Three junior faculty in the College of Medicine, Department of Physiology and Cell Biology, have received their first major grants from the National Institutes of Health. Together, the awards total more than $6.6 million and support research on bone aging, blood cancer, and osteoarthritis.
“These awards line up with what we’re working toward: more outside funding for our faculty, more opportunities for our students and trainees, and more basic and translational research that leads to better treatments for bone and cartilage diseases,” said Teresita Bellido, Ph.D., Chair of the Department of Physiology and Cell Biology. “Congratulations to all three. They’ve worked hard and stuck with it, and we can’t wait to see what comes next.”
Targeting Autophagy to Strengthen Aging Bones

Melda Onal, Ph.D., Associate Professor, received a $2,439,235 grant from the National Institute on Aging to study autophagy, the recycling process inside cells
that bone-forming cells need to survive and function. Autophagy is thought to be inadequate in both aging and osteogenesis imperfecta (OI), a genetic disorder known as “brittle bone disease.”
Dr. Onal’s lab will use a genetic approach called CRISPR activation to boost autophagy and test whether doing so increases bone formation, bone mass, and strength. The project aims to establish proof of principle for stimulating autophagy as a new way to build bone and reduce fracture risk in older adults and people with OI.
Her collaborators and co-investigators include Roy Morello, Ph.D., Professor, Department of Physiology and Cell Biology; Maria Schuller Almeida, Ph.D., Professor, Departments of Orthopaedic Surgery and Rehabilitation and Internal Medicine, Division of Endocrinology and Metabolism; and Intawat Nookaew, Ph.D., Professor, Department of Biomedical Informatics.
Does Bad Cholesterol Fuel Multiple Myeloma?

Ryan Allen, Ph.D., Assistant Professor, received a $2,119,890 grant from the National Cancer Institute to study whether low-density lipoprotein (LDL), often called “bad cholesterol,” affects multiple myeloma, an incurable blood cancer that forms in the bone marrow. Many myeloma patients initially respond to therapies but eventually relapse into a refractory disease state.
Dr. Allen’s team will test whether myeloma cells draw on LDL to grow and whether LDL-carried small RNAs help the cancer suppress the immune system. Their goal is to determine whether drugs that target cholesterol or an immune-cell switch called TLR8 could help patients stay in remission longer.
His co-investigators and collaborators include Jesus Delgado-Calle, Ph.D., Associate Professor, Department of Physiology and Cell Biology; Fenghuang “Frank” Zhan, M.D., Ph.D., Professor, Department of Internal Medicine and Director of UAMS Myeloma Center Basic Research; Martin Cannon, Ph.D., Professor, Department of Microbiology and Immunology; Cody Ashby, Ph.D, Associate Professor, Department of Biomedical Informatics; and Carolina Schinke, M.D., Associate Professor, Department of Internal Medicine, Division of Hematology and Oncology.
Examining Blood Vessels in Osteoarthritis

Sanja Novak, Ph.D., Assistant Professor, received a $2,058,011 grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to investigate how damage to the tiny blood vessels in the knee contributes to osteoarthritis (OA), a painful joint disease marked by the breakdown of cartilage.
Dr. Novak’s team will study whether unstable, leaky blood vessels help trigger and speed up OA after joint injury, and whether stabilizing those vessels can prevent or slow the disease. The findings could point to new therapies for a leading cause of pain and reduced mobility.
Her collaborators and co-investigators include Ryan Porter, Ph.D. (Co-Investigator), Associate Professor, Departments of Internal Medicine and Orthopaedic Surgery and Rehabilitation; Melda Onal, Ph.D. (Co-Investigator), Associate Professor, Department of Physiology and Cell Biology; Kimberly Stephens, Ph.D. (OSC), Assistant Professor, Department of Neuroscience; and Ruud Dings, Ph.D. (OSC), Associate Professor, Department of Radiation Oncology.
“Our department works hard to help faculty land outside funding,” said Bellido. “It starts with recruiting faculty whose work fits what UAMS already does well. Then we give each new faculty member a mentoring committee built around what they need, and we encourage them to collaborate within and beyond the department. We also have great partners in the Cancer Institute, the Centers of Biomedical Research Excellence, and the Translational Research Institute.”


















