July 19, 2017 | A University of Arkansas for Medical Sciences (UAMS) professor has secured $710,000 in grant funding for the continuation of an interdisciplinary training program for health professionals with the aim of improving services for children with developmental disabilities.

UAMS has directed the Arkansas Regional Leadership Education in Neuro-Developmental Disabilities (LEND) Project since 1994, funded by grants from the federal Health Resources and Services Administration.

As many as 15-18 percent of children have developmental and/or behavioral problems. This grouping includes autism spectrum disorders, which impact one in 65 children in Arkansas.

Eldon G. Schulz, M.D., of the UAMS Department of Pediatrics in the UAMS College of Medicine, is principal investigator of the program and administrator of the grant.

“Too few health professionals have the necessary skills to diagnose and provide the proper treatments for developmental disabilities,” Schulz said. “Participants in this program emerge with a better sense of the entire system that these children face and the barriers to care that they encounter.”

Thirty-two postgraduate trainees from 14 disciplines – ranging from audiology to nursing to psychiatry to health administration – complete a two-semester, 300-hour curriculum that includes classes, problem-based learning, clinical rotations and research and leadership projects.

“Our trainees are the cream of the crop in their fields, and we want tomorrow’s leaders in health care to already be thinking of ways they can intervene – be it as citizens or as professionals – on behalf of these families and children, with the ultimate goal of improving their treatment and their access to care; improving their lives; expanding their future possibilities for joining the workforce and participating in society,” Schulz said.

UAMS partners with the University of Arkansas at Fayetteville, University of Arkansas at Little Rock, University of Central Arkansas and the University of Southern Mississippi for the program. These institutions host the trainees’ coursework and provide faculty and mentors for the participants. Partners for Inclusive Communities, which is the University of Arkansas at Fayetteville’s Center on Disabilities program, organizes and administers the program.

“Traditionally, our health professionals have not gotten a lot of training on how to work in interprofessional teams,” said David Deere, executive director of Partners for Inclusive Communities. “For a lot of the complex conditions that kids with disabilities have – autism being an increasingly common example – it’s really important to be able to coordinate services, understand what other professions do, make referrals to other services when necessary and work collaboratively on everything from screening to diagnosis and interventions.”

Schulz said the LEND program “fits in beautifully” with UAMS’ overall mission as the state’s primary health sciences university.

“This really is a model interdisciplinary program,” Schulz said. “Increasingly, ‘interdisciplinary’ has become a key word in health education, and it’s been a major part of what we have been doing with LEND for years. It’s no longer enough for medical professionals to think about the traditional list of medical professionals that everyone knows. The treatment world has expanded, and they need to know how to take advantage of it and connect their patients to the right service providers and work interprofessionally to coordinate their care.”

LEND trainees have access to 25 different clinical rotation options, including some in rural Arkansas. Schulz has taken trainees to Marshall, Mountain View and Dumas, for example.

“They are experiences that are very much based in the real world and can be quite eye-opening,” Schulz said.

Part of the learning structure is for the trainees to learn by teaching. They take turns at periodic meetings teaching each other about things they’ve learned, and they also partner with a faculty mentor to teach students at Hall High School about different health care professions.

Portions of the program are also available to health professionals and state disability services professionals as continuing medical education.

More information is available from Partners for Inclusive Communities at 800-342-2923, deere@uark.edu.

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UAMS is the state’s only comprehensive academic health center, with colleges of Medicine, Nursing, Pharmacy, Health Professions and Public Health; a graduate school; a hospital; a northwest Arkansas regional campus; a statewide network of regional centers; and seven institutes: the Winthrop P. Rockefeller Cancer Institute, the Jackson T. Stephens Spine & Neurosciences Institute, the Myeloma Institute, the Harvey & Bernice Jones Eye Institute, the Psychiatric Research Institute, the Donald W. Reynolds Institute on Aging and the Translational Research Institute. It is the only adult Level 1 trauma center in the state. UAMS has 3,021 students, 789 medical residents and five dental residents. It is the state’s largest public employer with more than 10,000 employees, including about 1,000 physicians and other professionals who provide care to patients at UAMS, Arkansas Children’s Hospital, the VA Medical Center and UAMS regional centers throughout the state. Visit www.uams.edu or www.uamshealth.com. Find us on Facebook, Twitter, YouTube or Instagram.

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By Amy Widner | July 19th, 2017

July 18, 2017 | More than 50 Marshallese high school students and parents attended the Pathways to Health Professions conference June 9-10 in Springdale, where they were encouraged to pursue higher education and health care careers.

Sheldon Riklon, M.D., an associate professor in the UAMS College of Medicine, shared the story of his perseverance and efforts as one of only two Marshallese physicians to have graduated from U.S. medical schools.

“When I got to college, it was very difficult. I didn’t know anybody. Everyone spoke English. I had no chemistry, no physics, and only one year of biology,” said Riklon. “It took me six years in college to graduate because my first year I took all introductory courses to get to the same level everyone else was.”

Hosted by the UAMS Center for Pacific Islander Health, the UAMS Center for Diversity Affairs, and the Arkansas Coalition of Marshallese, the conference helps students and parents understand the college application process, options for higher education and job opportunities in health care. According to the Association of American Medical Colleges, less than 1 percent of medical school graduates in 2015 identified as Native Hawaiian or Pacific Islander.

For many of the parents, it is the first time to learn about programs and financing options to help their child into and through higher education.

“The participation of the parents shows us they are very supportive of their children’s education,” said Melisa Laelan, commissioner of the Arkansas Minority Health Commission. “They learned that there are ways their children can apply for scholarships. They learned about programs that are available like our Child Savings Account program spearheaded by the Arkansas Coalition of Marshallese.”

Laelan said parental support is needed to help students hurdle the challenge of getting into college and completing a bachelor’s degree before medical school is possible. “Most important is that parents learned it really takes a great deal of effort from them to encourage and nurture a student to reach his or her dreams.”

Kimberlyn Blann, director of outreach for the Center for Diversity Affairs, explained UAMS is able to help students figure out what kind of health career would be the best fit. Every summer, the center provides the Academy of Pre-Health Scholars, a free multi-week Little Rock-based program for high school students. Participants receive help preparing for the ACT and learn which classes to take in high school to succeed in college. They also gain valuable information about allied health professions and ways to build careers in health care without spending years in medical school.

“It’s not just doctors. It’s so much more than just doctors. With the allied health professions, you can become a respiratory therapist, a physician assistant, or an emergency medical technician. You can become an EMT with just a high school diploma,” Blann said.

Nia Aitaoto, Ph.D., co-director of the Center for Pacific Islander Health, echoed that sentiment in her presentation.

“We want more doctors, more nurses, more people in public health, more researchers. We want more people like us in the workforce,” said Aitaoto. “It’s easier to teach you to become health care providers than it is for us to teach all of the doctors and nurses and therapists about our culture and our language.”

Pearl McElfish, Ph.D., associate vice chancellor of UAMS Northwest Regional Campus, said, “Pathways is important to help nurture and develop that next generation of health care leaders that will be able to provide truly community-based care.”

Participants also questioned other Pacific Islanders working as doctors, nurses, and in allied health professions, as well as current Marshallese college students.

Speakers stressed the importance of preparing as much as possible in high school and taking advantage of available resources. They recommended those interested in pursuing a health care career take Advanced Placement classes to earn college credit while still in high school as well as higher level science and math classes. They emphasized the role of guidance counselors in selecting the right classes to take in high school and guiding them through scholarship and loan applications.

Andy Subica, Ph.D., a psychologist and researcher at the University of California Riverside School of Medicine, had an experience similar to Riklon’s.

“Everyone here is going to tell you that they struggled at some point, whether it’s in high school or college,” Subica said, “But you’ve got to keep working and remember that you belong. You belong there even if you might be the only Marshallese person in there. So don’t get discouraged.”

Educational attainment statistics for the Mashallese and Pacific Islanders are difficult to find because they are often aggregated with a larger Asian-American ethnicity. Some studies indicate less than 20 percent of Native Hawaiians and other Pacific Islanders have a bachelor’s degree, and it is not uncommon to not have a high school diploma. The annual Pathways conference shows examples of community members who persisted and worked hard to achieve their careers.

“Any journey starts with a canoe. We’re here to help you get in the canoe,” said Aitaoto. “That big blue ocean . . . It’s not what separates us. It’s what connects us. It’s our network. We need to be proud of that.”

By Ashley McNatt | July 18th, 2017

How President John F. Kennedy’s back pain affected his life and presidency along with the role it may have played in how he died are examined in a review of the 35^th president’s medical history written by a University of Arkansas for Medical Sciences (UAMS) physician and his co-author.

In their article, “John F. Kennedy’s Back: Chronic Pain, Failed Surgeries, and the Story of Its Effects on His Life and Death” published July 11 in the Journal of Neurosurgery: Spine, authors T. Glenn Pait, M.D., and Justin T. Dowdy, M.D., reviewed case notes written by various physicians who undertook care of Kennedy’s back. They also examined spinal imaging studies obtained over decades of treatment, documenting a history of debilitating structural changes.

The president’s public image as a young, healthy, strong-bodied man belies the truth that he was plagued by illnesses and discomfort and required strong medication to perform his tasks as president, the article shows. Pait and Dowdy also address the controversy over whether Kennedy’s use of a back brace contributed to his death at the hands of an assassin in 1963.

Kennedy’s other intermittent and chronic health problems, their relationships to his spinal disorder, and the possible effects that his ill health may have played in his career and even in his death also are examined. Scarlet fever, long-standing gastrointestinal disease, Addison’s disease, and chronic back pain are some of the medical issues faced by Kennedy during his short life.

Pait is a neurosurgeon and director of the T. Glenn Pait Spine Clinic at the UAMS Jackson T. Stephens Spine & Neurosciences Institute. Dowdy, a UAMS neurosurgical resident at the time the article was written, is a neurosurgeon in Hot Springs.

Kennedy first experienced low-back pain after a football injury as an undergraduate student at Harvard University in 1937. While serving in the U.S. Navy during World War II, Kennedy further injured his back, leading in 1944 to the first of his four spine surgeries.

The authors describe physical and imaging findings before and after each of the surgeries, which spanned the years 1944 through 1957. The first two surgeries did little to improve Kennedy’s condition and in fact resulted in severe complications and additional pain. The third operation was performed to remedy the effects of the second operation, and the fourth operation to clear out infection at the previous operative site.

The relative value of diagnostic tests of the time and the decisions leading to the spine surgeries is examined by Pait and Dowdy. They also discuss the means used to reduce Kennedy’s chronic pain so that he could function as president and maintain his image of a strong, vibrant leader at the top of his game.

The Journal of Neurosurgery: Spine is a monthly peer-reviewed journal focused on neurosurgical approaches to treatment of diseases and disorders of the spine. It contains a variety of articles, including descriptions of preclinical and clinical research as well as case reports and technical notes. The Journal of Neurosurgery: Spine is one of four monthly journals published by the JNS Publishing Group, the scholarly journal division of the American Association of Neurological Surgeons.

By Ben Boulden | July 13th, 2017

July 12, 2017 | The National Institutes of Health (NIH) has awarded $11.5 million to the Arkansas Children’s Research Institute (ACRI) to develop the Center for Translational Pediatric Research (CTPR). The award is the largest-ever grant award that ACRI has received from NIH.  Under the direction of Alan Tackett, Ph.D., the center will result in new treatments and therapies developed specifically for children.

Dr. Tackett, an ACRI expert in systems biology, is the Scharlau Family Endowed Professor of Cancer Research and a professor of Biochemistry, Pediatrics and Pathology in the College of Medicine at the University of Arkansas for Medical Sciences (UAMS). The Center for Translational Pediatric Research at ACRI will use state-of-the-art technology and a systems biology approach to study how pediatric diseases develop, with the ultimate goal of identifying points in the intersection of disease and development that will produce targets for therapeutic intervention and the development of new treatments for children. Systems biology is a holistic approach that enables researchers to simultaneously study all of the events occurring in a cell that are leading to a particular outcome or disease.

“Historically, science has answered one question at a time,” Dr. Tackett said. “By employing a more comprehensive systems biology approach, we can ask many questions at the same time, which allows us to more quickly understand the fundamental reasons that a disease is occurring and how to more specifically develop treatments.

“To my knowledge, there is not a pediatric research center in the U.S. and probably in the world that focuses on utilizing these specific approaches. In that way, we are uniquely positioned to develop ways to improve children’s health in Arkansas and our nation.”

The NIH Institutional Development Award (IDeA) program will fund the CTPR as one of NIH’s prestigious Centers of Biological Research Excellence (COBRE). These grants create world-class research environments for young faculty who are identified as the next generation of excellence in research. The awards focus on building research in states that have historically had low levels of NIH funding. This first phase of COBRE funding will start in July of 2017 and last five years. A total of 15 years of funding is available through this federal program, and Tackett’s award is the second COBRE grant ACRI has received from NIH in the last year.

“This award is a promise to the children of Arkansas that we will create a healthier tomorrow specifically for them,” said Gregory Kearns, PharmD, Ph.D., FAAP, president of ACRI and Arkansas Children’s senior vice president/chief research officer. He is also the Ross & Mary Whipple Family Distinguished Research Scientist Endowed Chair and a professor of Pediatrics at UAMS. “NIH sees that we have the potential to create a transformational center that will improve children’s lives directly where they live, learn and play.”

Dr. Tackett will serve as director of the CTPR and Sonet Weed, MS, will oversee the administration of the grant. The junior faculty that were selected to seed this center include:

• Jason Farrar, M.D., UAMS Assistant Professor of Pediatrics
• Xiawei Ou, Ph.D., UAMS Assistant Professor of Radiology and Pediatrics
• Laxmi Yeruva, Ph.D., UAMS Assistant Professor of Pediatrics
• Boris Zybailov, Ph.D., UAMS Assistant Professor of Biochemistry & Molecular Biology

Their research focuses on pediatric blood disorders, infant brain development in obese mothers, immune system development in breastfed infants, and pediatric chronic kidney disease – respectively.

All-in-all, the Center for Translational Pediatric Research will support 30 faculty – making it one of the largest centers of its kind. Located at ACRI, the CTPR will also partner with the Arkansas Children’s Nutrition Center and UAMS and its Winthrop P. Rockefeller Cancer Institute. The cutting-edge research technology investment will create discoveries in proteomics, genomics, and bioinformatics – overseen by:

• Rick Emondson, Ph.D., UAMS Associate Professor of Medicine
• Samuel Mackintosh, Ph.D., UAMS Research Assistant Professor of Biochemistry & Molecular Biology
• Stewart MacLeod, Ph.D., UAMS Assistant Professor of Pediatrics
• Stephanie Byrum, Ph.D., UAMS Research Assistant Professor of Biochemistry & Molecular Biology
• Galina Glazko, Ph.D., UAMS Assistant Professor of Biomedical Informatics

Arkansas Children’s, Inc. is the only health system in the state solely dedicated to caring for children, which allows the organization to uniquely shape the landscape of pediatric care in Arkansas. The system includes a 359-bed hospital in Little Rock with the state’s only pediatric Level 1 trauma center, burn center, Level 4 neonatal intensive care and pediatric intensive care, and research institute as well as a nationally-recognized transport service. It is one of the 25 largest children’s hospitals in the United States and is nationally ranked by U.S. News World & Report in pulmonology and neonatal care. A sister campus is under development in Northwest Arkansas and will bring 233,613 square feet of inpatient beds, emergency care, clinic rooms and diagnostic services to children in that corner of the state. Arkansas Children’s also blankets the state with outreach programs that include telemedicine, mobile health, and school-based health solutions. A private not-for-profit, Arkansas Children’s boasts an internationally renowned reputation for medical breakthroughs and intensive treatments, unique surgical procedures and forward-thinking research and is committed to providing every child with access to the best care available, regardless of location or resources. Founded as an orphanage, Arkansas Children’s has championed children by making them better today and healthier tomorrow for more than 100 years. For more info, visit archildrens.org.

ACRI is a free-standing state-of-the-art pediatric research center which provides a research environment on the ACH campus to foster research and scholarship of faculty members of University of Arkansas for Medical Sciences who are investigating questions relative to development, disease and treatment as it relates to the health of infants, children and adolescents. Physician and biomedical scientist investigators at ACRI and the Arkansas Children’s Nutrition Center (ACNC) conduct clinical, basic science, and health services research for the purpose of treating illnesses and preventing disease and thereby, improving the health of the children of Arkansas and beyond.

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UAMS is the state’s only comprehensive academic health center, with colleges of Medicine, Nursing, Pharmacy, Health Professions and Public Health; a graduate school; a hospital; a northwest Arkansas regional campus; a statewide network of regional centers; and seven institutes: the Winthrop P. Rockefeller Cancer Institute, the Jackson T. Stephens Spine & Neurosciences Institute, the Myeloma Institute, the Harvey & Bernice Jones Eye Institute, the Psychiatric Research Institute, the Donald W. Reynolds Institute on Aging and the Translational Research Institute. It is the only adult Level 1 trauma center in the state. UAMS has 3,021 students, 789 medical residents and five dental residents. It is the state’s largest public employer with more than 10,000 employees, including about 1,000 physicians and other professionals who provide care to patients at UAMS, Arkansas Children’s Hospital, the VA Medical Center and UAMS regional centers throughout the state. Visit www.uams.edu or www.uamshealth.com. Find us on Facebook, Twitter, YouTube or Instagram.

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By Amy Widner | July 12th, 2017

LITTLE ROCK —Jerad Gardner, M.D., an associate professor in the University of Arkansas for Medical Sciences (UAMS) College of Medicine’s Departments of Pathology and Dermatology, was named to the American Society for Clinical Pathology’s “40 Under 40” 2017 list which honors pathologists and laboratory medicine professionals globally under the age of 40.

The honorees come from various health systems and universities around the world. Each were selected based on their achievements and leadership qualities that impact the field of pathology and laboratory medicine.

“It is such an honor not only to be recognized by the American Society for Clinical Pathology, but even more importantly, to be named alongside so many of my fantastic friends and colleagues who also made this list,” said Gardner. “Having colleagues like these makes me proud to be a pathologist.”

Gardner is a dermatopathologist and bone/soft tissue sarcoma pathologist. He directs the dermatopathology fellowship program and co-directs the musculoskeletal/skin module, both in the College of Medicine.

Gardner has lectured internationally on bone and soft tissue tumors and skin disease. He also speaks to health care professionals nationally and internationally on how to use Facebook, Twitter and Instagram professionally. Gardner was one of the first to use social media in his field and is now the chair of social media subcommittees for two pathology organizations — the American Society of Dermatopathology and the United States and Canadian Academy of Pathology. He has created Facebook discussion groups for pathologists that now have 18,000 and 25,000 followers and has created a social media guide for pathologists. He also volunteers with rare cancer patient support groups on Facebook.

UAMS is the state’s only health sciences university, with colleges of Medicine, Nursing, Pharmacy, Health Professions and Public Health; a graduate school; a hospital; a northwest Arkansas regional campus; a statewide network of regional centers; and seven institutes: the Winthrop P. Rockefeller Cancer Institute, the Jackson T. Stephens Spine & Neurosciences Institute, the Myeloma Institute, the Harvey & Bernice Jones Eye Institute, the Psychiatric Research Institute, the Donald W. Reynolds Institute on Aging and the Translational Research Institute. It is the only adult Level 1 trauma center in the state. UAMS has 2,870 students, 799 medical residents and five dental residents. It is the state’s largest public employer with more than 10,000 employees, including about 1,200 physicians who provide care to patients at UAMS and its regional campuses throughout the state, Arkansas Children’s Hospital, the VA Medical Center and Baptist Health. Visit www.uams.edu or www.uamshealth.com. Find us on Facebook, Twitter, YouTube or Instagram.

U.S. News & World Report has ranked our affiliate facility, Arkansas Children’s Hospital, in four specialties – the most ever – in its new 2017-18 Best Children’s Hospitals rankings published online today. Our Department of Pediatrics partners with Arkansas Children’s Hospital and the Arkansas Children’s Research Institute. The department’s services include pediatric training, clinical assessment, diagnosis and treatment of acute and chronic disorders, and cutting-edge research on techniques to enhance a child’s home and medical environment.

The Arkansas Children’s specialties highlighted include:

• Pediatric Cardiology & Heart Surgery, ranked No. 37
• Neonatology, ranked No. 38
• Pediatric Pulmonology, ranked No. 47
• Pediatric Urology, ranked No. 48

Learn more on the Children’s Hospital site.

Potential patents for medical inventions as small as a molecule prompted big discussions among UAMS researchers who gathered for a showcase hosted June 6 by the College of Medicine to highlight medical research.

“Every poster you see here today has a patent application on file with the Patent and Trademark Office,” said Nancy Gray, Ph.D., director of BioVentures, UAMS’ technology licensing office and business incubator.

Eight projects were featured at the Showcase of Medical Discoveries: Inventors— the 18th in a series to foster communication and collaboration among UAMS investigators and clinicians. About 70 researchers, physicians, staff and students attended the event, held at the UAMS Winthrop P. Rockefeller Cancer Institute.

Each group of researchers had applied for a patent within the last two years, Gray said. Receiving a patent is often a lengthy process that takes several years to complete, she said.

“We are very interested in making sure that research ultimately makes its way to the patient, and it’s not going to make it to the patient if it doesn’t have a commercial path,” Gray said.

“Most faculty in academic health centers think about writing papers and disseminating their research findings through publications, but they don’t always think about protecting their intellectual property,” said Lawrence Cornett, Ph.D., UAMS vice chancellor for research. “The patent is just the beginning, so that you can go forward with the research and no one will steal your idea.”

Many projects focused on small molecule therapies to fight cancer and infection.

A small-molecule drug is a substance that is able to enter cells easily because it has a low molecular weight. Once inside the cells, it can affect other molecules, such as proteins, and may cause cancer cells to die. This is different from drugs that have a large molecular weight, such as monoclonal antibodies, which are not able to get inside cells very easily. Many targeted therapies are small-molecule drugs or small-molecule inhibitors.

Mark Smeltzer, Ph.D., professor in the Department of Microbiology and Immunology and Department of Orthopaedic Surgery, presented his team’s research on using antibiotic-loaded gold nanocages to target staphylococcal infections. Gold nanoparticles are emerging as promising agents for cancer therapy. Smeltzer’s team is using that approach to target infections.

Gold nanocages carry antibiotics to a specific location for treatment, only releasing the antibiotics after the nanocage is targeted with a laser. This releases energy that damages the pathogen, making it easier for the antibiotic to do its work. It’s a one-two punch that aims to combat growing antibiotic resistance, Smeltzer said.

“If you can use it to therapeutic advantage in the context of cancer, why can’t you use it for therapeutic advantage in the context of an infection?” Smeltzer said. “At the end of the day, what you’re trying to do is eradicate some sort of cell that has pathological consequences and do it in a manner that does not harm the human host.”

The Showcase of Medical Discoveries is organized by Cornett and supported by Pope Moseley, M.D., UAMS executive vice chancellor and dean of the College of Medicine. It originated from discussions about the faculty’s desire for more opportunities to display their scientific work in a social setting.

Posters at the showcase described the researchers’ work. They were:

Looking for drugs in all the wrong places: Are antibiotic-loaded gold nanocages the solution for treating Staphylococcus aureus biofilm infections?

Researchers: Daniel Meeker, Karen Beenken, Weston Blake Mills, Dmitry Nedosekin, Mark Smeltzer

Design and Synthesis of Bcl-xL Degraders as Potent Senolytic Agents

Researchers: Xuan Zhang, Yingying Wang, Daohong Zhou, and Guangrong Zheng

Assessing the Interest of UAMS Investigators in fastPACE Biomedical Commercialization Course

Researchers: Nancy Gray, Nancy Rusch, Curtis Lowery

Development and Commercialization of Tocol-containing Pharmaceuticals

Researchers: Ujwani Nukala, Shraddha Thakkar, Awantika Singh, Nukhet Aykin-Burns, Rajeshkumar Manian, John House, Guangrong Zheng, Sanchita Ghosh, Mahmoud Kiaei, Marjan Boerma, Martin Hauer-Jensen, Philip J. Breen and Cesar M. Compadre

Novel Potent Anti-leukemia Stem Cell Compounds

Researchers: Paola E. Ordóñez, Krishan K. Sharma, Laura M. Bystrom, Ujwani Nukala, Rajeskumar Manian, Maria A. Alas, William F. Reynolds, Raul G. Enriquez, Darcy C. Burns, Omar Malagón, Darin E. Jones, Michael Balick, Shraddha Thakkar, Philip J. Breen, Monica L. Guzman and Cesar M. Compadre

Valchlor gel (Mechlorethamine): an approved FDA drug in the USA, and marketed in Europe as Ledaga for the treatment of Mycosis fungoides and cutaneous T-cell lymphoma (MF-CTCL)

Researchers: Zaineb A.F. Albayati, Vipin P. Nair, Sundar Neelakantan, David R. Worthen, Marhaba Hojahmat and Peter A. Crooks

Combretastatin A-4 and Apysinopsin Analogs as Lead Anti-cancer Agents

Researchers: Narsimha R. Penthala, Grace Coggins, Maddukuri Leena; Jessica H. Hartman, Dae Song Jang; Alexei G. Basnakian, Suja Arattuthodiyil, Kevin M. Raney, Nikhil R. Madadi, Thirupathi R. Yerramreddy, Rajashekar Konjeti, Michael L. Freeman, Robert L. Eoff and Peter A. Crooks

Aryl Esters of Melampomagnolide B as Anticancer Agents

Researchers: Shobanbabu Bommagani, Jessica Ponder, Craig T. Jordan, Michael J. Borrelli, Meenakshisundram Balasubramaniam, Robert Reis, and Peter A. Crooks

Sesquiterpene Lactone Derivatives as Potential Lead Molecules for Treatment of Acute Myelogenous Leukemia

Researchers: Venumadhav Janganati, Jessica Ponder, Craig T. Jordan and Peter A. Crooks

UAMS is the state’s only comprehensive academic health center, with colleges of Medicine, Nursing, Pharmacy, Health Professions and Public Health; a graduate school; a hospital; a northwest Arkansas regional campus; a statewide network of regional centers; and seven institutes: the Winthrop P. Rockefeller Cancer Institute, the Jackson T. Stephens Spine & Neurosciences Institute, the Myeloma Institute, the Harvey & Bernice Jones Eye Institute, the Psychiatric Research Institute, the Donald W. Reynolds Institute on Aging and the Translational Research Institute. It is the only adult Level 1 trauma center in the state. UAMS has 3,021 students, 789 medical residents and five dental residents. It is the state’s largest public employer with more than 10,000 employees, including about 1,000 physicians and other professionals who provide care to patients at UAMS, Arkansas Children’s Hospital, the VA Medical Center and UAMS regional centers throughout the state. Visit www.uams.edu or www.uamshealth.com. Find us on Facebook, Twitter, YouTube or Instagram.

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By Benjamin Waldrum | June 14th, 2017

June 13, 2017 | Two residents from the University of Arkansas for Medical Sciences (UAMS) have been selected for a prestigious fellowship in neuro-oncology administered jointly by the Johns Hopkins University School of Medicine and the National Institutes of Health Neuro-Oncology Branch.

A maximum of two fellows per year are selected for the program, and this year, both are from UAMS.

Carlos Romo, M.D., co-chief resident physician; and Orwa Aboud, M.D., Ph.D., will complete their residencies in the Department of Neurology in the UAMS College of Medicine in June and begin their fellowships in July.

The fellowship provides advanced training for neurosurgeons, radiation therapists, medical and pediatric oncologists and neurologists to prepare them for academic careers in neuro-oncology. The experience is tailored individually to the needs of the fellow. Both Romo and Aboud will spend three years expanding both their research and clinical experience through courses, research projects, mentoring and clinical rotations.

“It is extremely prestigious for us to have not just one of the two, but both,” said Robert L. “Lee” Archer, M.D., professor and interim chairman of the Department of Neurology. “Their selection says a lot about the level of residents we are producing. Dr. Romo and Dr. Aboud have done outstanding work during their time here, and I would also like to credit their adviser, Dr. Shirley Ong, and our residency director, Dr. Kinshuk Sahaya, for contributing to their success.”

Ong, M.D., said that both have unique skillsets to offer their patients and expand the future of neuro-oncology.

“There are very few good neuro-oncology fellowship training programs in the U.S., and they are extremely competitive,” Ong said. “Neuro-oncology is a small field and requires hard work and a strong fortitude, and I had zero hesitation in recommending Drs. Aboud and Romo to the Johns Hopkins/NIH fellowship program. I know they will represent UAMS well.”

Romo is from Aguascalientes, Mexico, and earned his medical degree at Tec de Monterrey in Monterrey, Mexico. Sahaya, M.D., described him as a dynamic and multifaceted resident whose teaching ability is appreciated by students and faculty alike. For example, Romo helped Sahaya redesign part of the neurology residency curriculum. Ong described him as a leader who sets goals and accomplishes them.

Romo said his time at UAMS exposed him to a wide variety of patients, especially because of UAMS’ partnerships with Arkansas Children’s Hospital and the Central Arkansas Veterans Healthcare System. He is looking forward to expanding his experiences even further.

“This fellowship, unlike any other in the country, provides the fellows with access to two different institutions that are leaders in the field,” Romo said. “Faculty members at Johns Hopkins and NIH are recognized worldwide for their contributions in the area of neuro-oncology. NIH also offers opportunities for collaboration between basic and clinical scientists, and particularly among scientists across other disciplines. This collaboration creates a nurturing environment for the development of ideas that can improve outcomes for patients with cancer of the nervous system.”

Aboud is from Swaida, Syria. He attended medical school at the University of Damascus in Syria and graduate school at UAMS. Sahaya described him as an outstanding resident and researcher and a skilled physician. He is a great team leader who is loved by colleagues, faculty, students and patients alike. His research is already garnering him top honors. Ong said Aboud is extremely compassionate and goes above-and-beyond with his patients.

Aboud said that early in his neurology residency, he took part in a neuro-oncology rotation that exposed him to how big the impact of basic and clinical research can be on patients’ treatment options and quality of life. He values the fact that both the UAMS residency and the NIH/Johns Hopkins fellowship give him both research and clinical exposure.

“The field of neuro-oncology is about giving patients options for a better quality of life, longer survival, and, hopefully, a cure,” Aboud said. “In preparation for my career as a neuro-oncologist, this training is essential to gain a broad knowledge of the science of brain tumor development and the scientific strategies used in the development of the next generation of treatment. As a clinician scientist, my goal is to achieve a more immediate and positive impact on my patients’ lives.”

The UAMS Neurology Residency is a four-year program open to students who already have a medical degree and are looking for advanced training in neurology. Residents can then move on to become practicing neurologists or pursue additional specialized training through fellowships, like Romo and Aboud.

“Both are very different in their interests and approach, and they exemplify the diversity of our learning approach, both culturally and academically,” Sahaya said. “It’s our goal to provide a supportive environment for our residents where they can both learn the essentials and develop their own interests while we assist them in that process. We support our residents in all career choices, from general to specialized neurology. These two are just another example of the careers we hope to nurture with our residency.”

For more information, visit neurology.uams.edu.

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UAMS is the state’s only comprehensive academic health center, with colleges of Medicine, Nursing, Pharmacy, Health Professions and Public Health; a graduate school; a hospital; a northwest Arkansas regional campus; a statewide network of regional centers; and seven institutes: the Winthrop P. Rockefeller Cancer Institute, the Jackson T. Stephens Spine & Neurosciences Institute, the Myeloma Institute, the Harvey & Bernice Jones Eye Institute, the Psychiatric Research Institute, the Donald W. Reynolds Institute on Aging and the Translational Research Institute. It is the only adult Level 1 trauma center in the state. UAMS has 3,021 students, 789 medical residents and five dental residents. It is the state’s largest public employer with more than 10,000 employees, including about 1,000 physicians and other professionals who provide care to patients at UAMS, Arkansas Children’s Hospital, the VA Medical Center and UAMS regional centers throughout the state. Visit www.uams.edu or www.uamshealth.com. Find us on Facebook, Twitter, YouTube or Instagram.

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By Amy Widner

June 15, 2017 | Justin Treas is a busy man. The 29-year-old has a Ph.D. in environmental toxicology and has worked in cancer research. He’s married with three children and just earned his medical degree from the UAMS College of Medicine. On March 28, 2017, Treas had a stroke that his doctors believe would have killed him if those around him hadn’t acted quickly and efficiently.

“I remember being with other students. The professors were teaching us about geriatrics,” Treas said. “I remember going outside because I wasn’t feeling well. Some friends came to check on me and quickly called Dr. Mendiratta. She took me to the clinic. They checked my glucose and other vitals. I was doing very poorly so they took me to the emergency department.”

Benedict Tan, M.D., listened as Treas recounted the events of that day.

“The fact that you can recall that much is very impressive,” Tan told his patient. “Once you see your CT scans, you’ll be impressed, too. Your clot was massive.”

Tan is the director of neurocritical care at UAMS, treating the most serious brain and spine cases in emergency and intensive care. He is the only neurointensivist in Arkansas.

“The stroke pager was activated, and we were called to the emergency room,” Tan said. “As soon as the CT scan was complete you could see the clot. That’s very unusual because it was probably the biggest clot I have seen without using further imaging techniques. We knew right away that he needed treatment immediately.”

Mehmet Akdol, M.D., an interventional neuroradiologist and assistant professor in the UAMS College of Medicine’s Department of Radiology, removed the clot after Treas received tPA. The tissue plasminogen activator is a clot-busting agent used to quickly improve blood flow to the brain. Tan says since the onset of the stroke was clear and verified by multiple witnesses, he felt confident to give him the clot-busting drug. Clot-busting medication is the first line of medication for stroke patients but must be used in the first three hours after onset of symptoms. Treas received tPA 19 minutes after he entered the emergency department.

“We used a microcatheter to grab the clot and pull it down like a cork screw, resuming blood flow to the brain,” Akdol said. “We have several cases that received this kind of treatment. What is unique in this case is the timing and aggressive treatment with no delay, which brought an excellent neurological result.”

“The staff, physicians and nurses were amazing,” said Debra Johnson, R.N., stroke nurse coordinator and outreach nurse for the AR SAVES program. “He was ranked a 26 on the National Institutes of Health (NIH) Stroke Scale. Twenty-four hours later, he was at a two.”

The NIH stroke scale increases with severity. The lower the score the less severe it is; anything above 20 is extremely severe.. Three nurses and a resident physician were recognized for their distinct aptitude in treating Treas by receiving an “I Saved a Brain” pin: Stacy Bennett, R.N; Emily Boyd, R.N.; Erin Sanders, R.N., and Heather McLemore, M.D.

It is uncommon for a person as young as Treas to have a stroke except in the case of traumatic injury. The size of the clot prompted Tan to examine Treas for signs of trauma around his neck.

“We later found out that the stroke was caused from a carotid artery dissection,” Tan said.

Carotid artery dissection is a tear in one of the two main arteries in the neck. It’s almost exclusively caused by trauma. Over time, the tear can get bigger and a clot will form around it, cutting blood flow to the brain. Tan says the trauma doesn’t have to come from an assault or something very severe. He says there have been examples of carotid artery tears caused from being hit too quickly, falling, whiplash, dancing violently or riding a roller coaster. Treas’ physicians believe a roller coaster may have caused his tear. He’d visited an amusement park two weeks prior.

“Rides like that can cause a tear because of the abrupt changes in gravity,” Tan said. “That creates a reversal in blood flow and in some degree can cause stress on the vessel itself. If the vessels obtain stress, they can tear and over time cause a clot.”

Akdol says Treas’ ability to make a complete recovery is because of swift reaction from those around him. “There was no waste of time. We have implemented a system here at UAMS that allows us to deal with these cases very quickly. This is why we want people to know the symptoms and remember the acronym FAST.”

F – Face Drooping.

A – Arm Weakness.

S – Slurred Speech.

T – Time to call 911.

Since the stroke, Treas has been recovering and says he’s been improving daily. He and his wife have a baby, Lillie Belle, born April 20. He graduated from UAMS on May 20 and he soon starts his internal medicine residency with hopes to eventually be an oncologist or cardiologist.

By Katrina Dupins | June 15th, 2017 |