Dr. Donald Johann, Associate Professor of Biomedical Informatics and Internal Medicine, authored a paper in the high-impact journal Nature Scientific Data on the analytic validity of liquid biopsies. The use of routine blood draws to diagnose and monitor the status of cancer patients, rather than tissue biopsies, is revolutionizing the practice of clinical oncology and […]
Publications
High School Student Earns Spot on UAMS Research Team
When a UAMS Parkinson’s disease research project needed someone with machine learning expertise, Fred Prior, Ph.D., asked Anu Iyer if she would be interested. It would have been a routine invitation among researchers at the University of Arkansas for Medical Sciences (UAMS), but Iyer is a junior at Little Rock’s Central High School. Prior, Iyer’s mentor […]
Genome Sequence of the Oocydin A-Producing Rhizobacterium Serratia plymuthica 4Rx5
Matilla MA1,2, Udaondo Z3, Salmond GPC1. Abstract Serratia plymuthica 4Rx5 was isolated from the rhizosphere of oilseed rape due to its antagonistic properties against plant-pathogenic fungi. The strain 4Rx5 produces the antifungal and antioomycete haterumalide, oocydin A. Analysis of its genome revealed the presence of various gene clusters putatively involved in the biosynthesis of additional secondary metabolites. […]
Genome Sequences of Zika Virus Strains Recovered from Amniotic Fluid, Placenta, and Fetal Brain of a Microcephaly Patient in Thailand, 2017
Wongsurawat T1, Jenjaroenpun P1, Athipanyasilp N2, Kaewnapan B2, Leelahakorn N2, Angkasekwinai N3, Kantakamalakul W2, Sutthent R2, Ussery DW1,4, Horthongkham N2, Nookaew I1,4. Abstract We present here the complete genome sequences of Zika virus strains isolated from aborted fetal tissue (brain and placenta) and amniotic fluid of a microcephaly patient in Thailand in 2017. The virus genomes that were sequenced have an average length of 10,807 […]
Author Correction: Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy
Grossberg AJ1,2, Mohamed ASR3,4, Elhalawani H3, Bennett WC5, Smith KE5, Nolan TS5, Williams B3, Chamchod S3,6, Heukelom J3,7, Kantor ME3, Browne T3, Hutcheson KA8, Gunn GB3, Garden AS3, Morrison WH3, Frank SJ3, Rosenthal DI3, Freymann JB9, Fuller CD10. Abstract In the original version of the Data Descriptor the surname of author Hesham Elhalawani was misspelled. This has now been corrected in the HTML and PDF versions. Erratum for Imaging and clinical data archive […]
A Database Study of Visual Outcomes and Intraoperative Complications of Postvitrectomy Cataract Surgery
Soliman MK1, Hardin JS2, Jawed F3, Uwaydat SH2, Faramawi MF4, Chu CJ5, Yang YC6, Sallam AB7. Abstract PURPOSE: To analyze the visual outcomes and rate of intraoperative complications of phacoemulsification surgery after prior pars plana vitrectomy (PPV). DESIGN: Retrospective, multicenter database study. PARTICIPANTS: Eyes that underwent phacoemulsification between June 2005 and March 2015 at 8 sites in the United Kingdom. METHODS: Study […]
RNA-Seq Analysis of Spinal Cord Tissues from hPFN1G118V Transgenic Mouse Model of ALS at Pre-symptomatic and End-Stages of Disease
Barham C1, Fil D1,2, Byrum SD3, Rahmatallah Y4, Glazko G4, Kiaei M5,6,7. Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to the loss of motor neurons. The molecular mechanisms of motor neuron degeneration are largely unknown and there are currently no effective therapies to treat this disease. In this work, we report whole transcriptome profiling of […]
Toward predictive R-loop computational biology: genome-scale prediction of R-loops reveals their association with complex promoter structures, G-quadruplexes and transcriptionally active enhancers
Kuznetsov VA1,2, Bondarenko V1, Wongsurawat T1,3, Yenamandra SP1, Jenjaroenpun P1,3. PMID: 30053183 | PMCID: PMC6125685 | DOI: 10.1093/nar/gky690 Free PMC Article
Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy
Grossberg AJ1,2, Mohamed ASR1,3, Elhalawani H1, Bennett WC4, Smith KE4, Nolan TS4, Williams B1, Chamchod S1,5, Heukelom J1,6, Kantor ME1, Browne T1, Hutcheson KA7, Gunn GB1, Garden AS1, Morrison WH1, Frank SJ1, Rosenthal DI1, Freymann JB8, Fuller CD1. Erratum in Author Correction: Imaging and clinical data archive for head and neck squamous cell carcinoma patients treated with radiotherapy. [Sci Data. 2018] Abstract Cross sectional imaging is essential for the patient-specific planning and delivery of […]
The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells
McCormick JJ1, VanDusseldorp TA1,2, Ulrich CG1, Lanphere RL3, Dokladny K4, Mosely PL5, Mermier CM1. Abstract Autophagy is a lysosome degradation pathway through which damaged organelles and macromolecules are degraded within the cell. A decrease in activity of the autophagic process has been linked to several age-associated pathologies, including triglyceride accumulation, mitochondrial dysfunction, muscle degeneration, and cardiac malfunction. Here, we examined the […]