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  1. University of Arkansas for Medical Sciences
  2. College of Medicine
  3. Department of Biomedical Informatics
  4. autophagy

autophagy

The effect of aging on the autophagic and heat shock response in human peripheral blood mononuclear cells

McCormick JJ1, VanDusseldorp TA1,2, Ulrich CG1, Lanphere RL3, Dokladny K4, Mosely PL5, Mermier CM1. Abstract Autophagy is a lysosome degradation pathway through which damaged organelles and macromolecules are degraded within the cell. A decrease in activity of the autophagic process has been linked to several age-associated pathologies, including triglyceride accumulation, mitochondrial dysfunction, muscle degeneration, and cardiac malfunction. Here, we examined the […]

Filed Under: Publications Tagged With: aging, autophagy, HSP, PBMC, rapamycin

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