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  5. Host diabetes status is the major regulator of gut microbiome in the UCD-T2DM Rat

Host diabetes status is the major regulator of gut microbiome in the UCD-T2DM Rat

The FASEB  Journal 31 (1 Supplement), 138.1-138.1(2017)

Brian Piccolo, James Graham, Umesh Wankhade, Intawat Nookaew, Kartik Shankar, Peter Havel, Sean Adams

Abstract

There is strong evidence in humans and in animal models that the gut microbiome is altered in obesity and/or the insulin resistant condition. Poor metabolic health is often linked to overnutrition and poor-quality diets, and the gut microbiome is highly dependent on these factors. Less well appreciated is the potential role of host metabolic physiology in modifying gut microbial ecology. To address this question, we have used the UCD-T2DM Rat model to test whether the gut microbiome is altered during the progression of diabetes when controlling for exogenous factors (sex, strain, age, diet and vivarium housing).

Read more: https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.138.1

Posted by Chris Lesher on April 1, 2017

Filed Under: Publications Tagged With: Brian Piccolo, Intawat Nookaew, James Graham, Kartik Shankar, Peter Havel, Sean Adams, Umesh Wankhade

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