Leukemia. 2018 Jul;32(7):1561-1566. doi: 10.1038/s41375-018-0017-0. Epub 2018 Feb 2 Pawlyn C, Loehr A, Ashby C, Tytarenko R, Deshpande S, Sun J, Fedorchak K, Mughal T, Davies FE, Walker BA, Morgan GJ Abstract PARP inhibitors can induce synthetic lethality in tumors characterized by homologous recombination deficiency (HRD), which can be detected by evaluating genome-wide loss of […]
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Liquid biopsy and its role in an advanced clinical trial for lung cancer
Exp Biol Med (Maywood). 2018 Feb;243(3):262-271. doi: 10.1177/1535370217750087 Johann DJ Jr, Steliga M, Shin IJ, Yoon D, Arnaoutakis K, Hutchins L, Liu M, Liem J, Walker K, Pereira A, Yang M, Jeffus SK, Peterson E, Xu J Abstract Liquid biopsy methodologies, for the purpose of plasma genotyping of cell-free DNA (cfDNA) of solid tumors, are […]
HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target
Clin Cancer Res. 2018 May 15;24(10):2395-2407. doi: 10.1158/1078-0432.CCR-17-1594. Epub 2018 Feb 1. Fok JHL, Hedayat S, Zhang L, Aronson LI, Mirabella F, Pawlyn C, Bright MD, Wardell CP, Keats JJ, De Billy E, Rye CS, Chessum NEA, Jones K, Morgan GJ, Eccles SA, Workman P, Davies FE Abstract Myeloma is a plasma cell malignancy characterized […]
Genomic Characterization of biliary tract cancers identifies driver genes and predisposing mutations
J Hepatol. 2018 May;68(5):959-969. doi: 10.1016/j.jhep.2018.01.009. Epub 2018 Jan 31 Wardell CP, Fujita M, Yamada T, Simbolo M, Fassan M, Karlic R, Polak P, Kim J, Hatanaka Y, Maejima K, Lawlor RT, Nakanishi Y, Mitsuhashi T, Fujimoto A, Furuta M, Ruzzenente A, Conci S, Oosawa A, Sasaki-Oku A, Nakano K, Tanaka H, Yamamoto Y, Michiaki […]
Genome Characterization of Oleaginous Aspergillus oryzae BCC7051: A Potential Fungal-Based Platform for Lipid Production
Curr Microbiol. 2018 Jan;75(1):57-70. doi: 10.1007/s00284-017-1350-7. Epub 2017 Sep 1. Thammarongtham C, Nookaew I, Vorapreeda T, Srisuk T, Land ML, Jeennor S, Laoteng K Abstract The selected robust fungus, Aspergillus oryzae strain BCC7051 is of interest for biotechnological production of lipid-derived products due to its capability to accumulate high amount of intracellular lipids using various […]
Abiotic Stresses Shift Belowground Populus-Associated Bacteria Toward a Core Stress Microbiome
mSystems, 3:e00070-17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5781258/ DOI: 10.1128/mSystems.00070-17 Abiotic Stresses Shift Belowground Populus-Associated Bacteria Toward a Core Stress Microbiome Collin M. Timm, Kelsey R. Carter, Alyssa A. Carrell, Se-Ran Jun, Sara S. Jawdy, Jessica M. Vélez, Lee E. Gunter, Zamin Yang, Intawat Nookaew, Nancy L. Engle, Tse-Yuan S. Lu, Christopher W. Schadt, Timothy J. Tschaplinski, Mitchel J. Doktycz, […]
HL7 Developmental Screening Standard Published
In 2016, UAMS (DBMI) supported the effort to complete the work on the HL7 Developmental Screening Standard. The project is now complete and the standard is published. The standard serves as a framework for the functional requirements of child health developmental screening and reporting services for electronic health record (EHR) systems. The HL7 Developmental Screening […]
Gender Differences in the Pathogenesis and Management of Heart Disease
Chapter 7 in the book “Gender Differences in the Pathogenesis and Management of Heart Disease”, Springer/Nature publishing company, in the press (January 2018). ISBN:978-3-319-71134-8 Adriana Cabal, Trudy M. Wassenaar, and David W. Ussery Abstract The literature was reviewed to search for consistently reported differences in the gut microbiome between females and males, in an […]
Distinctive molecular signature and activated signaling pathways in aortic smooth muscle cells of patients with myocardial infarction
http://www.atherosclerosis-journal.com/article/S0021-9150(18)30024-8/fulltext DOI: http://dx.doi.org/10.1016/j.atherosclerosis.2018.01.024 Atherosclerosis, manuscript in the press, accepted 16 January, 2028 Thidathip Wongsurawat, Chin Cheng Woo, Antonis Giannakakis, Xiao Yun Lin, Esther Sok Hwee Cheow, Chuen Neng Lee, Mark Richards, Siu Kwan Sze, Intawat Nookaew, Vladimir A. Kuznetsov’Correspondence information about the author Vladimir A. Kuznetsov, Vitaly Sorokin Abstract Background and aims: We aim to […]
Complete genomic and transcriptional landscape analysis using third-generation sequencing: a case study of Saccharomyces cerevisiae CEN.PK113-7D
Introduction: The genome of the most well studied eukaryotic model organism, Saccharomyces cerevisiae strain S288c, was sequenced and released in 1996; it was the first complete, high quality genome sequence of an eukaryal organism (1). Since then, the development ofDNAsequencing technologies has yielded scientific breakthroughs that enable us to obtain and analyze genomic DNA sequences […]