I joined Dr. Aachoui lab as a post-doctoral fellow in January 2019. In the Aachoui lab, we are interested in studying host-pathogen interaction using various bacterial species. We specifically focus on the innate immune system sensors called inflammasomes and associated cell death. Canonical inflammasome pathway activates caspase-1, which subsequently mediates the maturation of proinflammatory cytokines pro-IL-1b and pro-IL-18 or promotes pyroptosis. In non-canonical pathway, caspase-11 directly binds the LPS, inducing pyroptosis and the production of proinflammatory cytokines. Pyroptosis removes the replication niche of intracellular bacteria and promotes bacterial clearance through the recruited neutrophils.
My current study examines the cell type specific regulation of canonical and non-canonical inflammasome pathway. I also investigate the role of caspase-11 in neutrophil and bacterila immune evasion strategies targeting inflammasome complex using Burkhloderia thailandensis and Shigella flexneri as model bacteria.
- Oh C, Ryoo J, Park K, Kim B, Daly M, Cho D and Ahn K. A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature. Scientific Reports. 2018 Jan 8;8:84.
- Ryoo J, Hwang S-Y, Choi J, Oh C and Ahn K. SAMHD1, The Aicradi-Goutieres syndrome gene and retroviral restriction factor, is a phosphorolytic ribonuclease rather than a hydrolytic ribonuclease. Biochem Biophys Res Commun. 2016 Sep 2;477(4):977-981.
- Choi J, Ryoo J, Oh C, Hwang S and Ahn K. SAMHD1 specifically restricts retroviruses through its RNase activity. Retrovirology. 2015 Jun 2;12:46.
- Ryoo J, Choi J, Oh C, Kim S, Seo M, Kim S, Seo D, Kim J, White TE Brandariz-Nunez A, Diaz-Griffero F, Yun CH, Hollenbaugh JA, Kim B, Baek D and Ahn K. The ribonuclease activity of SAMHD1 is required for HIV-1 restriction. Nat Med. 2014 Aug;20(8):936-41.