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  1. University of Arkansas for Medical Sciences
  2. College of Medicine
  3. Department of Radiation Oncology
  4. Faculty
  5. Robert J. Griffin, Ph.D.

Robert J. Griffin, Ph.D.

Robert Griffin

Professor

Education and Training

  • Ph.D. Biophysical Sciences, 1998, University of Minnesota
  • B.A. Biology/Music, 1991, St. Olaf College, Northfield, MN

Research Interests

  • Molecular and physiological mechanisms of radiation and thermal sensitization
  • Modulation of tumor blood flow, angiogenesis and oxygenation
  • Biology and physiology of thermal therapy
  • Oxygen partial pressure as predictor of cancer treatment response

Clinical Research

  • Interested in translational clinical studies to answer questions about the biological response of tumors to treatment with radiation or chemotherapy in order to move towards new standards of care

Publications

  • Griffin RJ, Okajima K, Barrios B, Song CW: Mild temperature hyperthermia combined with carbogen breathing increases tumor pO2and radiosensitivity.  Cancer Res, 56:  5590-5593, 1996.
  •  Dings RPMD, Heun H, Griffioen AW, Mayo KM, Griffin RJ: Scheduling of radiation with angiogenesis inhibitors Avastin and Anginex improves therapeutic outcome via vessel normalization.  13(11):3395-402, Clin Cancer Res, 2007.
  •  Upreti M, Jamshidi-Parsian A, Apana S, Berridge M, Fologea DA, Koonce NA, Henry RL, Griffin RJ: Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature.   Journal of Mol Med, Apr;91(4):497-506, 2013.
  •  Koonce, NA, Raleigh, J, Dings RPM, Griffin RJ: Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia.  PLoS One, 10(8):e0135607, 2015.  PMID: 26308944
  •  Koonce, NA, Dings RPM, Quick, Griffin RJ: Combination of gold nanoparticle-conjugated TNF-a and radiation therapy results in a synergistic anti-tumor response. Int J Radiat Oncol Biol Phys.  93(3):588-96, 2015.  PMID:  26461001

More information on Dr. Griffin’s Lab and Lab research.

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