• Skip to primary navigation
  • Skip to main content
  • Skip to primary navigation
  • Skip to main content
Choose which site to search.
University of Arkansas for Medical Sciences Logo University of Arkansas for Medical Sciences
College of Medicine: Department of Biomedical Informatics
  • UAMS Health
  • Jobs
  • Giving
  • About Us
    • Employment
    • News
    • Links
    • Department Intranet
  • Faculty
    • Primary Faculty
    • Secondary Faculty
    • Adjunct Faculty
  • Staff
  • Education
    • Admission Information
    • Student Funding Opportunities
    • Graduate Programs
    • Current Course Offerings
    • DBMI FAQs
    • Research & Application Seminar
    • Recorded Sessions for CME Credit
  • INBRE
    • INBRE Bioinformatics Core Support Request Form
  • Research Labs
    • Publications
    • Arkansas Center for Genomic & Ecological Medicine (ArC-GEM)
    • Arkansas Clinical Data Repository (AR-CDR)
    • Biomedical Ontologies Arkansas (BOAR)
  • Clinical Informatics Fellowship
    • Fellowship Overview
    • Training Sites
    • Faculty
    • Current Fellows
    • Welcome to Little Rock!
  • Databases
  • Diversity, Equity, and Inclusion
    • About DBMI-DEI
    • DBMI-DEI Committee Members
    • DBMI-DEI Resources
    • DBMI-DEI Committee Events
  1. University of Arkansas for Medical Sciences
  2. College of Medicine
  3. Department of Biomedical Informatics
  4. News
  5. Kinase domain activation through gene rearrangement in multiple myeloma

Kinase domain activation through gene rearrangement in multiple myeloma

Leukemia. 2018 Mar 23. doi: 10.1038/s41375-018-0108-y

Morgan GJ, He J, Tytarenko R, Patel P, Stephens OW, Zhong S, Deshpande S, Bauer M, Weinhold N, Schinke C, Rasche L, Bailey M, Ali S, Ross J, Miller VA, Stephens P, Thanendrarajan S, Zangari M, van Rhee F, Mughal T, Davies FE, Walker BA

Abstract

Chromosomal rearrangements that result in oncogenic kinase activation are present in many solid and hematological malignancies, but none have been reported in multiple myeloma (MM). Here we analyzed 1421 samples from 958 myeloma patients using a targeted assay and detected fusion genes in 1.5% of patients. These fusion genes were in-frame and the majority of them contained kinase domains from either receptor tyrosine kinases (ALK, ROS1, NTRK3, and FGFR1) or cytoplasmic kinases (BRAF, MAP3K14, and MAPK14), which would result in the activation of MEK/ERK, NF-κB, or inflammatory signaling pathways. Fusion genes were present in smoldering MM, newly diagnosed MM, and relapse patient samples indicating they are…

Read more: https://www.ncbi.nlm.nih.gov/pubmed/29654269

Posted by Chris Lesher on March 23, 2018

Filed Under: Publications Tagged With: Ali S, Bailey M, Bauer M, Davies FE, Deshpande S, He J, Miller VA, Morgan GJ, Mughal T, Patel P, Rasche L, Ross J, Schinke C, Stephens OW, Stephens P, Thanendrarajan S, Tytarenko R, van Rhee F, Walker BA, Weinhold N, Zangari M, Zhong S

UAMS College of Medicine LogoUAMS College of MedicineUniversity of Arkansas for Medical Sciences
Mailing Address: 4301 West Markham Street, Little Rock, AR 72205
Phone: (501) 686-7000
  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • LinkedIn
  • Pinterest
  • Disclaimer
  • Terms of Use
  • Privacy

© 2023 University of Arkansas for Medical Sciences