry.uams.edu/research/brain-imaging-research-center/ |
Bone Imaging Core Shared Resource
Musculoskeletal imaging
Details
Summary: State-of-the-art musculoskeletal imaging and analytical technologies to generate, analyze, and interpret bone-imaging data. Also provides training in bone imaging and supports educational activities.
| Contact Email | JDelgadocalle@uams.edu |
| Key Resources | Faxitron UltraFocus with Dexa, 2 Scanco microCT 40, Zeiss Axioimager M2 with motorized stage |
| Director | Jesús Delgado-Calle, Ph.D. |
| Location | Multiple |
| Further detail | https://medicine.uams.edu/cmdr/cores/technical-cores/ |
Histology, Biomechanics, and Human Tissue Core Shared Resource
Hard tissue histology, and in vivo and ex vivo biomechanical testing
Details
Summary: Highly specialized instrumentation and expertise for biomechanics and analysis of murine bones, human bone biopsies, and human joints.
| Contact Email | JXIONG@uams.edu , EAmbrogini@uams.edu |
| Key resources | Electroforce 5500, MTS machines, microtomes, embedding , vacuum ovens, multiple capabilities in histology staining |
| Director | Jinhu Xiong, Ph.D., Elena Ambrogini, M.D., Ph.D. |
| Location | Multiple |
| More | https://medicine.uams.edu/cmdr/cores/technical-cores/ |
Comprehensive Informatics Resource Core (CIRC) Shared Resource
Biomedical informatics
Details
Summary: Consulting and informatics support of clinical trials, radiological imaging, and clinical data reporting.
| Contact Email | FWPrior@uams.edu |
| Key Resources | Biomedical informatics consultation, development of surveys and data collection forms, data management and sharing plan support, collection and management of research images and multimedia data, access and analysis support for population databases |
| Director | Fred Prior, Ph.D. |
| Location | Multiple |
| Further detail | https://tri.uams.edu/resources-and-services/tri-services/comprehensive-informatics-resource-core-circ/ |
Digital Microscopy Core Facility
Microscopy and cryo-resonance imaging
Details
Summary: Both walk-up and staff-assisted imaging and microscopy. Added support available in experimental setup, consultation, training and user support for equipment operation and sample preparation.
| Contact Email | LupashinVladimirV@uams.edu |
| Key Resources | Tecnai F20 TEM Transmission electron microscope; fluorescent, inverted, light microscopy |
| Director | Vladimir Lupashin, Ph.D. |
| Location | Biomed-II |
| Further detail | https://medicine.uams.edu/physiology/cores/ |
DNA Damage & Toxicology Shared Resource
Cellular and molecular toxicology
Details
Summary: This core offers expertise in the areas of cellular and molecular analysis of tissue injury, with capabilities related to toxic or hypoxic tissue/cell injury in drug development, diseases or aging.
| Contact Email | BasnakianAlexeiG@uams.edu |
| Key Resources | Cytotoxicity assays in vitro and in vivo, DNA isolation, in vitro and in-cell DNA fragmentation assays, quantitative cytochemistry and immunocytochemistry, 3-D imaging, molecular cytogenetics, consultation |
| Director | Alexei G. Basnakian, M.D., Ph.D., D.Sc. |
| Location | Biomed-I |
| Further detail | https://pharmacy.uams.edu/cobre/cores/technical-cores/cellular-and-molecular-toxicology-core/ |
DNA and Next Generation Sequencing Core Facility
DNA sequencing
Details
Summary: The UAMS DNA and NGS Core Facility was established in 1997 to provide cost-effective, cutting-edge sequencing resources available to the campus.
| Contact Email | JSBlevins@uams.edu |
| Key Resources | Sanger sequencing, small genome sequencing, and DNA and RNA quality analysis, metagenomics, and RNA-seq |
| Director | Jon Blevins, Ph.D. |
| Location | Biomed-II |
| Further detail | https://medicine.uams.edu/mbim/research-cores/dna-sequencing-core-facility/ |
Experimental Pathology Core Facility
Histology and immunostaining
Details
Summary: The UAMS Experimental Pathology (ExPath) Core Laboratory provides researchers with centralized, comprehensive histological services for human and animal tissues in biochemical, molecular, and pathologic studies.
| Contact Email | SPost@uams.edu |
| Key Resources | Tissue processing and embedding, custom immunostaining, multiplexed immunohistochemistry, sectioning of paraffin-embedded and frozen tissue, slide scanning and imaging, consultation |
| Director | Steven Post, Ph.D. |
| Location | Winthrop P. Rockefeller Cancer Institute, floor 4 |
| Further detail | https://medicine.uams.edu/pathology/divisions/research/translational-pathology-shared-resource/experimental-pathology-core-lab |
Flow Cytometry Core Facility
Walk-up and staff-assisted services
Details
Summary: The Flow Cytometry Core Facility offers analysis of samples by traditional cytometry, cell sorting, full spectrum flow cytometry, sterile cell sorting, and imaging flow cytometry.
| Contact Email | JStumhofer@uams.edu |
| Key Resources | BD LSRFortessa, BD FACSAria III, Cytek Northern Lights, BD FACSCelesta, Vetscan HM5 Hematology Analyzer |
| Director | Jason Stumhofer, Ph.D. |
| Location | Biomed-II, Floor 3 |
| Further detail | https://medicine.uams.edu/mbim/research-cores/flow-cytometry-core-facility/ |
Genetic Models Shared Resource
Custom murine models and cell lines
Details
Summary: Advanced gene-editing, cell line and transgenic mouse services, with long-term supporting maintenance, including sperm cryopreservation, in vitro fertilization, and strain rederivation
| Contact Email | QFu@uams.edu |
| Key Resources | Dedicated laboratory space with a microinjection suite, cryopreservation lab, and isolator rack animal wards, CRISPR-Cas gene-editing technology |
| Director | Qiang Fu, M.D., Ph.D. |
| Location | Winthrop P. Rockefeller Cancer Institute, Floor 8 |
| Further detail | https://medicine.uams.edu/cmdr/cores/technical-cores/ |
Genomics Shared Resource
NGS and molecular profiling
Details
Summary: Our mission is to provide UAMS investigators with convenient access to the latest technologies for genomic interrogation using Next Generation Sequencing (NGS), microarray, and ddPCR analysis.
| Contact Email | DJJohann@uams.edu |
| Key Resources | Illumina NovaSeq 6000, Illumina NextSeq 2000, Illumina miniSeq, nucleic acid extraction, NGS Library Preparation and QC , study consultation |
| Director | Donald Johann, M.D. |
| Location | Winthrop P. Rockefeller Cancer Institute |
| Further detail | https://cancer.uams.edu/research/research-resources/genomics/ |
IDeA National Resource for Quantitative Proteomics
Comprehensive quantitative and discovery proteomics analysis
Details
Summary: The IDeA National Resource for Quantitative Proteomics provides a full range of services for protein characterization by mass spectrometry, including protein identification, mapping of post-translational modifications, global proteomics, and quantitative comparison of proteins in biological samples using state-of-the-art equipment.
| Contact Email | SWEED@uams.edu |
| Key Resources | Orbitrap Astral, Orbitrap Eclipse, Orbitrap Exploris 480, discovery proteomics, targeted proteomics, bioinformatics |
| Director | Alan Tackett, Ph.D. |
| Location | Winthrop P. Rockefeller Cancer Institute |
| Further detail | https://cancer.uams.edu/research/research-resources/proteomics/ |