• Skip to primary navigation
  • Skip to main content
  • Skip to primary navigation
  • Skip to main content
Choose which site to search.
University of Arkansas for Medical Sciences Logo University of Arkansas for Medical Sciences
College of Medicine: Department of Biomedical Informatics
  • UAMS Health
  • Jobs
  • Giving
  • About Us
    • Employment
    • Access, Opportunity, and Advocacy
      • About DBMI-AOA
      • Current DBMI-AOA Committee Members
      • DBMI-AOA Resources
      • DBMI-AOA Committee Events
    • Links
    • News
    • Department Intranet
  • Faculty & Staff
    • Primary Faculty
    • Secondary Faculty
    • Adjunct Faculty
    • Staff
  • Education
    • Admission Information
    • Clinical Informatics Fellowship
      • Fellowship Overview
      • Training Sites
      • Faculty
      • Current Fellows
      • Welcome to Little Rock!
    • Graduate Programs
    • Current Course Offerings
    • DBMI FAQs
    • Research & Application Seminar
    • Recorded Sessions for CME Credit
    • Student Funding Opportunities
    • Graduate Students
  • Cores and Shared Resources
    • Arkansas Clinical Data Repository (AR-CDR)
    • Bioinformatics Collaborative Resource Center
    • INBRE
      • INBRE Bioinformatics Core Support Request Form
  • Research
    • Databases
    • Research Labs
      • Biomedical Ontologies Arkansas (BOAR)
    • Publications
  • Artificial Intelligence for Health
  1. University of Arkansas for Medical Sciences
  2. College of Medicine
  3. Department of Biomedical Informatics
  4. News
  5. Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Blood. 2018 Jun 8. pii: blood-2018-03-840132. doi: 10.1182/blood-2018-03-840132

Walker BA, Mavrommatis K, Wardell CP, Ashby TC, Bauer M, Davies FE, Rosenthal A, Wang H, Qu P, Hoering A, Samur M, Towfic F, Ortiz M, Flynt E, Yu Z, Yang Z, Rozelle D, Obenauer J, Trotter M, Auclair D, Keats J, Bolli N, Fulciniti M, Szalat R, Moreau P, Durie B, Stewart AK, Goldschmidt H, Raab MS, Einsele H, Sonneveld P, San Miguel J, Lonial S, Jackson GH, Anderson KC, Avet-Loiseau H, Munshi N, Thakurta A, Morgan GJ

Abstract

Understanding the profile of oncogene and tumor suppressor gene mutations with their interactions and impact on the prognosis of multiple myeloma (MM) can improve the definition of disease subsets and identify pathways important in disease pathobiology. Using integrated genomics of 1,273 newly diagnosed patients with multiple myeloma we identify 63 driver genes, some of which are novel including IDH1, IDH2, HUWE1, KLHL6, and PTPN11. Oncogene mutations are significantly more clonal than tumor suppressor mutations, indicating they may exert…

Read more: http://www.bloodjournal.org/blood/article/132/6/587/39419/Identification-of-novel-mutational-drivers-reveals?searchresult=1

Posted by Chris Lesher on June 8, 2018

Filed Under: Publications Tagged With: Anderson KC, Ashby TC, Auclair D, Avet-Loiseau H, Bauer M, Bolli N, Davies FE, Durie B, Einsele H, Flynt E, Fulciniti M, Goldschmidt H, Hoering A, Jackson GH, Keats J, Lonial S, Mavrommatis K, Moreau P, Morgan GJ, Munshi N, Obenauer J, Ortiz M, Qu P, Raab MS, Rosenthal A, Rozelle D, Samur M, San Miguel J, Sonneveld P, Stewart AK, Szalat R, Thakurta A, Towfic F, Trotter M, Walker BA, Wang H, Wardell CP, Yang Z, Yu Z

UAMS College of Medicine LogoUAMS College of MedicineUniversity of Arkansas for Medical Sciences
Mailing Address: 4301 West Markham Street, Little Rock, AR 72205
Phone: (501) 686-7000
  • Facebook
  • X
  • Instagram
  • YouTube
  • LinkedIn
  • Pinterest
  • Disclaimer
  • Terms of Use
  • Privacy Statement

© 2025 University of Arkansas for Medical Sciences