Any questions about the information below, any additions or edits? Or simply interested in getting involved? Please email Dr. Marie Burdine at MBurdine@uams.edu.
| Lead | Project Title | Description | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| David Harrison | DNA-PKcs Inhibitors as Transplant Therapy | Use of pig kidney transplant model to determine the effect of DNA-PKcs inhibitors on transplant rejection | |||||||||||||||||||||
| Zach Waldrip | Characterizing the function of DNA-PKcs in T cell biology | Use of in vitro models and a novel mouse strain to analyze the role of DNA-PKcs in T cell activation and differentiation | |||||||||||||||||||||
| Ana Azevedo-Pouly | DNA-PKcs in the epigenetic regulation of cytokine transcription | Exploring the role of DNA-PKcs in regulating chromatin remodeling and transcriptional complex formation to induce cytokine production in T cells using a genomic approaches including chIP-Seq and ATAC-seq. | |||||||||||||||||||||
| Ana Azevedo-Pouly | The effects of DNA-PKcs on T cell response to tumor antigens | Using a melanoma model, we are investigating how DNA-PKcs affects the response of T cells to tumors. A phospho-proteomics approach using clinical samples will allow us to identify mechanisms used by DNA-PKcs to control T cell response. | |||||||||||||||||||||
| Ana Azevedo-Pouly | DNA-PKcs Promotes Pancreatic Cancer Metastasis | Using in vitro and in vivo models, we are exploring the ability of DNA-PKcs to promote tumor cell EMT to drive metastasis of pancreatic cancer. | |||||||||||||||||||||
| Lauren Appell | DNA-PKcs inhibition prevents GVHD | In collaboration with Dr. Marjan Boerma at UAMS, we are using an murine allogeneic stem cell transplant model to determine if DNA-PKcs inhibitors can prevent GVHD. | |||||||||||||||||||||
| Lauren Appell | DNA-PKcs is critical for T cell differentiation | Using in vitro analysis and Flow cytometry, we are analyzing the effects of DNA-PKcs on naïve T cell differentiation into subtypes, T reg, Th17, Th1, Th2 | |||||||||||||||||||||
| Nadir El Sharawi (Anesthesiology) | Plasma Concentration of Biological Markers in Placental Accreta Spectrum | Analyzing microparticle levels and protein concentrations by flow cytometry and mass spectrometry to identify potential markers for early placental accreta | |||||||||||||||||||||