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  1. University of Arkansas for Medical Sciences
  2. College of Medicine
  3. Department of Biomedical Informatics
  4. Author: Chris Lesher
  5. Page 3

Chris Lesher

PARP1 is up-regulated in Non-small cell lung cancer tissues in the presence of the cyanobacterial toxin microcystin

Front. Microbiol. | doi: 10.3389/fmicb.2018.01757 Patrick Apopa, Lisa Alley, Rosalind Penney, Konstantinos Arnaoutakis, Mathew Steliga, Susan Jeffus, Emine Bircan, Banu Gopalan, Jing Jin, Preecha Patumcharoenpol, Piroon Jenjaroenpun, Thidathip Wongsurawat, Nishi Shah, Gunnar Boysen, David Ussery, Intawat Nookaew, Pebbles Fagan, Gurkan Bebek, Mohammed Orloff Abstract Non-small cell lung cancer (NSCLC) is the major form of lung […]

Filed Under: Publications Tagged With: Banu Gopalan, David Ussery, Emine Bircan, Gunnar Boysen, Gurkan Bebek, Intawat Nookaew, Jing Jin, Konstantinos Arnaoutakis, Lisa Alley, Mathew Steliga, Mohammed Orloff, Nishi Shah, Patrick Apopa, Pebbles Fagan, Piroon Jenjaroenpun, Preecha Patumcharoenpol, Rosalind Penney, Susan Jeffus, Thidathip Wongsurawat

Highly accurate model for prediction of lung nodule malignancy with CT scans

Scientific Reports, Nature. volume 8, Article number: 9286 (2018) Jason L. Causey, Junyu Zhang, Shiqian Ma, Bo Jiang, Jake A. Qualls, David G. Politte, Fred Prior, Shuzhong Zhang, Xiuzhen Huang Abstract Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for […]

Filed Under: Publications Tagged With: Bo Jiang, David G. Politte, Fred Prior, Jake A. Qualls, Jason L. Causey, Junyu Zhang, Shiqian Ma, Shuzhong Zhang, Xiuzhen Huang

E. coli and colorectal cancer, a complex relationship that deserves a critical mindset

Crit Rev Microbiol. 2018 Jun 17:1-14. doi: 10.1080/1040841X.2018.1481013 Trudy M. Wassenaar Abstract To the multiple factors that may eventually result in colorectal cancer (CRC), strains of E. coli have now been added, in particular strains producing colibactin from their polyketide synthesis (pks) locus. The evidence and mechanistic explanations for this unfortunate effect of what is in […]

Filed Under: Publications Tagged With: colorectal cancer, E. coli, Trudy M. Wassenaar

Reengineering Workflow for Curation of DICOM Datasets

J Digital Imaging (15 Jun 2018). https://doi.org/10.1007/s10278-018-0097-4 William Bennett, Kirk Smith, Quasar Jarosz, Tracy Nolan, Walter Bosch Abstract Reusable, publicly available data is a pillar of open science and rapid advancement of cancer imaging research. Sharing data from completed research studies not only saves research dollars required to collect data, but also helps insure that […]

Filed Under: Publications Tagged With: Curation, De-identification, DICOM, Image archive, Kirk Smith, Open science, Posda, Quasar Jarosz, Scalability, TCIA, Tracy Nolan, Walter Bosch, William Bennett

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Blood. 2018 Jun 8. pii: blood-2018-03-840132. doi: 10.1182/blood-2018-03-840132 Walker BA, Mavrommatis K, Wardell CP, Ashby TC, Bauer M, Davies FE, Rosenthal A, Wang H, Qu P, Hoering A, Samur M, Towfic F, Ortiz M, Flynt E, Yu Z, Yang Z, Rozelle D, Obenauer J, Trotter M, Auclair D, Keats J, Bolli N, Fulciniti M, Szalat […]

Filed Under: Publications Tagged With: Anderson KC, Ashby TC, Auclair D, Avet-Loiseau H, Bauer M, Bolli N, Davies FE, Durie B, Einsele H, Flynt E, Fulciniti M, Goldschmidt H, Hoering A, Jackson GH, Keats J, Lonial S, Mavrommatis K, Moreau P, Morgan GJ, Munshi N, Obenauer J, Ortiz M, Qu P, Raab MS, Rosenthal A, Rozelle D, Samur M, San Miguel J, Sonneveld P, Stewart AK, Szalat R, Thakurta A, Towfic F, Trotter M, Walker BA, Wang H, Wardell CP, Yang Z, Yu Z

Gene expression profile analysis of aortic vascular smooth muscle cells reveals upregulation of cadherin genes in myocardial infarction patients

Physiol Genomics. 2018 May 18. doi: 10.1152/physiolgenomics.00042.2017 Derda AA, Woo CC, Wongsurawat T, Richards M, Lee CN, Kofidis T, Kuznetsov VA, Sorokin VA Abstract Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques may promote plaque rupture. […]

Filed Under: Publications Tagged With: Derda AA, Kofidis T, Kuznetsov VA, Lee CN, Richards M, Sorokin VA, Wongsurawat T, Woo CC

Microcephaly by Zika Virus in Thailand Emerging Infectious Diseases

Thidathip Wongsurawat, Niracha Athipanyasilp, Piroon Jenjaroenpun, Se-Ran Jun, Bualan Kaewnapan, Trudy M. Wassenaar, Nuttawut Leelahakorn, Nasikarn Angkasekwinai, Wannee Kantakamalakul, David W. Ussery, Ruengpung Sutthent, Intawat Nookaew, Navin Horthongkham Abstract We report a confirmed case of congenital Zika virus infection with microcephaly (CZVIM) caused by autochthonous infection at week 9 of pregnancy with Zika virus (ZIKV) […]

Filed Under: Publications Tagged With: Bualan Kaewnapan, David W. Ussery, Intawat Nookaew, Microcephaly, Nasikarn Angkasekwinai, Navin Horthongkham, Niracha Athipanyasilp, Nuttawut Leelahakorn, Piroon Jenjaroenpun, Ruengpung Sutthent, Se-Ran Jun, Thailand, Thidathip Wongsurawat, Trudy M. Wassenaar, Wannee Kantakamalakul, Zika

DNAp: A Pipeline for DNA-seq Data Analysis

Scientific Reports (2018) volume 8, Article number: 6793  doi:10.1038/s41598-018-25022-6 Jason L. Causey, Cody Ashby, Karl Walker, Zhiping Paul Wang, Mary Yang, Yuanfang Guan, Jason H. Moore & Xiuzhen Huang ABSTRACT: Next-generation sequencing is empowering genetic disease research. However, it also brings significant challenges for efficient and effective sequencing data analysis. We built a pipeline, called […]

Filed Under: Department News, Publications Tagged With: Cody Ashby, Jason H. Moore, Jason L. Causey, Karl Walker, Mary Yang, Xiuzhen Huang, Yuanfang Guan, Zhiping Paul Wang

A Review of Connectivity Map and Computational Approaches in Pharmacogenomics

Briefings in Bioinformatics, 19(3):506-523 | DOI: 10.1093/bib/bbw112 Musa A., Ghoraie L.S., Zhang S.,Glazko G., Yli-Harja O., Dehmer M., Haibe-Kains B., Emmert-Streib F. Abstract Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast […]

Filed Under: Publications Tagged With: Dehmer M., Emmert-Streib F., Ghoraie L.S., Glazko G., Haibe-Kains B., Musa A., Yli-Harja O., Zhang S.

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2103-2108. doi: 10.1016/j.bmcl.2018.04.035. Epub 2018 Apr 17 Boezio AA, Andrews K, Boezio C, Chu-Moyer M, Copeland KW, DiMauro EF, Foti RS, Fremeau RT Jr, Gao H, Geuns-Meyer S, Graceffa RF, Gunaydin H, Huang H, La DS, Ligutti J, Moyer BD, Peterson EA, Yu V, Weiss MM Abstract Recently, the […]

Filed Under: Publications Tagged With: Andrews K, Boezio AA, Boezio C, Chu-Moyer M, Copeland KW, DiMauro EF, Foti RS, Fremeau RT Jr, Gao H, Geuns-Meyer S, Graceffa RF, Gunaydin H, Huang H, La DS, Ligutti J, Moyer BD, Peterson EA, Weiss MM, Yu V

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