Any questions about the information below, any additions or edits? Or simply interested in getting involved? Please email Dr. Marie Burdine at MBurdine@uams.edu.
|Zachary Waldrip, Ph.D
|DNA-PKcs Inhibitors as Transplant Therapy
|Use of pig kidney transplant model to determine the effect of DNA-PKcs inhibitors on transplant rejection
|Ana Azevedo-Pouly, Ph.D.
Randall Rainwater, MD/Ph.D. student
|Characterizing the function of DNA-PKcs in T cell biology
|Use of in vitro models and a novel mouse strain to analyze the role of DNA-PKcs in T cell activation and differentiation
|The effects of DNA-PKcs on T cell response to tumor antigens
|Using a melanoma model, we are investigating how DNA-PKcs affects the response of T cells to tumors. A phospho-proteomics approach using clinical samples will allow us to identify mechanisms used by DNA-PKcs to control T cell response.
|Seana Corbin, M.D.
|Novel technique for in vivo generation of Car-T cells
|The lab investigates a novel mechanism to generate in vivo Car-T cells which will improve the use of Car-T cells for therapy but improving generation lead times and decreasing costs.