Physiol Genomics. 2018 May 18. doi: 10.1152/physiolgenomics.00042.2017 Derda AA, Woo CC, Wongsurawat T, Richards M, Lee CN, Kofidis T, Kuznetsov VA, Sorokin VA Abstract Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques may promote plaque rupture. […]
Publications
Microcephaly by Zika Virus in Thailand Emerging Infectious Diseases
Thidathip Wongsurawat, Niracha Athipanyasilp, Piroon Jenjaroenpun, Se-Ran Jun, Bualan Kaewnapan, Trudy M. Wassenaar, Nuttawut Leelahakorn, Nasikarn Angkasekwinai, Wannee Kantakamalakul, David W. Ussery, Ruengpung Sutthent, Intawat Nookaew, Navin Horthongkham Abstract We report a confirmed case of congenital Zika virus infection with microcephaly (CZVIM) caused by autochthonous infection at week 9 of pregnancy with Zika virus (ZIKV) […]
DNAp: A Pipeline for DNA-seq Data Analysis
Scientific Reports (2018) volume 8, Article number: 6793 doi:10.1038/s41598-018-25022-6 Jason L. Causey, Cody Ashby, Karl Walker, Zhiping Paul Wang, Mary Yang, Yuanfang Guan, Jason H. Moore & Xiuzhen Huang ABSTRACT: Next-generation sequencing is empowering genetic disease research. However, it also brings significant challenges for efficient and effective sequencing data analysis. We built a pipeline, called […]
A Review of Connectivity Map and Computational Approaches in Pharmacogenomics
Briefings in Bioinformatics, 19(3):506-523 | DOI: 10.1093/bib/bbw112 Musa A., Ghoraie L.S., Zhang S.,Glazko G., Yli-Harja O., Dehmer M., Haibe-Kains B., Emmert-Streib F. Abstract Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast […]
1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition
Bioorg Med Chem Lett. 2018 Jun 15;28(11):2103-2108. doi: 10.1016/j.bmcl.2018.04.035. Epub 2018 Apr 17 Boezio AA, Andrews K, Boezio C, Chu-Moyer M, Copeland KW, DiMauro EF, Foti RS, Fremeau RT Jr, Gao H, Geuns-Meyer S, Graceffa RF, Gunaydin H, Huang H, La DS, Ligutti J, Moyer BD, Peterson EA, Yu V, Weiss MM Abstract Recently, the […]
Temporal Dynamics of Gut Microbiota in Triclocarban-Exposed Weaned Rats
Authors: Rebekah C. Kennedy, Russell R. Fling, Michael S. Robeson, Arnold M. Saxton, Liesel G. Schneider, John L. Darcy, David A. Bemis, Ling Zhao, Jiangang Chen ABSTRACT: Widely used as an antimicrobial in antibacterial bar soaps, triclocarban (3,4,4′-trichlorocarbanilide; TCC) is effective against Gram-positive bacteria but shows little efficacy against Gram-negative strains, potentially altering the composition […]
The diversity and specificity of the extracellular proteome in the cellulolytic bacterium Caldicellulosiruptor bescii is driven by the nature of the cellulosic growth substrate
Biotechnol Biofuels. 2018 Mar 23 | DOI: 10.1186/s13068-018-1076-1 Poudel S, Giannone RJ, Basen M, Nookaew I, Poole FL, Kelly RM, Adams MWW, Hettich RL Abstract Caldicellulosiruptor bescii is a thermophilic cellulolytic bacterium that efficiently deconstructs lignocellulosic biomass into sugars, which subsequently can be fermented into alcohols, such as ethanol, and other products. Deconstruction of complex substrates by C. bescii involves a […]
Kinase domain activation through gene rearrangement in multiple myeloma
Leukemia. 2018 Mar 23. doi: 10.1038/s41375-018-0108-y Morgan GJ, He J, Tytarenko R, Patel P, Stephens OW, Zhong S, Deshpande S, Bauer M, Weinhold N, Schinke C, Rasche L, Bailey M, Ali S, Ross J, Miller VA, Stephens P, Thanendrarajan S, Zangari M, van Rhee F, Mughal T, Davies FE, Walker BA Abstract Chromosomal rearrangements that […]
Modeling the Personal Health Ecosystem
Stud Health Technology Informatics. 2018;249:38-49 Blobel B, Brochhausen, Ruotsalainen P. Abstract Complex ecosystems like the pHealth one combine different domains represented by a huge variety of different actors (human beings, organizations, devices, applications, components) belonging to different policy domains, coming from different disciplines, deploying different methodologies, terminologies, and ontologies, offering different levels of knowledge, skills, […]
UAMS Team First to Add Directly Sequenced RNA to Public Database
A group of UAMS researchers is the first to deposit directly sequenced RNA to the National Center for Biotechnology Information databases, made possible by their utilization of a novel, handheld genetic sequencing technology. The federal government maintains a collection of databases with the aim of advancing science and health by providing public access to biomedical […]