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Ongoing Research — Basic Science

Any questions about the information below, any additions or edits? Or simply interested in getting involved? Please email Dr. Marie Burdine at MBurdine@uams.edu.

LeadProject TitleDescription
Zachary Waldrip, Ph.DDNA-PKcs Inhibitors as Transplant TherapyUse of pig kidney transplant model to determine the effect of DNA-PKcs inhibitors on transplant rejection
Ana Azevedo-Pouly, Ph.D.
Randall Rainwater, MD/Ph.D. student
Characterizing the function of DNA-PKcs in T cell biologyUse of in vitro models and a novel mouse strain to analyze the role of DNA-PKcs in T cell activation and differentiation
Ana Azevedo-PoulyThe effects of DNA-PKcs on T cell response to tumor antigensUsing a melanoma model, we are investigating how DNA-PKcs affects the response of T cells to tumors. A phospho-proteomics approach using clinical samples will allow us to identify mechanisms used by DNA-PKcs to control T cell response.
Seana Corbin, M.D.Novel technique for in vivo generation of Car-T cellsThe lab investigates a novel mechanism to generate in vivo Car-T cells which will improve the use of Car-T cells for therapy but improving generation lead times and decreasing costs.
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