Inhibition of BAK-mediated apoptosis by the BH3-only protein BNIP5.
Rühl S, Li Z, Srivastava S, Mari L, Guy CS, Yang M, Moldoveanu T, Green DR.
Cell Death Differ. 2024
Structural and functional insights into the interaction between the bacteriophage T4 DNA processing proteins gp32 and Dda.
He X, Yun MK, Li Z, Waddell MB, Nourse A, Churion KA, Kreuzer KN, Byrd AK, White SW.
Nucleic Acids Res. 2024
The Graduate School held a Research Induction Ceremony to celebrate the graduate students who passed their candidacy exams in the past year. Each student was presented with a white coat from their mentor and Dr. Mari Davidson, the director of the Biochemistry and Molecular Biology track. Biochemistry and Molecular Biology students who received their white coats were:
Congratulations to all!
Agar lot-specific inhibition in the plating efficiency of yeast spores and cells
Protacio RU, Davidson MK, Malone EG, Helmlinger D, Smith JR, Gibney, PA, Wahls WP.
G3: Genes / Genomes / Genetics 2024
Development of New Diffuse Large B Cell Lymphoma Mouse Models.
Mehdi SH, Xu YZ, Shultz LD, Kim E, Lee YG, Kendrick S, Yoon D.
Cancers (Basel). 2024
Untargeted CUT&Tag and BG4 CUT&Tag are both enriched at G-quadruplexes and accessible chromatin.
Thompson MD, Byrd AK.
bioRxiv [Preprint]. 2024
HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection.
Fry LG, Washam CL, Roys H, Bowlin AK, Venugopal G, Bird JT, Byrum SD, Weinkopff T.
bioRxiv [Preprint]. 2024
Alan Tackett, Ph.D., Distinguished Professor of Biochemistry, received an Odyssey Medal for Research from Hendrix College. The Odyssey Medal is presented to alumni whose life achievements exemplify the ideals of the Hendrix Odyssey Program. Medalists are selected by the Hendrix Board of Trustees for their accomplishments in one of the six Odyssey categories: Artistic Creativity, Global Awareness, Professional and Leadership Development, Research, Service to the World, or Special Projects.
Alan Tackett, Ph.D., earned a degree in chemistry with distinction from Hendrix College in 1998, and received his Doctor of Philosophy degree in biochemistry and molecular biology from the University of Arkansas for Medical Sciences (UAMS) in 2002. He performed postdoctoral training in cancer epigenetics and proteomics at The Rockefeller University in New York City from 2002-2005. He joined the faculty at UAMS in 2005 and has risen in the ranks to a tenured distinguished professor of biochemistry and molecular biology. Tackett received the Sharlau Family Endowed Chair for Cancer Research in 2016 and was nominated into the Arkansas Research Alliance in 2021. He currently serves as Deputy Director of the Winthrop P. Rockefeller Cancer Institute at UAMS.
As a UAMS faculty member, Tackett has built an internationally recognized research team focused on uncovering new therapeutic strategies to treat metastatic melanoma and developing the next generation of molecular profiling technologies to identify cancer biomarkers. He has published more than 150 scientific articles and holds multiple patents in these areas; and has received more than $40 million in government funding to support his research endeavors.
Tackett serves as director of two National Institutes of Health (NIH) research centers in Arkansas: a NIH Center of Biomedical Research Excellence in systems biology that has enabled critical infrastructure development for large data generating technologies and has provided tailored mentoring to numerous early career faculty resulting in their acquisition of over $25 million in government research funding; and a NIH National Resource for Quantitative Proteomics that has supported biomedical research in over 1,500 laboratories across every state in the U.S. and has provided training and workforce development to over 500 faculty and students, including many who are underrepresented in the biomedical research workforce.
Congratulations to Stephanie Byrum, Ph.D. who was honored as Distinguished Alumni by Atlanta High School in Atlanta, Texas.
MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture.
Griffin H, Hanson J, Phelan KD, Baldini G.
Cells. 2024
Creating meiotic recombination-regulating DNA sites by SpEDIT in fission yeast reveals inefficiencies, target-site duplications, and ectopic insertions
Protacio RU, Dixon S, Davidson MK, Wahls WP
biomolecules 2024
Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441.
Waldrip ZJ, Acharya B, Armstrong D, Hanafi M, Rainwater RR, Amole S, Fulmer M, Azevedo-Pouly AC, Burns A, Burdine L, Frett B, Burdine MS.
Sci Rep. 2024
Development of New Diffuse Large B Cell Lymphoma Mouse Models.
Mehdi SH, Xu Y-Z, Schultz LD, Kim E, Lee YG Kendrick S, Yoon D.
cancers. 2024
Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles.
Protacio RU, Malone EG, Wahls WP.
MicroPubl Biol. 2024
Climate Change and New Challenges for Rural Communities: Particulate Matter Matters.
Miousse IR, Hale RB, Alsbrook S, Boysen G, Broadnax T, Murry C, Williams C, Park CH, Richards R, Reedy J, Chalbot MC, Kavouras IG, Koturbash I.
Sustainability. 2023
Enhanced translational activity is linked to lymphatic endothelial cell activation in cutaneous leishmaniasis.
Fry L, Roys H, Bowlin A, Venugopal G, Bird JT, Weaver A, Byrum SD, Weinkopff T.
bioRxiv [Preprint]. 2024
Congratulations to Dr. Kevin Raney, Ph.D., Professor and Chair of the Department of Biochemistry and Molecular Biology. He has now published more than 100 scientific papers that are indexed by PubMed at the National Library of Medicine.
Research spearheaded by Dr. Reine Protacio, Staff Scientist in the Department of Biochemistry and Molecular Biology at UAMS, was recently highlighted in the journal Science. A full-length NEWS article describes how Protacio discovered that some batches of Agar—which is used to solidify solutions of nutrients in petri plates—were killing the fission yeast cells that the laboratory uses to study how chromosomes behave during cell divisions.
The original research article, published as a preprint in bioRxiv, was co-authored by Drs. Mari Davidson (UAMS), Wayne Wahls (UAMS) and Dominique Helmlinger (University of Montpellier in France).
Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles
Protacio RU, Malone EG, Wahls WP
MicroPubl Biol. 2024
Understanding proteome quantification in an interactive learning module on Google Cloud Platform.
O’Connell KA, Kopchick B, Carlson T, Belardo D, Byrum SD.
Brief Bioinform. 2024
Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge.
Hong Z, Byrd AK, Gao J, Das P, Tan VQ, Malone EG, Osei B, Marecki JC, Protacio RU, Wahls WP, Raney KD, Song H.
Nat Commun. 2024
Understanding PTM Cross Talk Through a Visualization Tool, PTMViz.
Chappell K, Byrum SD.
Methods Mol Biol. 2024
Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer.
Ferdous KU, Tesfay MZ, Cios A, Shelton RS, Hartupee C, Urbaniak A, Chamcheu JC, Mavros MN, Giorgakis E, Mustafa B, Simoes CC, Miousse IR, Basnakian AG, Moaven O, Post SR, Cannon MJ, Kelly T, Nagalo BM.
Biomedicines. 2024
Bioactivation and reactivity research advances – 2023 year in review.
Wang S, Argikar UA, Chatzopoulou M, Cho S, Crouch RD, Dhaware D, Gu TJ, Heck CJS, Johnson KM, Kalgutkar AS, Liu J, Ma B, Miller GP, Rowley JA, Seneviratne HK, Zhang D, Khojasteh SC.
Drug Metab Rev. 2024
Laboratory horror stories: Poison in the agars.
Davidson MK, Protacio RU, Helmlinger D, Wahls WP.
bioRxiv [Preprint]. 2024
Long-read sequencing for brain tumors.
Shelton WJ, Zandpazandi S, Nix JS, Gokden M, Bauer M, Ryan KR, Wardell CP, Vaske OM, Rodriguez A.
Front Oncol. 2024
Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex.
Nguyen MC, Rostamian H, Raman A, Wei P, Becht DC, Erbse AH, Klein BJ, Gilbert TM, Zhang G, Blanco MA, Strahl BD, Taverna SD, Kutateladze TG.
Nat Commun. 2024
Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis.
Tucker Andrews J, Zhang Z, Krishna Prasad GVR, Huey F, Nazarova EV, Wang J, Ranaraja A, Weinkopff T, Li LX, Mu S, Birrer MJ, Ching-Cheng Huang S, Zhang N, Argüello RJ, Philips JA, Mattila JT, Huang L.
Mucosal Immunol. 2024
An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy.
Pechous RD, Malaviarachchi PA, Banerjee SK, Byrum SD, Alkam DH, Ghaffarieh A, Kurten RC, Kennedy JL, Zhang X.
J Virol. 2024
