Any questions about the information below, any additions or edits? Or simply interested in getting involved? Please email Dr. Marie Burdine at MBurdine@uams.edu.
| Lead | Project Title | Description | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Zachary Waldrip, Ph.D | DNA-PKcs Inhibitors as Transplant Therapy | Use of pig kidney transplant model to determine the effect of DNA-PKcs inhibitors on transplant rejection | |||||||||||||||||||||
| Ana Azevedo-Pouly, Ph.D. Randall Rainwater, MD/Ph.D. student | Characterizing the function of DNA-PKcs in T cell biology | Use of in vitro models and a novel mouse strain to analyze the role of DNA-PKcs in T cell activation and differentiation | |||||||||||||||||||||
| Ana Azevedo-Pouly | The effects of DNA-PKcs on T cell response to tumor antigens | Using a melanoma model, we are investigating how DNA-PKcs affects the response of T cells to tumors. A phospho-proteomics approach using clinical samples will allow us to identify mechanisms used by DNA-PKcs to control T cell response. | |||||||||||||||||||||
| Seana Corbin, M.D. | Novel technique for in vivo generation of Car-T cells | The lab investigates a novel mechanism to generate in vivo Car-T cells which will improve the use of Car-T cells for therapy but improving generation lead times and decreasing costs. | |||||||||||||||||||||