• Skip to primary navigation
  • Skip to main content
  • Skip to primary navigation
  • Skip to main content
Choose which site to search.
University of Arkansas for Medical Sciences Logo University of Arkansas for Medical Sciences
College of Medicine: Department of Biomedical Informatics
  • UAMS Health
  • Jobs
  • Giving
  • About Us
    • Employment
    • News
    • Links
  • Faculty
    • Primary Faculty
    • Secondary Faculty
    • Adjunct Faculty
  • Staff
  • Education
    • Admission Information
    • Graduate Programs
    • Current Course Offerings
    • Course Descriptions
    • Clinical Informatics Board Prep Course
    • DBMI FAQs
    • Research & Application Seminar
    • Recorded Sessions for CME Credit
  • INBRE
    • INBRE Bioinformatics Core Support Request Form
  • Research Labs
    • Publications
    • Arkansas Center for Genomic & Ecological Medicine (ArC-GEM)
    • Arkansas Clinical Data Repository (AR-CDR)
    • Biomedical Ontologies Arkansas (BOAR)
  • Clinical Informatics Fellowship
    • Fellowship Overview
    • Training Sites
    • Faculty
    • Current Fellows
    • Welcome to Little Rock!
  • Databases
  1. University of Arkansas for Medical Sciences
  2. College of Medicine
  3. Department of Biomedical Informatics
  4. News
  5. Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis type 2-diabetes mellitus rat model

Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis type 2-diabetes mellitus rat model

AJP-Endocrinology and Metabolism, in the press, July 2018

Brian Piccolo, James Graham, Kimber Stanhope, Intawat Nookaew, Kelly Mecer, Sree Chintapalli, Umesh Wankhade, Kartik Shankar, Peter Havel, Sean Adams

Abstract

Many factors contribute to, or can modify, the development of diseases such as obesity and type 2 diabetes, including the naturally occurring bacteria residing in the gut (that make up the “gut microbiome”). Most studies have focused on how diet changes the gut bacteria in a negative way to cause obesity and type 2 diabetes, but little attention has been given to how changes in host health status influences the bacteria. We used a rodent model of diabetes that does not require a change in diet to develop obesity and diabetes, to understand which gut bacteria change and how the gut environment changes during the progression of these diseases. We found very few changes between groups from earlier stages of diabetes, but large changes in specific bacteria and bacterial genes when comparing rats from earlier stages versus rats from groups in later stages of uncontrolled diabetes…

Read more: https://www.ars.usda.gov/research/publications/publication/?seqNo115=351804

Posted by Chris Lesher on July 18, 2018

Filed Under: Publications Tagged With: Brian Piccolo, Intawat Nookaew, James Graham, Kartik Shankar, Kelly Mecer, Kimber Stanhope, Peter Havel, Sean Adams, Sree Chintapalli, Umesh Wankhade

UAMS College of Medicine LogoUAMS College of MedicineUniversity of Arkansas for Medical Sciences
Mailing Address: 4301 West Markham Street, Little Rock, AR 72205
Phone: (501) 686-7000
  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • LinkedIn
  • Pinterest
  • Disclaimer
  • Terms of Use
  • Privacy

© 2022 University of Arkansas for Medical Sciences